Amino acid dipepetide frequency for Trichoderma asperellum CBS 433.97

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.873AlaAla: 9.873 ± 0.057	1.159AlaCys: 1.159 ± 0.017	4.234AlaAsp: 4.234 ± 0.029	5.107AlaGlu: 5.107 ± 0.041	3.148AlaPhe: 3.148 ± 0.027	5.668AlaGly: 5.668 ± 0.039	1.754AlaHis: 1.754 ± 0.019	4.651AlaIle: 4.651 ± 0.037	4.256AlaLys: 4.256 ± 0.037	7.774AlaLeu: 7.774 ± 0.045	2.03AlaMet: 2.03 ± 0.02	3.129AlaAsn: 3.129 ± 0.024	4.676AlaPro: 4.676 ± 0.04	3.47AlaGln: 3.47 ± 0.033	4.774AlaArg: 4.774 ± 0.036	7.551AlaSer: 7.551 ± 0.042	5.354AlaThr: 5.354 ± 0.038	5.419AlaVal: 5.419 ± 0.037	1.206AlaTrp: 1.206 ± 0.018	2.223AlaTyr: 2.223 ± 0.023	0.001AlaXaa: 0.001 ± 0.0
Cys	0.983CysAla: 0.983 ± 0.012	0.322CysCys: 0.322 ± 0.01	0.716CysAsp: 0.716 ± 0.015	0.607CysGlu: 0.607 ± 0.01	0.626CysPhe: 0.626 ± 0.014	1.014CysGly: 1.014 ± 0.018	0.373CysHis: 0.373 ± 0.008	0.798CysIle: 0.798 ± 0.013	0.534CysLys: 0.534 ± 0.01	1.354CysLeu: 1.354 ± 0.018	0.292CysMet: 0.292 ± 0.008	0.487CysAsn: 0.487 ± 0.012	0.679CysPro: 0.679 ± 0.013	0.512CysGln: 0.512 ± 0.01	0.787CysArg: 0.787 ± 0.014	1.07CysSer: 1.07 ± 0.018	0.723CysThr: 0.723 ± 0.011	0.83CysVal: 0.83 ± 0.016	0.231CysTrp: 0.231 ± 0.008	0.39CysTyr: 0.39 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.769AspAla: 4.769 ± 0.028	0.67AspCys: 0.67 ± 0.015	4.32AspAsp: 4.32 ± 0.04	4.484AspGlu: 4.484 ± 0.042	2.215AspPhe: 2.215 ± 0.021	4.153AspGly: 4.153 ± 0.031	1.163AspHis: 1.163 ± 0.014	3.293AspIle: 3.293 ± 0.025	2.534AspLys: 2.534 ± 0.024	4.863AspLeu: 4.863 ± 0.033	1.305AspMet: 1.305 ± 0.014	1.94AspAsn: 1.94 ± 0.021	3.003AspPro: 3.003 ± 0.022	1.795AspGln: 1.795 ± 0.017	2.858AspArg: 2.858 ± 0.029	4.125AspSer: 4.125 ± 0.03	2.798AspThr: 2.798 ± 0.023	3.598AspVal: 3.598 ± 0.028	0.876AspTrp: 0.876 ± 0.013	1.59AspTyr: 1.59 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.58GluAla: 5.58 ± 0.043	0.64GluCys: 0.64 ± 0.012	4.099GluAsp: 4.099 ± 0.036	5.373GluGlu: 5.373 ± 0.066	1.97GluPhe: 1.97 ± 0.02	3.462GluGly: 3.462 ± 0.028	1.324GluHis: 1.324 ± 0.018	3.142GluIle: 3.142 ± 0.023	3.646GluLys: 3.646 ± 0.031	5.145GluLeu: 5.145 ± 0.043	1.494GluMet: 1.494 ± 0.018	2.279GluAsn: 2.279 ± 0.022	2.691GluPro: 2.691 ± 0.032	2.431GluGln: 2.431 ± 0.025	3.692GluArg: 3.692 ± 0.036	4.275GluSer: 4.275 ± 0.03	3.356GluThr: 3.356 ± 0.026	3.302GluVal: 3.302 ± 0.029	0.884GluTrp: 0.884 ± 0.013	1.656GluTyr: 1.656 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.062PheAla: 3.062 ± 0.023	0.6PheCys: 0.6 ± 0.01	2.298PheAsp: 2.298 ± 0.019	2.108PheGlu: 2.108 ± 0.017	1.818PhePhe: 1.818 ± 0.027	2.861PheGly: 2.861 ± 0.025	0.915PheHis: 0.915 ± 0.011	2.055PheIle: 2.055 ± 0.022	1.57PheLys: 1.57 ± 0.017	3.552PheLeu: 3.552 ± 0.032	0.797PheMet: 0.797 ± 0.012	1.526PheAsn: 1.526 ± 0.017	1.952PhePro: 1.952 ± 0.019	1.44PheGln: 1.44 ± 0.018	1.921PheArg: 1.921 ± 0.022	3.189PheSer: 3.189 ± 0.029	2.156PheThr: 2.156 ± 0.022	2.377PheVal: 2.377 ± 0.024	0.668PheTrp: 0.668 ± 0.012	1.171PheTyr: 1.171 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.274GlyAla: 5.274 ± 0.037	0.925GlyCys: 0.925 ± 0.016	3.578GlyAsp: 3.578 ± 0.028	3.594GlyGlu: 3.594 ± 0.026	2.777GlyPhe: 2.777 ± 0.026	5.59GlyGly: 5.59 ± 0.059	1.667GlyHis: 1.667 ± 0.022	3.681GlyIle: 3.681 ± 0.031	3.397GlyLys: 3.397 ± 0.026	6.043GlyLeu: 6.043 ± 0.041	1.53GlyMet: 1.53 ± 0.018	2.626GlyAsn: 2.626 ± 0.027	3.177GlyPro: 3.177 ± 0.035	2.51GlyGln: 2.51 ± 0.026	4.035GlyArg: 4.035 ± 0.032	5.762GlySer: 5.762 ± 0.041	3.821GlyThr: 3.821 ± 0.044	4.212GlyVal: 4.212 ± 0.036	1.177GlyTrp: 1.177 ± 0.016	2.136GlyTyr: 2.136 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.767HisAla: 1.767 ± 0.018	0.356HisCys: 0.356 ± 0.009	1.302HisAsp: 1.302 ± 0.016	1.275HisGlu: 1.275 ± 0.016	0.932HisPhe: 0.932 ± 0.013	1.689HisGly: 1.689 ± 0.02	0.893HisHis: 0.893 ± 0.018	1.289HisIle: 1.289 ± 0.015	0.946HisLys: 0.946 ± 0.015	2.247HisLeu: 2.247 ± 0.024	0.522HisMet: 0.522 ± 0.01	0.863HisAsn: 0.863 ± 0.012	1.53HisPro: 1.53 ± 0.02	1.044HisGln: 1.044 ± 0.014	1.491HisArg: 1.491 ± 0.018	1.852HisSer: 1.852 ± 0.02	1.211HisThr: 1.211 ± 0.017	1.425HisVal: 1.425 ± 0.017	0.349HisTrp: 0.349 ± 0.008	0.692HisTyr: 0.692 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.405IleAla: 4.405 ± 0.03	0.824IleCys: 0.824 ± 0.013	3.002IleAsp: 3.002 ± 0.026	3.022IleGlu: 3.022 ± 0.028	2.177IlePhe: 2.177 ± 0.024	3.377IleGly: 3.377 ± 0.033	1.311IleHis: 1.311 ± 0.015	2.885IleIle: 2.885 ± 0.032	2.447IleLys: 2.447 ± 0.024	4.753IleLeu: 4.753 ± 0.033	1.093IleMet: 1.093 ± 0.014	1.998IleAsn: 1.998 ± 0.021	3.093IlePro: 3.093 ± 0.024	2.109IleGln: 2.109 ± 0.024	2.956IleArg: 2.956 ± 0.026	4.264IleSer: 4.264 ± 0.029	2.966IleThr: 2.966 ± 0.028	3.268IleVal: 3.268 ± 0.027	0.791IleTrp: 0.791 ± 0.012	1.503IleTyr: 1.503 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.395LysAla: 4.395 ± 0.032	0.523LysCys: 0.523 ± 0.011	2.83LysAsp: 2.83 ± 0.026	3.337LysGlu: 3.337 ± 0.032	1.552LysPhe: 1.552 ± 0.016	2.937LysGly: 2.937 ± 0.028	1.122LysHis: 1.122 ± 0.014	2.429LysIle: 2.429 ± 0.022	3.449LysLys: 3.449 ± 0.042	4.256LysLeu: 4.256 ± 0.028	1.077LysMet: 1.077 ± 0.014	1.821LysAsn: 1.821 ± 0.021	2.704LysPro: 2.704 ± 0.029	1.913LysGln: 1.913 ± 0.019	3.396LysArg: 3.396 ± 0.035	3.595LysSer: 3.595 ± 0.032	2.864LysThr: 2.864 ± 0.023	2.73LysVal: 2.73 ± 0.024	0.685LysTrp: 0.685 ± 0.014	1.434LysTyr: 1.434 ± 0.017	0.001LysXaa: 0.001 ± 0.0
Leu	7.983LeuAla: 7.983 ± 0.047	1.309LeuCys: 1.309 ± 0.018	5.164LeuAsp: 5.164 ± 0.034	5.38LeuGlu: 5.38 ± 0.038	3.469LeuPhe: 3.469 ± 0.03	5.91LeuGly: 5.91 ± 0.046	2.204LeuHis: 2.204 ± 0.021	4.17LeuIle: 4.17 ± 0.037	4.25LeuLys: 4.25 ± 0.03	8.544LeuLeu: 8.544 ± 0.069	1.868LeuMet: 1.868 ± 0.018	3.226LeuAsn: 3.226 ± 0.034	5.471LeuPro: 5.471 ± 0.04	3.895LeuGln: 3.895 ± 0.031	5.589LeuArg: 5.589 ± 0.041	7.577LeuSer: 7.577 ± 0.043	4.704LeuThr: 4.704 ± 0.035	5.427LeuVal: 5.427 ± 0.035	1.258LeuTrp: 1.258 ± 0.019	2.415LeuTyr: 2.415 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.39MetAla: 2.39 ± 0.022	0.257MetCys: 0.257 ± 0.007	1.263MetAsp: 1.263 ± 0.016	1.305MetGlu: 1.305 ± 0.016	0.724MetPhe: 0.724 ± 0.012	1.487MetGly: 1.487 ± 0.017	0.475MetHis: 0.475 ± 0.009	1.044MetIle: 1.044 ± 0.014	1.042MetLys: 1.042 ± 0.015	1.913MetLeu: 1.913 ± 0.02	0.618MetMet: 0.618 ± 0.012	0.845MetAsn: 0.845 ± 0.012	1.354MetPro: 1.354 ± 0.016	0.894MetGln: 0.894 ± 0.013	1.297MetArg: 1.297 ± 0.018	1.849MetSer: 1.849 ± 0.019	1.276MetThr: 1.276 ± 0.017	1.275MetVal: 1.275 ± 0.015	0.273MetTrp: 0.273 ± 0.007	0.548MetTyr: 0.548 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.172AsnAla: 3.172 ± 0.026	0.49AsnCys: 0.49 ± 0.011	2.016AsnAsp: 2.016 ± 0.022	2.058AsnGlu: 2.058 ± 0.02	1.454AsnPhe: 1.454 ± 0.018	3.068AsnGly: 3.068 ± 0.039	0.87AsnHis: 0.87 ± 0.014	2.219AsnIle: 2.219 ± 0.019	1.707AsnLys: 1.707 ± 0.019	3.339AsnLeu: 3.339 ± 0.024	0.901AsnMet: 0.901 ± 0.012	1.668AsnAsn: 1.668 ± 0.02	2.371AsnPro: 2.371 ± 0.023	1.384AsnGln: 1.384 ± 0.016	1.97AsnArg: 1.97 ± 0.019	2.91AsnSer: 2.91 ± 0.024	2.166AsnThr: 2.166 ± 0.021	2.311AsnVal: 2.311 ± 0.022	0.585AsnTrp: 0.585 ± 0.01	1.108AsnTyr: 1.108 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.047ProAla: 5.047 ± 0.042	0.619ProCys: 0.619 ± 0.011	3.003ProAsp: 3.003 ± 0.027	3.601ProGlu: 3.601 ± 0.031	2.086ProPhe: 2.086 ± 0.02	3.756ProGly: 3.756 ± 0.037	1.28ProHis: 1.28 ± 0.017	2.666ProIle: 2.666 ± 0.023	2.637ProLys: 2.637 ± 0.026	4.8ProLeu: 4.8 ± 0.032	1.104ProMet: 1.104 ± 0.018	2.226ProAsn: 2.226 ± 0.02	4.943ProPro: 4.943 ± 0.068	2.411ProGln: 2.411 ± 0.029	3.289ProArg: 3.289 ± 0.032	5.766ProSer: 5.766 ± 0.043	3.658ProThr: 3.658 ± 0.029	3.373ProVal: 3.373 ± 0.029	0.751ProTrp: 0.751 ± 0.014	1.471ProTyr: 1.471 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.549GlnAla: 3.549 ± 0.033	0.478GlnCys: 0.478 ± 0.01	2.071GlnAsp: 2.071 ± 0.017	2.328GlnGlu: 2.328 ± 0.024	1.339GlnPhe: 1.339 ± 0.016	2.442GlnGly: 2.442 ± 0.02	1.062GlnHis: 1.062 ± 0.016	1.959GlnIle: 1.959 ± 0.02	1.985GlnLys: 1.985 ± 0.019	3.614GlnLeu: 3.614 ± 0.03	0.9GlnMet: 0.9 ± 0.014	1.565GlnAsn: 1.565 ± 0.018	2.545GlnPro: 2.545 ± 0.031	2.626GlnGln: 2.626 ± 0.055	2.626GlnArg: 2.626 ± 0.024	3.12GlnSer: 3.12 ± 0.025	2.255GlnThr: 2.255 ± 0.024	2.158GlnVal: 2.158 ± 0.02	0.596GlnTrp: 0.596 ± 0.012	1.187GlnTyr: 1.187 ± 0.015	0.001GlnXaa: 0.001 ± 0.0
Arg	4.528ArgAla: 4.528 ± 0.03	0.802ArgCys: 0.802 ± 0.014	3.321ArgAsp: 3.321 ± 0.03	3.658ArgGlu: 3.658 ± 0.036	2.1ArgPhe: 2.1 ± 0.018	3.64ArgGly: 3.64 ± 0.03	1.594ArgHis: 1.594 ± 0.018	3.0ArgIle: 3.0 ± 0.026	3.317ArgLys: 3.317 ± 0.033	5.517ArgLeu: 5.517 ± 0.041	1.294ArgMet: 1.294 ± 0.014	2.223ArgAsn: 2.223 ± 0.021	3.413ArgPro: 3.413 ± 0.032	2.598ArgGln: 2.598 ± 0.023	4.996ArgArg: 4.996 ± 0.051	4.648ArgSer: 4.648 ± 0.035	3.024ArgThr: 3.024 ± 0.023	3.223ArgVal: 3.223 ± 0.021	0.907ArgTrp: 0.907 ± 0.013	1.662ArgTyr: 1.662 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.808SerAla: 6.808 ± 0.045	1.007SerCys: 1.007 ± 0.015	4.209SerAsp: 4.209 ± 0.031	4.098SerGlu: 4.098 ± 0.033	3.163SerPhe: 3.163 ± 0.026	5.605SerGly: 5.605 ± 0.038	1.996SerHis: 1.996 ± 0.023	4.341SerIle: 4.341 ± 0.031	3.881SerLys: 3.881 ± 0.028	7.488SerLeu: 7.488 ± 0.04	1.776SerMet: 1.776 ± 0.019	3.121SerAsn: 3.121 ± 0.025	5.335SerPro: 5.335 ± 0.05	3.418SerGln: 3.418 ± 0.026	5.007SerArg: 5.007 ± 0.042	9.054SerSer: 9.054 ± 0.072	5.357SerThr: 5.357 ± 0.041	4.546SerVal: 4.546 ± 0.03	1.179SerTrp: 1.179 ± 0.016	2.158SerTyr: 2.158 ± 0.022	0.001SerXaa: 0.001 ± 0.0
Thr	5.244ThrAla: 5.244 ± 0.038	0.805ThrCys: 0.805 ± 0.014	2.71ThrAsp: 2.71 ± 0.023	3.031ThrGlu: 3.031 ± 0.027	2.228ThrPhe: 2.228 ± 0.021	4.011ThrGly: 4.011 ± 0.044	1.215ThrHis: 1.215 ± 0.016	3.199ThrIle: 3.199 ± 0.029	2.626ThrLys: 2.626 ± 0.024	5.089ThrLeu: 5.089 ± 0.039	1.17ThrMet: 1.17 ± 0.015	2.12ThrAsn: 2.12 ± 0.023	3.975ThrPro: 3.975 ± 0.033	2.011ThrGln: 2.011 ± 0.018	2.984ThrArg: 2.984 ± 0.022	5.114ThrSer: 5.114 ± 0.038	4.026ThrThr: 4.026 ± 0.043	3.628ThrVal: 3.628 ± 0.029	0.848ThrTrp: 0.848 ± 0.012	1.6ThrTyr: 1.6 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.291ValAla: 5.291 ± 0.038	0.872ValCys: 0.872 ± 0.016	3.609ValAsp: 3.609 ± 0.026	3.658ValGlu: 3.658 ± 0.03	2.475ValPhe: 2.475 ± 0.026	3.822ValGly: 3.822 ± 0.032	1.316ValHis: 1.316 ± 0.016	3.094ValIle: 3.094 ± 0.027	2.863ValLys: 2.863 ± 0.024	5.453ValLeu: 5.453 ± 0.041	1.326ValMet: 1.326 ± 0.015	2.247ValAsn: 2.247 ± 0.021	3.443ValPro: 3.443 ± 0.031	2.275ValGln: 2.275 ± 0.021	3.19ValArg: 3.19 ± 0.025	4.63ValSer: 4.63 ± 0.031	3.447ValThr: 3.447 ± 0.025	4.163ValVal: 4.163 ± 0.032	0.856ValTrp: 0.856 ± 0.014	1.7ValTyr: 1.7 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.187TrpAla: 1.187 ± 0.018	0.211TrpCys: 0.211 ± 0.007	0.932TrpAsp: 0.932 ± 0.017	0.845TrpGlu: 0.845 ± 0.014	0.546TrpPhe: 0.546 ± 0.01	0.931TrpGly: 0.931 ± 0.014	0.367TrpHis: 0.367 ± 0.008	0.824TrpIle: 0.824 ± 0.013	0.795TrpLys: 0.795 ± 0.013	1.406TrpLeu: 1.406 ± 0.021	0.365TrpMet: 0.365 ± 0.008	0.675TrpAsn: 0.675 ± 0.013	0.666TrpPro: 0.666 ± 0.012	0.571TrpGln: 0.571 ± 0.011	0.995TrpArg: 0.995 ± 0.014	1.075TrpSer: 1.075 ± 0.015	0.895TrpThr: 0.895 ± 0.013	0.871TrpVal: 0.871 ± 0.014	0.299TrpTrp: 0.299 ± 0.008	0.422TrpTyr: 0.422 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.15TyrAla: 2.15 ± 0.021	0.458TyrCys: 0.458 ± 0.01	1.677TyrAsp: 1.677 ± 0.021	1.573TyrGlu: 1.573 ± 0.018	1.238TyrPhe: 1.238 ± 0.018	2.09TyrGly: 2.09 ± 0.024	0.772TyrHis: 0.772 ± 0.013	1.507TyrIle: 1.507 ± 0.017	1.167TyrLys: 1.167 ± 0.014	2.662TyrLeu: 2.662 ± 0.025	0.661TyrMet: 0.661 ± 0.012	1.18TyrAsn: 1.18 ± 0.014	1.463TyrPro: 1.463 ± 0.017	1.1TyrGln: 1.1 ± 0.015	1.615TyrArg: 1.615 ± 0.018	2.121TyrSer: 2.121 ± 0.02	1.58TyrThr: 1.58 ± 0.014	1.594TyrVal: 1.594 ± 0.018	0.458TyrTrp: 0.458 ± 0.01	0.959TyrTyr: 0.959 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.023XaaXaa: 0.023 ± 0.01

Statistics based on 12547 proteins (5543688 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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