Amino acid dipepetide frequency for Intrasporangium chromatireducens Q5-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.878AlaAla: 19.878 ± 0.184	0.964AlaCys: 0.964 ± 0.028	7.794AlaAsp: 7.794 ± 0.081	7.716AlaGlu: 7.716 ± 0.098	3.486AlaPhe: 3.486 ± 0.05	12.418AlaGly: 12.418 ± 0.12	2.739AlaHis: 2.739 ± 0.045	4.753AlaIle: 4.753 ± 0.057	2.876AlaLys: 2.876 ± 0.061	13.733AlaLeu: 13.733 ± 0.122	2.763AlaMet: 2.763 ± 0.045	2.1AlaAsn: 2.1 ± 0.04	6.234AlaPro: 6.234 ± 0.09	3.964AlaGln: 3.964 ± 0.057	9.756AlaArg: 9.756 ± 0.09	6.466AlaSer: 6.466 ± 0.086	7.638AlaThr: 7.638 ± 0.089	11.655AlaVal: 11.655 ± 0.113	1.982AlaTrp: 1.982 ± 0.041	2.434AlaTyr: 2.434 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.827CysAla: 0.827 ± 0.026	0.085CysCys: 0.085 ± 0.008	0.411CysAsp: 0.411 ± 0.018	0.388CysGlu: 0.388 ± 0.017	0.22CysPhe: 0.22 ± 0.012	0.864CysGly: 0.864 ± 0.027	0.184CysHis: 0.184 ± 0.011	0.247CysIle: 0.247 ± 0.014	0.099CysLys: 0.099 ± 0.009	0.644CysLeu: 0.644 ± 0.023	0.105CysMet: 0.105 ± 0.009	0.122CysAsn: 0.122 ± 0.009	0.443CysPro: 0.443 ± 0.022	0.164CysGln: 0.164 ± 0.012	0.573CysArg: 0.573 ± 0.021	0.409CysSer: 0.409 ± 0.02	0.467CysThr: 0.467 ± 0.02	0.55CysVal: 0.55 ± 0.017	0.102CysTrp: 0.102 ± 0.009	0.155CysTyr: 0.155 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.52AspAla: 7.52 ± 0.082	0.374AspCys: 0.374 ± 0.016	3.695AspAsp: 3.695 ± 0.06	4.384AspGlu: 4.384 ± 0.07	1.54AspPhe: 1.54 ± 0.035	5.666AspGly: 5.666 ± 0.071	1.393AspHis: 1.393 ± 0.035	1.982AspIle: 1.982 ± 0.042	1.122AspLys: 1.122 ± 0.029	6.839AspLeu: 6.839 ± 0.07	0.796AspMet: 0.796 ± 0.02	0.92AspAsn: 0.92 ± 0.028	4.317AspPro: 4.317 ± 0.06	1.687AspGln: 1.687 ± 0.03	4.975AspArg: 4.975 ± 0.059	2.335AspSer: 2.335 ± 0.047	2.847AspThr: 2.847 ± 0.051	5.723AspVal: 5.723 ± 0.073	0.942AspTrp: 0.942 ± 0.028	1.188AspTyr: 1.188 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.223GluAla: 7.223 ± 0.09	0.33GluCys: 0.33 ± 0.016	2.881GluAsp: 2.881 ± 0.057	3.084GluGlu: 3.084 ± 0.06	1.407GluPhe: 1.407 ± 0.029	4.211GluGly: 4.211 ± 0.059	1.715GluHis: 1.715 ± 0.038	2.182GluIle: 2.182 ± 0.04	1.12GluLys: 1.12 ± 0.032	6.197GluLeu: 6.197 ± 0.072	0.929GluMet: 0.929 ± 0.024	0.857GluAsn: 0.857 ± 0.025	3.281GluPro: 3.281 ± 0.054	2.554GluGln: 2.554 ± 0.051	5.544GluArg: 5.544 ± 0.078	2.737GluSer: 2.737 ± 0.049	2.776GluThr: 2.776 ± 0.048	5.043GluVal: 5.043 ± 0.07	0.855GluTrp: 0.855 ± 0.027	0.901GluTyr: 0.901 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.522PheAla: 3.522 ± 0.045	0.242PheCys: 0.242 ± 0.014	1.951PheAsp: 1.951 ± 0.042	1.488PheGlu: 1.488 ± 0.031	0.961PhePhe: 0.961 ± 0.035	3.026PheGly: 3.026 ± 0.048	0.622PheHis: 0.622 ± 0.024	1.01PheIle: 1.01 ± 0.029	0.469PheLys: 0.469 ± 0.02	2.561PheLeu: 2.561 ± 0.047	0.417PheMet: 0.417 ± 0.016	0.579PheAsn: 0.579 ± 0.022	1.351PhePro: 1.351 ± 0.032	0.645PheGln: 0.645 ± 0.021	1.729PheArg: 1.729 ± 0.034	1.444PheSer: 1.444 ± 0.034	1.908PheThr: 1.908 ± 0.04	2.622PheVal: 2.622 ± 0.045	0.412PheTrp: 0.412 ± 0.02	0.591PheTyr: 0.591 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.686GlyAla: 10.686 ± 0.11	0.722GlyCys: 0.722 ± 0.025	4.935GlyAsp: 4.935 ± 0.065	4.746GlyGlu: 4.746 ± 0.067	2.871GlyPhe: 2.871 ± 0.045	8.064GlyGly: 8.064 ± 0.098	2.227GlyHis: 2.227 ± 0.037	4.117GlyIle: 4.117 ± 0.057	2.19GlyLys: 2.19 ± 0.046	9.709GlyLeu: 9.709 ± 0.095	2.064GlyMet: 2.064 ± 0.04	1.689GlyAsn: 1.689 ± 0.044	4.774GlyPro: 4.774 ± 0.062	3.022GlyGln: 3.022 ± 0.052	7.481GlyArg: 7.481 ± 0.082	5.527GlySer: 5.527 ± 0.076	5.695GlyThr: 5.695 ± 0.067	7.811GlyVal: 7.811 ± 0.079	1.868GlyTrp: 1.868 ± 0.038	2.155GlyTyr: 2.155 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.671HisAla: 2.671 ± 0.044	0.187HisCys: 0.187 ± 0.012	1.498HisAsp: 1.498 ± 0.037	1.436HisGlu: 1.436 ± 0.034	0.598HisPhe: 0.598 ± 0.022	2.322HisGly: 2.322 ± 0.04	0.693HisHis: 0.693 ± 0.025	0.665HisIle: 0.665 ± 0.022	0.317HisLys: 0.317 ± 0.016	2.551HisLeu: 2.551 ± 0.038	0.333HisMet: 0.333 ± 0.018	0.374HisAsn: 0.374 ± 0.019	1.648HisPro: 1.648 ± 0.034	0.625HisGln: 0.625 ± 0.02	1.967HisArg: 1.967 ± 0.037	0.918HisSer: 0.918 ± 0.027	1.173HisThr: 1.173 ± 0.03	2.22HisVal: 2.22 ± 0.039	0.327HisTrp: 0.327 ± 0.015	0.452HisTyr: 0.452 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.248IleAla: 5.248 ± 0.068	0.306IleCys: 0.306 ± 0.016	2.799IleAsp: 2.799 ± 0.038	2.463IleGlu: 2.463 ± 0.043	0.945IlePhe: 0.945 ± 0.031	3.95IleGly: 3.95 ± 0.054	0.761IleHis: 0.761 ± 0.025	1.409IleIle: 1.409 ± 0.039	0.825IleLys: 0.825 ± 0.025	3.019IleLeu: 3.019 ± 0.055	0.552IleMet: 0.552 ± 0.022	0.813IleAsn: 0.813 ± 0.024	1.953IlePro: 1.953 ± 0.04	0.891IleGln: 0.891 ± 0.026	2.575IleArg: 2.575 ± 0.042	1.864IleSer: 1.864 ± 0.038	2.356IleThr: 2.356 ± 0.042	3.68IleVal: 3.68 ± 0.052	0.501IleTrp: 0.501 ± 0.019	0.664IleTyr: 0.664 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.705LysAla: 2.705 ± 0.055	0.101LysCys: 0.101 ± 0.009	1.258LysAsp: 1.258 ± 0.036	1.049LysGlu: 1.049 ± 0.028	0.464LysPhe: 0.464 ± 0.021	1.78LysGly: 1.78 ± 0.05	0.42LysHis: 0.42 ± 0.019	0.79LysIle: 0.79 ± 0.025	0.685LysLys: 0.685 ± 0.03	1.713LysLeu: 1.713 ± 0.038	0.339LysMet: 0.339 ± 0.016	0.433LysAsn: 0.433 ± 0.019	1.186LysPro: 1.186 ± 0.038	0.746LysGln: 0.746 ± 0.025	1.482LysArg: 1.482 ± 0.036	1.066LysSer: 1.066 ± 0.033	1.194LysThr: 1.194 ± 0.031	1.976LysVal: 1.976 ± 0.043	0.264LysTrp: 0.264 ± 0.015	0.427LysTyr: 0.427 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.825LeuAla: 14.825 ± 0.134	0.66LeuCys: 0.66 ± 0.023	6.697LeuAsp: 6.697 ± 0.075	5.385LeuGlu: 5.385 ± 0.068	2.504LeuPhe: 2.504 ± 0.05	9.972LeuGly: 9.972 ± 0.101	2.206LeuHis: 2.206 ± 0.042	3.415LeuIle: 3.415 ± 0.055	1.817LeuLys: 1.817 ± 0.04	10.382LeuLeu: 10.382 ± 0.112	1.719LeuMet: 1.719 ± 0.035	1.597LeuAsn: 1.597 ± 0.034	5.806LeuPro: 5.806 ± 0.068	2.451LeuGln: 2.451 ± 0.042	7.942LeuArg: 7.942 ± 0.09	5.388LeuSer: 5.388 ± 0.07	6.603LeuThr: 6.603 ± 0.069	10.195LeuVal: 10.195 ± 0.122	1.242LeuTrp: 1.242 ± 0.033	1.595LeuTyr: 1.595 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.363MetAla: 2.363 ± 0.039	0.126MetCys: 0.126 ± 0.01	0.887MetAsp: 0.887 ± 0.025	0.759MetGlu: 0.759 ± 0.027	0.471MetPhe: 0.471 ± 0.019	1.448MetGly: 1.448 ± 0.03	0.37MetHis: 0.37 ± 0.014	0.685MetIle: 0.685 ± 0.024	0.431MetLys: 0.431 ± 0.022	1.803MetLeu: 1.803 ± 0.04	0.316MetMet: 0.316 ± 0.017	0.409MetAsn: 0.409 ± 0.016	1.197MetPro: 1.197 ± 0.028	0.521MetGln: 0.521 ± 0.021	1.467MetArg: 1.467 ± 0.033	1.498MetSer: 1.498 ± 0.03	1.759MetThr: 1.759 ± 0.037	1.515MetVal: 1.515 ± 0.037	0.223MetTrp: 0.223 ± 0.013	0.257MetTyr: 0.257 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.226AsnAla: 2.226 ± 0.045	0.139AsnCys: 0.139 ± 0.01	0.992AsnAsp: 0.992 ± 0.029	0.89AsnGlu: 0.89 ± 0.026	0.534AsnPhe: 0.534 ± 0.024	1.718AsnGly: 1.718 ± 0.04	0.388AsnHis: 0.388 ± 0.017	0.703AsnIle: 0.703 ± 0.026	0.396AsnLys: 0.396 ± 0.019	1.794AsnLeu: 1.794 ± 0.035	0.293AsnMet: 0.293 ± 0.014	0.423AsnAsn: 0.423 ± 0.021	1.398AsnPro: 1.398 ± 0.033	0.498AsnGln: 0.498 ± 0.022	1.261AsnArg: 1.261 ± 0.031	0.795AsnSer: 0.795 ± 0.027	0.977AsnThr: 0.977 ± 0.028	1.523AsnVal: 1.523 ± 0.034	0.283AsnTrp: 0.283 ± 0.014	0.409AsnTyr: 0.409 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.204ProAla: 7.204 ± 0.094	0.301ProCys: 0.301 ± 0.014	4.175ProAsp: 4.175 ± 0.05	3.954ProGlu: 3.954 ± 0.056	1.505ProPhe: 1.505 ± 0.029	5.726ProGly: 5.726 ± 0.076	1.225ProHis: 1.225 ± 0.029	1.933ProIle: 1.933 ± 0.041	1.16ProLys: 1.16 ± 0.035	4.909ProLeu: 4.909 ± 0.057	1.08ProMet: 1.08 ± 0.027	1.027ProAsn: 1.027 ± 0.026	2.923ProPro: 2.923 ± 0.055	1.64ProGln: 1.64 ± 0.034	3.753ProArg: 3.753 ± 0.058	3.366ProSer: 3.366 ± 0.052	3.819ProThr: 3.819 ± 0.051	5.192ProVal: 5.192 ± 0.068	0.925ProTrp: 0.925 ± 0.027	1.116ProTyr: 1.116 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.935GlnAla: 3.935 ± 0.059	0.188GlnCys: 0.188 ± 0.013	1.395GlnAsp: 1.395 ± 0.032	1.345GlnGlu: 1.345 ± 0.035	0.798GlnPhe: 0.798 ± 0.024	2.267GlnGly: 2.267 ± 0.043	0.744GlnHis: 0.744 ± 0.024	1.161GlnIle: 1.161 ± 0.031	0.603GlnLys: 0.603 ± 0.022	3.322GlnLeu: 3.322 ± 0.052	0.609GlnMet: 0.609 ± 0.019	0.464GlnAsn: 0.464 ± 0.019	1.853GlnPro: 1.853 ± 0.038	1.375GlnGln: 1.375 ± 0.043	2.567GlnArg: 2.567 ± 0.048	1.442GlnSer: 1.442 ± 0.034	1.658GlnThr: 1.658 ± 0.035	2.821GlnVal: 2.821 ± 0.047	0.466GlnTrp: 0.466 ± 0.02	0.503GlnTyr: 0.503 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.562ArgAla: 9.562 ± 0.094	0.517ArgCys: 0.517 ± 0.022	4.577ArgAsp: 4.577 ± 0.07	4.364ArgGlu: 4.364 ± 0.069	2.339ArgPhe: 2.339 ± 0.046	5.872ArgGly: 5.872 ± 0.079	2.081ArgHis: 2.081 ± 0.042	3.234ArgIle: 3.234 ± 0.046	1.395ArgLys: 1.395 ± 0.033	8.559ArgLeu: 8.559 ± 0.083	1.685ArgMet: 1.685 ± 0.04	1.335ArgAsn: 1.335 ± 0.031	4.625ArgPro: 4.625 ± 0.055	2.456ArgGln: 2.456 ± 0.043	7.526ArgArg: 7.526 ± 0.094	4.376ArgSer: 4.376 ± 0.06	4.685ArgThr: 4.685 ± 0.06	6.355ArgVal: 6.355 ± 0.068	1.397ArgTrp: 1.397 ± 0.035	1.629ArgTyr: 1.629 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.655SerAla: 6.655 ± 0.085	0.369SerCys: 0.369 ± 0.017	2.808SerAsp: 2.808 ± 0.048	2.509SerGlu: 2.509 ± 0.046	1.617SerPhe: 1.617 ± 0.034	5.913SerGly: 5.913 ± 0.075	1.123SerHis: 1.123 ± 0.025	1.961SerIle: 1.961 ± 0.036	0.994SerLys: 0.994 ± 0.027	5.217SerLeu: 5.217 ± 0.065	1.292SerMet: 1.292 ± 0.029	0.976SerAsn: 0.976 ± 0.029	3.01SerPro: 3.01 ± 0.046	1.437SerGln: 1.437 ± 0.034	4.044SerArg: 4.044 ± 0.057	3.105SerSer: 3.105 ± 0.065	3.433SerThr: 3.433 ± 0.062	4.58SerVal: 4.58 ± 0.06	0.894SerTrp: 0.894 ± 0.027	1.105SerTyr: 1.105 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	7.809ThrAla: 7.809 ± 0.091	0.443ThrCys: 0.443 ± 0.018	3.564ThrAsp: 3.564 ± 0.052	3.016ThrGlu: 3.016 ± 0.055	1.813ThrPhe: 1.813 ± 0.036	6.171ThrGly: 6.171 ± 0.067	1.316ThrHis: 1.316 ± 0.031	2.508ThrIle: 2.508 ± 0.042	1.296ThrLys: 1.296 ± 0.034	5.599ThrLeu: 5.599 ± 0.06	1.161ThrMet: 1.161 ± 0.028	1.185ThrAsn: 1.185 ± 0.032	3.933ThrPro: 3.933 ± 0.052	1.524ThrGln: 1.524 ± 0.035	4.081ThrArg: 4.081 ± 0.06	3.552ThrSer: 3.552 ± 0.055	4.328ThrThr: 4.328 ± 0.069	5.855ThrVal: 5.855 ± 0.074	0.987ThrTrp: 0.987 ± 0.029	1.29ThrTyr: 1.29 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	12.256ValAla: 12.256 ± 0.123	0.701ValCys: 0.701 ± 0.022	5.76ValAsp: 5.76 ± 0.069	5.195ValGlu: 5.195 ± 0.076	2.35ValPhe: 2.35 ± 0.039	7.898ValGly: 7.898 ± 0.089	2.014ValHis: 2.014 ± 0.042	3.767ValIle: 3.767 ± 0.059	1.661ValLys: 1.661 ± 0.042	9.87ValLeu: 9.87 ± 0.115	1.546ValMet: 1.546 ± 0.039	1.614ValAsn: 1.614 ± 0.038	5.198ValPro: 5.198 ± 0.061	2.21ValGln: 2.21 ± 0.046	6.869ValArg: 6.869 ± 0.067	4.805ValSer: 4.805 ± 0.06	6.078ValThr: 6.078 ± 0.067	10.048ValVal: 10.048 ± 0.114	1.175ValTrp: 1.175 ± 0.029	1.401ValTyr: 1.401 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.719TrpAla: 1.719 ± 0.036	0.145TrpCys: 0.145 ± 0.01	0.839TrpAsp: 0.839 ± 0.026	0.619TrpGlu: 0.619 ± 0.023	0.543TrpPhe: 0.543 ± 0.02	1.125TrpGly: 1.125 ± 0.029	0.396TrpHis: 0.396 ± 0.018	0.531TrpIle: 0.531 ± 0.017	0.275TrpLys: 0.275 ± 0.014	1.869TrpLeu: 1.869 ± 0.043	0.289TrpMet: 0.289 ± 0.014	0.337TrpAsn: 0.337 ± 0.016	0.807TrpPro: 0.807 ± 0.026	0.559TrpGln: 0.559 ± 0.021	1.434TrpArg: 1.434 ± 0.035	1.027TrpSer: 1.027 ± 0.029	0.986TrpThr: 0.986 ± 0.029	1.319TrpVal: 1.319 ± 0.036	0.388TrpTrp: 0.388 ± 0.018	0.32TrpTyr: 0.32 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.518TyrAla: 2.518 ± 0.046	0.157TyrCys: 0.157 ± 0.01	1.33TyrAsp: 1.33 ± 0.03	1.038TyrGlu: 1.038 ± 0.024	0.581TyrPhe: 0.581 ± 0.022	1.94TyrGly: 1.94 ± 0.042	0.357TyrHis: 0.357 ± 0.017	0.522TyrIle: 0.522 ± 0.019	0.35TyrLys: 0.35 ± 0.018	2.107TyrLeu: 2.107 ± 0.043	0.218TyrMet: 0.218 ± 0.013	0.385TyrAsn: 0.385 ± 0.018	0.995TyrPro: 0.995 ± 0.027	0.549TyrGln: 0.549 ± 0.018	1.543TyrArg: 1.543 ± 0.033	0.922TyrSer: 0.922 ± 0.028	1.053TyrThr: 1.053 ± 0.035	1.732TyrVal: 1.732 ± 0.041	0.294TyrTrp: 0.294 ± 0.014	0.419TyrTyr: 0.419 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4363 proteins (1380227 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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