Amino acid dipepetide frequency for Limimaricola soesokkakensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.734AlaAla: 18.734 ± 0.216	1.097AlaCys: 1.097 ± 0.034	6.684AlaAsp: 6.684 ± 0.095	9.79AlaGlu: 9.79 ± 0.136	4.12AlaPhe: 4.12 ± 0.072	11.477AlaGly: 11.477 ± 0.119	2.448AlaHis: 2.448 ± 0.049	5.902AlaIle: 5.902 ± 0.075	3.31AlaLys: 3.31 ± 0.07	15.004AlaLeu: 15.004 ± 0.154	4.06AlaMet: 4.06 ± 0.068	2.34AlaAsn: 2.34 ± 0.052	6.891AlaPro: 6.891 ± 0.094	4.635AlaGln: 4.635 ± 0.068	10.834AlaArg: 10.834 ± 0.148	5.562AlaSer: 5.562 ± 0.081	6.15AlaThr: 6.15 ± 0.087	8.531AlaVal: 8.531 ± 0.099	1.512AlaTrp: 1.512 ± 0.041	2.302AlaTyr: 2.302 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.117CysAla: 1.117 ± 0.032	0.092CysCys: 0.092 ± 0.01	0.646CysAsp: 0.646 ± 0.028	0.452CysGlu: 0.452 ± 0.023	0.283CysPhe: 0.283 ± 0.015	0.939CysGly: 0.939 ± 0.03	0.291CysHis: 0.291 ± 0.023	0.361CysIle: 0.361 ± 0.015	0.147CysLys: 0.147 ± 0.012	0.782CysLeu: 0.782 ± 0.025	0.161CysMet: 0.161 ± 0.012	0.17CysAsn: 0.17 ± 0.012	0.472CysPro: 0.472 ± 0.025	0.196CysGln: 0.196 ± 0.014	0.584CysArg: 0.584 ± 0.024	0.384CysSer: 0.384 ± 0.019	0.362CysThr: 0.362 ± 0.018	0.549CysVal: 0.549 ± 0.021	0.113CysTrp: 0.113 ± 0.01	0.176CysTyr: 0.176 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.606AspAla: 7.606 ± 0.111	0.506AspCys: 0.506 ± 0.021	3.325AspAsp: 3.325 ± 0.093	3.803AspGlu: 3.803 ± 0.068	2.136AspPhe: 2.136 ± 0.05	5.607AspGly: 5.607 ± 0.119	1.368AspHis: 1.368 ± 0.037	2.767AspIle: 2.767 ± 0.053	1.298AspLys: 1.298 ± 0.036	6.589AspLeu: 6.589 ± 0.086	1.472AspMet: 1.472 ± 0.039	1.08AspAsn: 1.08 ± 0.038	4.036AspPro: 4.036 ± 0.055	1.494AspGln: 1.494 ± 0.041	5.069AspArg: 5.069 ± 0.085	2.003AspSer: 2.003 ± 0.047	2.8AspThr: 2.8 ± 0.056	3.62AspVal: 3.62 ± 0.061	1.258AspTrp: 1.258 ± 0.034	1.478AspTyr: 1.478 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	10.164GluAla: 10.164 ± 0.13	0.328GluCys: 0.328 ± 0.017	3.4GluAsp: 3.4 ± 0.062	4.193GluGlu: 4.193 ± 0.073	1.704GluPhe: 1.704 ± 0.037	5.84GluGly: 5.84 ± 0.069	1.18GluHis: 1.18 ± 0.035	4.302GluIle: 4.302 ± 0.063	1.974GluLys: 1.974 ± 0.056	5.668GluLeu: 5.668 ± 0.084	2.094GluMet: 2.094 ± 0.042	1.609GluAsn: 1.609 ± 0.044	2.837GluPro: 2.837 ± 0.062	1.899GluGln: 1.899 ± 0.045	5.209GluArg: 5.209 ± 0.081	2.448GluSer: 2.448 ± 0.053	4.294GluThr: 4.294 ± 0.066	4.655GluVal: 4.655 ± 0.071	0.726GluTrp: 0.726 ± 0.026	0.929GluTyr: 0.929 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.424PheAla: 4.424 ± 0.076	0.363PheCys: 0.363 ± 0.018	2.817PheAsp: 2.817 ± 0.062	2.533PheGlu: 2.533 ± 0.056	1.23PhePhe: 1.23 ± 0.036	3.608PheGly: 3.608 ± 0.064	0.712PheHis: 0.712 ± 0.028	1.357PheIle: 1.357 ± 0.039	0.74PheLys: 0.74 ± 0.024	3.131PheLeu: 3.131 ± 0.065	0.709PheMet: 0.709 ± 0.026	0.81PheAsn: 0.81 ± 0.03	1.468PhePro: 1.468 ± 0.035	0.821PheGln: 0.821 ± 0.025	2.149PheArg: 2.149 ± 0.043	1.898PheSer: 1.898 ± 0.047	1.877PheThr: 1.877 ± 0.052	2.535PheVal: 2.535 ± 0.047	0.555PheTrp: 0.555 ± 0.026	0.839PheTyr: 0.839 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.89GlyAla: 10.89 ± 0.101	0.892GlyCys: 0.892 ± 0.033	4.954GlyAsp: 4.954 ± 0.099	5.28GlyGlu: 5.28 ± 0.083	3.85GlyPhe: 3.85 ± 0.063	7.937GlyGly: 7.937 ± 0.152	2.102GlyHis: 2.102 ± 0.045	4.325GlyIle: 4.325 ± 0.075	2.503GlyLys: 2.503 ± 0.053	10.101GlyLeu: 10.101 ± 0.117	2.602GlyMet: 2.602 ± 0.049	1.883GlyAsn: 1.883 ± 0.058	4.24GlyPro: 4.24 ± 0.06	2.967GlyGln: 2.967 ± 0.064	7.324GlyArg: 7.324 ± 0.096	4.156GlySer: 4.156 ± 0.07	4.735GlyThr: 4.735 ± 0.09	6.331GlyVal: 6.331 ± 0.084	1.602GlyTrp: 1.602 ± 0.042	2.247GlyTyr: 2.247 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.588HisAla: 2.588 ± 0.047	0.228HisCys: 0.228 ± 0.015	1.428HisAsp: 1.428 ± 0.041	1.336HisGlu: 1.336 ± 0.035	0.781HisPhe: 0.781 ± 0.026	2.119HisGly: 2.119 ± 0.049	0.586HisHis: 0.586 ± 0.03	0.757HisIle: 0.757 ± 0.025	0.419HisLys: 0.419 ± 0.021	2.161HisLeu: 2.161 ± 0.048	0.525HisMet: 0.525 ± 0.021	0.405HisAsn: 0.405 ± 0.021	1.402HisPro: 1.402 ± 0.037	0.525HisGln: 0.525 ± 0.022	1.519HisArg: 1.519 ± 0.041	0.845HisSer: 0.845 ± 0.026	0.656HisThr: 0.656 ± 0.023	1.599HisVal: 1.599 ± 0.039	0.311HisTrp: 0.311 ± 0.016	0.529HisTyr: 0.529 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.005IleAla: 7.005 ± 0.091	0.543IleCys: 0.543 ± 0.022	3.602IleAsp: 3.602 ± 0.059	3.885IleGlu: 3.885 ± 0.056	1.616IlePhe: 1.616 ± 0.041	5.01IleGly: 5.01 ± 0.075	0.901IleHis: 0.901 ± 0.03	1.812IleIle: 1.812 ± 0.048	1.033IleLys: 1.033 ± 0.035	4.338IleLeu: 4.338 ± 0.068	0.939IleMet: 0.939 ± 0.031	1.098IleAsn: 1.098 ± 0.035	2.169IlePro: 2.169 ± 0.053	0.949IleGln: 0.949 ± 0.031	3.376IleArg: 3.376 ± 0.053	2.547IleSer: 2.547 ± 0.046	2.541IleThr: 2.541 ± 0.052	3.464IleVal: 3.464 ± 0.061	0.704IleTrp: 0.704 ± 0.026	1.065IleTyr: 1.065 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.163LysAla: 3.163 ± 0.066	0.128LysCys: 0.128 ± 0.01	1.319LysAsp: 1.319 ± 0.038	1.244LysGlu: 1.244 ± 0.041	0.694LysPhe: 0.694 ± 0.025	2.383LysGly: 2.383 ± 0.055	0.535LysHis: 0.535 ± 0.022	1.391LysIle: 1.391 ± 0.036	0.893LysLys: 0.893 ± 0.038	2.613LysLeu: 2.613 ± 0.053	0.72LysMet: 0.72 ± 0.027	0.591LysAsn: 0.591 ± 0.023	1.546LysPro: 1.546 ± 0.054	0.689LysGln: 0.689 ± 0.025	2.019LysArg: 2.019 ± 0.047	1.461LysSer: 1.461 ± 0.039	1.546LysThr: 1.546 ± 0.041	1.919LysVal: 1.919 ± 0.049	0.315LysTrp: 0.315 ± 0.017	0.448LysTyr: 0.448 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.093LeuAla: 14.093 ± 0.125	0.925LeuCys: 0.925 ± 0.028	6.502LeuAsp: 6.502 ± 0.08	5.689LeuGlu: 5.689 ± 0.082	3.289LeuPhe: 3.289 ± 0.066	9.181LeuGly: 9.181 ± 0.086	2.026LeuHis: 2.026 ± 0.044	4.856LeuIle: 4.856 ± 0.074	2.811LeuLys: 2.811 ± 0.051	9.566LeuLeu: 9.566 ± 0.125	2.667LeuMet: 2.667 ± 0.054	2.207LeuAsn: 2.207 ± 0.042	6.09LeuPro: 6.09 ± 0.09	2.438LeuGln: 2.438 ± 0.049	8.182LeuArg: 8.182 ± 0.1	6.517LeuSer: 6.517 ± 0.078	5.32LeuThr: 5.32 ± 0.06	7.344LeuVal: 7.344 ± 0.091	1.437LeuTrp: 1.437 ± 0.041	1.901LeuTyr: 1.901 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.554MetAla: 3.554 ± 0.059	0.161MetCys: 0.161 ± 0.011	1.249MetAsp: 1.249 ± 0.037	1.346MetGlu: 1.346 ± 0.038	0.748MetPhe: 0.748 ± 0.024	2.273MetGly: 2.273 ± 0.052	0.438MetHis: 0.438 ± 0.022	1.451MetIle: 1.451 ± 0.04	0.884MetLys: 0.884 ± 0.027	2.717MetLeu: 2.717 ± 0.052	0.707MetMet: 0.707 ± 0.023	0.765MetAsn: 0.765 ± 0.025	1.605MetPro: 1.605 ± 0.038	0.892MetGln: 0.892 ± 0.025	2.096MetArg: 2.096 ± 0.044	1.654MetSer: 1.654 ± 0.036	2.018MetThr: 2.018 ± 0.04	1.791MetVal: 1.791 ± 0.047	0.223MetTrp: 0.223 ± 0.017	0.267MetTyr: 0.267 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.801AsnAla: 2.801 ± 0.048	0.212AsnCys: 0.212 ± 0.013	1.218AsnAsp: 1.218 ± 0.039	1.127AsnGlu: 1.127 ± 0.041	0.861AsnPhe: 0.861 ± 0.027	2.068AsnGly: 2.068 ± 0.058	0.45AsnHis: 0.45 ± 0.019	1.066AsnIle: 1.066 ± 0.034	0.474AsnLys: 0.474 ± 0.022	2.166AsnLeu: 2.166 ± 0.044	0.566AsnMet: 0.566 ± 0.023	0.544AsnAsn: 0.544 ± 0.03	1.611AsnPro: 1.611 ± 0.038	0.569AsnGln: 0.569 ± 0.023	1.619AsnArg: 1.619 ± 0.042	0.976AsnSer: 0.976 ± 0.034	1.023AsnThr: 1.023 ± 0.035	1.492AsnVal: 1.492 ± 0.039	0.37AsnTrp: 0.37 ± 0.021	0.549AsnTyr: 0.549 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.411ProAla: 6.411 ± 0.085	0.373ProCys: 0.373 ± 0.02	3.945ProAsp: 3.945 ± 0.07	4.9ProGlu: 4.9 ± 0.075	1.858ProPhe: 1.858 ± 0.038	5.227ProGly: 5.227 ± 0.082	1.096ProHis: 1.096 ± 0.031	2.106ProIle: 2.106 ± 0.046	1.404ProLys: 1.404 ± 0.044	5.066ProLeu: 5.066 ± 0.069	1.279ProMet: 1.279 ± 0.036	1.152ProAsn: 1.152 ± 0.03	2.524ProPro: 2.524 ± 0.057	1.713ProGln: 1.713 ± 0.04	3.496ProArg: 3.496 ± 0.068	2.481ProSer: 2.481 ± 0.052	2.177ProThr: 2.177 ± 0.043	4.576ProVal: 4.576 ± 0.062	0.765ProTrp: 0.765 ± 0.028	1.073ProTyr: 1.073 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.907GlnAla: 3.907 ± 0.07	0.152GlnCys: 0.152 ± 0.011	1.451GlnAsp: 1.451 ± 0.044	1.623GlnGlu: 1.623 ± 0.041	0.899GlnPhe: 0.899 ± 0.029	2.673GlnGly: 2.673 ± 0.048	0.533GlnHis: 0.533 ± 0.022	1.729GlnIle: 1.729 ± 0.04	0.84GlnLys: 0.84 ± 0.024	2.745GlnLeu: 2.745 ± 0.057	0.905GlnMet: 0.905 ± 0.027	0.656GlnAsn: 0.656 ± 0.025	1.565GlnPro: 1.565 ± 0.041	0.958GlnGln: 0.958 ± 0.033	2.121GlnArg: 2.121 ± 0.052	1.554GlnSer: 1.554 ± 0.039	1.451GlnThr: 1.451 ± 0.039	2.17GlnVal: 2.17 ± 0.043	0.373GlnTrp: 0.373 ± 0.019	0.498GlnTyr: 0.498 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.856ArgAla: 9.856 ± 0.118	0.503ArgCys: 0.503 ± 0.022	4.981ArgAsp: 4.981 ± 0.082	4.931ArgGlu: 4.931 ± 0.07	2.799ArgPhe: 2.799 ± 0.052	5.553ArgGly: 5.553 ± 0.065	1.934ArgHis: 1.934 ± 0.054	4.274ArgIle: 4.274 ± 0.058	1.944ArgLys: 1.944 ± 0.048	8.846ArgLeu: 8.846 ± 0.118	2.151ArgMet: 2.151 ± 0.043	1.59ArgAsn: 1.59 ± 0.037	4.053ArgPro: 4.053 ± 0.079	2.347ArgGln: 2.347 ± 0.04	6.474ArgArg: 6.474 ± 0.105	3.458ArgSer: 3.458 ± 0.058	2.94ArgThr: 2.94 ± 0.059	5.126ArgVal: 5.126 ± 0.07	1.033ArgTrp: 1.033 ± 0.033	1.555ArgTyr: 1.555 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.525SerAla: 5.525 ± 0.077	0.445SerCys: 0.445 ± 0.024	2.932SerAsp: 2.932 ± 0.058	3.082SerGlu: 3.082 ± 0.063	2.179SerPhe: 2.179 ± 0.046	5.291SerGly: 5.291 ± 0.07	0.996SerHis: 0.996 ± 0.03	2.24SerIle: 2.24 ± 0.052	1.261SerLys: 1.261 ± 0.035	4.745SerLeu: 4.745 ± 0.068	1.286SerMet: 1.286 ± 0.042	1.206SerAsn: 1.206 ± 0.037	2.405SerPro: 2.405 ± 0.047	1.399SerGln: 1.399 ± 0.034	3.571SerArg: 3.571 ± 0.059	2.407SerSer: 2.407 ± 0.055	2.292SerThr: 2.292 ± 0.052	3.478SerVal: 3.478 ± 0.058	0.707SerTrp: 0.707 ± 0.026	1.199SerTyr: 1.199 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.265ThrAla: 6.265 ± 0.085	0.43ThrCys: 0.43 ± 0.023	3.017ThrAsp: 3.017 ± 0.048	3.211ThrGlu: 3.211 ± 0.06	1.592ThrPhe: 1.592 ± 0.038	5.514ThrGly: 5.514 ± 0.086	1.08ThrHis: 1.08 ± 0.031	2.431ThrIle: 2.431 ± 0.051	1.144ThrLys: 1.144 ± 0.039	5.563ThrLeu: 5.563 ± 0.074	1.165ThrMet: 1.165 ± 0.032	1.063ThrAsn: 1.063 ± 0.031	3.388ThrPro: 3.388 ± 0.056	1.344ThrGln: 1.344 ± 0.042	3.538ThrArg: 3.538 ± 0.06	2.463ThrSer: 2.463 ± 0.049	2.553ThrThr: 2.553 ± 0.055	3.806ThrVal: 3.806 ± 0.065	0.575ThrTrp: 0.575 ± 0.025	0.982ThrTyr: 0.982 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.428ValAla: 9.428 ± 0.102	0.543ValCys: 0.543 ± 0.023	3.628ValAsp: 3.628 ± 0.068	5.045ValGlu: 5.045 ± 0.063	2.564ValPhe: 2.564 ± 0.054	5.195ValGly: 5.195 ± 0.08	1.26ValHis: 1.26 ± 0.03	3.962ValIle: 3.962 ± 0.062	1.701ValLys: 1.701 ± 0.038	7.38ValLeu: 7.38 ± 0.084	2.014ValMet: 2.014 ± 0.046	1.725ValAsn: 1.725 ± 0.046	3.61ValPro: 3.61 ± 0.066	1.857ValGln: 1.857 ± 0.044	4.278ValArg: 4.278 ± 0.055	4.022ValSer: 4.022 ± 0.065	4.727ValThr: 4.727 ± 0.068	5.524ValVal: 5.524 ± 0.087	0.961ValTrp: 0.961 ± 0.03	1.309ValTyr: 1.309 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.404TrpAla: 1.404 ± 0.034	0.142TrpCys: 0.142 ± 0.012	0.758TrpAsp: 0.758 ± 0.03	0.684TrpGlu: 0.684 ± 0.025	0.573TrpPhe: 0.573 ± 0.023	1.056TrpGly: 1.056 ± 0.034	0.33TrpHis: 0.33 ± 0.018	0.745TrpIle: 0.745 ± 0.021	0.384TrpLys: 0.384 ± 0.017	1.721TrpLeu: 1.721 ± 0.041	0.397TrpMet: 0.397 ± 0.019	0.387TrpAsn: 0.387 ± 0.018	0.726TrpPro: 0.726 ± 0.023	0.574TrpGln: 0.574 ± 0.021	1.308TrpArg: 1.308 ± 0.037	0.859TrpSer: 0.859 ± 0.027	0.751TrpThr: 0.751 ± 0.023	0.821TrpVal: 0.821 ± 0.028	0.232TrpTrp: 0.232 ± 0.014	0.254TrpTyr: 0.254 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.45TyrAla: 2.45 ± 0.042	0.215TyrCys: 0.215 ± 0.013	1.459TyrAsp: 1.459 ± 0.038	1.299TyrGlu: 1.299 ± 0.037	0.803TyrPhe: 0.803 ± 0.028	1.971TyrGly: 1.971 ± 0.045	0.453TyrHis: 0.453 ± 0.022	0.758TyrIle: 0.758 ± 0.025	0.454TyrLys: 0.454 ± 0.023	2.138TyrLeu: 2.138 ± 0.046	0.42TyrMet: 0.42 ± 0.017	0.48TyrAsn: 0.48 ± 0.019	0.988TyrPro: 0.988 ± 0.03	0.536TyrGln: 0.536 ± 0.022	1.581TyrArg: 1.581 ± 0.04	0.952TyrSer: 0.952 ± 0.029	0.907TyrThr: 0.907 ± 0.029	1.402TyrVal: 1.402 ± 0.036	0.336TyrTrp: 0.336 ± 0.017	0.517TyrTyr: 0.517 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3683 proteins (1159187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---