Amino acid dipepetide frequency for Planococcus sp. PAMC 21323

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.732AlaAla: 6.732 ± 0.114
0.536AlaCys: 0.536 ± 0.027
3.86AlaAsp: 3.86 ± 0.07
5.625AlaGlu: 5.625 ± 0.1
3.652AlaPhe: 3.652 ± 0.074
5.832AlaGly: 5.832 ± 0.102
1.406AlaHis: 1.406 ± 0.043
6.577AlaIle: 6.577 ± 0.104
4.715AlaLys: 4.715 ± 0.081
7.761AlaLeu: 7.761 ± 0.101
2.252AlaMet: 2.252 ± 0.053
2.882AlaAsn: 2.882 ± 0.064
2.224AlaPro: 2.224 ± 0.056
2.521AlaGln: 2.521 ± 0.053
2.783AlaArg: 2.783 ± 0.056
4.422AlaSer: 4.422 ± 0.084
3.969AlaThr: 3.969 ± 0.067
6.031AlaVal: 6.031 ± 0.092
0.666AlaTrp: 0.666 ± 0.029
2.514AlaTyr: 2.514 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.369CysAla: 0.369 ± 0.024
0.063CysCys: 0.063 ± 0.009
0.314CysAsp: 0.314 ± 0.022
0.355CysGlu: 0.355 ± 0.021
0.236CysPhe: 0.236 ± 0.016
0.539CysGly: 0.539 ± 0.026
0.162CysHis: 0.162 ± 0.015
0.395CysIle: 0.395 ± 0.019
0.261CysLys: 0.261 ± 0.018
0.542CysLeu: 0.542 ± 0.029
0.131CysMet: 0.131 ± 0.012
0.218CysAsn: 0.218 ± 0.016
0.3CysPro: 0.3 ± 0.018
0.203CysGln: 0.203 ± 0.016
0.259CysArg: 0.259 ± 0.018
0.391CysSer: 0.391 ± 0.021
0.331CysThr: 0.331 ± 0.018
0.338CysVal: 0.338 ± 0.021
0.045CysTrp: 0.045 ± 0.007
0.178CysTyr: 0.178 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.802AspAla: 3.802 ± 0.062
0.304AspCys: 0.304 ± 0.02
2.493AspAsp: 2.493 ± 0.056
4.34AspGlu: 4.34 ± 0.078
2.711AspPhe: 2.711 ± 0.057
3.532AspGly: 3.532 ± 0.067
1.118AspHis: 1.118 ± 0.037
3.912AspIle: 3.912 ± 0.063
2.93AspLys: 2.93 ± 0.061
5.176AspLeu: 5.176 ± 0.086
1.555AspMet: 1.555 ± 0.044
1.777AspAsn: 1.777 ± 0.043
2.055AspPro: 2.055 ± 0.055
2.184AspGln: 2.184 ± 0.051
2.315AspArg: 2.315 ± 0.052
2.971AspSer: 2.971 ± 0.057
2.561AspThr: 2.561 ± 0.059
3.889AspVal: 3.889 ± 0.072
0.68AspTrp: 0.68 ± 0.024
2.125AspTyr: 2.125 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.558GluAla: 5.558 ± 0.083
0.331GluCys: 0.331 ± 0.018
4.019GluAsp: 4.019 ± 0.073
7.21GluGlu: 7.21 ± 0.111
2.901GluPhe: 2.901 ± 0.061
4.387GluGly: 4.387 ± 0.082
1.422GluHis: 1.422 ± 0.043
5.447GluIle: 5.447 ± 0.084
6.296GluLys: 6.296 ± 0.096
7.656GluLeu: 7.656 ± 0.096
2.511GluMet: 2.511 ± 0.052
3.608GluAsn: 3.608 ± 0.067
2.03GluPro: 2.03 ± 0.049
3.751GluGln: 3.751 ± 0.082
3.591GluArg: 3.591 ± 0.071
3.947GluSer: 3.947 ± 0.071
4.277GluThr: 4.277 ± 0.075
5.15GluVal: 5.15 ± 0.082
0.882GluTrp: 0.882 ± 0.03
2.08GluTyr: 2.08 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.349PheAla: 3.349 ± 0.075
0.266PheCys: 0.266 ± 0.018
2.651PheAsp: 2.651 ± 0.048
3.103PheGlu: 3.103 ± 0.065
2.329PhePhe: 2.329 ± 0.061
3.611PheGly: 3.611 ± 0.065
0.919PheHis: 0.919 ± 0.032
3.741PheIle: 3.741 ± 0.076
2.298PheLys: 2.298 ± 0.053
4.498PheLeu: 4.498 ± 0.072
1.254PheMet: 1.254 ± 0.036
1.81PheAsn: 1.81 ± 0.048
1.622PhePro: 1.622 ± 0.042
1.522PheGln: 1.522 ± 0.039
1.542PheArg: 1.542 ± 0.043
3.26PheSer: 3.26 ± 0.063
2.629PheThr: 2.629 ± 0.056
3.418PheVal: 3.418 ± 0.064
0.491PheTrp: 0.491 ± 0.027
1.662PheTyr: 1.662 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.265GlyAla: 5.265 ± 0.098
0.45GlyCys: 0.45 ± 0.023
3.551GlyAsp: 3.551 ± 0.057
4.559GlyGlu: 4.559 ± 0.082
3.497GlyPhe: 3.497 ± 0.064
4.955GlyGly: 4.955 ± 0.1
1.439GlyHis: 1.439 ± 0.044
5.94GlyIle: 5.94 ± 0.099
4.606GlyLys: 4.606 ± 0.075
6.658GlyLeu: 6.658 ± 0.11
2.252GlyMet: 2.252 ± 0.049
2.534GlyAsn: 2.534 ± 0.059
1.727GlyPro: 1.727 ± 0.047
2.427GlyGln: 2.427 ± 0.052
2.667GlyArg: 2.667 ± 0.056
4.084GlySer: 4.084 ± 0.074
4.092GlyThr: 4.092 ± 0.066
5.214GlyVal: 5.214 ± 0.078
0.771GlyTrp: 0.771 ± 0.031
2.615GlyTyr: 2.615 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.437HisAla: 1.437 ± 0.039
0.156HisCys: 0.156 ± 0.014
0.992HisAsp: 0.992 ± 0.037
1.44HisGlu: 1.44 ± 0.034
0.999HisPhe: 0.999 ± 0.035
1.349HisGly: 1.349 ± 0.042
0.558HisHis: 0.558 ± 0.027
1.461HisIle: 1.461 ± 0.041
0.984HisLys: 0.984 ± 0.034
1.942HisLeu: 1.942 ± 0.048
0.562HisMet: 0.562 ± 0.024
0.67HisAsn: 0.67 ± 0.026
1.135HisPro: 1.135 ± 0.037
0.869HisGln: 0.869 ± 0.033
0.857HisArg: 0.857 ± 0.033
1.182HisSer: 1.182 ± 0.033
1.032HisThr: 1.032 ± 0.032
1.419HisVal: 1.419 ± 0.037
0.186HisTrp: 0.186 ± 0.015
0.74HisTyr: 0.74 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.503IleAla: 6.503 ± 0.103
0.52IleCys: 0.52 ± 0.026
4.439IleAsp: 4.439 ± 0.074
5.884IleGlu: 5.884 ± 0.095
3.137IlePhe: 3.137 ± 0.067
6.05IleGly: 6.05 ± 0.097
1.536IleHis: 1.536 ± 0.04
5.344IleIle: 5.344 ± 0.089
3.818IleLys: 3.818 ± 0.074
6.863IleLeu: 6.863 ± 0.108
1.797IleMet: 1.797 ± 0.041
2.918IleAsn: 2.918 ± 0.056
3.132IlePro: 3.132 ± 0.061
2.835IleGln: 2.835 ± 0.056
3.093IleArg: 3.093 ± 0.055
4.926IleSer: 4.926 ± 0.096
4.126IleThr: 4.126 ± 0.071
5.579IleVal: 5.579 ± 0.085
0.604IleTrp: 0.604 ± 0.025
2.234IleTyr: 2.234 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.693LysAla: 4.693 ± 0.067
0.207LysCys: 0.207 ± 0.014
3.484LysAsp: 3.484 ± 0.073
6.037LysGlu: 6.037 ± 0.097
1.966LysPhe: 1.966 ± 0.043
3.888LysGly: 3.888 ± 0.068
1.128LysHis: 1.128 ± 0.036
4.136LysIle: 4.136 ± 0.072
5.422LysLys: 5.422 ± 0.089
5.478LysLeu: 5.478 ± 0.074
2.222LysMet: 2.222 ± 0.053
3.009LysAsn: 3.009 ± 0.071
2.177LysPro: 2.177 ± 0.056
2.739LysGln: 2.739 ± 0.058
2.963LysArg: 2.963 ± 0.054
3.495LysSer: 3.495 ± 0.064
3.569LysThr: 3.569 ± 0.064
4.326LysVal: 4.326 ± 0.078
0.705LysTrp: 0.705 ± 0.029
1.721LysTyr: 1.721 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
8.133LeuAla: 8.133 ± 0.11
0.509LeuCys: 0.509 ± 0.027
4.815LeuAsp: 4.815 ± 0.073
7.052LeuGlu: 7.052 ± 0.096
4.779LeuPhe: 4.779 ± 0.09
6.257LeuGly: 6.257 ± 0.112
1.824LeuHis: 1.824 ± 0.048
6.956LeuIle: 6.956 ± 0.107
6.08LeuLys: 6.08 ± 0.087
10.468LeuLeu: 10.468 ± 0.154
2.727LeuMet: 2.727 ± 0.057
3.848LeuAsn: 3.848 ± 0.075
3.988LeuPro: 3.988 ± 0.064
3.665LeuGln: 3.665 ± 0.073
3.551LeuArg: 3.551 ± 0.063
6.754LeuSer: 6.754 ± 0.1
6.02LeuThr: 6.02 ± 0.073
6.859LeuVal: 6.859 ± 0.095
0.867LeuTrp: 0.867 ± 0.034
3.079LeuTyr: 3.079 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.348MetAla: 2.348 ± 0.054
0.114MetCys: 0.114 ± 0.013
1.597MetAsp: 1.597 ± 0.042
2.091MetGlu: 2.091 ± 0.049
1.077MetPhe: 1.077 ± 0.033
1.871MetGly: 1.871 ± 0.046
0.51MetHis: 0.51 ± 0.021
2.145MetIle: 2.145 ± 0.046
2.509MetLys: 2.509 ± 0.054
2.567MetLeu: 2.567 ± 0.052
0.972MetMet: 0.972 ± 0.032
1.522MetAsn: 1.522 ± 0.042
1.128MetPro: 1.128 ± 0.034
0.978MetGln: 0.978 ± 0.035
1.184MetArg: 1.184 ± 0.031
1.709MetSer: 1.709 ± 0.048
2.08MetThr: 2.08 ± 0.048
1.803MetVal: 1.803 ± 0.048
0.214MetTrp: 0.214 ± 0.016
0.778MetTyr: 0.778 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.857AsnAla: 2.857 ± 0.058
0.276AsnCys: 0.276 ± 0.017
2.168AsnAsp: 2.168 ± 0.056
3.116AsnGlu: 3.116 ± 0.068
1.688AsnPhe: 1.688 ± 0.044
2.986AsnGly: 2.986 ± 0.059
0.877AsnHis: 0.877 ± 0.034
2.938AsnIle: 2.938 ± 0.061
2.493AsnLys: 2.493 ± 0.06
3.662AsnLeu: 3.662 ± 0.06
1.154AsnMet: 1.154 ± 0.039
1.702AsnAsn: 1.702 ± 0.049
2.026AsnPro: 2.026 ± 0.048
1.673AsnGln: 1.673 ± 0.049
1.987AsnArg: 1.987 ± 0.048
2.3AsnSer: 2.3 ± 0.057
2.027AsnThr: 2.027 ± 0.052
2.683AsnVal: 2.683 ± 0.062
0.456AsnTrp: 0.456 ± 0.024
1.438AsnTyr: 1.438 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
2.639ProAla: 2.639 ± 0.062
0.157ProCys: 0.157 ± 0.014
1.946ProAsp: 1.946 ± 0.053
3.413ProGlu: 3.413 ± 0.071
1.947ProPhe: 1.947 ± 0.046
2.267ProGly: 2.267 ± 0.059
0.82ProHis: 0.82 ± 0.033
2.734ProIle: 2.734 ± 0.05
2.121ProLys: 2.121 ± 0.049
3.486ProLeu: 3.486 ± 0.063
0.911ProMet: 0.911 ± 0.035
1.565ProAsn: 1.565 ± 0.039
0.932ProPro: 0.932 ± 0.033
1.157ProGln: 1.157 ± 0.036
1.073ProArg: 1.073 ± 0.034
2.173ProSer: 2.173 ± 0.049
2.033ProThr: 2.033 ± 0.048
3.001ProVal: 3.001 ± 0.054
0.33ProTrp: 0.33 ± 0.02
1.298ProTyr: 1.298 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.09GlnAla: 3.09 ± 0.067
0.145GlnCys: 0.145 ± 0.012
1.769GlnAsp: 1.769 ± 0.049
2.962GlnGlu: 2.962 ± 0.057
1.65GlnPhe: 1.65 ± 0.041
2.228GlnGly: 2.228 ± 0.061
0.816GlnHis: 0.816 ± 0.032
2.465GlnIle: 2.465 ± 0.054
2.525GlnLys: 2.525 ± 0.059
4.304GlnLeu: 4.304 ± 0.081
1.145GlnMet: 1.145 ± 0.039
1.522GlnAsn: 1.522 ± 0.04
1.22GlnPro: 1.22 ± 0.039
2.172GlnGln: 2.172 ± 0.061
1.539GlnArg: 1.539 ± 0.046
2.212GlnSer: 2.212 ± 0.052
2.188GlnThr: 2.188 ± 0.055
2.639GlnVal: 2.639 ± 0.057
0.424GlnTrp: 0.424 ± 0.021
1.21GlnTyr: 1.21 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.652ArgAla: 2.652 ± 0.055
0.203ArgCys: 0.203 ± 0.014
2.114ArgAsp: 2.114 ± 0.045
3.105ArgGlu: 3.105 ± 0.059
1.996ArgPhe: 1.996 ± 0.048
2.363ArgGly: 2.363 ± 0.047
0.855ArgHis: 0.855 ± 0.029
3.092ArgIle: 3.092 ± 0.064
2.915ArgLys: 2.915 ± 0.06
4.174ArgLeu: 4.174 ± 0.066
1.266ArgMet: 1.266 ± 0.036
1.737ArgAsn: 1.737 ± 0.044
1.37ArgPro: 1.37 ± 0.041
1.626ArgGln: 1.626 ± 0.044
1.672ArgArg: 1.672 ± 0.054
2.17ArgSer: 2.17 ± 0.047
2.13ArgThr: 2.13 ± 0.053
2.761ArgVal: 2.761 ± 0.053
0.381ArgTrp: 0.381 ± 0.022
1.452ArgTyr: 1.452 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.28SerAla: 4.28 ± 0.072
0.333SerCys: 0.333 ± 0.02
2.894SerAsp: 2.894 ± 0.06
4.122SerGlu: 4.122 ± 0.064
3.259SerPhe: 3.259 ± 0.06
4.766SerGly: 4.766 ± 0.074
1.216SerHis: 1.216 ± 0.035
4.897SerIle: 4.897 ± 0.08
3.52SerLys: 3.52 ± 0.064
6.07SerLeu: 6.07 ± 0.106
1.773SerMet: 1.773 ± 0.043
2.354SerAsn: 2.354 ± 0.047
2.179SerPro: 2.179 ± 0.047
2.019SerGln: 2.019 ± 0.053
2.415SerArg: 2.415 ± 0.054
4.029SerSer: 4.029 ± 0.071
3.37SerThr: 3.37 ± 0.07
4.226SerVal: 4.226 ± 0.069
0.681SerTrp: 0.681 ± 0.026
2.269SerTyr: 2.269 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.773ThrAla: 4.773 ± 0.08
0.292ThrCys: 0.292 ± 0.019
3.023ThrAsp: 3.023 ± 0.048
4.184ThrGlu: 4.184 ± 0.075
2.459ThrPhe: 2.459 ± 0.052
4.592ThrGly: 4.592 ± 0.083
1.106ThrHis: 1.106 ± 0.035
4.639ThrIle: 4.639 ± 0.074
3.282ThrLys: 3.282 ± 0.065
5.189ThrLeu: 5.189 ± 0.071
1.425ThrMet: 1.425 ± 0.037
2.259ThrAsn: 2.259 ± 0.051
2.372ThrPro: 2.372 ± 0.047
1.687ThrGln: 1.687 ± 0.045
1.916ThrArg: 1.916 ± 0.046
3.322ThrSer: 3.322 ± 0.061
3.133ThrThr: 3.133 ± 0.062
4.448ThrVal: 4.448 ± 0.076
0.493ThrTrp: 0.493 ± 0.027
1.836ThrTyr: 1.836 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
5.506ValAla: 5.506 ± 0.082
0.454ValCys: 0.454 ± 0.021
3.894ValAsp: 3.894 ± 0.07
5.408ValGlu: 5.408 ± 0.084
3.404ValPhe: 3.404 ± 0.076
4.785ValGly: 4.785 ± 0.08
1.341ValHis: 1.341 ± 0.045
5.41ValIle: 5.41 ± 0.081
4.144ValLys: 4.144 ± 0.072
7.336ValLeu: 7.336 ± 0.098
2.051ValMet: 2.051 ± 0.044
2.829ValAsn: 2.829 ± 0.059
2.739ValPro: 2.739 ± 0.046
2.469ValGln: 2.469 ± 0.05
2.72ValArg: 2.72 ± 0.059
4.72ValSer: 4.72 ± 0.079
4.355ValThr: 4.355 ± 0.078
5.228ValVal: 5.228 ± 0.084
0.629ValTrp: 0.629 ± 0.027
2.251ValTyr: 2.251 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.656TrpAla: 0.656 ± 0.031
0.06TrpCys: 0.06 ± 0.008
0.488TrpAsp: 0.488 ± 0.024
0.578TrpGlu: 0.578 ± 0.026
0.519TrpPhe: 0.519 ± 0.025
0.628TrpGly: 0.628 ± 0.028
0.202TrpHis: 0.202 ± 0.017
0.867TrpIle: 0.867 ± 0.032
0.634TrpLys: 0.634 ± 0.021
1.152TrpLeu: 1.152 ± 0.032
0.354TrpMet: 0.354 ± 0.02
0.513TrpAsn: 0.513 ± 0.027
0.267TrpPro: 0.267 ± 0.019
0.456TrpGln: 0.456 ± 0.023
0.395TrpArg: 0.395 ± 0.02
0.584TrpSer: 0.584 ± 0.028
0.585TrpThr: 0.585 ± 0.028
0.637TrpVal: 0.637 ± 0.023
0.134TrpTrp: 0.134 ± 0.012
0.29TrpTyr: 0.29 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.32TyrAla: 2.32 ± 0.048
0.254TyrCys: 0.254 ± 0.018
1.917TyrAsp: 1.917 ± 0.05
2.473TyrGlu: 2.473 ± 0.052
1.772TyrPhe: 1.772 ± 0.044
2.418TyrGly: 2.418 ± 0.055
0.718TyrHis: 0.718 ± 0.031
2.243TyrIle: 2.243 ± 0.052
1.808TyrLys: 1.808 ± 0.047
3.249TyrLeu: 3.249 ± 0.066
0.879TyrMet: 0.879 ± 0.026
1.229TyrAsn: 1.229 ± 0.038
1.376TyrPro: 1.376 ± 0.037
1.271TyrGln: 1.271 ± 0.04
1.513TyrArg: 1.513 ± 0.037
2.021TyrSer: 2.021 ± 0.043
1.924TyrThr: 1.924 ± 0.048
2.024TyrVal: 2.024 ± 0.047
0.36TyrTrp: 0.36 ± 0.019
1.23TyrTyr: 1.23 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3084 proteins (915920 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski