Amino acid dipepetide frequency for Prosthecochloris sp. CIB 2401

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.124AlaAla: 9.124 ± 0.185
1.02AlaCys: 1.02 ± 0.048
4.818AlaAsp: 4.818 ± 0.143
6.289AlaGlu: 6.289 ± 0.105
3.521AlaPhe: 3.521 ± 0.105
7.998AlaGly: 7.998 ± 0.307
1.586AlaHis: 1.586 ± 0.052
5.19AlaIle: 5.19 ± 0.096
3.379AlaLys: 3.379 ± 0.102
9.438AlaLeu: 9.438 ± 0.157
2.658AlaMet: 2.658 ± 0.064
2.337AlaAsn: 2.337 ± 0.083
2.963AlaPro: 2.963 ± 0.084
2.277AlaGln: 2.277 ± 0.057
5.182AlaArg: 5.182 ± 0.133
5.714AlaSer: 5.714 ± 0.167
4.382AlaThr: 4.382 ± 0.16
6.618AlaVal: 6.618 ± 0.129
1.013AlaTrp: 1.013 ± 0.045
2.37AlaTyr: 2.37 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.749CysAla: 0.749 ± 0.034
0.179CysCys: 0.179 ± 0.019
0.614CysAsp: 0.614 ± 0.036
0.477CysGlu: 0.477 ± 0.028
0.437CysPhe: 0.437 ± 0.028
1.051CysGly: 1.051 ± 0.049
0.293CysHis: 0.293 ± 0.024
0.632CysIle: 0.632 ± 0.033
0.383CysLys: 0.383 ± 0.024
0.808CysLeu: 0.808 ± 0.038
0.262CysMet: 0.262 ± 0.023
0.409CysAsn: 0.409 ± 0.024
0.533CysPro: 0.533 ± 0.033
0.316CysGln: 0.316 ± 0.023
0.781CysArg: 0.781 ± 0.037
0.809CysSer: 0.809 ± 0.042
0.513CysThr: 0.513 ± 0.034
0.618CysVal: 0.618 ± 0.032
0.1CysTrp: 0.1 ± 0.012
0.315CysTyr: 0.315 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.26AspAla: 5.26 ± 0.141
0.467AspCys: 0.467 ± 0.027
2.989AspAsp: 2.989 ± 0.103
4.132AspGlu: 4.132 ± 0.091
2.461AspPhe: 2.461 ± 0.076
4.597AspGly: 4.597 ± 0.287
0.995AspHis: 0.995 ± 0.044
4.436AspIle: 4.436 ± 0.127
2.2AspLys: 2.2 ± 0.069
5.189AspLeu: 5.189 ± 0.112
1.448AspMet: 1.448 ± 0.045
1.894AspAsn: 1.894 ± 0.054
2.581AspPro: 2.581 ± 0.072
1.483AspGln: 1.483 ± 0.045
3.308AspArg: 3.308 ± 0.096
2.842AspSer: 2.842 ± 0.085
3.025AspThr: 3.025 ± 0.1
3.909AspVal: 3.909 ± 0.125
0.609AspTrp: 0.609 ± 0.032
1.865AspTyr: 1.865 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.299GluAla: 6.299 ± 0.118
0.59GluCys: 0.59 ± 0.034
3.199GluAsp: 3.199 ± 0.094
5.699GluGlu: 5.699 ± 0.141
2.582GluPhe: 2.582 ± 0.06
4.768GluGly: 4.768 ± 0.089
1.836GluHis: 1.836 ± 0.069
4.013GluIle: 4.013 ± 0.095
4.406GluLys: 4.406 ± 0.109
7.937GluLeu: 7.937 ± 0.128
1.837GluMet: 1.837 ± 0.063
2.423GluAsn: 2.423 ± 0.064
2.446GluPro: 2.446 ± 0.07
3.133GluGln: 3.133 ± 0.066
4.557GluArg: 4.557 ± 0.127
3.742GluSer: 3.742 ± 0.089
3.477GluThr: 3.477 ± 0.085
4.812GluVal: 4.812 ± 0.091
0.779GluTrp: 0.779 ± 0.039
1.955GluTyr: 1.955 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
3.372PheAla: 3.372 ± 0.084
0.503PheCys: 0.503 ± 0.031
2.577PheAsp: 2.577 ± 0.058
2.542PheGlu: 2.542 ± 0.098
2.057PhePhe: 2.057 ± 0.079
3.303PheGly: 3.303 ± 0.113
0.833PheHis: 0.833 ± 0.036
2.707PheIle: 2.707 ± 0.078
1.403PheLys: 1.403 ± 0.047
4.055PheLeu: 4.055 ± 0.106
1.103PheMet: 1.103 ± 0.045
1.42PheAsn: 1.42 ± 0.047
1.72PhePro: 1.72 ± 0.06
1.15PheGln: 1.15 ± 0.038
2.641PheArg: 2.641 ± 0.078
3.411PheSer: 3.411 ± 0.086
2.281PheThr: 2.281 ± 0.06
2.664PheVal: 2.664 ± 0.064
0.522PheTrp: 0.522 ± 0.029
1.294PheTyr: 1.294 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
6.07GlyAla: 6.07 ± 0.181
0.919GlyCys: 0.919 ± 0.04
4.171GlyAsp: 4.171 ± 0.238
4.889GlyGlu: 4.889 ± 0.1
3.754GlyPhe: 3.754 ± 0.157
6.055GlyGly: 6.055 ± 0.19
1.678GlyHis: 1.678 ± 0.057
5.815GlyIle: 5.815 ± 0.115
4.23GlyLys: 4.23 ± 0.109
7.141GlyLeu: 7.141 ± 0.122
2.593GlyMet: 2.593 ± 0.063
2.757GlyAsn: 2.757 ± 0.146
2.001GlyPro: 2.001 ± 0.057
2.255GlyGln: 2.255 ± 0.062
4.498GlyArg: 4.498 ± 0.102
5.289GlySer: 5.289 ± 0.241
4.492GlyThr: 4.492 ± 0.173
5.578GlyVal: 5.578 ± 0.123
0.925GlyTrp: 0.925 ± 0.038
2.744GlyTyr: 2.744 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.954HisAla: 1.954 ± 0.062
0.243HisCys: 0.243 ± 0.019
1.267HisAsp: 1.267 ± 0.049
1.543HisGlu: 1.543 ± 0.059
0.837HisPhe: 0.837 ± 0.041
1.725HisGly: 1.725 ± 0.056
0.655HisHis: 0.655 ± 0.036
1.428HisIle: 1.428 ± 0.047
0.919HisLys: 0.919 ± 0.035
2.064HisLeu: 2.064 ± 0.057
0.517HisMet: 0.517 ± 0.031
0.798HisAsn: 0.798 ± 0.035
1.264HisPro: 1.264 ± 0.05
0.701HisGln: 0.701 ± 0.034
1.259HisArg: 1.259 ± 0.051
1.119HisSer: 1.119 ± 0.043
1.135HisThr: 1.135 ± 0.044
1.38HisVal: 1.38 ± 0.06
0.245HisTrp: 0.245 ± 0.019
0.752HisTyr: 0.752 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.137IleAla: 6.137 ± 0.108
0.673IleCys: 0.673 ± 0.032
4.282IleAsp: 4.282 ± 0.097
4.588IleGlu: 4.588 ± 0.094
2.317IlePhe: 2.317 ± 0.069
4.976IleGly: 4.976 ± 0.088
1.194IleHis: 1.194 ± 0.042
3.827IleIle: 3.827 ± 0.093
2.263IleLys: 2.263 ± 0.072
5.494IleLeu: 5.494 ± 0.114
1.491IleMet: 1.491 ± 0.047
1.998IleAsn: 1.998 ± 0.057
2.873IlePro: 2.873 ± 0.071
1.711IleGln: 1.711 ± 0.05
3.783IleArg: 3.783 ± 0.078
4.322IleSer: 4.322 ± 0.122
3.725IleThr: 3.725 ± 0.117
4.232IleVal: 4.232 ± 0.074
0.495IleTrp: 0.495 ± 0.03
1.678IleTyr: 1.678 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.25LysAla: 4.25 ± 0.104
0.276LysCys: 0.276 ± 0.023
2.135LysAsp: 2.135 ± 0.073
3.532LysGlu: 3.532 ± 0.111
1.338LysPhe: 1.338 ± 0.048
3.548LysGly: 3.548 ± 0.085
0.93LysHis: 0.93 ± 0.047
2.78LysIle: 2.78 ± 0.082
3.269LysLys: 3.269 ± 0.082
4.356LysLeu: 4.356 ± 0.114
1.108LysMet: 1.108 ± 0.05
1.814LysAsn: 1.814 ± 0.067
2.13LysPro: 2.13 ± 0.073
1.747LysGln: 1.747 ± 0.074
2.633LysArg: 2.633 ± 0.095
2.744LysSer: 2.744 ± 0.066
2.736LysThr: 2.736 ± 0.075
3.235LysVal: 3.235 ± 0.083
0.419LysTrp: 0.419 ± 0.025
1.205LysTyr: 1.205 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
8.85LeuAla: 8.85 ± 0.125
1.11LeuCys: 1.11 ± 0.049
6.119LeuAsp: 6.119 ± 0.115
7.484LeuGlu: 7.484 ± 0.117
4.543LeuPhe: 4.543 ± 0.097
7.332LeuGly: 7.332 ± 0.119
2.291LeuHis: 2.291 ± 0.06
4.94LeuIle: 4.94 ± 0.089
4.829LeuLys: 4.829 ± 0.123
11.184LeuLeu: 11.184 ± 0.208
2.484LeuMet: 2.484 ± 0.069
3.122LeuAsn: 3.122 ± 0.071
4.763LeuPro: 4.763 ± 0.106
4.419LeuGln: 4.419 ± 0.081
6.059LeuArg: 6.059 ± 0.12
6.821LeuSer: 6.821 ± 0.17
4.985LeuThr: 4.985 ± 0.122
7.323LeuVal: 7.323 ± 0.133
0.999LeuTrp: 0.999 ± 0.047
2.823LeuTyr: 2.823 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.401MetAla: 2.401 ± 0.071
0.176MetCys: 0.176 ± 0.015
1.296MetAsp: 1.296 ± 0.051
1.716MetGlu: 1.716 ± 0.061
1.026MetPhe: 1.026 ± 0.047
1.744MetGly: 1.744 ± 0.049
0.71MetHis: 0.71 ± 0.038
1.36MetIle: 1.36 ± 0.047
1.626MetLys: 1.626 ± 0.061
3.123MetLeu: 3.123 ± 0.089
0.76MetMet: 0.76 ± 0.039
1.059MetAsn: 1.059 ± 0.041
1.326MetPro: 1.326 ± 0.056
1.367MetGln: 1.367 ± 0.046
1.399MetArg: 1.399 ± 0.047
1.701MetSer: 1.701 ± 0.05
1.487MetThr: 1.487 ± 0.048
1.969MetVal: 1.969 ± 0.058
0.142MetTrp: 0.142 ± 0.014
0.532MetTyr: 0.532 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.942AsnAla: 2.942 ± 0.089
0.357AsnCys: 0.357 ± 0.026
1.715AsnAsp: 1.715 ± 0.054
2.002AsnGlu: 2.002 ± 0.056
1.226AsnPhe: 1.226 ± 0.048
2.597AsnGly: 2.597 ± 0.125
0.701AsnHis: 0.701 ± 0.034
2.579AsnIle: 2.579 ± 0.07
1.369AsnLys: 1.369 ± 0.054
3.319AsnLeu: 3.319 ± 0.076
0.848AsnMet: 0.848 ± 0.036
1.234AsnAsn: 1.234 ± 0.048
2.034AsnPro: 2.034 ± 0.064
0.984AsnGln: 0.984 ± 0.041
2.174AsnArg: 2.174 ± 0.064
1.802AsnSer: 1.802 ± 0.051
1.786AsnThr: 1.786 ± 0.065
2.238AsnVal: 2.238 ± 0.105
0.359AsnTrp: 0.359 ± 0.021
1.022AsnTyr: 1.022 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
3.813ProAla: 3.813 ± 0.091
0.425ProCys: 0.425 ± 0.028
3.158ProAsp: 3.158 ± 0.072
4.219ProGlu: 4.219 ± 0.119
1.907ProPhe: 1.907 ± 0.064
3.687ProGly: 3.687 ± 0.082
0.884ProHis: 0.884 ± 0.039
1.744ProIle: 1.744 ± 0.054
1.488ProLys: 1.488 ± 0.061
4.265ProLeu: 4.265 ± 0.104
1.013ProMet: 1.013 ± 0.04
1.072ProAsn: 1.072 ± 0.042
1.56ProPro: 1.56 ± 0.06
1.29ProGln: 1.29 ± 0.05
1.763ProArg: 1.763 ± 0.066
2.579ProSer: 2.579 ± 0.073
1.572ProThr: 1.572 ± 0.047
3.787ProVal: 3.787 ± 0.094
0.463ProTrp: 0.463 ± 0.025
1.333ProTyr: 1.333 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.292GlnAla: 3.292 ± 0.102
0.275GlnCys: 0.275 ± 0.018
1.753GlnAsp: 1.753 ± 0.051
2.7GlnGlu: 2.7 ± 0.073
1.136GlnPhe: 1.136 ± 0.044
2.424GlnGly: 2.424 ± 0.06
0.966GlnHis: 0.966 ± 0.044
1.714GlnIle: 1.714 ± 0.049
1.94GlnLys: 1.94 ± 0.071
3.713GlnLeu: 3.713 ± 0.075
0.779GlnMet: 0.779 ± 0.036
1.217GlnAsn: 1.217 ± 0.041
1.399GlnPro: 1.399 ± 0.058
1.759GlnGln: 1.759 ± 0.057
2.076GlnArg: 2.076 ± 0.069
1.852GlnSer: 1.852 ± 0.05
1.532GlnThr: 1.532 ± 0.043
2.346GlnVal: 2.346 ± 0.059
0.36GlnTrp: 0.36 ± 0.022
0.928GlnTyr: 0.928 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.85ArgAla: 3.85 ± 0.098
0.607ArgCys: 0.607 ± 0.036
3.008ArgAsp: 3.008 ± 0.078
4.874ArgGlu: 4.874 ± 0.14
2.864ArgPhe: 2.864 ± 0.089
3.334ArgGly: 3.334 ± 0.08
1.534ArgHis: 1.534 ± 0.066
4.177ArgIle: 4.177 ± 0.1
3.797ArgLys: 3.797 ± 0.107
6.259ArgLeu: 6.259 ± 0.133
1.598ArgMet: 1.598 ± 0.057
2.43ArgAsn: 2.43 ± 0.075
2.127ArgPro: 2.127 ± 0.064
2.725ArgGln: 2.725 ± 0.084
3.372ArgArg: 3.372 ± 0.113
3.613ArgSer: 3.613 ± 0.094
2.721ArgThr: 2.721 ± 0.066
3.626ArgVal: 3.626 ± 0.095
0.649ArgTrp: 0.649 ± 0.034
2.238ArgTyr: 2.238 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.231SerAla: 5.231 ± 0.145
0.768SerCys: 0.768 ± 0.041
3.339SerAsp: 3.339 ± 0.147
3.554SerGlu: 3.554 ± 0.078
2.785SerPhe: 2.785 ± 0.074
5.993SerGly: 5.993 ± 0.219
1.299SerHis: 1.299 ± 0.046
4.061SerIle: 4.061 ± 0.103
2.355SerLys: 2.355 ± 0.074
6.611SerLeu: 6.611 ± 0.161
1.949SerMet: 1.949 ± 0.054
1.91SerAsn: 1.91 ± 0.056
2.772SerPro: 2.772 ± 0.069
1.73SerGln: 1.73 ± 0.053
4.081SerArg: 4.081 ± 0.105
4.532SerSer: 4.532 ± 0.125
3.354SerThr: 3.354 ± 0.115
4.602SerVal: 4.602 ± 0.154
0.815SerTrp: 0.815 ± 0.039
1.903SerTyr: 1.903 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.796ThrAla: 4.796 ± 0.185
0.493ThrCys: 0.493 ± 0.03
2.85ThrAsp: 2.85 ± 0.087
3.169ThrGlu: 3.169 ± 0.068
2.052ThrPhe: 2.052 ± 0.057
4.914ThrGly: 4.914 ± 0.168
0.974ThrHis: 0.974 ± 0.045
3.673ThrIle: 3.673 ± 0.127
1.795ThrLys: 1.795 ± 0.072
5.682ThrLeu: 5.682 ± 0.173
1.378ThrMet: 1.378 ± 0.045
1.535ThrAsn: 1.535 ± 0.051
2.781ThrPro: 2.781 ± 0.087
1.314ThrGln: 1.314 ± 0.045
2.715ThrArg: 2.715 ± 0.082
3.437ThrSer: 3.437 ± 0.135
3.079ThrThr: 3.079 ± 0.141
4.173ThrVal: 4.173 ± 0.168
0.555ThrTrp: 0.555 ± 0.03
1.56ThrTyr: 1.56 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
6.311ValAla: 6.311 ± 0.127
0.771ValCys: 0.771 ± 0.04
4.087ValAsp: 4.087 ± 0.116
4.634ValGlu: 4.634 ± 0.091
2.954ValPhe: 2.954 ± 0.077
4.623ValGly: 4.623 ± 0.16
1.391ValHis: 1.391 ± 0.057
4.683ValIle: 4.683 ± 0.103
2.824ValLys: 2.824 ± 0.077
7.412ValLeu: 7.412 ± 0.137
2.078ValMet: 2.078 ± 0.061
2.328ValAsn: 2.328 ± 0.069
2.93ValPro: 2.93 ± 0.081
2.27ValGln: 2.27 ± 0.079
4.283ValArg: 4.283 ± 0.099
4.81ValSer: 4.81 ± 0.134
4.487ValThr: 4.487 ± 0.189
5.499ValVal: 5.499 ± 0.117
0.657ValTrp: 0.657 ± 0.031
1.954ValTyr: 1.954 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.713TrpAla: 0.713 ± 0.037
0.11TrpCys: 0.11 ± 0.014
0.544TrpAsp: 0.544 ± 0.033
0.677TrpGlu: 0.677 ± 0.034
0.515TrpPhe: 0.515 ± 0.029
0.679TrpGly: 0.679 ± 0.031
0.293TrpHis: 0.293 ± 0.023
0.649TrpIle: 0.649 ± 0.029
0.621TrpLys: 0.621 ± 0.031
1.325TrpLeu: 1.325 ± 0.049
0.32TrpMet: 0.32 ± 0.022
0.456TrpAsn: 0.456 ± 0.025
0.367TrpPro: 0.367 ± 0.024
0.524TrpGln: 0.524 ± 0.031
0.548TrpArg: 0.548 ± 0.033
0.642TrpSer: 0.642 ± 0.032
0.519TrpThr: 0.519 ± 0.029
0.611TrpVal: 0.611 ± 0.034
0.158TrpTrp: 0.158 ± 0.016
0.33TrpTyr: 0.33 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.46TyrAla: 2.46 ± 0.061
0.317TyrCys: 0.317 ± 0.022
1.767TyrAsp: 1.767 ± 0.067
1.769TyrGlu: 1.769 ± 0.059
1.246TyrPhe: 1.246 ± 0.049
2.506TyrGly: 2.506 ± 0.056
0.763TyrHis: 0.763 ± 0.038
1.652TyrIle: 1.652 ± 0.05
1.091TyrLys: 1.091 ± 0.043
3.104TyrLeu: 3.104 ± 0.078
0.695TyrMet: 0.695 ± 0.039
1.075TyrAsn: 1.075 ± 0.043
1.452TyrPro: 1.452 ± 0.057
1.009TyrGln: 1.009 ± 0.037
2.292TyrArg: 2.292 ± 0.072
1.865TyrSer: 1.865 ± 0.057
1.637TyrThr: 1.637 ± 0.085
1.762TyrVal: 1.762 ± 0.058
0.339TyrTrp: 0.339 ± 0.022
0.974TyrTyr: 0.974 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2188 proteins (727722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski