Amino acid dipepetide frequency for Raspberry leaf mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.395AlaAla: 6.395 ± 1.317
1.317AlaCys: 1.317 ± 0.457
4.138AlaAsp: 4.138 ± 0.932
2.821AlaGlu: 2.821 ± 0.713
4.514AlaPhe: 4.514 ± 1.059
3.573AlaGly: 3.573 ± 1.209
1.128AlaHis: 1.128 ± 0.462
4.138AlaIle: 4.138 ± 1.575
4.514AlaLys: 4.514 ± 0.805
8.087AlaLeu: 8.087 ± 0.698
0.752AlaMet: 0.752 ± 0.442
2.633AlaAsn: 2.633 ± 0.971
2.821AlaPro: 2.821 ± 0.941
0.94AlaGln: 0.94 ± 0.32
3.009AlaArg: 3.009 ± 0.781
5.642AlaSer: 5.642 ± 0.847
3.197AlaThr: 3.197 ± 1.097
5.266AlaVal: 5.266 ± 1.832
0.752AlaTrp: 0.752 ± 0.374
2.633AlaTyr: 2.633 ± 0.503
0.0AlaXaa: 0.0 ± 0.0
Cys
2.069CysAla: 2.069 ± 0.681
0.376CysCys: 0.376 ± 0.28
0.752CysAsp: 0.752 ± 0.295
0.94CysGlu: 0.94 ± 0.406
1.881CysPhe: 1.881 ± 0.766
1.505CysGly: 1.505 ± 0.286
0.564CysHis: 0.564 ± 0.277
1.317CysIle: 1.317 ± 0.317
0.564CysLys: 0.564 ± 0.347
2.257CysLeu: 2.257 ± 0.76
0.376CysMet: 0.376 ± 0.353
0.94CysAsn: 0.94 ± 0.331
0.564CysPro: 0.564 ± 0.347
0.188CysGln: 0.188 ± 0.116
1.881CysArg: 1.881 ± 0.654
3.009CysSer: 3.009 ± 0.763
1.128CysThr: 1.128 ± 0.49
0.94CysVal: 0.94 ± 0.306
0.0CysTrp: 0.0 ± 0.0
0.94CysTyr: 0.94 ± 0.37
0.0CysXaa: 0.0 ± 0.0
Asp
3.95AspAla: 3.95 ± 0.552
1.128AspCys: 1.128 ± 0.394
3.95AspAsp: 3.95 ± 1.363
2.821AspGlu: 2.821 ± 0.756
4.89AspPhe: 4.89 ± 0.787
2.445AspGly: 2.445 ± 0.595
2.069AspHis: 2.069 ± 1.435
3.009AspIle: 3.009 ± 0.669
2.069AspLys: 2.069 ± 0.966
6.583AspLeu: 6.583 ± 1.095
0.752AspMet: 0.752 ± 1.025
1.317AspAsn: 1.317 ± 0.721
1.693AspPro: 1.693 ± 0.54
0.752AspGln: 0.752 ± 0.377
3.009AspArg: 3.009 ± 0.591
6.771AspSer: 6.771 ± 1.108
3.197AspThr: 3.197 ± 0.929
6.018AspVal: 6.018 ± 1.212
0.188AspTrp: 0.188 ± 0.116
1.128AspTyr: 1.128 ± 0.604
0.0AspXaa: 0.0 ± 0.0
Glu
4.326GluAla: 4.326 ± 1.142
0.94GluCys: 0.94 ± 0.578
3.009GluAsp: 3.009 ± 0.671
1.693GluGlu: 1.693 ± 0.545
2.633GluPhe: 2.633 ± 1.013
1.693GluGly: 1.693 ± 0.6
1.317GluHis: 1.317 ± 0.571
3.197GluIle: 3.197 ± 0.687
2.257GluLys: 2.257 ± 0.665
3.009GluLeu: 3.009 ± 0.762
2.257GluMet: 2.257 ± 1.016
0.752GluAsn: 0.752 ± 0.563
1.693GluPro: 1.693 ± 0.486
0.752GluGln: 0.752 ± 0.237
2.257GluArg: 2.257 ± 0.851
4.138GluSer: 4.138 ± 0.838
2.633GluThr: 2.633 ± 1.582
3.95GluVal: 3.95 ± 0.611
0.564GluTrp: 0.564 ± 0.344
1.881GluTyr: 1.881 ± 0.874
0.0GluXaa: 0.0 ± 0.0
Phe
3.009PheAla: 3.009 ± 1.119
2.069PheCys: 2.069 ± 0.504
3.573PheAsp: 3.573 ± 1.187
2.069PheGlu: 2.069 ± 0.456
3.197PhePhe: 3.197 ± 0.909
2.633PheGly: 2.633 ± 0.985
1.128PheHis: 1.128 ± 0.575
3.009PheIle: 3.009 ± 0.646
2.633PheLys: 2.633 ± 0.778
6.207PheLeu: 6.207 ± 1.549
0.94PheMet: 0.94 ± 0.629
1.317PheAsn: 1.317 ± 0.605
3.009PhePro: 3.009 ± 0.903
0.564PheGln: 0.564 ± 0.221
3.573PheArg: 3.573 ± 0.619
9.404PheSer: 9.404 ± 1.581
4.138PheThr: 4.138 ± 0.799
4.702PheVal: 4.702 ± 0.861
0.376PheTrp: 0.376 ± 0.231
1.693PheTyr: 1.693 ± 0.537
0.0PheXaa: 0.0 ± 0.0
Gly
3.762GlyAla: 3.762 ± 0.812
1.693GlyCys: 1.693 ± 0.734
3.573GlyAsp: 3.573 ± 0.414
3.573GlyGlu: 3.573 ± 0.577
2.069GlyPhe: 2.069 ± 0.671
4.514GlyGly: 4.514 ± 1.317
1.128GlyHis: 1.128 ± 0.852
3.197GlyIle: 3.197 ± 0.798
2.821GlyLys: 2.821 ± 0.813
4.89GlyLeu: 4.89 ± 0.958
0.752GlyMet: 0.752 ± 0.52
1.128GlyAsn: 1.128 ± 0.238
1.128GlyPro: 1.128 ± 0.486
0.564GlyGln: 0.564 ± 0.319
3.385GlyArg: 3.385 ± 0.946
6.207GlySer: 6.207 ± 0.929
1.881GlyThr: 1.881 ± 1.493
5.266GlyVal: 5.266 ± 1.325
0.376GlyTrp: 0.376 ± 0.347
3.009GlyTyr: 3.009 ± 0.654
0.0GlyXaa: 0.0 ± 0.0
His
1.881HisAla: 1.881 ± 0.931
0.752HisCys: 0.752 ± 0.442
1.505HisAsp: 1.505 ± 0.491
0.564HisGlu: 0.564 ± 0.322
1.317HisPhe: 1.317 ± 0.522
0.752HisGly: 0.752 ± 0.447
0.564HisHis: 0.564 ± 0.225
0.94HisIle: 0.94 ± 0.296
0.376HisLys: 0.376 ± 0.231
1.881HisLeu: 1.881 ± 0.411
0.0HisMet: 0.0 ± 0.0
0.376HisAsn: 0.376 ± 0.199
0.376HisPro: 0.376 ± 0.352
0.752HisGln: 0.752 ± 0.481
1.881HisArg: 1.881 ± 0.703
2.445HisSer: 2.445 ± 0.538
2.257HisThr: 2.257 ± 0.537
2.069HisVal: 2.069 ± 0.719
0.0HisTrp: 0.0 ± 0.0
0.752HisTyr: 0.752 ± 0.478
0.0HisXaa: 0.0 ± 0.0
Ile
2.633IleAla: 2.633 ± 0.796
0.94IleCys: 0.94 ± 0.328
2.069IleAsp: 2.069 ± 0.633
1.505IleGlu: 1.505 ± 0.917
1.881IlePhe: 1.881 ± 0.774
3.197IleGly: 3.197 ± 0.897
1.317IleHis: 1.317 ± 0.385
1.505IleIle: 1.505 ± 0.883
2.821IleLys: 2.821 ± 0.768
4.326IleLeu: 4.326 ± 0.986
0.752IleMet: 0.752 ± 0.632
1.881IleAsn: 1.881 ± 0.732
3.762IlePro: 3.762 ± 1.335
0.752IleGln: 0.752 ± 0.398
4.514IleArg: 4.514 ± 1.846
5.454IleSer: 5.454 ± 1.457
3.95IleThr: 3.95 ± 2.027
4.138IleVal: 4.138 ± 0.711
0.376IleTrp: 0.376 ± 0.478
0.94IleTyr: 0.94 ± 0.533
0.0IleXaa: 0.0 ± 0.0
Lys
3.197LysAla: 3.197 ± 1.095
0.752LysCys: 0.752 ± 0.622
2.069LysAsp: 2.069 ± 0.471
2.257LysGlu: 2.257 ± 1.055
5.078LysPhe: 5.078 ± 0.841
3.009LysGly: 3.009 ± 0.703
1.128LysHis: 1.128 ± 0.91
2.633LysIle: 2.633 ± 0.968
1.317LysLys: 1.317 ± 0.482
6.207LysLeu: 6.207 ± 2.932
1.128LysMet: 1.128 ± 0.687
1.128LysAsn: 1.128 ± 0.333
1.693LysPro: 1.693 ± 0.345
1.128LysGln: 1.128 ± 0.391
3.197LysArg: 3.197 ± 0.591
5.078LysSer: 5.078 ± 1.16
2.633LysThr: 2.633 ± 0.315
4.326LysVal: 4.326 ± 0.785
0.376LysTrp: 0.376 ± 0.208
2.633LysTyr: 2.633 ± 1.035
0.0LysXaa: 0.0 ± 0.0
Leu
5.83LeuAla: 5.83 ± 0.887
3.197LeuCys: 3.197 ± 0.549
5.454LeuAsp: 5.454 ± 0.996
4.89LeuGlu: 4.89 ± 0.798
4.138LeuPhe: 4.138 ± 0.798
4.514LeuGly: 4.514 ± 1.623
2.257LeuHis: 2.257 ± 0.627
3.762LeuIle: 3.762 ± 1.313
6.207LeuLys: 6.207 ± 2.115
10.532LeuLeu: 10.532 ± 1.298
2.257LeuMet: 2.257 ± 0.84
4.138LeuAsn: 4.138 ± 1.594
6.018LeuPro: 6.018 ± 0.94
2.445LeuGln: 2.445 ± 0.555
6.771LeuArg: 6.771 ± 1.388
12.977LeuSer: 12.977 ± 1.724
5.266LeuThr: 5.266 ± 1.257
7.711LeuVal: 7.711 ± 0.78
0.376LeuTrp: 0.376 ± 0.231
4.89LeuTyr: 4.89 ± 0.577
0.0LeuXaa: 0.0 ± 0.0
Met
0.752MetAla: 0.752 ± 0.612
0.188MetCys: 0.188 ± 0.34
0.94MetAsp: 0.94 ± 0.816
0.376MetGlu: 0.376 ± 0.347
0.94MetPhe: 0.94 ± 0.587
1.505MetGly: 1.505 ± 0.79
0.564MetHis: 0.564 ± 0.425
1.317MetIle: 1.317 ± 1.003
1.505MetLys: 1.505 ± 1.181
1.505MetLeu: 1.505 ± 0.339
0.188MetMet: 0.188 ± 0.239
0.752MetAsn: 0.752 ± 0.291
0.564MetPro: 0.564 ± 0.374
0.188MetGln: 0.188 ± 0.116
0.188MetArg: 0.188 ± 0.33
1.128MetSer: 1.128 ± 0.49
1.128MetThr: 1.128 ± 0.71
1.693MetVal: 1.693 ± 0.619
0.376MetTrp: 0.376 ± 0.347
0.564MetTyr: 0.564 ± 0.283
0.0MetXaa: 0.0 ± 0.0
Asn
2.821AsnAla: 2.821 ± 0.653
0.752AsnCys: 0.752 ± 0.291
2.069AsnAsp: 2.069 ± 1.032
1.693AsnGlu: 1.693 ± 0.366
2.069AsnPhe: 2.069 ± 0.662
1.317AsnGly: 1.317 ± 0.598
0.752AsnHis: 0.752 ± 0.393
1.881AsnIle: 1.881 ± 1.224
0.752AsnLys: 0.752 ± 0.666
3.762AsnLeu: 3.762 ± 0.668
0.376AsnMet: 0.376 ± 0.309
0.752AsnAsn: 0.752 ± 0.462
1.693AsnPro: 1.693 ± 0.875
0.564AsnGln: 0.564 ± 0.622
1.693AsnArg: 1.693 ± 0.45
3.009AsnSer: 3.009 ± 0.672
2.821AsnThr: 2.821 ± 1.099
3.009AsnVal: 3.009 ± 0.728
0.188AsnTrp: 0.188 ± 0.116
0.94AsnTyr: 0.94 ± 0.267
0.0AsnXaa: 0.0 ± 0.0
Pro
3.573ProAla: 3.573 ± 0.634
0.752ProCys: 0.752 ± 0.251
2.445ProAsp: 2.445 ± 0.676
2.445ProGlu: 2.445 ± 0.52
3.573ProPhe: 3.573 ± 1.059
4.514ProGly: 4.514 ± 1.267
0.564ProHis: 0.564 ± 0.347
2.257ProIle: 2.257 ± 0.836
2.445ProLys: 2.445 ± 0.688
4.326ProLeu: 4.326 ± 1.026
0.188ProMet: 0.188 ± 0.116
1.128ProAsn: 1.128 ± 0.459
3.197ProPro: 3.197 ± 0.593
0.752ProGln: 0.752 ± 0.295
3.009ProArg: 3.009 ± 0.705
5.454ProSer: 5.454 ± 0.681
2.821ProThr: 2.821 ± 0.586
4.138ProVal: 4.138 ± 0.758
0.188ProTrp: 0.188 ± 0.116
1.881ProTyr: 1.881 ± 0.397
0.0ProXaa: 0.0 ± 0.0
Gln
0.376GlnAla: 0.376 ± 0.208
0.564GlnCys: 0.564 ± 0.425
2.069GlnAsp: 2.069 ± 0.337
1.317GlnGlu: 1.317 ± 0.344
0.752GlnPhe: 0.752 ± 0.462
1.128GlnGly: 1.128 ± 0.389
0.0GlnHis: 0.0 ± 0.0
1.317GlnIle: 1.317 ± 0.502
0.376GlnLys: 0.376 ± 0.282
2.633GlnLeu: 2.633 ± 1.197
0.564GlnMet: 0.564 ± 0.268
0.752GlnAsn: 0.752 ± 0.312
0.94GlnPro: 0.94 ± 0.405
0.376GlnGln: 0.376 ± 0.231
1.693GlnArg: 1.693 ± 0.307
1.505GlnSer: 1.505 ± 0.458
0.94GlnThr: 0.94 ± 0.371
0.564GlnVal: 0.564 ± 0.431
0.0GlnTrp: 0.0 ± 0.0
0.376GlnTyr: 0.376 ± 0.199
0.0GlnXaa: 0.0 ± 0.0
Arg
5.454ArgAla: 5.454 ± 1.348
1.505ArgCys: 1.505 ± 0.591
4.702ArgAsp: 4.702 ± 0.936
2.821ArgGlu: 2.821 ± 1.167
4.326ArgPhe: 4.326 ± 1.087
3.009ArgGly: 3.009 ± 0.735
1.128ArgHis: 1.128 ± 0.538
2.445ArgIle: 2.445 ± 0.557
2.257ArgLys: 2.257 ± 0.442
5.078ArgLeu: 5.078 ± 1.142
0.376ArgMet: 0.376 ± 0.231
1.693ArgAsn: 1.693 ± 0.366
3.95ArgPro: 3.95 ± 1.119
1.128ArgGln: 1.128 ± 0.464
5.266ArgArg: 5.266 ± 1.017
4.89ArgSer: 4.89 ± 0.866
3.197ArgThr: 3.197 ± 0.739
5.078ArgVal: 5.078 ± 1.807
0.752ArgTrp: 0.752 ± 0.291
1.693ArgTyr: 1.693 ± 0.593
0.0ArgXaa: 0.0 ± 0.0
Ser
6.959SerAla: 6.959 ± 1.91
1.505SerCys: 1.505 ± 0.54
5.454SerAsp: 5.454 ± 0.787
5.266SerGlu: 5.266 ± 1.646
5.83SerPhe: 5.83 ± 1.077
4.89SerGly: 4.89 ± 0.969
1.505SerHis: 1.505 ± 0.526
5.454SerIle: 5.454 ± 1.771
6.583SerLys: 6.583 ± 1.28
10.908SerLeu: 10.908 ± 1.674
1.317SerMet: 1.317 ± 0.544
3.573SerAsn: 3.573 ± 1.108
5.454SerPro: 5.454 ± 1.379
2.821SerGln: 2.821 ± 1.025
7.147SerArg: 7.147 ± 1.397
11.849SerSer: 11.849 ± 1.928
5.83SerThr: 5.83 ± 1.025
9.968SerVal: 9.968 ± 2.554
0.752SerTrp: 0.752 ± 0.365
3.197SerTyr: 3.197 ± 0.52
0.0SerXaa: 0.0 ± 0.0
Thr
4.514ThrAla: 4.514 ± 1.056
0.752ThrCys: 0.752 ± 0.353
2.445ThrAsp: 2.445 ± 0.996
1.881ThrGlu: 1.881 ± 0.377
3.385ThrPhe: 3.385 ± 0.711
3.573ThrGly: 3.573 ± 0.812
0.94ThrHis: 0.94 ± 0.442
2.069ThrIle: 2.069 ± 0.765
3.385ThrLys: 3.385 ± 0.807
6.959ThrLeu: 6.959 ± 2.106
0.94ThrMet: 0.94 ± 0.325
3.197ThrAsn: 3.197 ± 0.463
3.95ThrPro: 3.95 ± 0.859
1.505ThrGln: 1.505 ± 0.583
2.633ThrArg: 2.633 ± 0.574
5.078ThrSer: 5.078 ± 1.044
3.95ThrThr: 3.95 ± 1.214
3.762ThrVal: 3.762 ± 0.771
0.564ThrTrp: 0.564 ± 0.239
1.693ThrTyr: 1.693 ± 0.606
0.0ThrXaa: 0.0 ± 0.0
Val
4.326ValAla: 4.326 ± 1.076
1.505ValCys: 1.505 ± 0.924
4.326ValAsp: 4.326 ± 0.997
3.762ValGlu: 3.762 ± 0.641
4.326ValPhe: 4.326 ± 0.813
4.138ValGly: 4.138 ± 1.175
2.069ValHis: 2.069 ± 0.833
3.197ValIle: 3.197 ± 0.989
6.018ValLys: 6.018 ± 0.789
8.651ValLeu: 8.651 ± 2.275
1.505ValMet: 1.505 ± 0.246
3.385ValAsn: 3.385 ± 0.614
5.642ValPro: 5.642 ± 0.586
1.317ValGln: 1.317 ± 0.409
3.95ValArg: 3.95 ± 1.064
7.899ValSer: 7.899 ± 0.878
4.702ValThr: 4.702 ± 0.575
7.523ValVal: 7.523 ± 1.632
0.376ValTrp: 0.376 ± 0.231
4.138ValTyr: 4.138 ± 0.738
0.0ValXaa: 0.0 ± 0.0
Trp
1.128TrpAla: 1.128 ± 0.449
0.0TrpCys: 0.0 ± 0.0
0.376TrpAsp: 0.376 ± 0.295
0.376TrpGlu: 0.376 ± 0.353
0.564TrpPhe: 0.564 ± 0.347
0.752TrpGly: 0.752 ± 0.326
0.0TrpHis: 0.0 ± 0.0
0.376TrpIle: 0.376 ± 0.347
0.188TrpLys: 0.188 ± 0.116
0.94TrpLeu: 0.94 ± 0.463
0.188TrpMet: 0.188 ± 0.237
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.376TrpArg: 0.376 ± 0.231
0.376TrpSer: 0.376 ± 0.201
0.564TrpThr: 0.564 ± 0.347
0.188TrpVal: 0.188 ± 0.239
0.188TrpTrp: 0.188 ± 0.237
0.376TrpTyr: 0.376 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.317TyrAla: 1.317 ± 0.435
1.505TyrCys: 1.505 ± 0.487
3.009TyrAsp: 3.009 ± 0.949
1.881TyrGlu: 1.881 ± 0.901
1.881TyrPhe: 1.881 ± 0.641
2.257TyrGly: 2.257 ± 0.964
1.317TyrHis: 1.317 ± 0.581
1.693TyrIle: 1.693 ± 0.307
1.881TyrLys: 1.881 ± 1.083
4.89TyrLeu: 4.89 ± 0.886
0.564TyrMet: 0.564 ± 0.361
2.069TyrAsn: 2.069 ± 1.136
1.505TyrPro: 1.505 ± 0.363
0.752TyrGln: 0.752 ± 0.462
1.317TyrArg: 1.317 ± 0.464
3.95TyrSer: 3.95 ± 0.75
0.94TyrThr: 0.94 ± 0.392
2.445TyrVal: 2.445 ± 0.618
0.188TyrTrp: 0.188 ± 0.116
1.505TyrTyr: 1.505 ± 0.503
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (5318 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski