Amino acid dipepetide frequency for Grapevine virus I

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.271AlaAla: 3.271 ± 3.27
0.818AlaCys: 0.818 ± 0.442
2.453AlaAsp: 2.453 ± 0.889
5.315AlaGlu: 5.315 ± 1.13
3.679AlaPhe: 3.679 ± 1.304
4.088AlaGly: 4.088 ± 1.458
2.044AlaHis: 2.044 ± 0.723
4.088AlaIle: 4.088 ± 3.734
5.724AlaLys: 5.724 ± 1.759
4.906AlaLeu: 4.906 ± 1.45
0.818AlaMet: 0.818 ± 0.551
4.088AlaAsn: 4.088 ± 1.194
1.635AlaPro: 1.635 ± 0.58
3.271AlaGln: 3.271 ± 0.686
3.271AlaArg: 3.271 ± 0.567
4.497AlaSer: 4.497 ± 1.806
2.862AlaThr: 2.862 ± 2.319
5.315AlaVal: 5.315 ± 1.179
0.409AlaTrp: 0.409 ± 0.652
2.044AlaTyr: 2.044 ± 0.736
0.0AlaXaa: 0.0 ± 0.0
Cys
1.226CysAla: 1.226 ± 1.187
0.409CysCys: 0.409 ± 0.738
0.0CysAsp: 0.0 ± 0.0
0.818CysGlu: 0.818 ± 0.733
2.044CysPhe: 2.044 ± 0.68
2.044CysGly: 2.044 ± 0.68
0.0CysHis: 0.0 ± 0.0
2.044CysIle: 2.044 ± 1.223
1.226CysLys: 1.226 ± 0.663
1.635CysLeu: 1.635 ± 0.884
0.0CysMet: 0.0 ± 0.0
1.226CysAsn: 1.226 ± 0.555
0.409CysPro: 0.409 ± 0.221
0.409CysGln: 0.409 ± 0.221
1.635CysArg: 1.635 ± 0.593
1.635CysSer: 1.635 ± 0.893
2.044CysThr: 2.044 ± 0.736
0.409CysVal: 0.409 ± 0.652
0.0CysTrp: 0.0 ± 0.0
1.226CysTyr: 1.226 ± 1.594
0.0CysXaa: 0.0 ± 0.0
Asp
3.679AspAla: 3.679 ± 1.007
1.226AspCys: 1.226 ± 0.555
4.497AspAsp: 4.497 ± 0.399
6.541AspGlu: 6.541 ± 1.284
2.862AspPhe: 2.862 ± 0.818
2.862AspGly: 2.862 ± 1.547
2.044AspHis: 2.044 ± 0.723
2.044AspIle: 2.044 ± 0.684
4.497AspLys: 4.497 ± 2.694
7.359AspLeu: 7.359 ± 1.288
1.226AspMet: 1.226 ± 0.663
1.226AspAsn: 1.226 ± 0.528
4.088AspPro: 4.088 ± 1.686
1.226AspGln: 1.226 ± 0.555
2.862AspArg: 2.862 ± 1.101
3.679AspSer: 3.679 ± 0.896
2.044AspThr: 2.044 ± 0.612
2.044AspVal: 2.044 ± 1.105
1.226AspTrp: 1.226 ± 0.663
2.453AspTyr: 2.453 ± 0.889
0.0AspXaa: 0.0 ± 0.0
Glu
3.679GluAla: 3.679 ± 1.486
0.0GluCys: 0.0 ± 0.0
3.271GluAsp: 3.271 ± 1.107
7.768GluGlu: 7.768 ± 1.119
4.088GluPhe: 4.088 ± 1.046
3.271GluGly: 3.271 ± 0.654
1.635GluHis: 1.635 ± 0.884
3.271GluIle: 3.271 ± 1.166
2.862GluLys: 2.862 ± 1.076
6.95GluLeu: 6.95 ± 0.917
5.315GluMet: 5.315 ± 1.927
3.271GluAsn: 3.271 ± 1.01
2.044GluPro: 2.044 ± 1.875
0.818GluGln: 0.818 ± 0.442
0.409GluArg: 0.409 ± 0.652
5.724GluSer: 5.724 ± 2.634
3.271GluThr: 3.271 ± 0.954
9.812GluVal: 9.812 ± 2.008
0.818GluTrp: 0.818 ± 0.733
2.453GluTyr: 2.453 ± 1.111
0.0GluXaa: 0.0 ± 0.0
Phe
4.088PheAla: 4.088 ± 1.884
1.635PheCys: 1.635 ± 0.58
3.271PheAsp: 3.271 ± 1.596
2.044PheGlu: 2.044 ± 0.723
3.679PhePhe: 3.679 ± 1.321
3.679PheGly: 3.679 ± 0.412
0.0PheHis: 0.0 ± 0.0
0.818PheIle: 0.818 ± 0.733
3.679PheLys: 3.679 ± 2.235
5.315PheLeu: 5.315 ± 1.468
2.044PheMet: 2.044 ± 1.056
1.226PheAsn: 1.226 ± 0.663
0.818PhePro: 0.818 ± 1.096
2.044PheGln: 2.044 ± 0.723
2.453PheArg: 2.453 ± 0.855
7.359PheSer: 7.359 ± 2.571
3.679PheThr: 3.679 ± 1.321
1.635PheVal: 1.635 ± 1.101
0.0PheTrp: 0.0 ± 0.0
3.271PheTyr: 3.271 ± 2.38
0.0PheXaa: 0.0 ± 0.0
Gly
4.906GlyAla: 4.906 ± 1.186
1.635GlyCys: 1.635 ± 0.593
7.359GlyAsp: 7.359 ± 2.213
2.862GlyGlu: 2.862 ± 1.633
4.088GlyPhe: 4.088 ± 1.085
2.862GlyGly: 2.862 ± 0.8
0.0GlyHis: 0.0 ± 0.0
2.453GlyIle: 2.453 ± 0.889
4.906GlyLys: 4.906 ± 1.318
6.95GlyLeu: 6.95 ± 1.878
2.453GlyMet: 2.453 ± 1.04
3.271GlyAsn: 3.271 ± 0.654
1.635GlyPro: 1.635 ± 0.884
2.044GlyGln: 2.044 ± 0.962
2.862GlyArg: 2.862 ± 1.466
6.132GlySer: 6.132 ± 1.476
2.453GlyThr: 2.453 ± 1.568
4.497GlyVal: 4.497 ± 2.383
0.818GlyTrp: 0.818 ± 0.442
2.453GlyTyr: 2.453 ± 1.326
0.0GlyXaa: 0.0 ± 0.0
His
2.044HisAla: 2.044 ± 1.105
0.409HisCys: 0.409 ± 0.221
0.409HisAsp: 0.409 ± 0.221
1.635HisGlu: 1.635 ± 0.593
1.226HisPhe: 1.226 ± 0.663
1.226HisGly: 1.226 ± 0.528
1.226HisHis: 1.226 ± 0.663
1.226HisIle: 1.226 ± 0.663
1.635HisLys: 1.635 ± 0.593
0.818HisLeu: 0.818 ± 0.442
1.226HisMet: 1.226 ± 0.528
0.0HisAsn: 0.0 ± 0.0
1.226HisPro: 1.226 ± 1.044
0.409HisGln: 0.409 ± 0.874
0.409HisArg: 0.409 ± 0.221
2.862HisSer: 2.862 ± 1.547
0.409HisThr: 0.409 ± 0.221
0.409HisVal: 0.409 ± 0.652
0.0HisTrp: 0.0 ± 0.0
1.226HisTyr: 1.226 ± 0.663
0.0HisXaa: 0.0 ± 0.0
Ile
3.679IleAla: 3.679 ± 0.8
2.453IleCys: 2.453 ± 1.652
2.862IleAsp: 2.862 ± 1.547
4.497IleGlu: 4.497 ± 0.932
4.088IlePhe: 4.088 ± 2.0
3.679IleGly: 3.679 ± 1.107
0.818IleHis: 0.818 ± 0.442
1.635IleIle: 1.635 ± 0.743
4.497IleLys: 4.497 ± 1.473
4.088IleLeu: 4.088 ± 1.57
1.226IleMet: 1.226 ± 0.959
1.635IleAsn: 1.635 ± 1.578
0.818IlePro: 0.818 ± 0.442
1.635IleGln: 1.635 ± 1.36
3.271IleArg: 3.271 ± 1.217
2.044IleSer: 2.044 ± 1.249
1.635IleThr: 1.635 ± 0.628
2.862IleVal: 2.862 ± 0.559
0.0IleTrp: 0.0 ± 0.0
1.635IleTyr: 1.635 ± 0.884
0.0IleXaa: 0.0 ± 0.0
Lys
4.497LysAla: 4.497 ± 1.282
0.818LysCys: 0.818 ± 0.442
1.635LysAsp: 1.635 ± 0.593
7.359LysGlu: 7.359 ± 0.824
1.635LysPhe: 1.635 ± 0.893
8.994LysGly: 8.994 ± 1.774
2.044LysHis: 2.044 ± 0.723
2.453LysIle: 2.453 ± 0.889
3.271LysLys: 3.271 ± 1.273
10.63LysLeu: 10.63 ± 0.726
3.679LysMet: 3.679 ± 1.107
2.862LysAsn: 2.862 ± 1.076
2.453LysPro: 2.453 ± 1.326
0.409LysGln: 0.409 ± 0.221
4.497LysArg: 4.497 ± 1.122
4.497LysSer: 4.497 ± 1.461
4.906LysThr: 4.906 ± 2.015
7.768LysVal: 7.768 ± 3.456
0.818LysTrp: 0.818 ± 0.442
2.453LysTyr: 2.453 ± 0.828
0.0LysXaa: 0.0 ± 0.0
Leu
8.585LeuAla: 8.585 ± 3.609
2.862LeuCys: 2.862 ± 1.547
8.994LeuAsp: 8.994 ± 2.69
6.95LeuGlu: 6.95 ± 2.428
4.497LeuPhe: 4.497 ± 0.614
7.768LeuGly: 7.768 ± 2.766
2.862LeuHis: 2.862 ± 1.076
4.497LeuIle: 4.497 ± 1.22
11.038LeuLys: 11.038 ± 1.215
7.768LeuLeu: 7.768 ± 1.728
1.635LeuMet: 1.635 ± 0.884
5.315LeuAsn: 5.315 ± 1.42
3.271LeuPro: 3.271 ± 1.184
2.044LeuGln: 2.044 ± 0.736
3.679LeuArg: 3.679 ± 1.373
5.724LeuSer: 5.724 ± 2.124
8.177LeuThr: 8.177 ± 1.493
6.132LeuVal: 6.132 ± 2.362
0.0LeuTrp: 0.0 ± 0.0
2.453LeuTyr: 2.453 ± 0.855
0.0LeuXaa: 0.0 ± 0.0
Met
1.635MetAla: 1.635 ± 1.499
0.409MetCys: 0.409 ± 0.221
1.226MetAsp: 1.226 ± 0.528
2.453MetGlu: 2.453 ± 0.855
1.226MetPhe: 1.226 ± 0.528
2.453MetGly: 2.453 ± 0.828
0.818MetHis: 0.818 ± 1.096
1.226MetIle: 1.226 ± 0.663
1.635MetLys: 1.635 ± 0.884
3.679MetLeu: 3.679 ± 1.304
1.226MetMet: 1.226 ± 0.646
1.635MetAsn: 1.635 ± 0.628
0.409MetPro: 0.409 ± 0.221
1.226MetGln: 1.226 ± 0.663
2.862MetArg: 2.862 ± 0.611
3.271MetSer: 3.271 ± 0.954
0.818MetThr: 0.818 ± 0.75
2.453MetVal: 2.453 ± 0.855
0.0MetTrp: 0.0 ± 0.0
0.409MetTyr: 0.409 ± 0.652
0.0MetXaa: 0.0 ± 0.0
Asn
2.453AsnAla: 2.453 ± 0.566
0.409AsnCys: 0.409 ± 0.221
1.635AsnAsp: 1.635 ± 0.884
1.635AsnGlu: 1.635 ± 0.628
3.271AsnPhe: 3.271 ± 0.779
3.271AsnGly: 3.271 ± 0.954
0.409AsnHis: 0.409 ± 0.221
4.906AsnIle: 4.906 ± 0.865
1.635AsnLys: 1.635 ± 1.071
3.679AsnLeu: 3.679 ± 2.682
1.226AsnMet: 1.226 ± 0.663
1.635AsnAsn: 1.635 ± 1.831
2.862AsnPro: 2.862 ± 0.954
0.409AsnGln: 0.409 ± 0.221
1.635AsnArg: 1.635 ± 1.467
2.862AsnSer: 2.862 ± 1.951
0.818AsnThr: 0.818 ± 0.551
4.088AsnVal: 4.088 ± 2.111
0.0AsnTrp: 0.0 ± 0.0
1.635AsnTyr: 1.635 ± 0.628
0.0AsnXaa: 0.0 ± 0.0
Pro
2.044ProAla: 2.044 ± 0.604
0.818ProCys: 0.818 ± 0.442
2.862ProAsp: 2.862 ± 0.611
3.271ProGlu: 3.271 ± 2.143
0.818ProPhe: 0.818 ± 1.096
2.044ProGly: 2.044 ± 0.736
0.409ProHis: 0.409 ± 0.221
2.044ProIle: 2.044 ± 1.105
1.226ProLys: 1.226 ± 0.677
4.906ProLeu: 4.906 ± 0.548
1.226ProMet: 1.226 ± 1.212
2.044ProAsn: 2.044 ± 0.684
1.635ProPro: 1.635 ± 0.986
0.818ProGln: 0.818 ± 0.75
1.635ProArg: 1.635 ± 0.884
3.271ProSer: 3.271 ± 1.273
1.226ProThr: 1.226 ± 0.528
1.635ProVal: 1.635 ± 0.884
0.0ProTrp: 0.0 ± 0.0
1.226ProTyr: 1.226 ± 0.663
0.0ProXaa: 0.0 ± 0.0
Gln
0.818GlnAla: 0.818 ± 0.442
0.409GlnCys: 0.409 ± 0.87
1.635GlnAsp: 1.635 ± 0.713
1.635GlnGlu: 1.635 ± 0.884
0.409GlnPhe: 0.409 ± 0.221
2.453GlnGly: 2.453 ± 0.711
0.0GlnHis: 0.0 ± 0.0
0.818GlnIle: 0.818 ± 0.75
2.862GlnLys: 2.862 ± 1.547
5.315GlnLeu: 5.315 ± 1.468
0.409GlnMet: 0.409 ± 0.221
0.0GlnAsn: 0.0 ± 0.0
1.635GlnPro: 1.635 ± 0.743
0.818GlnGln: 0.818 ± 0.733
1.635GlnArg: 1.635 ± 2.032
0.818GlnSer: 0.818 ± 1.096
0.818GlnThr: 0.818 ± 0.442
2.862GlnVal: 2.862 ± 4.013
0.409GlnTrp: 0.409 ± 0.221
0.409GlnTyr: 0.409 ± 0.738
0.0GlnXaa: 0.0 ± 0.0
Arg
3.271ArgAla: 3.271 ± 1.195
0.409ArgCys: 0.409 ± 0.738
2.044ArgAsp: 2.044 ± 0.723
1.226ArgGlu: 1.226 ± 0.663
2.862ArgPhe: 2.862 ± 1.67
1.226ArgGly: 1.226 ± 0.663
0.409ArgHis: 0.409 ± 0.221
3.679ArgIle: 3.679 ± 0.829
5.724ArgLys: 5.724 ± 2.018
6.132ArgLeu: 6.132 ± 3.152
1.635ArgMet: 1.635 ± 0.63
0.409ArgAsn: 0.409 ± 0.221
0.409ArgPro: 0.409 ± 0.221
2.044ArgGln: 2.044 ± 1.223
1.635ArgArg: 1.635 ± 0.58
4.906ArgSer: 4.906 ± 1.733
3.679ArgThr: 3.679 ± 1.311
2.044ArgVal: 2.044 ± 0.684
0.409ArgTrp: 0.409 ± 0.87
2.044ArgTyr: 2.044 ± 0.68
0.0ArgXaa: 0.0 ± 0.0
Ser
4.497SerAla: 4.497 ± 1.522
2.862SerCys: 2.862 ± 1.42
6.132SerAsp: 6.132 ± 2.169
4.906SerGlu: 4.906 ± 1.846
3.271SerPhe: 3.271 ± 0.681
4.906SerGly: 4.906 ± 1.45
1.635SerHis: 1.635 ± 0.884
3.679SerIle: 3.679 ± 0.896
6.541SerLys: 6.541 ± 1.63
6.132SerLeu: 6.132 ± 1.665
1.635SerMet: 1.635 ± 0.672
4.088SerAsn: 4.088 ± 1.123
2.453SerPro: 2.453 ± 0.566
2.453SerGln: 2.453 ± 1.307
4.088SerArg: 4.088 ± 1.589
5.315SerSer: 5.315 ± 1.613
2.044SerThr: 2.044 ± 1.682
5.724SerVal: 5.724 ± 2.043
0.409SerTrp: 0.409 ± 0.221
2.862SerTyr: 2.862 ± 1.076
0.0SerXaa: 0.0 ± 0.0
Thr
2.453ThrAla: 2.453 ± 1.819
0.409ThrCys: 0.409 ± 0.221
2.862ThrAsp: 2.862 ± 1.547
4.497ThrGlu: 4.497 ± 1.975
3.271ThrPhe: 3.271 ± 1.195
2.862ThrGly: 2.862 ± 1.42
1.226ThrHis: 1.226 ± 0.663
2.453ThrIle: 2.453 ± 0.828
3.271ThrLys: 3.271 ± 0.654
6.541ThrLeu: 6.541 ± 1.688
0.409ThrMet: 0.409 ± 0.221
1.635ThrAsn: 1.635 ± 0.986
2.453ThrPro: 2.453 ± 2.678
1.226ThrGln: 1.226 ± 1.16
2.862ThrArg: 2.862 ± 1.633
2.453ThrSer: 2.453 ± 0.855
2.862ThrThr: 2.862 ± 1.555
2.862ThrVal: 2.862 ± 0.712
0.818ThrTrp: 0.818 ± 0.442
0.818ThrTyr: 0.818 ± 0.733
0.0ThrXaa: 0.0 ± 0.0
Val
4.497ValAla: 4.497 ± 1.473
1.635ValCys: 1.635 ± 2.032
4.088ValAsp: 4.088 ± 1.446
4.088ValGlu: 4.088 ± 0.34
3.679ValPhe: 3.679 ± 1.916
5.315ValGly: 5.315 ± 3.475
1.635ValHis: 1.635 ± 0.893
3.679ValIle: 3.679 ± 1.671
7.359ValLys: 7.359 ± 1.094
6.132ValLeu: 6.132 ± 1.727
2.044ValMet: 2.044 ± 1.261
2.862ValAsn: 2.862 ± 1.725
2.862ValPro: 2.862 ± 1.009
1.635ValGln: 1.635 ± 1.467
1.635ValArg: 1.635 ± 0.628
6.95ValSer: 6.95 ± 1.718
0.818ValThr: 0.818 ± 0.615
4.906ValVal: 4.906 ± 1.496
0.0ValTrp: 0.0 ± 0.0
3.679ValTyr: 3.679 ± 0.8
0.0ValXaa: 0.0 ± 0.0
Trp
1.226TrpAla: 1.226 ± 0.528
0.409TrpCys: 0.409 ± 0.221
0.409TrpAsp: 0.409 ± 0.221
0.0TrpGlu: 0.0 ± 0.0
0.409TrpPhe: 0.409 ± 0.221
0.409TrpGly: 0.409 ± 0.221
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.409TrpLys: 0.409 ± 0.221
0.818TrpLeu: 0.818 ± 0.733
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.226TrpPro: 1.226 ± 0.663
0.0TrpGln: 0.0 ± 0.0
0.409TrpArg: 0.409 ± 0.221
0.0TrpSer: 0.0 ± 0.0
0.409TrpThr: 0.409 ± 0.221
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.409TrpTyr: 0.409 ± 0.87
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.044TyrAla: 2.044 ± 0.68
0.409TyrCys: 0.409 ± 0.652
2.044TyrAsp: 2.044 ± 0.612
1.226TyrGlu: 1.226 ± 0.663
1.635TyrPhe: 1.635 ± 0.884
1.635TyrGly: 1.635 ± 0.58
0.818TyrHis: 0.818 ± 0.442
2.044TyrIle: 2.044 ± 0.836
3.679TyrLys: 3.679 ± 0.896
4.497TyrLeu: 4.497 ± 1.875
1.226TyrMet: 1.226 ± 0.663
2.044TyrAsn: 2.044 ± 0.908
0.818TyrPro: 0.818 ± 0.442
1.226TyrGln: 1.226 ± 0.528
2.453TyrArg: 2.453 ± 0.828
1.635TyrSer: 1.635 ± 0.628
3.271TyrThr: 3.271 ± 0.919
2.044TyrVal: 2.044 ± 0.908
0.409TyrTrp: 0.409 ± 0.221
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski