Amino acid dipepetide frequency for Ferrovibrio terrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.405AlaAla: 18.405 ± 0.199	1.136AlaCys: 1.136 ± 0.034	6.819AlaAsp: 6.819 ± 0.079	7.704AlaGlu: 7.704 ± 0.095	4.286AlaPhe: 4.286 ± 0.073	10.91AlaGly: 10.91 ± 0.101	2.029AlaHis: 2.029 ± 0.041	6.289AlaIle: 6.289 ± 0.075	4.725AlaLys: 4.725 ± 0.081	13.726AlaLeu: 13.726 ± 0.26	3.935AlaMet: 3.935 ± 0.05	2.981AlaAsn: 2.981 ± 0.058	5.463AlaPro: 5.463 ± 0.096	4.712AlaGln: 4.712 ± 0.096	8.136AlaArg: 8.136 ± 0.09	5.699AlaSer: 5.699 ± 0.073	6.045AlaThr: 6.045 ± 0.069	9.071AlaVal: 9.071 ± 0.095	1.552AlaTrp: 1.552 ± 0.043	2.495AlaTyr: 2.495 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.027	0.111CysCys: 0.111 ± 0.01	0.548CysAsp: 0.548 ± 0.022	0.371CysGlu: 0.371 ± 0.017	0.374CysPhe: 0.374 ± 0.016	0.927CysGly: 0.927 ± 0.029	0.215CysHis: 0.215 ± 0.011	0.426CysIle: 0.426 ± 0.021	0.21CysLys: 0.21 ± 0.013	0.823CysLeu: 0.823 ± 0.029	0.206CysMet: 0.206 ± 0.013	0.226CysAsn: 0.226 ± 0.014	0.408CysPro: 0.408 ± 0.022	0.212CysGln: 0.212 ± 0.014	0.629CysArg: 0.629 ± 0.023	0.457CysSer: 0.457 ± 0.016	0.432CysThr: 0.432 ± 0.017	0.542CysVal: 0.542 ± 0.021	0.108CysTrp: 0.108 ± 0.009	0.219CysTyr: 0.219 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.75AspAla: 6.75 ± 0.084	0.485AspCys: 0.485 ± 0.019	2.82AspAsp: 2.82 ± 0.054	3.044AspGlu: 3.044 ± 0.056	2.304AspPhe: 2.304 ± 0.045	4.895AspGly: 4.895 ± 0.076	1.163AspHis: 1.163 ± 0.035	3.042AspIle: 3.042 ± 0.058	1.971AspLys: 1.971 ± 0.048	6.077AspLeu: 6.077 ± 0.079	1.413AspMet: 1.413 ± 0.031	1.289AspAsn: 1.289 ± 0.033	3.132AspPro: 3.132 ± 0.059	1.683AspGln: 1.683 ± 0.037	3.968AspArg: 3.968 ± 0.064	2.307AspSer: 2.307 ± 0.048	2.545AspThr: 2.545 ± 0.058	3.843AspVal: 3.843 ± 0.059	1.005AspTrp: 1.005 ± 0.029	1.549AspTyr: 1.549 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.996GluAla: 6.996 ± 0.08	0.31GluCys: 0.31 ± 0.016	2.466GluAsp: 2.466 ± 0.049	2.582GluGlu: 2.582 ± 0.05	1.639GluPhe: 1.639 ± 0.034	3.551GluGly: 3.551 ± 0.056	1.136GluHis: 1.136 ± 0.031	3.362GluIle: 3.362 ± 0.058	2.454GluLys: 2.454 ± 0.044	5.143GluLeu: 5.143 ± 0.072	1.522GluMet: 1.522 ± 0.034	1.471GluAsn: 1.471 ± 0.035	2.41GluPro: 2.41 ± 0.046	2.347GluGln: 2.347 ± 0.045	4.257GluArg: 4.257 ± 0.068	2.284GluSer: 2.284 ± 0.045	3.249GluThr: 3.249 ± 0.063	3.515GluVal: 3.515 ± 0.062	0.61GluTrp: 0.61 ± 0.022	1.015GluTyr: 1.015 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.601PheAla: 4.601 ± 0.064	0.466PheCys: 0.466 ± 0.019	2.407PheAsp: 2.407 ± 0.05	1.885PheGlu: 1.885 ± 0.042	1.465PhePhe: 1.465 ± 0.039	3.709PheGly: 3.709 ± 0.06	0.777PheHis: 0.777 ± 0.024	1.76PheIle: 1.76 ± 0.042	1.054PheLys: 1.054 ± 0.031	3.244PheLeu: 3.244 ± 0.059	0.845PheMet: 0.845 ± 0.024	1.097PheAsn: 1.097 ± 0.032	1.567PhePro: 1.567 ± 0.039	0.971PheGln: 0.971 ± 0.028	2.26PheArg: 2.26 ± 0.05	2.158PheSer: 2.158 ± 0.042	2.093PheThr: 2.093 ± 0.039	2.667PheVal: 2.667 ± 0.059	0.556PheTrp: 0.556 ± 0.021	0.907PheTyr: 0.907 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.917GlyAla: 8.917 ± 0.114	0.82GlyCys: 0.82 ± 0.027	4.197GlyAsp: 4.197 ± 0.063	4.43GlyGlu: 4.43 ± 0.062	3.684GlyPhe: 3.684 ± 0.056	7.317GlyGly: 7.317 ± 0.116	1.889GlyHis: 1.889 ± 0.044	4.836GlyIle: 4.836 ± 0.069	3.657GlyLys: 3.657 ± 0.064	9.354GlyLeu: 9.354 ± 0.112	2.491GlyMet: 2.491 ± 0.048	2.328GlyAsn: 2.328 ± 0.056	3.341GlyPro: 3.341 ± 0.056	3.017GlyGln: 3.017 ± 0.05	5.917GlyArg: 5.917 ± 0.08	4.596GlySer: 4.596 ± 0.062	4.281GlyThr: 4.281 ± 0.069	5.942GlyVal: 5.942 ± 0.075	1.417GlyTrp: 1.417 ± 0.037	2.379GlyTyr: 2.379 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.331HisAla: 2.331 ± 0.045	0.232HisCys: 0.232 ± 0.015	1.286HisAsp: 1.286 ± 0.034	0.963HisGlu: 0.963 ± 0.029	0.807HisPhe: 0.807 ± 0.025	1.991HisGly: 1.991 ± 0.043	0.585HisHis: 0.585 ± 0.027	0.955HisIle: 0.955 ± 0.027	0.599HisLys: 0.599 ± 0.02	2.163HisLeu: 2.163 ± 0.043	0.531HisMet: 0.531 ± 0.02	0.544HisAsn: 0.544 ± 0.021	1.281HisPro: 1.281 ± 0.033	0.593HisGln: 0.593 ± 0.021	1.4HisArg: 1.4 ± 0.036	0.902HisSer: 0.902 ± 0.025	0.81HisThr: 0.81 ± 0.026	1.494HisVal: 1.494 ± 0.041	0.391HisTrp: 0.391 ± 0.017	0.576HisTyr: 0.576 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.469IleAla: 7.469 ± 0.121	0.519IleCys: 0.519 ± 0.022	3.491IleAsp: 3.491 ± 0.053	3.329IleGlu: 3.329 ± 0.049	1.753IlePhe: 1.753 ± 0.037	5.171IleGly: 5.171 ± 0.081	0.893IleHis: 0.893 ± 0.026	2.1IleIle: 2.1 ± 0.053	1.651IleLys: 1.651 ± 0.05	4.591IleLeu: 4.591 ± 0.068	1.001IleMet: 1.001 ± 0.027	1.54IleAsn: 1.54 ± 0.034	2.289IlePro: 2.289 ± 0.045	1.296IleGln: 1.296 ± 0.031	3.148IleArg: 3.148 ± 0.045	2.791IleSer: 2.791 ± 0.052	2.856IleThr: 2.856 ± 0.049	4.024IleVal: 4.024 ± 0.056	0.605IleTrp: 0.605 ± 0.021	1.161IleTyr: 1.161 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.775LysAla: 4.775 ± 0.073	0.163LysCys: 0.163 ± 0.01	1.982LysAsp: 1.982 ± 0.04	1.522LysGlu: 1.522 ± 0.037	1.098LysPhe: 1.098 ± 0.032	2.828LysGly: 2.828 ± 0.054	0.738LysHis: 0.738 ± 0.024	1.921LysIle: 1.921 ± 0.048	1.676LysLys: 1.676 ± 0.048	4.154LysLeu: 4.154 ± 0.059	0.925LysMet: 0.925 ± 0.03	0.892LysAsn: 0.892 ± 0.029	2.548LysPro: 2.548 ± 0.059	1.419LysGln: 1.419 ± 0.037	2.489LysArg: 2.489 ± 0.044	1.866LysSer: 1.866 ± 0.043	2.159LysThr: 2.159 ± 0.044	2.749LysVal: 2.749 ± 0.052	0.338LysTrp: 0.338 ± 0.018	0.741LysTyr: 0.741 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.482LeuAla: 13.482 ± 0.123	0.952LeuCys: 0.952 ± 0.029	5.873LeuAsp: 5.873 ± 0.077	4.867LeuGlu: 4.867 ± 0.062	3.617LeuPhe: 3.617 ± 0.064	8.71LeuGly: 8.71 ± 0.101	2.123LeuHis: 2.123 ± 0.046	5.116LeuIle: 5.116 ± 0.077	4.22LeuLys: 4.22 ± 0.059	11.151LeuLeu: 11.151 ± 0.16	2.372LeuMet: 2.372 ± 0.045	2.989LeuAsn: 2.989 ± 0.069	6.355LeuPro: 6.355 ± 0.093	3.659LeuGln: 3.659 ± 0.057	7.37LeuArg: 7.37 ± 0.099	6.147LeuSer: 6.147 ± 0.121	5.886LeuThr: 5.886 ± 0.19	7.492LeuVal: 7.492 ± 0.093	1.232LeuTrp: 1.232 ± 0.035	2.154LeuTyr: 2.154 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.466MetAla: 3.466 ± 0.055	0.131MetCys: 0.131 ± 0.009	1.12MetAsp: 1.12 ± 0.032	1.047MetGlu: 1.047 ± 0.031	0.708MetPhe: 0.708 ± 0.024	1.852MetGly: 1.852 ± 0.039	0.468MetHis: 0.468 ± 0.021	1.35MetIle: 1.35 ± 0.036	1.079MetLys: 1.079 ± 0.029	2.947MetLeu: 2.947 ± 0.055	0.714MetMet: 0.714 ± 0.027	0.773MetAsn: 0.773 ± 0.026	1.675MetPro: 1.675 ± 0.036	1.12MetGln: 1.12 ± 0.032	1.745MetArg: 1.745 ± 0.043	1.692MetSer: 1.692 ± 0.036	1.964MetThr: 1.964 ± 0.038	1.849MetVal: 1.849 ± 0.038	0.217MetTrp: 0.217 ± 0.013	0.359MetTyr: 0.359 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.369AsnAla: 3.369 ± 0.07	0.236AsnCys: 0.236 ± 0.016	1.453AsnAsp: 1.453 ± 0.037	1.23AsnGlu: 1.23 ± 0.029	1.003AsnPhe: 1.003 ± 0.032	2.334AsnGly: 2.334 ± 0.05	0.49AsnHis: 0.49 ± 0.021	1.423AsnIle: 1.423 ± 0.038	0.803AsnLys: 0.803 ± 0.026	2.95AsnLeu: 2.95 ± 0.054	0.71AsnMet: 0.71 ± 0.027	0.733AsnAsn: 0.733 ± 0.026	1.9AsnPro: 1.9 ± 0.047	0.858AsnGln: 0.858 ± 0.029	1.877AsnArg: 1.877 ± 0.039	1.202AsnSer: 1.202 ± 0.031	1.425AsnThr: 1.425 ± 0.038	1.891AsnVal: 1.891 ± 0.047	0.403AsnTrp: 0.403 ± 0.019	0.683AsnTyr: 0.683 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.689ProAla: 6.689 ± 0.092	0.318ProCys: 0.318 ± 0.017	3.511ProAsp: 3.511 ± 0.056	3.336ProGlu: 3.336 ± 0.057	1.878ProPhe: 1.878 ± 0.038	4.567ProGly: 4.567 ± 0.057	1.087ProHis: 1.087 ± 0.033	2.127ProIle: 2.127 ± 0.039	1.974ProLys: 1.974 ± 0.046	5.075ProLeu: 5.075 ± 0.073	1.262ProMet: 1.262 ± 0.032	1.407ProAsn: 1.407 ± 0.032	2.726ProPro: 2.726 ± 0.065	2.072ProGln: 2.072 ± 0.042	2.869ProArg: 2.869 ± 0.05	2.464ProSer: 2.464 ± 0.045	2.39ProThr: 2.39 ± 0.047	4.32ProVal: 4.32 ± 0.064	0.666ProTrp: 0.666 ± 0.024	1.183ProTyr: 1.183 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.914GlnAla: 4.914 ± 0.096	0.208GlnCys: 0.208 ± 0.013	1.579GlnAsp: 1.579 ± 0.034	1.412GlnGlu: 1.412 ± 0.036	1.146GlnPhe: 1.146 ± 0.034	2.617GlnGly: 2.617 ± 0.051	0.852GlnHis: 0.852 ± 0.029	2.266GlnIle: 2.266 ± 0.155	1.329GlnLys: 1.329 ± 0.033	3.423GlnLeu: 3.423 ± 0.073	0.998GlnMet: 0.998 ± 0.027	0.927GlnAsn: 0.927 ± 0.023	2.227GlnPro: 2.227 ± 0.047	1.796GlnGln: 1.796 ± 0.058	2.91GlnArg: 2.91 ± 0.054	1.856GlnSer: 1.856 ± 0.047	1.872GlnThr: 1.872 ± 0.039	2.677GlnVal: 2.677 ± 0.087	0.422GlnTrp: 0.422 ± 0.02	0.708GlnTyr: 0.708 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.257ArgAla: 7.257 ± 0.085	0.518ArgCys: 0.518 ± 0.019	4.171ArgAsp: 4.171 ± 0.064	3.674ArgGlu: 3.674 ± 0.059	2.733ArgPhe: 2.733 ± 0.046	4.849ArgGly: 4.849 ± 0.068	1.819ArgHis: 1.819 ± 0.04	3.878ArgIle: 3.878 ± 0.054	2.471ArgLys: 2.471 ± 0.038	7.97ArgLeu: 7.97 ± 0.099	1.908ArgMet: 1.908 ± 0.038	1.987ArgAsn: 1.987 ± 0.044	3.347ArgPro: 3.347 ± 0.055	2.858ArgGln: 2.858 ± 0.051	5.513ArgArg: 5.513 ± 0.083	3.416ArgSer: 3.416 ± 0.053	2.871ArgThr: 2.871 ± 0.05	4.487ArgVal: 4.487 ± 0.062	0.996ArgTrp: 0.996 ± 0.035	1.721ArgTyr: 1.721 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.843SerAla: 5.843 ± 0.068	0.402SerCys: 0.402 ± 0.021	2.809SerAsp: 2.809 ± 0.047	2.482SerGlu: 2.482 ± 0.041	2.159SerPhe: 2.159 ± 0.04	5.157SerGly: 5.157 ± 0.069	1.07SerHis: 1.07 ± 0.032	2.518SerIle: 2.518 ± 0.045	1.628SerLys: 1.628 ± 0.039	5.433SerLeu: 5.433 ± 0.073	1.317SerMet: 1.317 ± 0.032	1.369SerAsn: 1.369 ± 0.034	2.502SerPro: 2.502 ± 0.044	1.735SerGln: 1.735 ± 0.053	3.416SerArg: 3.416 ± 0.054	2.623SerSer: 2.623 ± 0.052	2.654SerThr: 2.654 ± 0.124	3.597SerVal: 3.597 ± 0.049	0.698SerTrp: 0.698 ± 0.025	1.321SerTyr: 1.321 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.775ThrAla: 6.775 ± 0.111	0.393ThrCys: 0.393 ± 0.017	2.821ThrAsp: 2.821 ± 0.053	2.724ThrGlu: 2.724 ± 0.05	1.722ThrPhe: 1.722 ± 0.038	5.026ThrGly: 5.026 ± 0.081	0.953ThrHis: 0.953 ± 0.029	2.562ThrIle: 2.562 ± 0.045	1.6ThrLys: 1.6 ± 0.04	5.659ThrLeu: 5.659 ± 0.062	1.227ThrMet: 1.227 ± 0.027	1.259ThrAsn: 1.259 ± 0.039	3.287ThrPro: 3.287 ± 0.055	1.958ThrGln: 1.958 ± 0.219	3.219ThrArg: 3.219 ± 0.047	2.505ThrSer: 2.505 ± 0.066	3.174ThrThr: 3.174 ± 0.279	4.187ThrVal: 4.187 ± 0.061	0.671ThrTrp: 0.671 ± 0.021	1.12ThrTyr: 1.12 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.262ValAla: 9.262 ± 0.096	0.615ValCys: 0.615 ± 0.022	3.861ValAsp: 3.861 ± 0.055	4.082ValGlu: 4.082 ± 0.067	2.687ValPhe: 2.687 ± 0.051	5.31ValGly: 5.31 ± 0.067	1.296ValHis: 1.296 ± 0.035	4.057ValIle: 4.057 ± 0.063	2.73ValLys: 2.73 ± 0.054	7.575ValLeu: 7.575 ± 0.088	2.061ValMet: 2.061 ± 0.044	2.146ValAsn: 2.146 ± 0.053	3.66ValPro: 3.66 ± 0.056	2.451ValGln: 2.451 ± 0.042	4.253ValArg: 4.253 ± 0.061	3.914ValSer: 3.914 ± 0.056	4.325ValThr: 4.325 ± 0.065	5.652ValVal: 5.652 ± 0.092	0.853ValTrp: 0.853 ± 0.025	1.499ValTyr: 1.499 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.212TrpAla: 1.212 ± 0.033	0.146TrpCys: 0.146 ± 0.011	0.612TrpAsp: 0.612 ± 0.021	0.521TrpGlu: 0.521 ± 0.02	0.519TrpPhe: 0.519 ± 0.02	0.924TrpGly: 0.924 ± 0.029	0.353TrpHis: 0.353 ± 0.016	0.679TrpIle: 0.679 ± 0.024	0.46TrpLys: 0.46 ± 0.018	1.907TrpLeu: 1.907 ± 0.049	0.355TrpMet: 0.355 ± 0.014	0.408TrpAsn: 0.408 ± 0.017	0.731TrpPro: 0.731 ± 0.024	0.697TrpGln: 0.697 ± 0.025	1.218TrpArg: 1.218 ± 0.036	0.707TrpSer: 0.707 ± 0.021	0.65TrpThr: 0.65 ± 0.021	0.739TrpVal: 0.739 ± 0.026	0.248TrpTrp: 0.248 ± 0.014	0.302TrpTyr: 0.302 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.65TyrAla: 2.65 ± 0.048	0.238TyrCys: 0.238 ± 0.013	1.458TyrAsp: 1.458 ± 0.036	1.112TyrGlu: 1.112 ± 0.032	0.907TyrPhe: 0.907 ± 0.026	2.165TyrGly: 2.165 ± 0.045	0.5TyrHis: 0.5 ± 0.019	1.011TyrIle: 1.011 ± 0.026	0.694TyrLys: 0.694 ± 0.023	2.401TyrLeu: 2.401 ± 0.047	0.483TyrMet: 0.483 ± 0.021	0.604TyrAsn: 0.604 ± 0.021	1.074TyrPro: 1.074 ± 0.031	0.687TyrGln: 0.687 ± 0.022	1.85TyrArg: 1.85 ± 0.041	1.15TyrSer: 1.15 ± 0.03	1.159TyrThr: 1.159 ± 0.031	1.552TyrVal: 1.552 ± 0.034	0.397TyrTrp: 0.397 ± 0.017	0.619TyrTyr: 0.619 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4107 proteins (1303169 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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