Amino acid dipepetide frequency for Candidatus Berkiella aquae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.982AlaAla: 6.982 ± 0.103
0.924AlaCys: 0.924 ± 0.032
3.537AlaAsp: 3.537 ± 0.077
4.48AlaGlu: 4.48 ± 0.068
3.614AlaPhe: 3.614 ± 0.065
4.679AlaGly: 4.679 ± 0.082
1.928AlaHis: 1.928 ± 0.051
6.5AlaIle: 6.5 ± 0.091
6.387AlaLys: 6.387 ± 0.105
9.792AlaLeu: 9.792 ± 0.097
2.245AlaMet: 2.245 ± 0.054
3.873AlaAsn: 3.873 ± 0.075
2.919AlaPro: 2.919 ± 0.068
4.071AlaGln: 4.071 ± 0.069
3.363AlaArg: 3.363 ± 0.057
4.865AlaSer: 4.865 ± 0.077
4.497AlaThr: 4.497 ± 0.084
4.772AlaVal: 4.772 ± 0.074
0.905AlaTrp: 0.905 ± 0.029
2.486AlaTyr: 2.486 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.876CysAla: 0.876 ± 0.028
0.17CysCys: 0.17 ± 0.014
0.536CysAsp: 0.536 ± 0.025
0.693CysGlu: 0.693 ± 0.03
0.555CysPhe: 0.555 ± 0.022
0.738CysGly: 0.738 ± 0.028
0.417CysHis: 0.417 ± 0.021
0.72CysIle: 0.72 ± 0.026
0.56CysLys: 0.56 ± 0.022
1.212CysLeu: 1.212 ± 0.037
0.235CysMet: 0.235 ± 0.017
0.417CysAsn: 0.417 ± 0.018
0.491CysPro: 0.491 ± 0.027
0.605CysGln: 0.605 ± 0.025
0.47CysArg: 0.47 ± 0.023
0.628CysSer: 0.628 ± 0.028
0.45CysThr: 0.45 ± 0.02
0.644CysVal: 0.644 ± 0.027
0.125CysTrp: 0.125 ± 0.013
0.418CysTyr: 0.418 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.839AspAla: 3.839 ± 0.089
0.546AspCys: 0.546 ± 0.024
2.572AspAsp: 2.572 ± 0.071
3.635AspGlu: 3.635 ± 0.072
2.496AspPhe: 2.496 ± 0.055
2.667AspGly: 2.667 ± 0.096
1.074AspHis: 1.074 ± 0.036
3.861AspIle: 3.861 ± 0.065
3.543AspLys: 3.543 ± 0.068
5.026AspLeu: 5.026 ± 0.077
1.009AspMet: 1.009 ± 0.03
2.467AspAsn: 2.467 ± 0.062
2.107AspPro: 2.107 ± 0.04
1.576AspGln: 1.576 ± 0.041
1.765AspArg: 1.765 ± 0.049
2.83AspSer: 2.83 ± 0.065
2.213AspThr: 2.213 ± 0.058
3.114AspVal: 3.114 ± 0.061
0.638AspTrp: 0.638 ± 0.028
1.881AspTyr: 1.881 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
4.966GluAla: 4.966 ± 0.097
0.627GluCys: 0.627 ± 0.026
2.597GluAsp: 2.597 ± 0.051
4.039GluGlu: 4.039 ± 0.127
2.244GluPhe: 2.244 ± 0.041
3.236GluGly: 3.236 ± 0.065
1.529GluHis: 1.529 ± 0.037
4.706GluIle: 4.706 ± 0.074
5.233GluLys: 5.233 ± 0.072
6.268GluLeu: 6.268 ± 0.078
1.619GluMet: 1.619 ± 0.039
3.47GluAsn: 3.47 ± 0.055
2.077GluPro: 2.077 ± 0.056
3.702GluGln: 3.702 ± 0.083
3.018GluArg: 3.018 ± 0.063
3.405GluSer: 3.405 ± 0.065
3.066GluThr: 3.066 ± 0.058
3.516GluVal: 3.516 ± 0.066
0.651GluTrp: 0.651 ± 0.024
1.774GluTyr: 1.774 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.649PheAla: 3.649 ± 0.064
0.62PheCys: 0.62 ± 0.025
2.309PheAsp: 2.309 ± 0.05
2.434PheGlu: 2.434 ± 0.045
1.904PhePhe: 1.904 ± 0.053
2.529PheGly: 2.529 ± 0.055
1.002PheHis: 1.002 ± 0.032
3.033PheIle: 3.033 ± 0.059
2.407PheLys: 2.407 ± 0.045
3.975PheLeu: 3.975 ± 0.061
1.01PheMet: 1.01 ± 0.034
2.194PheAsn: 2.194 ± 0.053
1.634PhePro: 1.634 ± 0.042
1.565PheGln: 1.565 ± 0.051
1.495PheArg: 1.495 ± 0.036
3.327PheSer: 3.327 ± 0.061
2.42PheThr: 2.42 ± 0.057
2.514PheVal: 2.514 ± 0.051
0.48PheTrp: 0.48 ± 0.025
1.622PheTyr: 1.622 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
4.61GlyAla: 4.61 ± 0.102
0.798GlyCys: 0.798 ± 0.029
2.691GlyAsp: 2.691 ± 0.065
3.17GlyGlu: 3.17 ± 0.056
2.892GlyPhe: 2.892 ± 0.05
3.949GlyGly: 3.949 ± 0.119
1.416GlyHis: 1.416 ± 0.043
4.677GlyIle: 4.677 ± 0.079
4.064GlyLys: 4.064 ± 0.064
6.172GlyLeu: 6.172 ± 0.084
1.678GlyMet: 1.678 ± 0.046
2.535GlyAsn: 2.535 ± 0.067
1.813GlyPro: 1.813 ± 0.051
2.458GlyGln: 2.458 ± 0.058
2.326GlyArg: 2.326 ± 0.052
3.394GlySer: 3.394 ± 0.079
3.209GlyThr: 3.209 ± 0.076
3.909GlyVal: 3.909 ± 0.087
0.815GlyTrp: 0.815 ± 0.032
2.318GlyTyr: 2.318 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.888HisAla: 1.888 ± 0.04
0.361HisCys: 0.361 ± 0.02
1.301HisAsp: 1.301 ± 0.036
1.515HisGlu: 1.515 ± 0.036
1.408HisPhe: 1.408 ± 0.043
1.535HisGly: 1.535 ± 0.044
1.017HisHis: 1.017 ± 0.038
1.629HisIle: 1.629 ± 0.043
1.267HisLys: 1.267 ± 0.036
2.945HisLeu: 2.945 ± 0.059
0.478HisMet: 0.478 ± 0.022
0.957HisAsn: 0.957 ± 0.03
1.445HisPro: 1.445 ± 0.039
1.42HisGln: 1.42 ± 0.039
1.129HisArg: 1.129 ± 0.033
1.542HisSer: 1.542 ± 0.039
1.082HisThr: 1.082 ± 0.032
1.231HisVal: 1.231 ± 0.034
0.34HisTrp: 0.34 ± 0.015
1.146HisTyr: 1.146 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.76IleAla: 6.76 ± 0.093
0.841IleCys: 0.841 ± 0.028
4.285IleAsp: 4.285 ± 0.064
4.909IleGlu: 4.909 ± 0.089
2.66IlePhe: 2.66 ± 0.057
4.319IleGly: 4.319 ± 0.076
1.725IleHis: 1.725 ± 0.038
4.743IleIle: 4.743 ± 0.074
4.449IleLys: 4.449 ± 0.064
6.998IleLeu: 6.998 ± 0.093
1.371IleMet: 1.371 ± 0.04
3.518IleAsn: 3.518 ± 0.071
3.247IlePro: 3.247 ± 0.057
3.044IleGln: 3.044 ± 0.057
2.812IleArg: 2.812 ± 0.051
4.843IleSer: 4.843 ± 0.073
3.931IleThr: 3.931 ± 0.078
4.348IleVal: 4.348 ± 0.072
0.605IleTrp: 0.605 ± 0.023
1.939IleTyr: 1.939 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
5.576LysAla: 5.576 ± 0.075
0.485LysCys: 0.485 ± 0.02
3.18LysAsp: 3.18 ± 0.067
4.746LysGlu: 4.746 ± 0.085
1.723LysPhe: 1.723 ± 0.042
3.475LysGly: 3.475 ± 0.063
1.588LysHis: 1.588 ± 0.044
4.891LysIle: 4.891 ± 0.082
4.82LysLys: 4.82 ± 0.093
6.321LysLeu: 6.321 ± 0.095
1.937LysMet: 1.937 ± 0.046
3.385LysAsn: 3.385 ± 0.068
2.843LysPro: 2.843 ± 0.052
3.607LysGln: 3.607 ± 0.066
3.257LysArg: 3.257 ± 0.059
3.799LysSer: 3.799 ± 0.065
3.749LysThr: 3.749 ± 0.071
3.699LysVal: 3.699 ± 0.069
0.612LysTrp: 0.612 ± 0.026
1.576LysTyr: 1.576 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
9.564LeuAla: 9.564 ± 0.107
1.322LeuCys: 1.322 ± 0.038
4.839LeuAsp: 4.839 ± 0.075
6.266LeuGlu: 6.266 ± 0.077
4.528LeuPhe: 4.528 ± 0.084
6.572LeuGly: 6.572 ± 0.097
2.536LeuHis: 2.536 ± 0.052
6.955LeuIle: 6.955 ± 0.102
7.017LeuLys: 7.017 ± 0.091
11.633LeuLeu: 11.633 ± 0.147
2.553LeuMet: 2.553 ± 0.055
5.252LeuAsn: 5.252 ± 0.08
5.038LeuPro: 5.038 ± 0.07
5.101LeuGln: 5.101 ± 0.073
4.435LeuArg: 4.435 ± 0.073
7.723LeuSer: 7.723 ± 0.091
6.132LeuThr: 6.132 ± 0.083
5.711LeuVal: 5.711 ± 0.083
1.066LeuTrp: 1.066 ± 0.033
3.005LeuTyr: 3.005 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.079MetAla: 2.079 ± 0.042
0.189MetCys: 0.189 ± 0.013
1.044MetAsp: 1.044 ± 0.036
1.025MetGlu: 1.025 ± 0.029
0.705MetPhe: 0.705 ± 0.03
1.553MetGly: 1.553 ± 0.05
0.655MetHis: 0.655 ± 0.024
1.777MetIle: 1.777 ± 0.042
1.557MetLys: 1.557 ± 0.044
2.784MetLeu: 2.784 ± 0.045
0.807MetMet: 0.807 ± 0.027
1.223MetAsn: 1.223 ± 0.039
1.347MetPro: 1.347 ± 0.047
1.391MetGln: 1.391 ± 0.036
1.155MetArg: 1.155 ± 0.034
1.606MetSer: 1.606 ± 0.035
1.437MetThr: 1.437 ± 0.034
1.462MetVal: 1.462 ± 0.035
0.153MetTrp: 0.153 ± 0.011
0.456MetTyr: 0.456 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.978AsnAla: 3.978 ± 0.074
0.426AsnCys: 0.426 ± 0.017
2.583AsnAsp: 2.583 ± 0.067
3.235AsnGlu: 3.235 ± 0.068
1.749AsnPhe: 1.749 ± 0.043
2.645AsnGly: 2.645 ± 0.067
1.45AsnHis: 1.45 ± 0.039
3.453AsnIle: 3.453 ± 0.058
3.065AsnLys: 3.065 ± 0.063
4.574AsnLeu: 4.574 ± 0.075
1.016AsnMet: 1.016 ± 0.032
2.647AsnAsn: 2.647 ± 0.076
2.471AsnPro: 2.471 ± 0.064
2.696AsnGln: 2.696 ± 0.052
1.993AsnArg: 1.993 ± 0.046
2.468AsnSer: 2.468 ± 0.059
2.489AsnThr: 2.489 ± 0.066
2.761AsnVal: 2.761 ± 0.065
0.508AsnTrp: 0.508 ± 0.029
1.419AsnTyr: 1.419 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
3.095ProAla: 3.095 ± 0.073
0.392ProCys: 0.392 ± 0.019
2.09ProAsp: 2.09 ± 0.049
3.115ProGlu: 3.115 ± 0.058
1.844ProPhe: 1.844 ± 0.046
2.305ProGly: 2.305 ± 0.058
1.104ProHis: 1.104 ± 0.034
3.037ProIle: 3.037 ± 0.067
2.644ProLys: 2.644 ± 0.057
4.697ProLeu: 4.697 ± 0.073
0.943ProMet: 0.943 ± 0.037
1.986ProAsn: 1.986 ± 0.056
1.674ProPro: 1.674 ± 0.057
2.085ProGln: 2.085 ± 0.05
1.418ProArg: 1.418 ± 0.04
2.945ProSer: 2.945 ± 0.053
2.535ProThr: 2.535 ± 0.058
2.75ProVal: 2.75 ± 0.057
0.458ProTrp: 0.458 ± 0.021
1.409ProTyr: 1.409 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.691GlnAla: 4.691 ± 0.085
0.44GlnCys: 0.44 ± 0.021
2.231GlnAsp: 2.231 ± 0.05
3.231GlnGlu: 3.231 ± 0.082
1.945GlnPhe: 1.945 ± 0.045
2.958GlnGly: 2.958 ± 0.054
1.317GlnHis: 1.317 ± 0.035
3.142GlnIle: 3.142 ± 0.057
3.246GlnLys: 3.246 ± 0.061
5.157GlnLeu: 5.157 ± 0.094
1.197GlnMet: 1.197 ± 0.034
2.306GlnAsn: 2.306 ± 0.046
1.806GlnPro: 1.806 ± 0.047
3.296GlnGln: 3.296 ± 0.086
2.361GlnArg: 2.361 ± 0.056
3.021GlnSer: 3.021 ± 0.057
2.678GlnThr: 2.678 ± 0.051
2.689GlnVal: 2.689 ± 0.056
0.561GlnTrp: 0.561 ± 0.024
1.681GlnTyr: 1.681 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.031ArgAla: 3.031 ± 0.055
0.434ArgCys: 0.434 ± 0.023
2.01ArgAsp: 2.01 ± 0.058
2.799ArgGlu: 2.799 ± 0.06
2.148ArgPhe: 2.148 ± 0.049
2.229ArgGly: 2.229 ± 0.047
1.119ArgHis: 1.119 ± 0.038
2.903ArgIle: 2.903 ± 0.056
2.733ArgLys: 2.733 ± 0.049
4.716ArgLeu: 4.716 ± 0.083
1.188ArgMet: 1.188 ± 0.033
1.886ArgAsn: 1.886 ± 0.049
1.421ArgPro: 1.421 ± 0.037
2.241ArgGln: 2.241 ± 0.053
2.063ArgArg: 2.063 ± 0.053
2.349ArgSer: 2.349 ± 0.055
2.057ArgThr: 2.057 ± 0.041
2.444ArgVal: 2.444 ± 0.052
0.544ArgTrp: 0.544 ± 0.022
1.707ArgTyr: 1.707 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.87SerAla: 4.87 ± 0.066
0.653SerCys: 0.653 ± 0.029
3.087SerAsp: 3.087 ± 0.062
3.727SerGlu: 3.727 ± 0.062
2.956SerPhe: 2.956 ± 0.048
3.76SerGly: 3.76 ± 0.075
1.733SerHis: 1.733 ± 0.041
4.387SerIle: 4.387 ± 0.072
3.557SerLys: 3.557 ± 0.064
7.22SerLeu: 7.22 ± 0.085
1.555SerMet: 1.555 ± 0.042
2.715SerAsn: 2.715 ± 0.077
2.799SerPro: 2.799 ± 0.056
3.157SerGln: 3.157 ± 0.07
2.501SerArg: 2.501 ± 0.053
4.625SerSer: 4.625 ± 0.094
3.498SerThr: 3.498 ± 0.069
3.553SerVal: 3.553 ± 0.065
0.705SerTrp: 0.705 ± 0.028
1.965SerTyr: 1.965 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.196ThrAla: 4.196 ± 0.076
0.505ThrCys: 0.505 ± 0.021
2.547ThrAsp: 2.547 ± 0.076
2.857ThrGlu: 2.857 ± 0.05
2.294ThrPhe: 2.294 ± 0.057
3.238ThrGly: 3.238 ± 0.08
1.383ThrHis: 1.383 ± 0.039
3.951ThrIle: 3.951 ± 0.065
2.977ThrLys: 2.977 ± 0.047
6.679ThrLeu: 6.679 ± 0.092
1.135ThrMet: 1.135 ± 0.034
2.174ThrAsn: 2.174 ± 0.057
3.15ThrPro: 3.15 ± 0.062
2.958ThrGln: 2.958 ± 0.054
2.03ThrArg: 2.03 ± 0.047
3.204ThrSer: 3.204 ± 0.065
3.228ThrThr: 3.228 ± 0.076
3.434ThrVal: 3.434 ± 0.068
0.539ThrTrp: 0.539 ± 0.023
1.619ThrTyr: 1.619 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.086ValAla: 5.086 ± 0.084
0.617ValCys: 0.617 ± 0.025
3.265ValAsp: 3.265 ± 0.087
3.5ValGlu: 3.5 ± 0.074
2.3ValPhe: 2.3 ± 0.045
3.807ValGly: 3.807 ± 0.082
1.171ValHis: 1.171 ± 0.034
4.478ValIle: 4.478 ± 0.071
3.895ValLys: 3.895 ± 0.072
5.949ValLeu: 5.949 ± 0.082
1.566ValMet: 1.566 ± 0.043
2.966ValAsn: 2.966 ± 0.058
2.464ValPro: 2.464 ± 0.055
2.067ValGln: 2.067 ± 0.044
2.252ValArg: 2.252 ± 0.049
3.91ValSer: 3.91 ± 0.058
3.525ValThr: 3.525 ± 0.072
4.001ValVal: 4.001 ± 0.077
0.514ValTrp: 0.514 ± 0.028
1.649ValTyr: 1.649 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.659TrpAla: 0.659 ± 0.025
0.138TrpCys: 0.138 ± 0.012
0.523TrpAsp: 0.523 ± 0.021
0.562TrpGlu: 0.562 ± 0.026
0.536TrpPhe: 0.536 ± 0.026
0.672TrpGly: 0.672 ± 0.026
0.401TrpHis: 0.401 ± 0.019
0.717TrpIle: 0.717 ± 0.025
0.461TrpLys: 0.461 ± 0.022
1.459TrpLeu: 1.459 ± 0.047
0.297TrpMet: 0.297 ± 0.016
0.409TrpAsn: 0.409 ± 0.024
0.377TrpPro: 0.377 ± 0.023
0.84TrpGln: 0.84 ± 0.029
0.549TrpArg: 0.549 ± 0.027
0.549TrpSer: 0.549 ± 0.023
0.395TrpThr: 0.395 ± 0.019
0.721TrpVal: 0.721 ± 0.029
0.149TrpTrp: 0.149 ± 0.013
0.365TrpTyr: 0.365 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.427TyrAla: 2.427 ± 0.046
0.472TyrCys: 0.472 ± 0.021
1.631TyrAsp: 1.631 ± 0.041
1.807TyrGlu: 1.807 ± 0.044
1.622TyrPhe: 1.622 ± 0.045
2.025TyrGly: 2.025 ± 0.045
1.066TyrHis: 1.066 ± 0.031
1.791TyrIle: 1.791 ± 0.037
1.385TyrLys: 1.385 ± 0.038
3.672TyrLeu: 3.672 ± 0.073
0.563TyrMet: 0.563 ± 0.022
1.249TyrAsn: 1.249 ± 0.034
1.405TyrPro: 1.405 ± 0.041
2.071TyrGln: 2.071 ± 0.052
1.632TyrArg: 1.632 ± 0.044
1.991TyrSer: 1.991 ± 0.051
1.506TyrThr: 1.506 ± 0.058
1.71TyrVal: 1.71 ± 0.042
0.412TyrTrp: 0.412 ± 0.024
1.257TyrTyr: 1.257 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3170 proteins (1075553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski