Amino acid dipepetide frequency for Only Syngen Nebraska virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.948AlaAla: 4.948 ± 0.389
0.843AlaCys: 0.843 ± 0.105
3.333AlaAsp: 3.333 ± 0.249
3.312AlaGlu: 3.312 ± 0.291
2.56AlaPhe: 2.56 ± 0.189
3.892AlaGly: 3.892 ± 0.32
0.843AlaHis: 0.843 ± 0.096
4.278AlaIle: 4.278 ± 0.211
4.796AlaLys: 4.796 ± 0.296
4.643AlaLeu: 4.643 ± 0.228
1.819AlaMet: 1.819 ± 0.144
4.481AlaAsn: 4.481 ± 0.594
4.501AlaPro: 4.501 ± 0.71
1.737AlaGln: 1.737 ± 0.161
2.703AlaArg: 2.703 ± 0.205
4.095AlaSer: 4.095 ± 0.338
4.166AlaThr: 4.166 ± 0.368
4.44AlaVal: 4.44 ± 0.256
0.518AlaTrp: 0.518 ± 0.06
2.266AlaTyr: 2.266 ± 0.19
0.0AlaXaa: 0.0 ± 0.0
Cys
0.833CysAla: 0.833 ± 0.105
0.295CysCys: 0.295 ± 0.051
0.925CysAsp: 0.925 ± 0.124
0.61CysGlu: 0.61 ± 0.081
0.589CysPhe: 0.589 ± 0.064
1.24CysGly: 1.24 ± 0.161
0.244CysHis: 0.244 ± 0.055
0.874CysIle: 0.874 ± 0.108
0.965CysLys: 0.965 ± 0.137
0.986CysLeu: 0.986 ± 0.112
0.437CysMet: 0.437 ± 0.071
0.803CysAsn: 0.803 ± 0.101
0.833CysPro: 0.833 ± 0.13
0.335CysGln: 0.335 ± 0.052
0.559CysArg: 0.559 ± 0.083
1.077CysSer: 1.077 ± 0.121
0.772CysThr: 0.772 ± 0.088
1.382CysVal: 1.382 ± 0.149
0.142CysTrp: 0.142 ± 0.044
0.396CysTyr: 0.396 ± 0.068
0.0CysXaa: 0.0 ± 0.0
Asp
3.678AspAla: 3.678 ± 0.188
0.823AspCys: 0.823 ± 0.1
4.45AspAsp: 4.45 ± 0.54
3.82AspGlu: 3.82 ± 0.273
2.682AspPhe: 2.682 ± 0.19
3.729AspGly: 3.729 ± 0.319
0.864AspHis: 0.864 ± 0.12
5.253AspIle: 5.253 ± 0.272
3.495AspLys: 3.495 ± 0.211
3.881AspLeu: 3.881 ± 0.243
1.453AspMet: 1.453 ± 0.137
2.723AspAsn: 2.723 ± 0.202
2.449AspPro: 2.449 ± 0.164
1.24AspGln: 1.24 ± 0.12
2.083AspArg: 2.083 ± 0.16
3.373AspSer: 3.373 ± 0.235
3.536AspThr: 3.536 ± 0.235
4.521AspVal: 4.521 ± 0.237
0.63AspTrp: 0.63 ± 0.104
2.439AspTyr: 2.439 ± 0.207
0.0AspXaa: 0.0 ± 0.0
Glu
3.119GluAla: 3.119 ± 0.263
0.701GluCys: 0.701 ± 0.097
3.77GluAsp: 3.77 ± 0.427
3.556GluGlu: 3.556 ± 0.295
2.611GluPhe: 2.611 ± 0.191
2.124GluGly: 2.124 ± 0.2
1.443GluHis: 1.443 ± 0.154
4.146GluIle: 4.146 ± 0.26
4.379GluLys: 4.379 ± 0.307
4.318GluLeu: 4.318 ± 0.24
1.372GluMet: 1.372 ± 0.125
3.251GluAsn: 3.251 ± 0.241
2.337GluPro: 2.337 ± 0.252
1.514GluGln: 1.514 ± 0.142
2.703GluArg: 2.703 ± 0.217
3.109GluSer: 3.109 ± 0.212
3.546GluThr: 3.546 ± 0.227
2.947GluVal: 2.947 ± 0.204
0.569GluTrp: 0.569 ± 0.073
2.875GluTyr: 2.875 ± 0.211
0.0GluXaa: 0.0 ± 0.0
Phe
2.804PheAla: 2.804 ± 0.178
0.569PheCys: 0.569 ± 0.075
3.008PheAsp: 3.008 ± 0.19
2.632PheGlu: 2.632 ± 0.205
2.256PhePhe: 2.256 ± 0.162
3.465PheGly: 3.465 ± 0.388
0.732PheHis: 0.732 ± 0.085
3.19PheIle: 3.19 ± 0.198
2.896PheLys: 2.896 ± 0.168
3.15PheLeu: 3.15 ± 0.2
1.158PheMet: 1.158 ± 0.116
2.398PheAsn: 2.398 ± 0.221
1.829PhePro: 1.829 ± 0.161
1.321PheGln: 1.321 ± 0.127
1.748PheArg: 1.748 ± 0.136
3.434PheSer: 3.434 ± 0.203
2.906PheThr: 2.906 ± 0.176
4.156PheVal: 4.156 ± 0.244
0.559PheTrp: 0.559 ± 0.073
1.626PheTyr: 1.626 ± 0.14
0.0PheXaa: 0.0 ± 0.0
Gly
3.526GlyAla: 3.526 ± 0.271
1.057GlyCys: 1.057 ± 0.121
3.688GlyAsp: 3.688 ± 0.224
3.363GlyGlu: 3.363 ± 0.315
2.997GlyPhe: 2.997 ± 0.188
5.253GlyGly: 5.253 ± 0.505
1.097GlyHis: 1.097 ± 0.116
4.034GlyIle: 4.034 ± 0.245
4.908GlyLys: 4.908 ± 0.277
3.739GlyLeu: 3.739 ± 0.204
1.351GlyMet: 1.351 ± 0.126
6.706GlyAsn: 6.706 ± 1.387
1.89GlyPro: 1.89 ± 0.254
2.154GlyGln: 2.154 ± 0.264
2.672GlyArg: 2.672 ± 0.183
4.857GlySer: 4.857 ± 0.416
3.871GlyThr: 3.871 ± 0.247
4.491GlyVal: 4.491 ± 0.287
0.813GlyTrp: 0.813 ± 0.097
2.672GlyTyr: 2.672 ± 0.223
0.0GlyXaa: 0.0 ± 0.0
His
1.036HisAla: 1.036 ± 0.105
0.224HisCys: 0.224 ± 0.052
1.138HisAsp: 1.138 ± 0.127
1.016HisGlu: 1.016 ± 0.107
0.599HisPhe: 0.599 ± 0.108
1.077HisGly: 1.077 ± 0.13
0.427HisHis: 0.427 ± 0.066
1.158HisIle: 1.158 ± 0.104
1.158HisLys: 1.158 ± 0.13
1.29HisLeu: 1.29 ± 0.126
0.478HisMet: 0.478 ± 0.07
0.945HisAsn: 0.945 ± 0.108
0.914HisPro: 0.914 ± 0.114
0.559HisGln: 0.559 ± 0.071
0.793HisArg: 0.793 ± 0.093
0.996HisSer: 0.996 ± 0.109
1.199HisThr: 1.199 ± 0.107
1.453HisVal: 1.453 ± 0.139
0.264HisTrp: 0.264 ± 0.05
0.64HisTyr: 0.64 ± 0.077
0.0HisXaa: 0.0 ± 0.0
Ile
4.542IleAla: 4.542 ± 0.311
0.986IleCys: 0.986 ± 0.113
4.41IleAsp: 4.41 ± 0.249
3.627IleGlu: 3.627 ± 0.264
3.018IlePhe: 3.018 ± 0.203
4.643IleGly: 4.643 ± 0.377
1.29IleHis: 1.29 ± 0.128
5.04IleIle: 5.04 ± 0.244
4.593IleLys: 4.593 ± 0.31
5.06IleLeu: 5.06 ± 0.244
1.585IleMet: 1.585 ± 0.158
3.912IleAsn: 3.912 ± 0.239
3.668IlePro: 3.668 ± 0.205
2.215IleGln: 2.215 ± 0.174
3.394IleArg: 3.394 ± 0.241
5.04IleSer: 5.04 ± 0.248
4.969IleThr: 4.969 ± 0.316
4.725IleVal: 4.725 ± 0.232
0.599IleTrp: 0.599 ± 0.1
2.418IleTyr: 2.418 ± 0.179
0.0IleXaa: 0.0 ± 0.0
Lys
3.841LysAla: 3.841 ± 0.316
1.25LysCys: 1.25 ± 0.167
3.952LysAsp: 3.952 ± 0.277
4.349LysGlu: 4.349 ± 0.286
3.272LysPhe: 3.272 ± 0.207
3.363LysGly: 3.363 ± 0.28
1.677LysHis: 1.677 ± 0.156
5.263LysIle: 5.263 ± 0.298
8.433LysLys: 8.433 ± 0.536
5.893LysLeu: 5.893 ± 0.324
2.581LysMet: 2.581 ± 0.174
4.948LysAsn: 4.948 ± 0.281
6.127LysPro: 6.127 ± 0.978
2.428LysGln: 2.428 ± 0.257
3.333LysArg: 3.333 ± 0.233
4.369LysSer: 4.369 ± 0.237
5.08LysThr: 5.08 ± 0.271
4.207LysVal: 4.207 ± 0.333
0.864LysTrp: 0.864 ± 0.118
3.77LysTyr: 3.77 ± 0.225
0.0LysXaa: 0.0 ± 0.0
Leu
4.41LeuAla: 4.41 ± 0.241
0.833LeuCys: 0.833 ± 0.087
3.892LeuAsp: 3.892 ± 0.247
4.095LeuGlu: 4.095 ± 0.226
3.516LeuPhe: 3.516 ± 0.223
4.207LeuGly: 4.207 ± 0.24
1.392LeuHis: 1.392 ± 0.167
4.389LeuIle: 4.389 ± 0.252
5.761LeuLys: 5.761 ± 0.319
5.72LeuLeu: 5.72 ± 0.387
1.89LeuMet: 1.89 ± 0.145
3.841LeuAsn: 3.841 ± 0.195
3.81LeuPro: 3.81 ± 0.244
2.235LeuGln: 2.235 ± 0.183
3.221LeuArg: 3.221 ± 0.16
5.162LeuSer: 5.162 ± 0.264
4.44LeuThr: 4.44 ± 0.315
4.379LeuVal: 4.379 ± 0.239
0.803LeuTrp: 0.803 ± 0.084
2.642LeuTyr: 2.642 ± 0.183
0.0LeuXaa: 0.0 ± 0.0
Met
1.636MetAla: 1.636 ± 0.14
0.539MetCys: 0.539 ± 0.07
1.148MetAsp: 1.148 ± 0.114
1.402MetGlu: 1.402 ± 0.13
1.473MetPhe: 1.473 ± 0.107
1.433MetGly: 1.433 ± 0.122
0.345MetHis: 0.345 ± 0.056
1.707MetIle: 1.707 ± 0.163
2.418MetLys: 2.418 ± 0.182
1.748MetLeu: 1.748 ± 0.146
0.762MetMet: 0.762 ± 0.089
1.809MetAsn: 1.809 ± 0.145
0.874MetPro: 0.874 ± 0.11
0.599MetGln: 0.599 ± 0.093
0.955MetArg: 0.955 ± 0.09
2.672MetSer: 2.672 ± 0.22
1.595MetThr: 1.595 ± 0.129
1.422MetVal: 1.422 ± 0.118
0.376MetTrp: 0.376 ± 0.075
1.036MetTyr: 1.036 ± 0.117
0.0MetXaa: 0.0 ± 0.0
Asn
3.902AsnAla: 3.902 ± 0.286
0.681AsnCys: 0.681 ± 0.09
2.774AsnAsp: 2.774 ± 0.194
2.51AsnGlu: 2.51 ± 0.221
2.784AsnPhe: 2.784 ± 0.158
4.918AsnGly: 4.918 ± 0.472
0.864AsnHis: 0.864 ± 0.106
5.842AsnIle: 5.842 ± 0.564
4.176AsnLys: 4.176 ± 0.31
3.658AsnLeu: 3.658 ± 0.227
1.798AsnMet: 1.798 ± 0.131
3.455AsnAsn: 3.455 ± 0.449
2.601AsnPro: 2.601 ± 0.196
1.209AsnGln: 1.209 ± 0.116
1.87AsnArg: 1.87 ± 0.172
2.875AsnSer: 2.875 ± 0.16
4.318AsnThr: 4.318 ± 0.417
7.163AsnVal: 7.163 ± 1.059
0.63AsnTrp: 0.63 ± 0.079
2.113AsnTyr: 2.113 ± 0.24
0.0AsnXaa: 0.0 ± 0.0
Pro
4.897ProAla: 4.897 ± 0.675
0.559ProCys: 0.559 ± 0.098
2.388ProAsp: 2.388 ± 0.191
3.414ProGlu: 3.414 ± 0.324
1.788ProPhe: 1.788 ± 0.163
3.373ProGly: 3.373 ± 0.354
0.63ProHis: 0.63 ± 0.083
2.52ProIle: 2.52 ± 0.169
6.117ProLys: 6.117 ± 0.894
2.865ProLeu: 2.865 ± 0.22
1.108ProMet: 1.108 ± 0.109
2.164ProAsn: 2.164 ± 0.196
2.703ProPro: 2.703 ± 0.462
1.585ProGln: 1.585 ± 0.169
2.032ProArg: 2.032 ± 0.158
4.45ProSer: 4.45 ± 0.578
3.577ProThr: 3.577 ± 0.254
3.424ProVal: 3.424 ± 0.271
0.447ProTrp: 0.447 ± 0.074
1.372ProTyr: 1.372 ± 0.116
0.0ProXaa: 0.0 ± 0.0
Gln
1.87GlnAla: 1.87 ± 0.208
0.406GlnCys: 0.406 ± 0.089
1.28GlnAsp: 1.28 ± 0.119
1.189GlnGlu: 1.189 ± 0.107
1.341GlnPhe: 1.341 ± 0.152
1.453GlnGly: 1.453 ± 0.157
0.549GlnHis: 0.549 ± 0.087
1.768GlnIle: 1.768 ± 0.139
2.672GlnLys: 2.672 ± 0.255
2.398GlnLeu: 2.398 ± 0.192
0.925GlnMet: 0.925 ± 0.122
1.494GlnAsn: 1.494 ± 0.15
1.199GlnPro: 1.199 ± 0.137
1.362GlnGln: 1.362 ± 0.209
1.605GlnArg: 1.605 ± 0.182
1.727GlnSer: 1.727 ± 0.138
2.215GlnThr: 2.215 ± 0.15
1.646GlnVal: 1.646 ± 0.122
0.366GlnTrp: 0.366 ± 0.062
1.321GlnTyr: 1.321 ± 0.118
0.0GlnXaa: 0.0 ± 0.0
Arg
2.398ArgAla: 2.398 ± 0.212
0.681ArgCys: 0.681 ± 0.103
2.357ArgAsp: 2.357 ± 0.16
2.591ArgGlu: 2.591 ± 0.205
1.575ArgPhe: 1.575 ± 0.122
2.957ArgGly: 2.957 ± 0.289
0.965ArgHis: 0.965 ± 0.105
2.977ArgIle: 2.977 ± 0.166
3.536ArgLys: 3.536 ± 0.311
3.19ArgLeu: 3.19 ± 0.161
1.148ArgMet: 1.148 ± 0.124
2.408ArgAsn: 2.408 ± 0.187
1.981ArgPro: 1.981 ± 0.163
1.341ArgGln: 1.341 ± 0.132
2.042ArgArg: 2.042 ± 0.239
2.632ArgSer: 2.632 ± 0.235
2.408ArgThr: 2.408 ± 0.149
2.926ArgVal: 2.926 ± 0.163
0.457ArgTrp: 0.457 ± 0.068
1.443ArgTyr: 1.443 ± 0.136
0.0ArgXaa: 0.0 ± 0.0
Ser
4.532SerAla: 4.532 ± 0.38
1.158SerCys: 1.158 ± 0.13
3.475SerAsp: 3.475 ± 0.235
3.333SerGlu: 3.333 ± 0.24
3.241SerPhe: 3.241 ± 0.194
5.334SerGly: 5.334 ± 0.466
1.026SerHis: 1.026 ± 0.112
4.308SerIle: 4.308 ± 0.228
5.04SerLys: 5.04 ± 0.318
4.877SerLeu: 4.877 ± 0.263
1.697SerMet: 1.697 ± 0.155
3.942SerAsn: 3.942 ± 0.316
4.156SerPro: 4.156 ± 0.569
1.88SerGln: 1.88 ± 0.221
3.028SerArg: 3.028 ± 0.192
4.877SerSer: 4.877 ± 0.341
4.085SerThr: 4.085 ± 0.257
5.182SerVal: 5.182 ± 0.308
0.782SerTrp: 0.782 ± 0.091
2.469SerTyr: 2.469 ± 0.174
0.0SerXaa: 0.0 ± 0.0
Thr
4.44ThrAla: 4.44 ± 0.647
0.843ThrCys: 0.843 ± 0.096
3.292ThrAsp: 3.292 ± 0.185
3.221ThrGlu: 3.221 ± 0.217
3.373ThrPhe: 3.373 ± 0.236
5.507ThrGly: 5.507 ± 0.481
1.108ThrHis: 1.108 ± 0.11
4.674ThrIle: 4.674 ± 0.278
4.755ThrLys: 4.755 ± 0.32
4.471ThrLeu: 4.471 ± 0.212
1.392ThrMet: 1.392 ± 0.117
3.617ThrAsn: 3.617 ± 0.262
4.318ThrPro: 4.318 ± 0.353
2.002ThrGln: 2.002 ± 0.167
2.886ThrArg: 2.886 ± 0.207
4.43ThrSer: 4.43 ± 0.283
4.278ThrThr: 4.278 ± 0.364
3.82ThrVal: 3.82 ± 0.205
0.843ThrTrp: 0.843 ± 0.098
2.002ThrTyr: 2.002 ± 0.148
0.0ThrXaa: 0.0 ± 0.0
Val
4.105ValAla: 4.105 ± 0.246
1.057ValCys: 1.057 ± 0.118
4.389ValAsp: 4.389 ± 0.241
3.587ValGlu: 3.587 ± 0.186
3.282ValPhe: 3.282 ± 0.196
4.196ValGly: 4.196 ± 0.415
1.108ValHis: 1.108 ± 0.111
4.857ValIle: 4.857 ± 0.232
5.192ValLys: 5.192 ± 0.309
5.395ValLeu: 5.395 ± 0.266
1.768ValMet: 1.768 ± 0.139
3.871ValAsn: 3.871 ± 0.268
3.577ValPro: 3.577 ± 0.274
1.971ValGln: 1.971 ± 0.164
2.713ValArg: 2.713 ± 0.189
5.67ValSer: 5.67 ± 0.411
5.09ValThr: 5.09 ± 0.722
5.558ValVal: 5.558 ± 0.339
0.528ValTrp: 0.528 ± 0.075
3.099ValTyr: 3.099 ± 0.232
0.0ValXaa: 0.0 ± 0.0
Trp
0.66TrpAla: 0.66 ± 0.082
0.234TrpCys: 0.234 ± 0.068
0.914TrpAsp: 0.914 ± 0.115
0.599TrpGlu: 0.599 ± 0.075
0.64TrpPhe: 0.64 ± 0.081
0.599TrpGly: 0.599 ± 0.087
0.132TrpHis: 0.132 ± 0.041
0.599TrpIle: 0.599 ± 0.086
0.833TrpLys: 0.833 ± 0.099
0.752TrpLeu: 0.752 ± 0.082
0.213TrpMet: 0.213 ± 0.05
0.782TrpAsn: 0.782 ± 0.123
0.295TrpPro: 0.295 ± 0.06
0.244TrpGln: 0.244 ± 0.048
0.295TrpArg: 0.295 ± 0.052
0.945TrpSer: 0.945 ± 0.1
0.569TrpThr: 0.569 ± 0.087
0.691TrpVal: 0.691 ± 0.099
0.213TrpTrp: 0.213 ± 0.053
0.498TrpTyr: 0.498 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.997TyrAla: 2.997 ± 0.243
0.559TyrCys: 0.559 ± 0.086
2.54TyrAsp: 2.54 ± 0.216
2.164TyrGlu: 2.164 ± 0.223
2.235TyrPhe: 2.235 ± 0.238
2.378TyrGly: 2.378 ± 0.179
0.63TyrHis: 0.63 ± 0.073
2.855TyrIle: 2.855 ± 0.169
2.886TyrLys: 2.886 ± 0.212
2.601TyrLeu: 2.601 ± 0.158
1.006TyrMet: 1.006 ± 0.105
2.591TyrAsn: 2.591 ± 0.211
1.351TyrPro: 1.351 ± 0.121
0.853TyrGln: 0.853 ± 0.086
1.382TyrArg: 1.382 ± 0.126
2.632TyrSer: 2.632 ± 0.178
2.652TyrThr: 2.652 ± 0.195
2.479TyrVal: 2.479 ± 0.208
0.305TyrTrp: 0.305 ± 0.055
1.494TyrTyr: 1.494 ± 0.182
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 355 proteins (98420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski