Amino acid dipepetide frequency for Virgibacillus indicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.0AlaAla: 6.0 ± 0.095	0.555AlaCys: 0.555 ± 0.022	3.724AlaAsp: 3.724 ± 0.063	5.055AlaGlu: 5.055 ± 0.082	3.326AlaPhe: 3.326 ± 0.059	5.451AlaGly: 5.451 ± 0.086	1.106AlaHis: 1.106 ± 0.034	6.14AlaIle: 6.14 ± 0.093	4.528AlaLys: 4.528 ± 0.075	6.773AlaLeu: 6.773 ± 0.084	2.062AlaMet: 2.062 ± 0.039	2.821AlaAsn: 2.821 ± 0.054	1.962AlaPro: 1.962 ± 0.048	1.885AlaGln: 1.885 ± 0.047	2.407AlaArg: 2.407 ± 0.054	3.947AlaSer: 3.947 ± 0.063	3.155AlaThr: 3.155 ± 0.056	5.582AlaVal: 5.582 ± 0.075	0.61AlaTrp: 0.61 ± 0.026	2.275AlaTyr: 2.275 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.351CysAla: 0.351 ± 0.02	0.076CysCys: 0.076 ± 0.01	0.335CysAsp: 0.335 ± 0.017	0.389CysGlu: 0.389 ± 0.018	0.26CysPhe: 0.26 ± 0.018	0.585CysGly: 0.585 ± 0.024	0.189CysHis: 0.189 ± 0.014	0.494CysIle: 0.494 ± 0.024	0.335CysLys: 0.335 ± 0.02	0.536CysLeu: 0.536 ± 0.024	0.157CysMet: 0.157 ± 0.012	0.288CysAsn: 0.288 ± 0.016	0.309CysPro: 0.309 ± 0.018	0.195CysGln: 0.195 ± 0.013	0.248CysArg: 0.248 ± 0.016	0.473CysSer: 0.473 ± 0.023	0.375CysThr: 0.375 ± 0.019	0.336CysVal: 0.336 ± 0.018	0.071CysTrp: 0.071 ± 0.009	0.195CysTyr: 0.195 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.411AspAla: 3.411 ± 0.057	0.323AspCys: 0.323 ± 0.016	2.842AspAsp: 2.842 ± 0.061	4.815AspGlu: 4.815 ± 0.078	2.618AspPhe: 2.618 ± 0.054	3.553AspGly: 3.553 ± 0.065	1.141AspHis: 1.141 ± 0.035	4.42AspIle: 4.42 ± 0.077	3.571AspLys: 3.571 ± 0.068	5.037AspLeu: 5.037 ± 0.069	1.399AspMet: 1.399 ± 0.036	2.368AspAsn: 2.368 ± 0.045	2.057AspPro: 2.057 ± 0.046	1.964AspGln: 1.964 ± 0.045	2.183AspArg: 2.183 ± 0.049	2.933AspSer: 2.933 ± 0.052	2.627AspThr: 2.627 ± 0.05	3.796AspVal: 3.796 ± 0.056	0.628AspTrp: 0.628 ± 0.029	2.341AspTyr: 2.341 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.563GluAla: 5.563 ± 0.085	0.31GluCys: 0.31 ± 0.016	4.06GluAsp: 4.06 ± 0.068	7.419GluGlu: 7.419 ± 0.112	2.722GluPhe: 2.722 ± 0.053	4.257GluGly: 4.257 ± 0.074	1.488GluHis: 1.488 ± 0.038	6.228GluIle: 6.228 ± 0.083	7.193GluLys: 7.193 ± 0.093	7.166GluLeu: 7.166 ± 0.085	2.499GluMet: 2.499 ± 0.043	4.536GluAsn: 4.536 ± 0.068	2.015GluPro: 2.015 ± 0.043	3.242GluGln: 3.242 ± 0.064	3.236GluArg: 3.236 ± 0.058	3.956GluSer: 3.956 ± 0.058	4.037GluThr: 4.037 ± 0.064	4.948GluVal: 4.948 ± 0.072	0.818GluTrp: 0.818 ± 0.029	2.37GluTyr: 2.37 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.082PheAla: 3.082 ± 0.064	0.307PheCys: 0.307 ± 0.018	2.511PheAsp: 2.511 ± 0.04	2.794PheGlu: 2.794 ± 0.052	2.375PhePhe: 2.375 ± 0.066	3.27PheGly: 3.27 ± 0.065	1.035PheHis: 1.035 ± 0.035	4.264PheIle: 4.264 ± 0.087	2.452PheLys: 2.452 ± 0.05	4.609PheLeu: 4.609 ± 0.082	1.233PheMet: 1.233 ± 0.037	2.019PheAsn: 2.019 ± 0.05	1.673PhePro: 1.673 ± 0.031	1.644PheGln: 1.644 ± 0.037	1.552PheArg: 1.552 ± 0.04	3.344PheSer: 3.344 ± 0.065	2.615PheThr: 2.615 ± 0.048	2.949PheVal: 2.949 ± 0.057	0.514PheTrp: 0.514 ± 0.025	1.841PheTyr: 1.841 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.704GlyAla: 4.704 ± 0.076	0.514GlyCys: 0.514 ± 0.023	3.291GlyAsp: 3.291 ± 0.058	4.745GlyGlu: 4.745 ± 0.074	3.468GlyPhe: 3.468 ± 0.064	4.677GlyGly: 4.677 ± 0.083	1.277GlyHis: 1.277 ± 0.035	6.124GlyIle: 6.124 ± 0.084	4.928GlyLys: 4.928 ± 0.078	6.461GlyLeu: 6.461 ± 0.087	2.202GlyMet: 2.202 ± 0.051	2.996GlyAsn: 2.996 ± 0.058	1.617GlyPro: 1.617 ± 0.038	1.986GlyGln: 1.986 ± 0.043	2.369GlyArg: 2.369 ± 0.049	4.007GlySer: 4.007 ± 0.075	3.955GlyThr: 3.955 ± 0.061	4.781GlyVal: 4.781 ± 0.08	0.78GlyTrp: 0.78 ± 0.031	2.726GlyTyr: 2.726 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.327HisAla: 1.327 ± 0.038	0.175HisCys: 0.175 ± 0.012	0.987HisAsp: 0.987 ± 0.03	1.375HisGlu: 1.375 ± 0.039	1.05HisPhe: 1.05 ± 0.033	1.37HisGly: 1.37 ± 0.042	0.584HisHis: 0.584 ± 0.028	1.531HisIle: 1.531 ± 0.04	1.075HisLys: 1.075 ± 0.032	1.972HisLeu: 1.972 ± 0.048	0.535HisMet: 0.535 ± 0.023	0.82HisAsn: 0.82 ± 0.025	1.02HisPro: 1.02 ± 0.031	0.795HisGln: 0.795 ± 0.029	0.882HisArg: 0.882 ± 0.03	1.122HisSer: 1.122 ± 0.033	1.007HisThr: 1.007 ± 0.031	1.36HisVal: 1.36 ± 0.037	0.224HisTrp: 0.224 ± 0.014	0.831HisTyr: 0.831 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.423IleAla: 6.423 ± 0.103	0.583IleCys: 0.583 ± 0.026	4.754IleAsp: 4.754 ± 0.064	5.774IleGlu: 5.774 ± 0.083	3.599IlePhe: 3.599 ± 0.079	6.129IleGly: 6.129 ± 0.096	1.764IleHis: 1.764 ± 0.038	7.042IleIle: 7.042 ± 0.101	4.86IleLys: 4.86 ± 0.082	7.445IleLeu: 7.445 ± 0.104	1.962IleMet: 1.962 ± 0.045	3.829IleAsn: 3.829 ± 0.061	3.598IlePro: 3.598 ± 0.059	2.948IleGln: 2.948 ± 0.042	3.068IleArg: 3.068 ± 0.058	5.404IleSer: 5.404 ± 0.073	4.743IleThr: 4.743 ± 0.067	5.49IleVal: 5.49 ± 0.079	0.755IleTrp: 0.755 ± 0.034	2.691IleTyr: 2.691 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.603LysAla: 4.603 ± 0.073	0.29LysCys: 0.29 ± 0.016	4.098LysAsp: 4.098 ± 0.074	7.122LysGlu: 7.122 ± 0.082	2.032LysPhe: 2.032 ± 0.048	4.25LysGly: 4.25 ± 0.071	1.362LysHis: 1.362 ± 0.034	4.943LysIle: 4.943 ± 0.068	6.067LysLys: 6.067 ± 0.088	6.085LysLeu: 6.085 ± 0.082	2.173LysMet: 2.173 ± 0.042	3.662LysAsn: 3.662 ± 0.066	2.17LysPro: 2.17 ± 0.047	3.376LysGln: 3.376 ± 0.073	3.296LysArg: 3.296 ± 0.063	3.785LysSer: 3.785 ± 0.06	3.583LysThr: 3.583 ± 0.066	4.295LysVal: 4.295 ± 0.067	0.763LysTrp: 0.763 ± 0.028	2.304LysTyr: 2.304 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.027LeuAla: 7.027 ± 0.088	0.519LeuCys: 0.519 ± 0.023	4.924LeuAsp: 4.924 ± 0.074	6.675LeuGlu: 6.675 ± 0.089	4.981LeuPhe: 4.981 ± 0.09	6.204LeuGly: 6.204 ± 0.088	1.889LeuHis: 1.889 ± 0.039	7.732LeuIle: 7.732 ± 0.106	6.555LeuLys: 6.555 ± 0.089	9.707LeuLeu: 9.707 ± 0.143	2.48LeuMet: 2.48 ± 0.055	4.433LeuAsn: 4.433 ± 0.068	3.669LeuPro: 3.669 ± 0.064	3.298LeuGln: 3.298 ± 0.059	3.38LeuArg: 3.38 ± 0.059	6.353LeuSer: 6.353 ± 0.085	5.492LeuThr: 5.492 ± 0.067	5.761LeuVal: 5.761 ± 0.09	0.773LeuTrp: 0.773 ± 0.03	3.069LeuTyr: 3.069 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.983MetAla: 1.983 ± 0.039	0.126MetCys: 0.126 ± 0.01	1.705MetAsp: 1.705 ± 0.038	2.317MetGlu: 2.317 ± 0.046	1.102MetPhe: 1.102 ± 0.032	1.821MetGly: 1.821 ± 0.039	0.456MetHis: 0.456 ± 0.023	2.189MetIle: 2.189 ± 0.048	2.519MetLys: 2.519 ± 0.049	2.564MetLeu: 2.564 ± 0.048	0.841MetMet: 0.841 ± 0.028	1.651MetAsn: 1.651 ± 0.039	1.005MetPro: 1.005 ± 0.036	1.02MetGln: 1.02 ± 0.031	1.094MetArg: 1.094 ± 0.029	1.636MetSer: 1.636 ± 0.036	1.572MetThr: 1.572 ± 0.037	1.722MetVal: 1.722 ± 0.038	0.187MetTrp: 0.187 ± 0.014	0.806MetTyr: 0.806 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.859AsnAla: 2.859 ± 0.051	0.325AsnCys: 0.325 ± 0.017	2.594AsnAsp: 2.594 ± 0.055	4.061AsnGlu: 4.061 ± 0.066	1.825AsnPhe: 1.825 ± 0.042	3.376AsnGly: 3.376 ± 0.061	1.116AsnHis: 1.116 ± 0.037	3.649AsnIle: 3.649 ± 0.058	3.509AsnLys: 3.509 ± 0.062	4.007AsnLeu: 4.007 ± 0.064	1.303AsnMet: 1.303 ± 0.037	2.569AsnAsn: 2.569 ± 0.063	2.198AsnPro: 2.198 ± 0.046	2.133AsnGln: 2.133 ± 0.051	2.063AsnArg: 2.063 ± 0.046	2.495AsnSer: 2.495 ± 0.046	2.375AsnThr: 2.375 ± 0.044	2.978AsnVal: 2.978 ± 0.057	0.568AsnTrp: 0.568 ± 0.025	1.868AsnTyr: 1.868 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.411ProAla: 2.411 ± 0.045	0.164ProCys: 0.164 ± 0.012	2.214ProAsp: 2.214 ± 0.053	3.225ProGlu: 3.225 ± 0.055	1.882ProPhe: 1.882 ± 0.042	2.345ProGly: 2.345 ± 0.051	0.738ProHis: 0.738 ± 0.03	2.697ProIle: 2.697 ± 0.049	2.117ProLys: 2.117 ± 0.045	3.23ProLeu: 3.23 ± 0.054	0.872ProMet: 0.872 ± 0.027	1.562ProAsn: 1.562 ± 0.038	0.917ProPro: 0.917 ± 0.029	0.966ProGln: 0.966 ± 0.03	0.974ProArg: 0.974 ± 0.032	2.142ProSer: 2.142 ± 0.049	1.723ProThr: 1.723 ± 0.035	2.902ProVal: 2.902 ± 0.054	0.343ProTrp: 0.343 ± 0.018	1.362ProTyr: 1.362 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.597GlnAla: 2.597 ± 0.056	0.17GlnCys: 0.17 ± 0.013	1.769GlnAsp: 1.769 ± 0.042	2.914GlnGlu: 2.914 ± 0.061	1.604GlnPhe: 1.604 ± 0.044	2.094GlnGly: 2.094 ± 0.051	0.717GlnHis: 0.717 ± 0.026	2.692GlnIle: 2.692 ± 0.048	2.681GlnLys: 2.681 ± 0.055	4.005GlnLeu: 4.005 ± 0.06	1.141GlnMet: 1.141 ± 0.036	1.671GlnAsn: 1.671 ± 0.043	1.109GlnPro: 1.109 ± 0.034	1.693GlnGln: 1.693 ± 0.059	1.347GlnArg: 1.347 ± 0.035	2.04GlnSer: 2.04 ± 0.044	1.964GlnThr: 1.964 ± 0.036	2.223GlnVal: 2.223 ± 0.045	0.386GlnTrp: 0.386 ± 0.022	1.152GlnTyr: 1.152 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.153ArgAla: 2.153 ± 0.046	0.246ArgCys: 0.246 ± 0.016	1.997ArgAsp: 1.997 ± 0.044	3.098ArgGlu: 3.098 ± 0.062	1.893ArgPhe: 1.893 ± 0.045	2.142ArgGly: 2.142 ± 0.052	0.661ArgHis: 0.661 ± 0.024	3.086ArgIle: 3.086 ± 0.059	3.26ArgLys: 3.26 ± 0.06	3.65ArgLeu: 3.65 ± 0.06	1.251ArgMet: 1.251 ± 0.036	2.013ArgAsn: 2.013 ± 0.047	1.141ArgPro: 1.141 ± 0.033	1.471ArgGln: 1.471 ± 0.039	1.684ArgArg: 1.684 ± 0.051	2.131ArgSer: 2.131 ± 0.046	1.967ArgThr: 1.967 ± 0.041	2.401ArgVal: 2.401 ± 0.055	0.398ArgTrp: 0.398 ± 0.017	1.47ArgTyr: 1.47 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.724SerAla: 3.724 ± 0.072	0.308SerCys: 0.308 ± 0.017	3.225SerAsp: 3.225 ± 0.05	4.267SerGlu: 4.267 ± 0.059	3.176SerPhe: 3.176 ± 0.06	4.575SerGly: 4.575 ± 0.076	1.206SerHis: 1.206 ± 0.035	5.217SerIle: 5.217 ± 0.079	3.851SerLys: 3.851 ± 0.06	5.792SerLeu: 5.792 ± 0.079	1.715SerMet: 1.715 ± 0.039	2.749SerAsn: 2.749 ± 0.049	2.011SerPro: 2.011 ± 0.047	1.859SerGln: 1.859 ± 0.046	2.285SerArg: 2.285 ± 0.049	3.831SerSer: 3.831 ± 0.067	2.974SerThr: 2.974 ± 0.053	4.009SerVal: 4.009 ± 0.061	0.634SerTrp: 0.634 ± 0.023	2.387SerTyr: 2.387 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.052ThrAla: 4.052 ± 0.067	0.325ThrCys: 0.325 ± 0.018	2.923ThrAsp: 2.923 ± 0.056	3.868ThrGlu: 3.868 ± 0.064	2.512ThrPhe: 2.512 ± 0.052	4.212ThrGly: 4.212 ± 0.067	0.994ThrHis: 0.994 ± 0.033	4.798ThrIle: 4.798 ± 0.067	3.318ThrLys: 3.318 ± 0.06	4.818ThrLeu: 4.818 ± 0.072	1.34ThrMet: 1.34 ± 0.034	2.485ThrAsn: 2.485 ± 0.051	2.113ThrPro: 2.113 ± 0.046	1.378ThrGln: 1.378 ± 0.038	1.742ThrArg: 1.742 ± 0.039	3.098ThrSer: 3.098 ± 0.05	2.675ThrThr: 2.675 ± 0.055	4.07ThrVal: 4.07 ± 0.063	0.496ThrTrp: 0.496 ± 0.024	1.869ThrTyr: 1.869 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.397ValAla: 4.397 ± 0.071	0.527ValCys: 0.527 ± 0.025	3.545ValAsp: 3.545 ± 0.062	4.748ValGlu: 4.748 ± 0.071	3.222ValPhe: 3.222 ± 0.065	4.212ValGly: 4.212 ± 0.073	1.273ValHis: 1.273 ± 0.038	6.016ValIle: 6.016 ± 0.078	4.482ValLys: 4.482 ± 0.065	6.546ValLeu: 6.546 ± 0.084	1.894ValMet: 1.894 ± 0.045	3.222ValAsn: 3.222 ± 0.063	2.461ValPro: 2.461 ± 0.05	2.207ValGln: 2.207 ± 0.049	2.434ValArg: 2.434 ± 0.048	4.453ValSer: 4.453 ± 0.061	3.896ValThr: 3.896 ± 0.075	4.429ValVal: 4.429 ± 0.07	0.586ValTrp: 0.586 ± 0.025	2.296ValTyr: 2.296 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.574TrpAla: 0.574 ± 0.025	0.062TrpCys: 0.062 ± 0.008	0.521TrpAsp: 0.521 ± 0.025	0.737TrpGlu: 0.737 ± 0.026	0.482TrpPhe: 0.482 ± 0.021	0.657TrpGly: 0.657 ± 0.025	0.18TrpHis: 0.18 ± 0.012	0.918TrpIle: 0.918 ± 0.035	0.742TrpLys: 0.742 ± 0.025	1.102TrpLeu: 1.102 ± 0.035	0.331TrpMet: 0.331 ± 0.016	0.564TrpAsn: 0.564 ± 0.023	0.272TrpPro: 0.272 ± 0.018	0.374TrpGln: 0.374 ± 0.018	0.351TrpArg: 0.351 ± 0.016	0.567TrpSer: 0.567 ± 0.023	0.48TrpThr: 0.48 ± 0.021	0.653TrpVal: 0.653 ± 0.026	0.139TrpTrp: 0.139 ± 0.012	0.378TrpTyr: 0.378 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.124TyrAla: 2.124 ± 0.037	0.291TyrCys: 0.291 ± 0.016	2.006TyrAsp: 2.006 ± 0.05	2.666TyrGlu: 2.666 ± 0.048	1.955TyrPhe: 1.955 ± 0.042	2.428TyrGly: 2.428 ± 0.05	0.865TyrHis: 0.865 ± 0.026	2.681TyrIle: 2.681 ± 0.055	2.216TyrLys: 2.216 ± 0.048	3.416TyrLeu: 3.416 ± 0.067	0.928TyrMet: 0.928 ± 0.031	1.615TyrAsn: 1.615 ± 0.047	1.468TyrPro: 1.468 ± 0.039	1.534TyrGln: 1.534 ± 0.035	1.518TyrArg: 1.518 ± 0.037	2.077TyrSer: 2.077 ± 0.047	1.873TyrThr: 1.873 ± 0.041	2.159TyrVal: 2.159 ± 0.05	0.411TyrTrp: 0.411 ± 0.021	1.482TyrTyr: 1.482 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3738 proteins (1086022 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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