Amino acid dipepetide frequency for Metarhizium rileyi (strain RCEF 4871) (Nomuraea rileyi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.456AlaAla: 9.456 ± 0.065	1.102AlaCys: 1.102 ± 0.016	4.475AlaAsp: 4.475 ± 0.037	5.165AlaGlu: 5.165 ± 0.046	3.131AlaPhe: 3.131 ± 0.03	5.943AlaGly: 5.943 ± 0.043	1.844AlaHis: 1.844 ± 0.02	4.157AlaIle: 4.157 ± 0.038	4.214AlaLys: 4.214 ± 0.036	7.641AlaLeu: 7.641 ± 0.052	2.124AlaMet: 2.124 ± 0.024	3.005AlaAsn: 3.005 ± 0.026	4.518AlaPro: 4.518 ± 0.039	3.454AlaGln: 3.454 ± 0.033	5.22AlaArg: 5.22 ± 0.037	7.582AlaSer: 7.582 ± 0.053	5.325AlaThr: 5.325 ± 0.039	5.694AlaVal: 5.694 ± 0.042	1.176AlaTrp: 1.176 ± 0.018	2.096AlaTyr: 2.096 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.016	0.236CysCys: 0.236 ± 0.009	0.687CysAsp: 0.687 ± 0.013	0.617CysGlu: 0.617 ± 0.011	0.544CysPhe: 0.544 ± 0.012	0.942CysGly: 0.942 ± 0.017	0.357CysHis: 0.357 ± 0.011	0.7CysIle: 0.7 ± 0.012	0.535CysLys: 0.535 ± 0.013	1.286CysLeu: 1.286 ± 0.019	0.264CysMet: 0.264 ± 0.007	0.443CysAsn: 0.443 ± 0.012	0.689CysPro: 0.689 ± 0.014	0.478CysGln: 0.478 ± 0.011	0.812CysArg: 0.812 ± 0.013	0.945CysSer: 0.945 ± 0.017	0.702CysThr: 0.702 ± 0.013	0.8CysVal: 0.8 ± 0.015	0.192CysTrp: 0.192 ± 0.007	0.352CysTyr: 0.352 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.063AspAla: 5.063 ± 0.035	0.684AspCys: 0.684 ± 0.014	4.72AspAsp: 4.72 ± 0.049	4.668AspGlu: 4.668 ± 0.046	2.258AspPhe: 2.258 ± 0.024	4.429AspGly: 4.429 ± 0.039	1.259AspHis: 1.259 ± 0.018	3.019AspIle: 3.019 ± 0.032	2.655AspLys: 2.655 ± 0.026	5.008AspLeu: 5.008 ± 0.035	1.446AspMet: 1.446 ± 0.019	1.952AspAsn: 1.952 ± 0.02	3.018AspPro: 3.018 ± 0.027	1.897AspGln: 1.897 ± 0.023	3.154AspArg: 3.154 ± 0.035	4.236AspSer: 4.236 ± 0.039	2.99AspThr: 2.99 ± 0.027	3.93AspVal: 3.93 ± 0.028	0.868AspTrp: 0.868 ± 0.016	1.523AspTyr: 1.523 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.528GluAla: 5.528 ± 0.046	0.612GluCys: 0.612 ± 0.012	4.148GluAsp: 4.148 ± 0.041	5.101GluGlu: 5.101 ± 0.059	1.867GluPhe: 1.867 ± 0.022	3.488GluGly: 3.488 ± 0.031	1.42GluHis: 1.42 ± 0.019	2.747GluIle: 2.747 ± 0.03	3.564GluLys: 3.564 ± 0.039	5.255GluLeu: 5.255 ± 0.04	1.508GluMet: 1.508 ± 0.019	2.165GluAsn: 2.165 ± 0.022	2.87GluPro: 2.87 ± 0.036	2.53GluGln: 2.53 ± 0.026	3.892GluArg: 3.892 ± 0.039	4.281GluSer: 4.281 ± 0.038	3.528GluThr: 3.528 ± 0.033	3.444GluVal: 3.444 ± 0.028	0.834GluTrp: 0.834 ± 0.013	1.612GluTyr: 1.612 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.022PheAla: 3.022 ± 0.027	0.549PheCys: 0.549 ± 0.011	2.321PheAsp: 2.321 ± 0.024	2.094PheGlu: 2.094 ± 0.024	1.579PhePhe: 1.579 ± 0.024	2.797PheGly: 2.797 ± 0.031	0.892PheHis: 0.892 ± 0.015	1.696PheIle: 1.696 ± 0.022	1.504PheLys: 1.504 ± 0.021	3.346PheLeu: 3.346 ± 0.034	0.808PheMet: 0.808 ± 0.014	1.395PheAsn: 1.395 ± 0.016	1.856PhePro: 1.856 ± 0.022	1.363PheGln: 1.363 ± 0.018	2.002PheArg: 2.002 ± 0.02	2.906PheSer: 2.906 ± 0.032	2.046PheThr: 2.046 ± 0.025	2.449PheVal: 2.449 ± 0.026	0.608PheTrp: 0.608 ± 0.013	1.043PheTyr: 1.043 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.293GlyAla: 5.293 ± 0.049	0.862GlyCys: 0.862 ± 0.016	3.828GlyAsp: 3.828 ± 0.032	3.713GlyGlu: 3.713 ± 0.033	2.728GlyPhe: 2.728 ± 0.032	5.697GlyGly: 5.697 ± 0.066	1.835GlyHis: 1.835 ± 0.022	3.479GlyIle: 3.479 ± 0.033	3.54GlyLys: 3.54 ± 0.036	6.086GlyLeu: 6.086 ± 0.049	1.615GlyMet: 1.615 ± 0.022	2.61GlyAsn: 2.61 ± 0.03	3.408GlyPro: 3.408 ± 0.053	2.74GlyGln: 2.74 ± 0.027	4.385GlyArg: 4.385 ± 0.042	5.915GlySer: 5.915 ± 0.047	3.949GlyThr: 3.949 ± 0.039	4.309GlyVal: 4.309 ± 0.038	1.121GlyTrp: 1.121 ± 0.017	2.012GlyTyr: 2.012 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.885HisAla: 1.885 ± 0.021	0.336HisCys: 0.336 ± 0.008	1.449HisAsp: 1.449 ± 0.019	1.36HisGlu: 1.36 ± 0.016	0.902HisPhe: 0.902 ± 0.013	1.903HisGly: 1.903 ± 0.022	0.936HisHis: 0.936 ± 0.022	1.208HisIle: 1.208 ± 0.016	0.971HisLys: 0.971 ± 0.016	2.24HisLeu: 2.24 ± 0.022	0.544HisMet: 0.544 ± 0.011	0.838HisAsn: 0.838 ± 0.013	1.56HisPro: 1.56 ± 0.02	1.077HisGln: 1.077 ± 0.021	1.623HisArg: 1.623 ± 0.024	1.861HisSer: 1.861 ± 0.024	1.28HisThr: 1.28 ± 0.021	1.612HisVal: 1.612 ± 0.02	0.328HisTrp: 0.328 ± 0.008	0.66HisTyr: 0.66 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.961IleAla: 3.961 ± 0.036	0.728IleCys: 0.728 ± 0.013	2.765IleAsp: 2.765 ± 0.028	2.688IleGlu: 2.688 ± 0.026	1.823IlePhe: 1.823 ± 0.023	3.075IleGly: 3.075 ± 0.028	1.182IleHis: 1.182 ± 0.017	2.303IleIle: 2.303 ± 0.028	2.183IleLys: 2.183 ± 0.028	4.345IleLeu: 4.345 ± 0.031	1.051IleMet: 1.051 ± 0.015	1.703IleAsn: 1.703 ± 0.021	2.85IlePro: 2.85 ± 0.032	1.813IleGln: 1.813 ± 0.022	2.844IleArg: 2.844 ± 0.03	3.734IleSer: 3.734 ± 0.029	2.657IleThr: 2.657 ± 0.028	3.067IleVal: 3.067 ± 0.034	0.704IleTrp: 0.704 ± 0.012	1.271IleTyr: 1.271 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.379LysAla: 4.379 ± 0.045	0.52LysCys: 0.52 ± 0.014	2.847LysAsp: 2.847 ± 0.027	3.197LysGlu: 3.197 ± 0.035	1.48LysPhe: 1.48 ± 0.019	2.981LysGly: 2.981 ± 0.03	1.187LysHis: 1.187 ± 0.017	2.158LysIle: 2.158 ± 0.021	3.357LysLys: 3.357 ± 0.062	4.236LysLeu: 4.236 ± 0.035	1.087LysMet: 1.087 ± 0.017	1.73LysAsn: 1.73 ± 0.024	2.797LysPro: 2.797 ± 0.033	1.955LysGln: 1.955 ± 0.025	3.521LysArg: 3.521 ± 0.041	3.67LysSer: 3.67 ± 0.031	2.968LysThr: 2.968 ± 0.029	2.766LysVal: 2.766 ± 0.03	0.655LysTrp: 0.655 ± 0.012	1.333LysTyr: 1.333 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.007LeuAla: 8.007 ± 0.052	1.246LeuCys: 1.246 ± 0.023	5.347LeuAsp: 5.347 ± 0.031	5.33LeuGlu: 5.33 ± 0.038	3.232LeuPhe: 3.232 ± 0.031	6.034LeuGly: 6.034 ± 0.04	2.188LeuHis: 2.188 ± 0.022	3.713LeuIle: 3.713 ± 0.031	4.112LeuLys: 4.112 ± 0.034	8.246LeuLeu: 8.246 ± 0.066	1.797LeuMet: 1.797 ± 0.021	3.006LeuAsn: 3.006 ± 0.028	5.414LeuPro: 5.414 ± 0.04	3.808LeuGln: 3.808 ± 0.031	5.978LeuArg: 5.978 ± 0.042	7.35LeuSer: 7.35 ± 0.049	4.701LeuThr: 4.701 ± 0.035	5.648LeuVal: 5.648 ± 0.045	1.152LeuTrp: 1.152 ± 0.018	2.251LeuTyr: 2.251 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.413MetAla: 2.413 ± 0.021	0.252MetCys: 0.252 ± 0.008	1.354MetAsp: 1.354 ± 0.017	1.309MetGlu: 1.309 ± 0.017	0.741MetPhe: 0.741 ± 0.014	1.52MetGly: 1.52 ± 0.018	0.483MetHis: 0.483 ± 0.011	0.949MetIle: 0.949 ± 0.015	1.08MetLys: 1.08 ± 0.016	1.914MetLeu: 1.914 ± 0.023	0.614MetMet: 0.614 ± 0.012	0.8MetAsn: 0.8 ± 0.015	1.352MetPro: 1.352 ± 0.019	0.892MetGln: 0.892 ± 0.014	1.343MetArg: 1.343 ± 0.016	2.005MetSer: 2.005 ± 0.022	1.403MetThr: 1.403 ± 0.017	1.371MetVal: 1.371 ± 0.017	0.266MetTrp: 0.266 ± 0.008	0.557MetTyr: 0.557 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.042AsnAla: 3.042 ± 0.029	0.459AsnCys: 0.459 ± 0.013	1.979AsnAsp: 1.979 ± 0.021	2.001AsnGlu: 2.001 ± 0.022	1.33AsnPhe: 1.33 ± 0.017	2.961AsnGly: 2.961 ± 0.032	0.868AsnHis: 0.868 ± 0.016	1.984AsnIle: 1.984 ± 0.02	1.665AsnLys: 1.665 ± 0.023	3.129AsnLeu: 3.129 ± 0.029	0.91AsnMet: 0.91 ± 0.017	1.489AsnAsn: 1.489 ± 0.023	2.239AsnPro: 2.239 ± 0.028	1.315AsnGln: 1.315 ± 0.023	2.034AsnArg: 2.034 ± 0.023	2.704AsnSer: 2.704 ± 0.027	2.103AsnThr: 2.103 ± 0.024	2.293AsnVal: 2.293 ± 0.025	0.516AsnTrp: 0.516 ± 0.012	0.969AsnTyr: 0.969 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.159ProAla: 5.159 ± 0.049	0.577ProCys: 0.577 ± 0.012	3.209ProAsp: 3.209 ± 0.029	3.6ProGlu: 3.6 ± 0.039	1.981ProPhe: 1.981 ± 0.021	4.101ProGly: 4.101 ± 0.035	1.298ProHis: 1.298 ± 0.02	2.386ProIle: 2.386 ± 0.028	2.597ProLys: 2.597 ± 0.028	4.643ProLeu: 4.643 ± 0.038	1.105ProMet: 1.105 ± 0.019	2.082ProAsn: 2.082 ± 0.028	5.028ProPro: 5.028 ± 0.078	2.391ProGln: 2.391 ± 0.028	3.595ProArg: 3.595 ± 0.039	5.875ProSer: 5.875 ± 0.05	3.761ProThr: 3.761 ± 0.038	3.649ProVal: 3.649 ± 0.033	0.745ProTrp: 0.745 ± 0.013	1.385ProTyr: 1.385 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.506GlnAla: 3.506 ± 0.032	0.445GlnCys: 0.445 ± 0.012	2.271GlnAsp: 2.271 ± 0.024	2.323GlnGlu: 2.323 ± 0.026	1.282GlnPhe: 1.282 ± 0.016	2.529GlnGly: 2.529 ± 0.028	1.16GlnHis: 1.16 ± 0.023	1.794GlnIle: 1.794 ± 0.021	1.987GlnLys: 1.987 ± 0.025	3.554GlnLeu: 3.554 ± 0.029	0.944GlnMet: 0.944 ± 0.015	1.496GlnAsn: 1.496 ± 0.021	2.592GlnPro: 2.592 ± 0.03	2.673GlnGln: 2.673 ± 0.06	2.755GlnArg: 2.755 ± 0.027	3.238GlnSer: 3.238 ± 0.029	2.358GlnThr: 2.358 ± 0.025	2.313GlnVal: 2.313 ± 0.024	0.544GlnTrp: 0.544 ± 0.012	1.113GlnTyr: 1.113 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.905ArgAla: 4.905 ± 0.038	0.761ArgCys: 0.761 ± 0.013	3.69ArgAsp: 3.69 ± 0.042	3.889ArgGlu: 3.889 ± 0.036	2.187ArgPhe: 2.187 ± 0.023	3.957ArgGly: 3.957 ± 0.032	1.769ArgHis: 1.769 ± 0.022	2.876ArgIle: 2.876 ± 0.026	3.514ArgLys: 3.514 ± 0.034	5.77ArgLeu: 5.77 ± 0.042	1.366ArgMet: 1.366 ± 0.018	2.35ArgAsn: 2.35 ± 0.025	3.703ArgPro: 3.703 ± 0.036	2.929ArgGln: 2.929 ± 0.027	5.624ArgArg: 5.624 ± 0.049	4.975ArgSer: 4.975 ± 0.039	3.373ArgThr: 3.373 ± 0.028	3.522ArgVal: 3.522 ± 0.033	0.908ArgTrp: 0.908 ± 0.015	1.627ArgTyr: 1.627 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.734SerAla: 6.734 ± 0.045	0.944SerCys: 0.944 ± 0.016	4.295SerAsp: 4.295 ± 0.037	4.151SerGlu: 4.151 ± 0.036	2.992SerPhe: 2.992 ± 0.03	5.646SerGly: 5.646 ± 0.045	2.078SerHis: 2.078 ± 0.023	3.836SerIle: 3.836 ± 0.035	3.834SerLys: 3.834 ± 0.037	7.288SerLeu: 7.288 ± 0.051	1.802SerMet: 1.802 ± 0.019	3.033SerAsn: 3.033 ± 0.026	5.537SerPro: 5.537 ± 0.054	3.484SerGln: 3.484 ± 0.036	5.504SerArg: 5.504 ± 0.047	8.879SerSer: 8.879 ± 0.068	5.465SerThr: 5.465 ± 0.053	4.655SerVal: 4.655 ± 0.035	1.125SerTrp: 1.125 ± 0.018	1.993SerTyr: 1.993 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.336ThrAla: 5.336 ± 0.04	0.765ThrCys: 0.765 ± 0.015	2.888ThrAsp: 2.888 ± 0.028	3.071ThrGlu: 3.071 ± 0.03	2.121ThrPhe: 2.121 ± 0.021	4.208ThrGly: 4.208 ± 0.052	1.279ThrHis: 1.279 ± 0.015	2.926ThrIle: 2.926 ± 0.029	2.662ThrLys: 2.662 ± 0.025	5.071ThrLeu: 5.071 ± 0.039	1.271ThrMet: 1.271 ± 0.017	2.014ThrAsn: 2.014 ± 0.023	4.173ThrPro: 4.173 ± 0.039	2.063ThrGln: 2.063 ± 0.022	3.312ThrArg: 3.312 ± 0.03	5.347ThrSer: 5.347 ± 0.039	4.172ThrThr: 4.172 ± 0.049	3.708ThrVal: 3.708 ± 0.031	0.828ThrTrp: 0.828 ± 0.014	1.525ThrTyr: 1.525 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.513ValAla: 5.513 ± 0.041	0.869ValCys: 0.869 ± 0.017	3.956ValAsp: 3.956 ± 0.03	3.802ValGlu: 3.802 ± 0.03	2.46ValPhe: 2.46 ± 0.026	4.071ValGly: 4.071 ± 0.034	1.435ValHis: 1.435 ± 0.022	2.847ValIle: 2.847 ± 0.03	2.987ValLys: 2.987 ± 0.031	5.666ValLeu: 5.666 ± 0.043	1.368ValMet: 1.368 ± 0.019	2.214ValAsn: 2.214 ± 0.025	3.629ValPro: 3.629 ± 0.033	2.408ValGln: 2.408 ± 0.022	3.578ValArg: 3.578 ± 0.029	4.795ValSer: 4.795 ± 0.035	3.561ValThr: 3.561 ± 0.032	4.46ValVal: 4.46 ± 0.04	0.845ValTrp: 0.845 ± 0.014	1.664ValTyr: 1.664 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.098TrpAla: 1.098 ± 0.016	0.197TrpCys: 0.197 ± 0.006	0.907TrpAsp: 0.907 ± 0.016	0.827TrpGlu: 0.827 ± 0.017	0.523TrpPhe: 0.523 ± 0.014	0.864TrpGly: 0.864 ± 0.015	0.377TrpHis: 0.377 ± 0.01	0.705TrpIle: 0.705 ± 0.013	0.762TrpLys: 0.762 ± 0.012	1.323TrpLeu: 1.323 ± 0.019	0.363TrpMet: 0.363 ± 0.01	0.618TrpAsn: 0.618 ± 0.013	0.604TrpPro: 0.604 ± 0.013	0.577TrpGln: 0.577 ± 0.012	0.927TrpArg: 0.927 ± 0.014	1.021TrpSer: 1.021 ± 0.016	0.915TrpThr: 0.915 ± 0.014	0.842TrpVal: 0.842 ± 0.014	0.267TrpTrp: 0.267 ± 0.009	0.385TrpTyr: 0.385 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.059TyrAla: 2.059 ± 0.024	0.404TyrCys: 0.404 ± 0.01	1.642TyrAsp: 1.642 ± 0.02	1.488TyrGlu: 1.488 ± 0.022	1.113TyrPhe: 1.113 ± 0.019	1.978TyrGly: 1.978 ± 0.024	0.726TyrHis: 0.726 ± 0.015	1.264TyrIle: 1.264 ± 0.018	1.101TyrLys: 1.101 ± 0.017	2.512TyrLeu: 2.512 ± 0.026	0.631TyrMet: 0.631 ± 0.012	1.046TyrAsn: 1.046 ± 0.016	1.331TyrPro: 1.331 ± 0.018	1.03TyrGln: 1.03 ± 0.016	1.59TyrArg: 1.59 ± 0.018	1.958TyrSer: 1.958 ± 0.023	1.482TyrThr: 1.482 ± 0.019	1.596TyrVal: 1.596 ± 0.019	0.419TyrTrp: 0.419 ± 0.009	0.899TyrTyr: 0.899 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8763 proteins (4465319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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