Amino acid dipepetide frequency for Methyloceanibacter methanicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.143AlaAla: 16.143 ± 0.243	1.163AlaCys: 1.163 ± 0.034	6.869AlaAsp: 6.869 ± 0.121	8.036AlaGlu: 8.036 ± 0.124	4.274AlaPhe: 4.274 ± 0.076	10.021AlaGly: 10.021 ± 0.136	2.304AlaHis: 2.304 ± 0.054	5.841AlaIle: 5.841 ± 0.101	4.754AlaLys: 4.754 ± 0.103	13.576AlaLeu: 13.576 ± 0.176	3.323AlaMet: 3.323 ± 0.067	2.862AlaAsn: 2.862 ± 0.065	6.135AlaPro: 6.135 ± 0.111	3.821AlaGln: 3.821 ± 0.075	8.676AlaArg: 8.676 ± 0.149	5.992AlaSer: 5.992 ± 0.099	5.706AlaThr: 5.706 ± 0.079	8.672AlaVal: 8.672 ± 0.12	1.5AlaTrp: 1.5 ± 0.045	2.751AlaTyr: 2.751 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.102CysAla: 1.102 ± 0.044	0.137CysCys: 0.137 ± 0.013	0.546CysAsp: 0.546 ± 0.03	0.476CysGlu: 0.476 ± 0.028	0.343CysPhe: 0.343 ± 0.019	1.036CysGly: 1.036 ± 0.038	0.265CysHis: 0.265 ± 0.021	0.381CysIle: 0.381 ± 0.022	0.259CysLys: 0.259 ± 0.021	0.873CysLeu: 0.873 ± 0.036	0.194CysMet: 0.194 ± 0.016	0.267CysAsn: 0.267 ± 0.018	0.553CysPro: 0.553 ± 0.03	0.255CysGln: 0.255 ± 0.018	0.731CysArg: 0.731 ± 0.031	0.513CysSer: 0.513 ± 0.027	0.45CysThr: 0.45 ± 0.026	0.652CysVal: 0.652 ± 0.033	0.122CysTrp: 0.122 ± 0.013	0.204CysTyr: 0.204 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.37AspAla: 7.37 ± 0.128	0.523AspCys: 0.523 ± 0.026	3.604AspAsp: 3.604 ± 0.092	4.043AspGlu: 4.043 ± 0.086	2.223AspPhe: 2.223 ± 0.052	5.499AspGly: 5.499 ± 0.101	1.192AspHis: 1.192 ± 0.041	2.992AspIle: 2.992 ± 0.064	2.118AspLys: 2.118 ± 0.061	5.991AspLeu: 5.991 ± 0.113	1.371AspMet: 1.371 ± 0.039	1.296AspAsn: 1.296 ± 0.047	3.488AspPro: 3.488 ± 0.078	1.765AspGln: 1.765 ± 0.053	4.107AspArg: 4.107 ± 0.08	2.322AspSer: 2.322 ± 0.055	2.853AspThr: 2.853 ± 0.065	4.59AspVal: 4.59 ± 0.082	0.991AspTrp: 0.991 ± 0.034	1.613AspTyr: 1.613 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.335GluAla: 8.335 ± 0.144	0.408GluCys: 0.408 ± 0.024	3.649GluAsp: 3.649 ± 0.08	3.754GluGlu: 3.754 ± 0.087	1.67GluPhe: 1.67 ± 0.049	4.571GluGly: 4.571 ± 0.083	1.233GluHis: 1.233 ± 0.044	3.555GluIle: 3.555 ± 0.066	2.464GluLys: 2.464 ± 0.058	5.489GluLeu: 5.489 ± 0.092	1.405GluMet: 1.405 ± 0.044	1.595GluAsn: 1.595 ± 0.048	3.204GluPro: 3.204 ± 0.083	2.015GluGln: 2.015 ± 0.05	4.96GluArg: 4.96 ± 0.081	2.749GluSer: 2.749 ± 0.062	4.15GluThr: 4.15 ± 0.082	3.999GluVal: 3.999 ± 0.085	0.702GluTrp: 0.702 ± 0.029	1.045GluTyr: 1.045 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.521PheAla: 4.521 ± 0.091	0.394PheCys: 0.394 ± 0.023	2.642PheAsp: 2.642 ± 0.062	2.309PheGlu: 2.309 ± 0.053	1.422PhePhe: 1.422 ± 0.045	3.687PheGly: 3.687 ± 0.07	0.667PheHis: 0.667 ± 0.028	1.56PheIle: 1.56 ± 0.052	1.125PheLys: 1.125 ± 0.039	3.31PheLeu: 3.31 ± 0.076	0.765PheMet: 0.765 ± 0.034	0.956PheAsn: 0.956 ± 0.036	1.578PhePro: 1.578 ± 0.042	0.993PheGln: 0.993 ± 0.036	2.219PheArg: 2.219 ± 0.053	2.166PheSer: 2.166 ± 0.056	1.876PheThr: 1.876 ± 0.045	3.043PheVal: 3.043 ± 0.069	0.579PheTrp: 0.579 ± 0.027	0.95PheTyr: 0.95 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.365GlyAla: 9.365 ± 0.124	0.942GlyCys: 0.942 ± 0.039	4.819GlyAsp: 4.819 ± 0.088	4.967GlyGlu: 4.967 ± 0.089	3.574GlyPhe: 3.574 ± 0.066	7.21GlyGly: 7.21 ± 0.147	1.989GlyHis: 1.989 ± 0.049	4.195GlyIle: 4.195 ± 0.076	3.441GlyLys: 3.441 ± 0.081	8.974GlyLeu: 8.974 ± 0.124	2.052GlyMet: 2.052 ± 0.047	2.118GlyAsn: 2.118 ± 0.064	3.861GlyPro: 3.861 ± 0.077	2.798GlyGln: 2.798 ± 0.078	5.837GlyArg: 5.837 ± 0.095	4.547GlySer: 4.547 ± 0.082	4.921GlyThr: 4.921 ± 0.088	6.058GlyVal: 6.058 ± 0.102	1.242GlyTrp: 1.242 ± 0.041	2.261GlyTyr: 2.261 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.36HisAla: 2.36 ± 0.059	0.228HisCys: 0.228 ± 0.016	1.276HisAsp: 1.276 ± 0.04	1.184HisGlu: 1.184 ± 0.043	0.865HisPhe: 0.865 ± 0.037	1.963HisGly: 1.963 ± 0.06	0.552HisHis: 0.552 ± 0.032	0.902HisIle: 0.902 ± 0.033	0.588HisLys: 0.588 ± 0.024	2.019HisLeu: 2.019 ± 0.05	0.455HisMet: 0.455 ± 0.024	0.509HisAsn: 0.509 ± 0.025	1.274HisPro: 1.274 ± 0.041	0.524HisGln: 0.524 ± 0.027	1.358HisArg: 1.358 ± 0.04	0.863HisSer: 0.863 ± 0.034	0.876HisThr: 0.876 ± 0.034	1.523HisVal: 1.523 ± 0.043	0.304HisTrp: 0.304 ± 0.018	0.578HisTyr: 0.578 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.849IleAla: 6.849 ± 0.105	0.5IleCys: 0.5 ± 0.023	3.429IleAsp: 3.429 ± 0.062	3.594IleGlu: 3.594 ± 0.061	1.577IlePhe: 1.577 ± 0.057	4.703IleGly: 4.703 ± 0.089	0.891IleHis: 0.891 ± 0.037	1.824IleIle: 1.824 ± 0.053	1.62IleLys: 1.62 ± 0.052	4.167IleLeu: 4.167 ± 0.077	0.887IleMet: 0.887 ± 0.031	1.133IleAsn: 1.133 ± 0.04	2.323IlePro: 2.323 ± 0.059	1.111IleGln: 1.111 ± 0.038	2.767IleArg: 2.767 ± 0.059	2.473IleSer: 2.473 ± 0.067	2.408IleThr: 2.408 ± 0.066	4.5IleVal: 4.5 ± 0.091	0.55IleTrp: 0.55 ± 0.026	1.099IleTyr: 1.099 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.41LysAla: 4.41 ± 0.086	0.22LysCys: 0.22 ± 0.017	2.334LysAsp: 2.334 ± 0.056	2.158LysGlu: 2.158 ± 0.054	1.002LysPhe: 1.002 ± 0.036	2.961LysGly: 2.961 ± 0.069	0.675LysHis: 0.675 ± 0.034	1.846LysIle: 1.846 ± 0.056	1.691LysLys: 1.691 ± 0.053	3.507LysLeu: 3.507 ± 0.075	0.761LysMet: 0.761 ± 0.035	1.008LysAsn: 1.008 ± 0.039	2.251LysPro: 2.251 ± 0.054	1.132LysGln: 1.132 ± 0.042	2.722LysArg: 2.722 ± 0.066	2.062LysSer: 2.062 ± 0.056	2.446LysThr: 2.446 ± 0.071	2.671LysVal: 2.671 ± 0.066	0.39LysTrp: 0.39 ± 0.027	0.726LysTyr: 0.726 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	13.113LeuAla: 13.113 ± 0.148	0.916LeuCys: 0.916 ± 0.037	6.066LeuAsp: 6.066 ± 0.094	5.619LeuGlu: 5.619 ± 0.092	3.657LeuPhe: 3.657 ± 0.084	8.455LeuGly: 8.455 ± 0.132	1.842LeuHis: 1.842 ± 0.045	4.934LeuIle: 4.934 ± 0.099	4.116LeuLys: 4.116 ± 0.081	9.333LeuLeu: 9.333 ± 0.149	2.126LeuMet: 2.126 ± 0.049	2.585LeuAsn: 2.585 ± 0.058	5.235LeuPro: 5.235 ± 0.09	2.763LeuGln: 2.763 ± 0.062	6.635LeuArg: 6.635 ± 0.102	6.099LeuSer: 6.099 ± 0.098	5.728LeuThr: 5.728 ± 0.085	7.443LeuVal: 7.443 ± 0.112	1.153LeuTrp: 1.153 ± 0.042	2.226LeuTyr: 2.226 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.888MetAla: 2.888 ± 0.063	0.165MetCys: 0.165 ± 0.013	1.151MetAsp: 1.151 ± 0.037	1.179MetGlu: 1.179 ± 0.04	0.736MetPhe: 0.736 ± 0.03	1.737MetGly: 1.737 ± 0.047	0.467MetHis: 0.467 ± 0.024	1.227MetIle: 1.227 ± 0.042	0.859MetLys: 0.859 ± 0.032	2.266MetLeu: 2.266 ± 0.06	0.532MetMet: 0.532 ± 0.025	0.63MetAsn: 0.63 ± 0.029	1.451MetPro: 1.451 ± 0.049	0.736MetGln: 0.736 ± 0.033	1.884MetArg: 1.884 ± 0.044	1.514MetSer: 1.514 ± 0.039	1.833MetThr: 1.833 ± 0.047	1.572MetVal: 1.572 ± 0.049	0.22MetTrp: 0.22 ± 0.017	0.304MetTyr: 0.304 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.086AsnAla: 3.086 ± 0.065	0.271AsnCys: 0.271 ± 0.018	1.487AsnAsp: 1.487 ± 0.052	1.385AsnGlu: 1.385 ± 0.049	0.926AsnPhe: 0.926 ± 0.038	2.282AsnGly: 2.282 ± 0.059	0.429AsnHis: 0.429 ± 0.02	1.215AsnIle: 1.215 ± 0.044	0.825AsnLys: 0.825 ± 0.032	2.344AsnLeu: 2.344 ± 0.058	0.637AsnMet: 0.637 ± 0.028	0.632AsnAsn: 0.632 ± 0.032	1.76AsnPro: 1.76 ± 0.047	0.714AsnGln: 0.714 ± 0.03	1.729AsnArg: 1.729 ± 0.049	1.073AsnSer: 1.073 ± 0.042	1.24AsnThr: 1.24 ± 0.043	2.076AsnVal: 2.076 ± 0.056	0.397AsnTrp: 0.397 ± 0.024	0.674AsnTyr: 0.674 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.894ProAla: 5.894 ± 0.108	0.428ProCys: 0.428 ± 0.025	3.879ProAsp: 3.879 ± 0.072	4.182ProGlu: 4.182 ± 0.084	1.998ProPhe: 1.998 ± 0.053	4.743ProGly: 4.743 ± 0.088	1.155ProHis: 1.155 ± 0.042	2.31ProIle: 2.31 ± 0.06	2.13ProLys: 2.13 ± 0.059	4.705ProLeu: 4.705 ± 0.085	1.238ProMet: 1.238 ± 0.04	1.454ProAsn: 1.454 ± 0.047	2.771ProPro: 2.771 ± 0.079	1.752ProGln: 1.752 ± 0.061	3.26ProArg: 3.26 ± 0.077	3.025ProSer: 3.025 ± 0.062	2.534ProThr: 2.534 ± 0.057	4.164ProVal: 4.164 ± 0.084	0.686ProTrp: 0.686 ± 0.033	1.339ProTyr: 1.339 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.738GlnAla: 3.738 ± 0.075	0.229GlnCys: 0.229 ± 0.017	1.621GlnAsp: 1.621 ± 0.049	1.613GlnGlu: 1.613 ± 0.046	1.045GlnPhe: 1.045 ± 0.038	2.403GlnGly: 2.403 ± 0.065	0.627GlnHis: 0.627 ± 0.032	1.583GlnIle: 1.583 ± 0.053	1.084GlnLys: 1.084 ± 0.039	2.788GlnLeu: 2.788 ± 0.062	0.787GlnMet: 0.787 ± 0.032	0.843GlnAsn: 0.843 ± 0.036	1.616GlnPro: 1.616 ± 0.06	1.052GlnGln: 1.052 ± 0.044	2.243GlnArg: 2.243 ± 0.058	1.746GlnSer: 1.746 ± 0.049	1.785GlnThr: 1.785 ± 0.048	2.193GlnVal: 2.193 ± 0.066	0.354GlnTrp: 0.354 ± 0.021	0.639GlnTyr: 0.639 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	8.025ArgAla: 8.025 ± 0.124	0.602ArgCys: 0.602 ± 0.031	4.029ArgAsp: 4.029 ± 0.058	4.073ArgGlu: 4.073 ± 0.069	2.848ArgPhe: 2.848 ± 0.066	4.864ArgGly: 4.864 ± 0.092	1.622ArgHis: 1.622 ± 0.045	3.626ArgIle: 3.626 ± 0.076	2.472ArgLys: 2.472 ± 0.062	7.711ArgLeu: 7.711 ± 0.11	1.672ArgMet: 1.672 ± 0.05	1.794ArgAsn: 1.794 ± 0.048	3.797ArgPro: 3.797 ± 0.09	2.268ArgGln: 2.268 ± 0.068	5.498ArgArg: 5.498 ± 0.108	3.686ArgSer: 3.686 ± 0.074	3.354ArgThr: 3.354 ± 0.072	4.676ArgVal: 4.676 ± 0.074	0.929ArgTrp: 0.929 ± 0.039	1.823ArgTyr: 1.823 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.138SerAla: 6.138 ± 0.089	0.49SerCys: 0.49 ± 0.027	3.048SerAsp: 3.048 ± 0.062	3.029SerGlu: 3.029 ± 0.068	2.176SerPhe: 2.176 ± 0.051	5.254SerGly: 5.254 ± 0.098	1.056SerHis: 1.056 ± 0.044	2.383SerIle: 2.383 ± 0.058	1.836SerLys: 1.836 ± 0.062	5.241SerLeu: 5.241 ± 0.098	1.357SerMet: 1.357 ± 0.045	1.341SerAsn: 1.341 ± 0.039	2.996SerPro: 2.996 ± 0.067	1.575SerGln: 1.575 ± 0.046	3.506SerArg: 3.506 ± 0.077	2.876SerSer: 2.876 ± 0.072	2.649SerThr: 2.649 ± 0.058	3.87SerVal: 3.87 ± 0.074	0.712SerTrp: 0.712 ± 0.034	1.244SerTyr: 1.244 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.269ThrAla: 6.269 ± 0.105	0.529ThrCys: 0.529 ± 0.028	2.958ThrAsp: 2.958 ± 0.07	2.99ThrGlu: 2.99 ± 0.064	2.074ThrPhe: 2.074 ± 0.053	5.033ThrGly: 5.033 ± 0.09	1.019ThrHis: 1.019 ± 0.042	2.731ThrIle: 2.731 ± 0.058	1.867ThrLys: 1.867 ± 0.05	5.848ThrLeu: 5.848 ± 0.08	1.233ThrMet: 1.233 ± 0.044	1.276ThrAsn: 1.276 ± 0.046	3.36ThrPro: 3.36 ± 0.072	1.453ThrGln: 1.453 ± 0.042	3.347ThrArg: 3.347 ± 0.067	2.771ThrSer: 2.771 ± 0.064	2.896ThrThr: 2.896 ± 0.072	4.48ThrVal: 4.48 ± 0.082	0.645ThrTrp: 0.645 ± 0.032	1.283ThrTyr: 1.283 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	9.036ValAla: 9.036 ± 0.106	0.73ValCys: 0.73 ± 0.03	4.342ValAsp: 4.342 ± 0.084	4.521ValGlu: 4.521 ± 0.068	2.803ValPhe: 2.803 ± 0.062	5.593ValGly: 5.593 ± 0.091	1.4ValHis: 1.4 ± 0.041	3.722ValIle: 3.722 ± 0.074	2.541ValLys: 2.541 ± 0.059	7.973ValLeu: 7.973 ± 0.135	1.707ValMet: 1.707 ± 0.048	1.912ValAsn: 1.912 ± 0.057	4.138ValPro: 4.138 ± 0.075	1.988ValGln: 1.988 ± 0.048	4.834ValArg: 4.834 ± 0.078	4.395ValSer: 4.395 ± 0.074	4.478ValThr: 4.478 ± 0.072	6.086ValVal: 6.086 ± 0.112	0.934ValTrp: 0.934 ± 0.043	1.719ValTyr: 1.719 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.172TrpAla: 1.172 ± 0.042	0.16TrpCys: 0.16 ± 0.017	0.639TrpAsp: 0.639 ± 0.027	0.523TrpGlu: 0.523 ± 0.028	0.527TrpPhe: 0.527 ± 0.027	0.92TrpGly: 0.92 ± 0.039	0.325TrpHis: 0.325 ± 0.02	0.666TrpIle: 0.666 ± 0.029	0.451TrpLys: 0.451 ± 0.027	1.579TrpLeu: 1.579 ± 0.044	0.345TrpMet: 0.345 ± 0.024	0.364TrpAsn: 0.364 ± 0.023	0.712TrpPro: 0.712 ± 0.031	0.523TrpGln: 0.523 ± 0.028	1.199TrpArg: 1.199 ± 0.038	0.812TrpSer: 0.812 ± 0.037	0.791TrpThr: 0.791 ± 0.034	0.797TrpVal: 0.797 ± 0.033	0.232TrpTrp: 0.232 ± 0.017	0.333TrpTyr: 0.333 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.604TyrAla: 2.604 ± 0.056	0.324TyrCys: 0.324 ± 0.02	1.561TyrAsp: 1.561 ± 0.054	1.319TyrGlu: 1.319 ± 0.045	1.021TyrPhe: 1.021 ± 0.043	2.238TyrGly: 2.238 ± 0.064	0.488TyrHis: 0.488 ± 0.025	0.912TyrIle: 0.912 ± 0.033	0.734TyrLys: 0.734 ± 0.032	2.348TyrLeu: 2.348 ± 0.063	0.502TyrMet: 0.502 ± 0.022	0.608TyrAsn: 0.608 ± 0.028	1.147TyrPro: 1.147 ± 0.039	0.748TyrGln: 0.748 ± 0.033	1.854TyrArg: 1.854 ± 0.045	1.097TyrSer: 1.097 ± 0.044	1.09TyrThr: 1.09 ± 0.043	1.786TyrVal: 1.786 ± 0.044	0.428TyrTrp: 0.428 ± 0.023	0.654TyrTyr: 0.654 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2710 proteins (768685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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