Amino acid dipepetide frequency for Rhodobacteraceae bacterium PARR1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.022AlaAla: 20.022 ± 0.189	1.066AlaCys: 1.066 ± 0.032	7.871AlaAsp: 7.871 ± 0.096	8.287AlaGlu: 8.287 ± 0.089	4.354AlaPhe: 4.354 ± 0.069	11.895AlaGly: 11.895 ± 0.13	2.35AlaHis: 2.35 ± 0.052	5.775AlaIle: 5.775 ± 0.073	4.038AlaLys: 4.038 ± 0.071	15.394AlaLeu: 15.394 ± 0.16	4.055AlaMet: 4.055 ± 0.069	2.644AlaAsn: 2.644 ± 0.056	6.309AlaPro: 6.309 ± 0.11	4.878AlaGln: 4.878 ± 0.063	9.475AlaArg: 9.475 ± 0.105	5.516AlaSer: 5.516 ± 0.075	6.936AlaThr: 6.936 ± 0.092	9.679AlaVal: 9.679 ± 0.106	1.487AlaTrp: 1.487 ± 0.034	2.43AlaTyr: 2.43 ± 0.047	0.003AlaXaa: 0.003 ± 0.001
Cys	1.049CysAla: 1.049 ± 0.029	0.091CysCys: 0.091 ± 0.008	0.581CysAsp: 0.581 ± 0.023	0.345CysGlu: 0.345 ± 0.019	0.325CysPhe: 0.325 ± 0.015	0.903CysGly: 0.903 ± 0.026	0.249CysHis: 0.249 ± 0.016	0.375CysIle: 0.375 ± 0.019	0.18CysLys: 0.18 ± 0.013	0.879CysLeu: 0.879 ± 0.026	0.159CysMet: 0.159 ± 0.011	0.2CysAsn: 0.2 ± 0.014	0.498CysPro: 0.498 ± 0.022	0.204CysGln: 0.204 ± 0.014	0.559CysArg: 0.559 ± 0.019	0.392CysSer: 0.392 ± 0.02	0.447CysThr: 0.447 ± 0.022	0.555CysVal: 0.555 ± 0.024	0.106CysTrp: 0.106 ± 0.01	0.172CysTyr: 0.172 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.594AspAla: 7.594 ± 0.09	0.516AspCys: 0.516 ± 0.023	3.281AspAsp: 3.281 ± 0.07	2.806AspGlu: 2.806 ± 0.049	2.26AspPhe: 2.26 ± 0.042	6.011AspGly: 6.011 ± 0.102	1.474AspHis: 1.474 ± 0.042	2.888AspIle: 2.888 ± 0.057	1.408AspLys: 1.408 ± 0.031	6.694AspLeu: 6.694 ± 0.088	1.566AspMet: 1.566 ± 0.039	1.201AspAsn: 1.201 ± 0.037	3.885AspPro: 3.885 ± 0.07	1.953AspGln: 1.953 ± 0.041	4.723AspArg: 4.723 ± 0.07	2.318AspSer: 2.318 ± 0.059	3.027AspThr: 3.027 ± 0.085	4.099AspVal: 4.099 ± 0.065	1.324AspTrp: 1.324 ± 0.036	1.422AspTyr: 1.422 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.281GluAla: 7.281 ± 0.089	0.299GluCys: 0.299 ± 0.015	2.658GluAsp: 2.658 ± 0.046	2.562GluGlu: 2.562 ± 0.052	1.612GluPhe: 1.612 ± 0.034	4.337GluGly: 4.337 ± 0.061	0.863GluHis: 0.863 ± 0.026	2.798GluIle: 2.798 ± 0.058	1.72GluLys: 1.72 ± 0.039	4.355GluLeu: 4.355 ± 0.067	1.556GluMet: 1.556 ± 0.036	1.301GluAsn: 1.301 ± 0.033	2.292GluPro: 2.292 ± 0.042	1.552GluGln: 1.552 ± 0.032	3.643GluArg: 3.643 ± 0.063	2.122GluSer: 2.122 ± 0.043	3.276GluThr: 3.276 ± 0.047	4.35GluVal: 4.35 ± 0.067	0.698GluTrp: 0.698 ± 0.026	0.879GluTyr: 0.879 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.799PheAla: 4.799 ± 0.075	0.381PheCys: 0.381 ± 0.019	2.822PheAsp: 2.822 ± 0.053	1.657PheGlu: 1.657 ± 0.039	1.323PhePhe: 1.323 ± 0.038	3.677PheGly: 3.677 ± 0.061	0.726PheHis: 0.726 ± 0.025	1.502PheIle: 1.502 ± 0.038	0.873PheLys: 0.873 ± 0.028	3.498PheLeu: 3.498 ± 0.058	0.736PheMet: 0.736 ± 0.023	0.947PheAsn: 0.947 ± 0.026	1.604PhePro: 1.604 ± 0.035	0.992PheGln: 0.992 ± 0.029	2.249PheArg: 2.249 ± 0.046	1.891PheSer: 1.891 ± 0.04	2.069PheThr: 2.069 ± 0.046	2.682PheVal: 2.682 ± 0.047	0.559PheTrp: 0.559 ± 0.023	0.843PheTyr: 0.843 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.741GlyAla: 10.741 ± 0.124	0.854GlyCys: 0.854 ± 0.028	4.876GlyAsp: 4.876 ± 0.091	4.071GlyGlu: 4.071 ± 0.062	3.79GlyPhe: 3.79 ± 0.06	8.075GlyGly: 8.075 ± 0.158	1.941GlyHis: 1.941 ± 0.043	4.41GlyIle: 4.41 ± 0.068	3.092GlyLys: 3.092 ± 0.053	9.722GlyLeu: 9.722 ± 0.098	2.773GlyMet: 2.773 ± 0.051	2.321GlyAsn: 2.321 ± 0.083	3.942GlyPro: 3.942 ± 0.061	3.461GlyGln: 3.461 ± 0.068	6.154GlyArg: 6.154 ± 0.076	4.212GlySer: 4.212 ± 0.076	5.06GlyThr: 5.06 ± 0.081	6.684GlyVal: 6.684 ± 0.079	1.589GlyTrp: 1.589 ± 0.044	2.113GlyTyr: 2.113 ± 0.038	0.001GlyXaa: 0.001 ± 0.001
His	2.477HisAla: 2.477 ± 0.055	0.211HisCys: 0.211 ± 0.014	1.279HisAsp: 1.279 ± 0.032	0.896HisGlu: 0.896 ± 0.029	0.76HisPhe: 0.76 ± 0.026	1.902HisGly: 1.902 ± 0.041	0.565HisHis: 0.565 ± 0.022	0.903HisIle: 0.903 ± 0.03	0.446HisLys: 0.446 ± 0.02	2.294HisLeu: 2.294 ± 0.05	0.512HisMet: 0.512 ± 0.019	0.418HisAsn: 0.418 ± 0.019	1.464HisPro: 1.464 ± 0.037	0.539HisGln: 0.539 ± 0.019	1.481HisArg: 1.481 ± 0.034	0.876HisSer: 0.876 ± 0.03	0.715HisThr: 0.715 ± 0.026	1.502HisVal: 1.502 ± 0.037	0.342HisTrp: 0.342 ± 0.016	0.499HisTyr: 0.499 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.959IleAla: 6.959 ± 0.087	0.527IleCys: 0.527 ± 0.022	3.364IleAsp: 3.364 ± 0.061	2.825IleGlu: 2.825 ± 0.053	1.554IlePhe: 1.554 ± 0.04	4.852IleGly: 4.852 ± 0.069	0.934IleHis: 0.934 ± 0.027	1.988IleIle: 1.988 ± 0.052	1.251IleLys: 1.251 ± 0.037	4.835IleLeu: 4.835 ± 0.061	0.916IleMet: 0.916 ± 0.032	1.242IleAsn: 1.242 ± 0.037	2.345IlePro: 2.345 ± 0.043	1.08IleGln: 1.08 ± 0.028	3.179IleArg: 3.179 ± 0.049	2.415IleSer: 2.415 ± 0.056	2.908IleThr: 2.908 ± 0.059	3.488IleVal: 3.488 ± 0.058	0.629IleTrp: 0.629 ± 0.026	1.014IleTyr: 1.014 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.976LysAla: 3.976 ± 0.072	0.162LysCys: 0.162 ± 0.013	1.596LysAsp: 1.596 ± 0.038	1.167LysGlu: 1.167 ± 0.031	0.763LysPhe: 0.763 ± 0.024	2.819LysGly: 2.819 ± 0.055	0.544LysHis: 0.544 ± 0.021	1.321LysIle: 1.321 ± 0.035	0.988LysLys: 0.988 ± 0.034	2.714LysLeu: 2.714 ± 0.05	0.795LysMet: 0.795 ± 0.028	0.695LysAsn: 0.695 ± 0.024	1.738LysPro: 1.738 ± 0.044	0.779LysGln: 0.779 ± 0.024	1.973LysArg: 1.973 ± 0.046	1.583LysSer: 1.583 ± 0.044	1.82LysThr: 1.82 ± 0.042	2.252LysVal: 2.252 ± 0.045	0.339LysTrp: 0.339 ± 0.016	0.5LysTyr: 0.5 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.452LeuAla: 14.452 ± 0.16	0.988LeuCys: 0.988 ± 0.029	6.036LeuAsp: 6.036 ± 0.078	4.506LeuGlu: 4.506 ± 0.059	3.494LeuPhe: 3.494 ± 0.063	8.502LeuGly: 8.502 ± 0.095	2.0LeuHis: 2.0 ± 0.045	5.055LeuIle: 5.055 ± 0.07	2.845LeuLys: 2.845 ± 0.053	8.877LeuLeu: 8.877 ± 0.11	2.764LeuMet: 2.764 ± 0.052	2.532LeuAsn: 2.532 ± 0.046	6.405LeuPro: 6.405 ± 0.089	2.75LeuGln: 2.75 ± 0.05	7.6LeuArg: 7.6 ± 0.083	6.906LeuSer: 6.906 ± 0.087	7.092LeuThr: 7.092 ± 0.097	7.132LeuVal: 7.132 ± 0.091	1.512LeuTrp: 1.512 ± 0.042	1.89LeuTyr: 1.89 ± 0.036	0.001LeuXaa: 0.001 ± 0.001
Met	3.841MetAla: 3.841 ± 0.066	0.148MetCys: 0.148 ± 0.011	1.455MetAsp: 1.455 ± 0.034	1.202MetGlu: 1.202 ± 0.037	0.735MetPhe: 0.735 ± 0.026	2.323MetGly: 2.323 ± 0.047	0.444MetHis: 0.444 ± 0.02	1.499MetIle: 1.499 ± 0.035	0.926MetLys: 0.926 ± 0.028	2.671MetLeu: 2.671 ± 0.051	0.743MetMet: 0.743 ± 0.032	0.733MetAsn: 0.733 ± 0.022	1.527MetPro: 1.527 ± 0.038	0.995MetGln: 0.995 ± 0.029	1.856MetArg: 1.856 ± 0.037	1.454MetSer: 1.454 ± 0.037	2.259MetThr: 2.259 ± 0.05	2.001MetVal: 2.001 ± 0.052	0.235MetTrp: 0.235 ± 0.014	0.32MetTyr: 0.32 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.027AsnAla: 3.027 ± 0.057	0.226AsnCys: 0.226 ± 0.015	1.585AsnAsp: 1.585 ± 0.086	0.916AsnGlu: 0.916 ± 0.029	0.89AsnPhe: 0.89 ± 0.025	2.282AsnGly: 2.282 ± 0.056	0.475AsnHis: 0.475 ± 0.019	1.214AsnIle: 1.214 ± 0.037	0.492AsnLys: 0.492 ± 0.02	2.438AsnLeu: 2.438 ± 0.043	0.594AsnMet: 0.594 ± 0.022	0.539AsnAsn: 0.539 ± 0.023	1.852AsnPro: 1.852 ± 0.039	0.594AsnGln: 0.594 ± 0.024	1.719AsnArg: 1.719 ± 0.036	1.009AsnSer: 1.009 ± 0.03	1.216AsnThr: 1.216 ± 0.034	1.77AsnVal: 1.77 ± 0.042	0.407AsnTrp: 0.407 ± 0.017	0.563AsnTyr: 0.563 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.039ProAla: 7.039 ± 0.101	0.395ProCys: 0.395 ± 0.017	4.159ProAsp: 4.159 ± 0.068	3.581ProGlu: 3.581 ± 0.061	1.955ProPhe: 1.955 ± 0.04	4.79ProGly: 4.79 ± 0.07	1.112ProHis: 1.112 ± 0.031	2.137ProIle: 2.137 ± 0.044	1.623ProLys: 1.623 ± 0.04	5.037ProLeu: 5.037 ± 0.07	1.457ProMet: 1.457 ± 0.038	1.223ProAsn: 1.223 ± 0.035	2.662ProPro: 2.662 ± 0.071	1.849ProGln: 1.849 ± 0.045	2.955ProArg: 2.955 ± 0.058	2.411ProSer: 2.411 ± 0.049	2.558ProThr: 2.558 ± 0.046	4.803ProVal: 4.803 ± 0.076	0.695ProTrp: 0.695 ± 0.027	1.047ProTyr: 1.047 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.534GlnAla: 4.534 ± 0.068	0.178GlnCys: 0.178 ± 0.012	1.755GlnAsp: 1.755 ± 0.038	1.28GlnGlu: 1.28 ± 0.035	1.0GlnPhe: 1.0 ± 0.029	3.12GlnGly: 3.12 ± 0.054	0.558GlnHis: 0.558 ± 0.025	1.807GlnIle: 1.807 ± 0.037	0.933GlnLys: 0.933 ± 0.029	2.464GlnLeu: 2.464 ± 0.045	1.072GlnMet: 1.072 ± 0.032	0.849GlnAsn: 0.849 ± 0.026	1.701GlnPro: 1.701 ± 0.042	0.967GlnGln: 0.967 ± 0.032	2.221GlnArg: 2.221 ± 0.039	1.817GlnSer: 1.817 ± 0.044	1.985GlnThr: 1.985 ± 0.043	2.638GlnVal: 2.638 ± 0.054	0.349GlnTrp: 0.349 ± 0.018	0.508GlnTyr: 0.508 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.064ArgAla: 9.064 ± 0.104	0.447ArgCys: 0.447 ± 0.022	4.323ArgAsp: 4.323 ± 0.061	3.133ArgGlu: 3.133 ± 0.059	2.763ArgPhe: 2.763 ± 0.049	4.801ArgGly: 4.801 ± 0.068	1.617ArgHis: 1.617 ± 0.032	3.846ArgIle: 3.846 ± 0.063	1.961ArgLys: 1.961 ± 0.043	8.258ArgLeu: 8.258 ± 0.098	2.078ArgMet: 2.078 ± 0.039	1.631ArgAsn: 1.631 ± 0.039	3.54ArgPro: 3.54 ± 0.064	2.376ArgGln: 2.376 ± 0.045	5.068ArgArg: 5.068 ± 0.069	3.057ArgSer: 3.057 ± 0.046	2.864ArgThr: 2.864 ± 0.046	5.112ArgVal: 5.112 ± 0.075	0.978ArgTrp: 0.978 ± 0.033	1.443ArgTyr: 1.443 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.002SerAla: 6.002 ± 0.076	0.367SerCys: 0.367 ± 0.018	3.039SerAsp: 3.039 ± 0.058	2.197SerGlu: 2.197 ± 0.04	2.057SerPhe: 2.057 ± 0.039	5.314SerGly: 5.314 ± 0.084	0.978SerHis: 0.978 ± 0.028	2.283SerIle: 2.283 ± 0.066	1.232SerLys: 1.232 ± 0.032	4.923SerLeu: 4.923 ± 0.07	1.154SerMet: 1.154 ± 0.033	1.19SerAsn: 1.19 ± 0.038	2.538SerPro: 2.538 ± 0.045	1.451SerGln: 1.451 ± 0.037	3.224SerArg: 3.224 ± 0.053	2.291SerSer: 2.291 ± 0.049	2.493SerThr: 2.493 ± 0.06	3.961SerVal: 3.961 ± 0.06	0.575SerTrp: 0.575 ± 0.026	1.158SerTyr: 1.158 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	7.388ThrAla: 7.388 ± 0.092	0.456ThrCys: 0.456 ± 0.022	3.426ThrAsp: 3.426 ± 0.063	2.911ThrGlu: 2.911 ± 0.047	2.025ThrPhe: 2.025 ± 0.043	5.779ThrGly: 5.779 ± 0.103	1.137ThrHis: 1.137 ± 0.033	2.679ThrIle: 2.679 ± 0.046	1.413ThrLys: 1.413 ± 0.043	6.461ThrLeu: 6.461 ± 0.092	1.274ThrMet: 1.274 ± 0.033	1.274ThrAsn: 1.274 ± 0.04	3.601ThrPro: 3.601 ± 0.057	1.586ThrGln: 1.586 ± 0.036	3.453ThrArg: 3.453 ± 0.057	2.466ThrSer: 2.466 ± 0.052	3.057ThrThr: 3.057 ± 0.067	4.895ThrVal: 4.895 ± 0.08	0.719ThrTrp: 0.719 ± 0.023	1.116ThrTyr: 1.116 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.171ValAla: 10.171 ± 0.109	0.628ValCys: 0.628 ± 0.02	4.167ValAsp: 4.167 ± 0.071	4.188ValGlu: 4.188 ± 0.068	2.833ValPhe: 2.833 ± 0.043	5.471ValGly: 5.471 ± 0.076	1.281ValHis: 1.281 ± 0.029	4.293ValIle: 4.293 ± 0.063	2.193ValLys: 2.193 ± 0.043	8.011ValLeu: 8.011 ± 0.086	2.332ValMet: 2.332 ± 0.046	1.932ValAsn: 1.932 ± 0.039	3.797ValPro: 3.797 ± 0.055	2.439ValGln: 2.439 ± 0.045	4.236ValArg: 4.236 ± 0.058	3.904ValSer: 3.904 ± 0.057	5.518ValThr: 5.518 ± 0.101	6.079ValVal: 6.079 ± 0.08	1.146ValTrp: 1.146 ± 0.035	1.44ValTyr: 1.44 ± 0.033	0.003ValXaa: 0.003 ± 0.001
Trp	1.558TrpAla: 1.558 ± 0.043	0.124TrpCys: 0.124 ± 0.01	0.76TrpAsp: 0.76 ± 0.028	0.609TrpGlu: 0.609 ± 0.024	0.583TrpPhe: 0.583 ± 0.023	1.092TrpGly: 1.092 ± 0.036	0.358TrpHis: 0.358 ± 0.014	0.644TrpIle: 0.644 ± 0.024	0.437TrpLys: 0.437 ± 0.021	1.751TrpLeu: 1.751 ± 0.045	0.424TrpMet: 0.424 ± 0.016	0.391TrpAsn: 0.391 ± 0.018	0.747TrpPro: 0.747 ± 0.024	0.693TrpGln: 0.693 ± 0.028	1.12TrpArg: 1.12 ± 0.034	0.75TrpSer: 0.75 ± 0.026	0.81TrpThr: 0.81 ± 0.025	0.943TrpVal: 0.943 ± 0.033	0.226TrpTrp: 0.226 ± 0.015	0.244TrpTyr: 0.244 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.489TyrAla: 2.489 ± 0.048	0.204TyrCys: 0.204 ± 0.014	1.416TyrAsp: 1.416 ± 0.034	1.011TyrGlu: 1.011 ± 0.028	0.755TyrPhe: 0.755 ± 0.023	1.935TyrGly: 1.935 ± 0.044	0.475TyrHis: 0.475 ± 0.021	0.885TyrIle: 0.885 ± 0.027	0.475TyrLys: 0.475 ± 0.019	2.062TyrLeu: 2.062 ± 0.041	0.407TyrMet: 0.407 ± 0.021	0.543TyrAsn: 0.543 ± 0.023	1.04TyrPro: 1.04 ± 0.031	0.599TyrGln: 0.599 ± 0.024	1.475TyrArg: 1.475 ± 0.034	1.035TyrSer: 1.035 ± 0.032	1.005TyrThr: 1.005 ± 0.025	1.438TyrVal: 1.438 ± 0.033	0.349TyrTrp: 0.349 ± 0.019	0.469TyrTyr: 0.469 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.015XaaXaa: 0.015 ± 0.005

Statistics based on 3887 proteins (1192774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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