Amino acid dipepetide frequency for Moranella endobia (strain PCIT)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.02AlaAla: 8.02 ± 0.286
1.096AlaCys: 1.096 ± 0.098
4.028AlaAsp: 4.028 ± 0.172
5.24AlaGlu: 5.24 ± 0.19
2.613AlaPhe: 2.613 ± 0.163
5.966AlaGly: 5.966 ± 0.248
1.56AlaHis: 1.56 ± 0.094
6.162AlaIle: 6.162 ± 0.216
4.572AlaLys: 4.572 ± 0.197
9.537AlaLeu: 9.537 ± 0.288
2.279AlaMet: 2.279 ± 0.129
3.672AlaAsn: 3.672 ± 0.17
2.584AlaPro: 2.584 ± 0.134
3.912AlaGln: 3.912 ± 0.154
5.081AlaArg: 5.081 ± 0.175
4.485AlaSer: 4.485 ± 0.18
4.478AlaThr: 4.478 ± 0.21
5.908AlaVal: 5.908 ± 0.208
0.806AlaTrp: 0.806 ± 0.08
2.279AlaTyr: 2.279 ± 0.12
0.0AlaXaa: 0.0 ± 0.0
Cys
0.944CysAla: 0.944 ± 0.087
0.218CysCys: 0.218 ± 0.04
0.791CysAsp: 0.791 ± 0.068
0.581CysGlu: 0.581 ± 0.069
0.428CysPhe: 0.428 ± 0.056
1.139CysGly: 1.139 ± 0.083
0.414CysHis: 0.414 ± 0.055
0.842CysIle: 0.842 ± 0.085
0.595CysLys: 0.595 ± 0.067
1.19CysLeu: 1.19 ± 0.092
0.298CysMet: 0.298 ± 0.05
0.508CysAsn: 0.508 ± 0.061
0.515CysPro: 0.515 ± 0.062
0.66CysGln: 0.66 ± 0.076
0.784CysArg: 0.784 ± 0.082
0.914CysSer: 0.914 ± 0.098
0.69CysThr: 0.69 ± 0.065
0.668CysVal: 0.668 ± 0.078
0.181CysTrp: 0.181 ± 0.039
0.508CysTyr: 0.508 ± 0.058
0.0CysXaa: 0.0 ± 0.0
Asp
3.781AspAla: 3.781 ± 0.184
0.581AspCys: 0.581 ± 0.063
2.352AspAsp: 2.352 ± 0.141
2.773AspGlu: 2.773 ± 0.148
1.938AspPhe: 1.938 ± 0.135
3.564AspGly: 3.564 ± 0.191
1.292AspHis: 1.292 ± 0.094
4.064AspIle: 4.064 ± 0.196
2.526AspLys: 2.526 ± 0.15
4.972AspLeu: 4.972 ± 0.184
1.51AspMet: 1.51 ± 0.127
2.453AspAsn: 2.453 ± 0.134
1.778AspPro: 1.778 ± 0.097
1.952AspGln: 1.952 ± 0.142
2.743AspArg: 2.743 ± 0.156
2.714AspSer: 2.714 ± 0.139
2.598AspThr: 2.598 ± 0.15
3.346AspVal: 3.346 ± 0.178
0.581AspTrp: 0.581 ± 0.071
1.952AspTyr: 1.952 ± 0.115
0.0AspXaa: 0.0 ± 0.0
Glu
5.131GluAla: 5.131 ± 0.233
0.501GluCys: 0.501 ± 0.056
2.33GluAsp: 2.33 ± 0.139
3.469GluGlu: 3.469 ± 0.206
1.902GluPhe: 1.902 ± 0.118
3.012GluGly: 3.012 ± 0.147
1.727GluHis: 1.727 ± 0.113
4.173GluIle: 4.173 ± 0.174
3.085GluLys: 3.085 ± 0.182
6.169GluLeu: 6.169 ± 0.238
1.408GluMet: 1.408 ± 0.096
2.388GluAsn: 2.388 ± 0.139
1.807GluPro: 1.807 ± 0.115
3.346GluGln: 3.346 ± 0.183
3.985GluArg: 3.985 ± 0.196
2.475GluSer: 2.475 ± 0.158
2.816GluThr: 2.816 ± 0.132
4.122GluVal: 4.122 ± 0.193
0.421GluTrp: 0.421 ± 0.053
1.531GluTyr: 1.531 ± 0.1
0.0GluXaa: 0.0 ± 0.0
Phe
2.773PheAla: 2.773 ± 0.167
0.762PheCys: 0.762 ± 0.073
2.359PheAsp: 2.359 ± 0.145
1.633PheGlu: 1.633 ± 0.113
1.423PhePhe: 1.423 ± 0.119
2.816PheGly: 2.816 ± 0.139
0.748PheHis: 0.748 ± 0.072
2.707PheIle: 2.707 ± 0.147
1.335PheLys: 1.335 ± 0.091
2.896PheLeu: 2.896 ± 0.167
0.922PheMet: 0.922 ± 0.087
1.88PheAsn: 1.88 ± 0.128
1.19PhePro: 1.19 ± 0.102
1.132PheGln: 1.132 ± 0.087
1.887PheArg: 1.887 ± 0.111
2.489PheSer: 2.489 ± 0.151
2.257PheThr: 2.257 ± 0.114
2.025PheVal: 2.025 ± 0.122
0.385PheTrp: 0.385 ± 0.053
1.372PheTyr: 1.372 ± 0.114
0.0PheXaa: 0.0 ± 0.0
Gly
4.834GlyAla: 4.834 ± 0.225
1.023GlyCys: 1.023 ± 0.097
3.353GlyAsp: 3.353 ± 0.172
4.181GlyGlu: 4.181 ± 0.16
2.504GlyPhe: 2.504 ± 0.126
4.768GlyGly: 4.768 ± 0.265
1.807GlyHis: 1.807 ± 0.124
5.806GlyIle: 5.806 ± 0.209
4.856GlyLys: 4.856 ± 0.187
6.648GlyLeu: 6.648 ± 0.217
2.083GlyMet: 2.083 ± 0.126
2.881GlyAsn: 2.881 ± 0.148
1.807GlyPro: 1.807 ± 0.109
2.903GlyGln: 2.903 ± 0.136
4.072GlyArg: 4.072 ± 0.192
3.745GlySer: 3.745 ± 0.179
3.723GlyThr: 3.723 ± 0.16
5.313GlyVal: 5.313 ± 0.225
0.849GlyTrp: 0.849 ± 0.088
2.214GlyTyr: 2.214 ± 0.137
0.0GlyXaa: 0.0 ± 0.0
His
1.873HisAla: 1.873 ± 0.105
0.363HisCys: 0.363 ± 0.054
1.06HisAsp: 1.06 ± 0.092
1.089HisGlu: 1.089 ± 0.08
0.965HisPhe: 0.965 ± 0.08
2.083HisGly: 2.083 ± 0.146
0.9HisHis: 0.9 ± 0.091
1.829HisIle: 1.829 ± 0.107
1.089HisLys: 1.089 ± 0.084
2.46HisLeu: 2.46 ± 0.141
0.719HisMet: 0.719 ± 0.071
1.096HisAsn: 1.096 ± 0.094
1.248HisPro: 1.248 ± 0.101
1.314HisGln: 1.314 ± 0.098
1.285HisArg: 1.285 ± 0.095
1.321HisSer: 1.321 ± 0.102
1.357HisThr: 1.357 ± 0.095
1.408HisVal: 1.408 ± 0.11
0.377HisTrp: 0.377 ± 0.057
0.994HisTyr: 0.994 ± 0.081
0.0HisXaa: 0.0 ± 0.0
Ile
6.888IleAla: 6.888 ± 0.247
0.893IleCys: 0.893 ± 0.08
4.609IleAsp: 4.609 ± 0.173
4.362IleGlu: 4.362 ± 0.203
2.156IlePhe: 2.156 ± 0.128
5.705IleGly: 5.705 ± 0.241
1.408IleHis: 1.408 ± 0.1
5.545IleIle: 5.545 ± 0.222
3.491IleLys: 3.491 ± 0.186
5.886IleLeu: 5.886 ± 0.224
1.902IleMet: 1.902 ± 0.146
3.948IleAsn: 3.948 ± 0.177
2.867IlePro: 2.867 ± 0.137
2.214IleGln: 2.214 ± 0.118
3.97IleArg: 3.97 ± 0.174
4.609IleSer: 4.609 ± 0.18
4.725IleThr: 4.725 ± 0.196
4.827IleVal: 4.827 ± 0.203
0.624IleTrp: 0.624 ± 0.077
2.032IleTyr: 2.032 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
3.934LysAla: 3.934 ± 0.19
0.581LysCys: 0.581 ± 0.063
2.388LysAsp: 2.388 ± 0.161
2.518LysGlu: 2.518 ± 0.127
1.648LysPhe: 1.648 ± 0.117
2.86LysGly: 2.86 ± 0.145
1.292LysHis: 1.292 ± 0.089
3.97LysIle: 3.97 ± 0.176
3.223LysLys: 3.223 ± 0.16
5.777LysLeu: 5.777 ± 0.219
1.531LysMet: 1.531 ± 0.121
2.235LysAsn: 2.235 ± 0.123
1.916LysPro: 1.916 ± 0.117
2.584LysGln: 2.584 ± 0.144
3.15LysArg: 3.15 ± 0.154
2.816LysSer: 2.816 ± 0.126
2.664LysThr: 2.664 ± 0.144
3.52LysVal: 3.52 ± 0.177
0.515LysTrp: 0.515 ± 0.063
1.539LysTyr: 1.539 ± 0.103
0.0LysXaa: 0.0 ± 0.0
Leu
10.11LeuAla: 10.11 ± 0.356
1.372LeuCys: 1.372 ± 0.101
5.538LeuAsp: 5.538 ± 0.211
6.22LeuGlu: 6.22 ± 0.253
3.44LeuPhe: 3.44 ± 0.189
6.612LeuGly: 6.612 ± 0.283
2.518LeuHis: 2.518 ± 0.128
6.474LeuIle: 6.474 ± 0.23
4.529LeuLys: 4.529 ± 0.179
11.547LeuLeu: 11.547 ± 0.503
2.968LeuMet: 2.968 ± 0.168
4.529LeuAsn: 4.529 ± 0.193
5.291LeuPro: 5.291 ± 0.245
4.529LeuGln: 4.529 ± 0.192
6.612LeuArg: 6.612 ± 0.264
6.401LeuSer: 6.401 ± 0.26
6.307LeuThr: 6.307 ± 0.22
7.693LeuVal: 7.693 ± 0.25
1.052LeuTrp: 1.052 ± 0.092
2.722LeuTyr: 2.722 ± 0.144
0.0LeuXaa: 0.0 ± 0.0
Met
2.46MetAla: 2.46 ± 0.137
0.218MetCys: 0.218 ± 0.041
1.118MetAsp: 1.118 ± 0.094
1.437MetGlu: 1.437 ± 0.107
0.958MetPhe: 0.958 ± 0.08
1.713MetGly: 1.713 ± 0.106
0.602MetHis: 0.602 ± 0.06
1.807MetIle: 1.807 ± 0.115
1.386MetLys: 1.386 ± 0.087
3.68MetLeu: 3.68 ± 0.197
0.82MetMet: 0.82 ± 0.087
1.103MetAsn: 1.103 ± 0.094
1.27MetPro: 1.27 ± 0.087
1.248MetGln: 1.248 ± 0.101
1.619MetArg: 1.619 ± 0.119
1.72MetSer: 1.72 ± 0.12
1.575MetThr: 1.575 ± 0.098
2.286MetVal: 2.286 ± 0.139
0.189MetTrp: 0.189 ± 0.041
0.595MetTyr: 0.595 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
3.252AsnAla: 3.252 ± 0.155
0.617AsnCys: 0.617 ± 0.067
2.214AsnAsp: 2.214 ± 0.132
2.083AsnGlu: 2.083 ± 0.137
1.814AsnPhe: 1.814 ± 0.113
3.23AsnGly: 3.23 ± 0.173
1.154AsnHis: 1.154 ± 0.102
3.818AsnIle: 3.818 ± 0.167
2.729AsnLys: 2.729 ± 0.152
4.355AsnLeu: 4.355 ± 0.182
1.299AsnMet: 1.299 ± 0.096
2.656AsnAsn: 2.656 ± 0.145
1.851AsnPro: 1.851 ± 0.131
1.858AsnGln: 1.858 ± 0.126
2.518AsnArg: 2.518 ± 0.125
2.439AsnSer: 2.439 ± 0.156
2.424AsnThr: 2.424 ± 0.135
2.707AsnVal: 2.707 ± 0.128
0.573AsnTrp: 0.573 ± 0.067
1.568AsnTyr: 1.568 ± 0.111
0.0AsnXaa: 0.0 ± 0.0
Pro
3.208ProAla: 3.208 ± 0.186
0.385ProCys: 0.385 ± 0.054
1.785ProAsp: 1.785 ± 0.124
2.533ProGlu: 2.533 ± 0.138
1.51ProPhe: 1.51 ± 0.105
2.743ProGly: 2.743 ± 0.161
0.806ProHis: 0.806 ± 0.092
2.511ProIle: 2.511 ± 0.123
1.669ProLys: 1.669 ± 0.103
4.064ProLeu: 4.064 ± 0.156
1.183ProMet: 1.183 ± 0.1
1.604ProAsn: 1.604 ± 0.104
1.379ProPro: 1.379 ± 0.111
1.698ProGln: 1.698 ± 0.103
1.669ProArg: 1.669 ± 0.13
2.112ProSer: 2.112 ± 0.125
2.069ProThr: 2.069 ± 0.113
3.382ProVal: 3.382 ± 0.136
0.457ProTrp: 0.457 ± 0.058
1.285ProTyr: 1.285 ± 0.103
0.0ProXaa: 0.0 ± 0.0
Gln
4.231GlnAla: 4.231 ± 0.194
0.515GlnCys: 0.515 ± 0.063
1.677GlnAsp: 1.677 ± 0.094
2.46GlnGlu: 2.46 ± 0.138
1.357GlnPhe: 1.357 ± 0.088
2.569GlnGly: 2.569 ± 0.144
1.343GlnHis: 1.343 ± 0.1
2.881GlnIle: 2.881 ± 0.154
2.112GlnLys: 2.112 ± 0.121
5.632GlnLeu: 5.632 ± 0.25
0.98GlnMet: 0.98 ± 0.077
1.35GlnAsn: 1.35 ± 0.097
1.88GlnPro: 1.88 ± 0.144
3.048GlnGln: 3.048 ± 0.171
2.7GlnArg: 2.7 ± 0.171
2.069GlnSer: 2.069 ± 0.125
2.069GlnThr: 2.069 ± 0.125
3.469GlnVal: 3.469 ± 0.16
0.45GlnTrp: 0.45 ± 0.061
1.604GlnTyr: 1.604 ± 0.12
0.0GlnXaa: 0.0 ± 0.0
Arg
4.863ArgAla: 4.863 ± 0.197
0.74ArgCys: 0.74 ± 0.077
2.881ArgAsp: 2.881 ± 0.153
3.281ArgGlu: 3.281 ± 0.181
2.54ArgPhe: 2.54 ± 0.127
3.738ArgGly: 3.738 ± 0.163
1.597ArgHis: 1.597 ± 0.106
4.318ArgIle: 4.318 ± 0.191
2.743ArgLys: 2.743 ± 0.144
6.641ArgLeu: 6.641 ± 0.247
1.713ArgMet: 1.713 ± 0.109
2.468ArgAsn: 2.468 ± 0.136
2.156ArgPro: 2.156 ± 0.138
3.128ArgGln: 3.128 ± 0.157
3.854ArgArg: 3.854 ± 0.207
3.085ArgSer: 3.085 ± 0.163
2.939ArgThr: 2.939 ± 0.155
3.847ArgVal: 3.847 ± 0.178
0.726ArgTrp: 0.726 ± 0.081
1.989ArgTyr: 1.989 ± 0.135
0.0ArgXaa: 0.0 ± 0.0
Ser
4.703SerAla: 4.703 ± 0.209
0.748SerCys: 0.748 ± 0.075
2.562SerAsp: 2.562 ± 0.127
2.831SerGlu: 2.831 ± 0.149
2.235SerPhe: 2.235 ± 0.122
4.514SerGly: 4.514 ± 0.187
1.394SerHis: 1.394 ± 0.121
3.905SerIle: 3.905 ± 0.188
2.7SerLys: 2.7 ± 0.155
6.191SerLeu: 6.191 ± 0.256
1.633SerMet: 1.633 ± 0.117
2.736SerAsn: 2.736 ± 0.15
1.902SerPro: 1.902 ± 0.113
2.105SerGln: 2.105 ± 0.114
3.477SerArg: 3.477 ± 0.159
3.76SerSer: 3.76 ± 0.166
3.186SerThr: 3.186 ± 0.156
3.731SerVal: 3.731 ± 0.17
0.711SerTrp: 0.711 ± 0.07
1.923SerTyr: 1.923 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
4.398ThrAla: 4.398 ± 0.168
0.726ThrCys: 0.726 ± 0.084
2.765ThrAsp: 2.765 ± 0.161
2.852ThrGlu: 2.852 ± 0.147
1.865ThrPhe: 1.865 ± 0.104
4.507ThrGly: 4.507 ± 0.187
1.277ThrHis: 1.277 ± 0.084
3.919ThrIle: 3.919 ± 0.171
2.896ThrLys: 2.896 ± 0.162
6.191ThrLeu: 6.191 ± 0.193
1.51ThrMet: 1.51 ± 0.102
2.555ThrAsn: 2.555 ± 0.136
2.417ThrPro: 2.417 ± 0.135
1.771ThrGln: 1.771 ± 0.112
2.802ThrArg: 2.802 ± 0.137
3.418ThrSer: 3.418 ± 0.141
3.15ThrThr: 3.15 ± 0.172
3.999ThrVal: 3.999 ± 0.181
0.544ThrTrp: 0.544 ± 0.061
1.328ThrTyr: 1.328 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
5.944ValAla: 5.944 ± 0.234
0.813ValCys: 0.813 ± 0.065
3.614ValAsp: 3.614 ± 0.16
4.333ValGlu: 4.333 ± 0.182
2.083ValPhe: 2.083 ± 0.128
4.957ValGly: 4.957 ± 0.193
1.706ValHis: 1.706 ± 0.123
5.487ValIle: 5.487 ± 0.226
3.593ValLys: 3.593 ± 0.196
7.193ValLeu: 7.193 ± 0.235
2.098ValMet: 2.098 ± 0.135
3.404ValAsn: 3.404 ± 0.166
2.707ValPro: 2.707 ± 0.125
2.344ValGln: 2.344 ± 0.138
4.297ValArg: 4.297 ± 0.178
4.122ValSer: 4.122 ± 0.182
4.064ValThr: 4.064 ± 0.161
5.85ValVal: 5.85 ± 0.25
0.66ValTrp: 0.66 ± 0.067
1.546ValTyr: 1.546 ± 0.112
0.0ValXaa: 0.0 ± 0.0
Trp
0.559TrpAla: 0.559 ± 0.062
0.16TrpCys: 0.16 ± 0.035
0.443TrpAsp: 0.443 ± 0.061
0.428TrpGlu: 0.428 ± 0.065
0.472TrpPhe: 0.472 ± 0.051
0.537TrpGly: 0.537 ± 0.072
0.334TrpHis: 0.334 ± 0.05
0.682TrpIle: 0.682 ± 0.072
0.443TrpLys: 0.443 ± 0.065
1.655TrpLeu: 1.655 ± 0.134
0.232TrpMet: 0.232 ± 0.041
0.363TrpAsn: 0.363 ± 0.049
0.472TrpPro: 0.472 ± 0.058
0.835TrpGln: 0.835 ± 0.09
0.871TrpArg: 0.871 ± 0.089
0.494TrpSer: 0.494 ± 0.067
0.37TrpThr: 0.37 ± 0.052
0.69TrpVal: 0.69 ± 0.075
0.102TrpTrp: 0.102 ± 0.028
0.428TrpTyr: 0.428 ± 0.055
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.373TyrAla: 2.373 ± 0.122
0.559TyrCys: 0.559 ± 0.061
1.604TyrAsp: 1.604 ± 0.115
1.495TyrGlu: 1.495 ± 0.116
1.139TyrPhe: 1.139 ± 0.099
2.337TyrGly: 2.337 ± 0.133
0.951TyrHis: 0.951 ± 0.08
1.756TyrIle: 1.756 ± 0.1
1.096TyrLys: 1.096 ± 0.097
3.781TyrLeu: 3.781 ± 0.175
0.711TyrMet: 0.711 ± 0.079
1.328TyrAsn: 1.328 ± 0.107
1.016TyrPro: 1.016 ± 0.098
1.814TyrGln: 1.814 ± 0.117
1.873TyrArg: 1.873 ± 0.102
1.756TyrSer: 1.756 ± 0.114
1.43TyrThr: 1.43 ± 0.102
2.025TyrVal: 2.025 ± 0.134
0.363TyrTrp: 0.363 ± 0.054
1.321TyrTyr: 1.321 ± 0.105
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 405 proteins (137782 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski