Amino acid dipepetide frequency for European catfish virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.982AlaAla: 9.982 ± 0.795
1.741AlaCys: 1.741 ± 0.223
4.324AlaAsp: 4.324 ± 0.393
5.629AlaGlu: 5.629 ± 0.411
2.554AlaPhe: 2.554 ± 0.256
6.993AlaGly: 6.993 ± 0.682
1.654AlaHis: 1.654 ± 0.231
2.292AlaIle: 2.292 ± 0.26
4.498AlaLys: 4.498 ± 0.481
6.848AlaLeu: 6.848 ± 0.565
2.815AlaMet: 2.815 ± 0.352
1.799AlaAsn: 1.799 ± 0.246
4.701AlaPro: 4.701 ± 0.478
2.554AlaGln: 2.554 ± 0.427
5.658AlaArg: 5.658 ± 0.95
6.065AlaSer: 6.065 ± 0.592
4.004AlaThr: 4.004 ± 0.383
8.444AlaVal: 8.444 ± 0.571
1.19AlaTrp: 1.19 ± 0.199
2.466AlaTyr: 2.466 ± 0.302
0.0AlaXaa: 0.0 ± 0.0
Cys
1.654CysAla: 1.654 ± 0.2
0.667CysCys: 0.667 ± 0.144
1.335CysAsp: 1.335 ± 0.185
1.074CysGlu: 1.074 ± 0.192
0.493CysPhe: 0.493 ± 0.133
1.538CysGly: 1.538 ± 0.255
0.493CysHis: 0.493 ± 0.133
0.725CysIle: 0.725 ± 0.161
1.364CysLys: 1.364 ± 0.238
1.48CysLeu: 1.48 ± 0.289
0.638CysMet: 0.638 ± 0.162
0.464CysAsn: 0.464 ± 0.135
1.364CysPro: 1.364 ± 0.296
0.493CysGln: 0.493 ± 0.131
1.364CysArg: 1.364 ± 0.203
1.683CysSer: 1.683 ± 0.244
0.871CysThr: 0.871 ± 0.153
1.683CysVal: 1.683 ± 0.243
0.493CysTrp: 0.493 ± 0.143
0.522CysTyr: 0.522 ± 0.123
0.0CysXaa: 0.0 ± 0.0
Asp
5.02AspAla: 5.02 ± 0.443
1.248AspCys: 1.248 ± 0.196
3.279AspAsp: 3.279 ± 0.304
2.902AspGlu: 2.902 ± 0.328
2.263AspPhe: 2.263 ± 0.457
4.614AspGly: 4.614 ± 0.49
1.016AspHis: 1.016 ± 0.161
2.321AspIle: 2.321 ± 0.25
2.612AspLys: 2.612 ± 0.299
5.513AspLeu: 5.513 ± 0.674
1.857AspMet: 1.857 ± 0.239
1.654AspAsn: 1.654 ± 0.371
4.44AspPro: 4.44 ± 0.466
1.654AspGln: 1.654 ± 0.289
3.975AspArg: 3.975 ± 0.351
4.556AspSer: 4.556 ± 0.412
2.466AspThr: 2.466 ± 0.315
4.962AspVal: 4.962 ± 0.373
0.9AspTrp: 0.9 ± 0.197
2.292AspTyr: 2.292 ± 0.291
0.0AspXaa: 0.0 ± 0.0
Glu
5.658GluAla: 5.658 ± 0.418
1.393GluCys: 1.393 ± 0.258
3.743GluAsp: 3.743 ± 0.465
3.279GluGlu: 3.279 ± 0.482
1.799GluPhe: 1.799 ± 0.253
4.353GluGly: 4.353 ± 0.441
0.783GluHis: 0.783 ± 0.179
1.77GluIle: 1.77 ± 0.216
2.844GluLys: 2.844 ± 0.311
3.917GluLeu: 3.917 ± 0.362
2.147GluMet: 2.147 ± 0.3
1.248GluAsn: 1.248 ± 0.215
2.67GluPro: 2.67 ± 0.25
1.915GluGln: 1.915 ± 0.579
4.208GluArg: 4.208 ± 0.409
4.004GluSer: 4.004 ± 0.566
3.627GluThr: 3.627 ± 0.364
2.989GluVal: 2.989 ± 0.317
1.132GluTrp: 1.132 ± 0.186
2.205GluTyr: 2.205 ± 0.253
0.0GluXaa: 0.0 ± 0.0
Phe
2.815PheAla: 2.815 ± 0.314
0.696PheCys: 0.696 ± 0.143
1.306PheAsp: 1.306 ± 0.2
1.741PheGlu: 1.741 ± 0.203
1.538PhePhe: 1.538 ± 0.311
2.699PheGly: 2.699 ± 0.305
0.58PheHis: 0.58 ± 0.14
0.987PheIle: 0.987 ± 0.18
1.509PheLys: 1.509 ± 0.206
3.366PheLeu: 3.366 ± 0.456
0.987PheMet: 0.987 ± 0.173
1.045PheAsn: 1.045 ± 0.149
1.741PhePro: 1.741 ± 0.228
1.161PheGln: 1.161 ± 0.236
2.931PheArg: 2.931 ± 0.419
3.047PheSer: 3.047 ± 0.356
2.466PheThr: 2.466 ± 0.578
2.728PheVal: 2.728 ± 0.304
0.29PheTrp: 0.29 ± 0.109
1.074PheTyr: 1.074 ± 0.165
0.0PheXaa: 0.0 ± 0.0
Gly
5.833GlyAla: 5.833 ± 0.456
1.451GlyCys: 1.451 ± 0.235
5.716GlyAsp: 5.716 ± 0.92
3.424GlyGlu: 3.424 ± 0.29
2.641GlyPhe: 2.641 ± 0.316
5.803GlyGly: 5.803 ± 0.524
1.857GlyHis: 1.857 ± 0.227
2.089GlyIle: 2.089 ± 0.254
4.12GlyLys: 4.12 ± 0.365
5.281GlyLeu: 5.281 ± 0.475
1.828GlyMet: 1.828 ± 0.243
1.364GlyAsn: 1.364 ± 0.222
5.165GlyPro: 5.165 ± 0.812
1.886GlyGln: 1.886 ± 0.242
5.862GlyArg: 5.862 ± 0.574
5.745GlySer: 5.745 ± 0.431
4.527GlyThr: 4.527 ± 0.395
5.049GlyVal: 5.049 ± 0.472
1.364GlyTrp: 1.364 ± 0.21
2.466GlyTyr: 2.466 ± 0.214
0.0GlyXaa: 0.0 ± 0.0
His
1.596HisAla: 1.596 ± 0.193
0.232HisCys: 0.232 ± 0.076
1.161HisAsp: 1.161 ± 0.17
0.551HisGlu: 0.551 ± 0.143
0.493HisPhe: 0.493 ± 0.11
1.683HisGly: 1.683 ± 0.244
0.609HisHis: 0.609 ± 0.206
0.842HisIle: 0.842 ± 0.164
0.667HisLys: 0.667 ± 0.14
2.321HisLeu: 2.321 ± 0.286
0.551HisMet: 0.551 ± 0.128
0.522HisAsn: 0.522 ± 0.149
1.364HisPro: 1.364 ± 0.207
0.58HisGln: 0.58 ± 0.144
1.306HisArg: 1.306 ± 0.192
1.393HisSer: 1.393 ± 0.244
1.161HisThr: 1.161 ± 0.203
2.176HisVal: 2.176 ± 0.275
0.174HisTrp: 0.174 ± 0.074
0.725HisTyr: 0.725 ± 0.138
0.0HisXaa: 0.0 ± 0.0
Ile
2.263IleAla: 2.263 ± 0.265
0.609IleCys: 0.609 ± 0.153
1.799IleAsp: 1.799 ± 0.248
1.944IleGlu: 1.944 ± 0.28
1.48IlePhe: 1.48 ± 0.218
1.567IleGly: 1.567 ± 0.254
0.783IleHis: 0.783 ± 0.167
0.958IleIle: 0.958 ± 0.163
2.089IleLys: 2.089 ± 0.212
3.888IleLeu: 3.888 ± 0.426
1.045IleMet: 1.045 ± 0.18
0.958IleAsn: 0.958 ± 0.191
2.031IlePro: 2.031 ± 0.255
0.725IleGln: 0.725 ± 0.141
2.525IleArg: 2.525 ± 0.27
2.699IleSer: 2.699 ± 0.272
1.915IleThr: 1.915 ± 0.311
2.641IleVal: 2.641 ± 0.334
0.174IleTrp: 0.174 ± 0.075
1.074IleTyr: 1.074 ± 0.261
0.0IleXaa: 0.0 ± 0.0
Lys
4.44LysAla: 4.44 ± 0.53
0.987LysCys: 0.987 ± 0.194
2.728LysAsp: 2.728 ± 0.315
2.902LysGlu: 2.902 ± 0.358
1.306LysPhe: 1.306 ± 0.173
4.091LysGly: 4.091 ± 0.433
0.783LysHis: 0.783 ± 0.122
2.699LysIle: 2.699 ± 0.336
3.801LysLys: 3.801 ± 0.472
3.743LysLeu: 3.743 ± 0.341
2.205LysMet: 2.205 ± 0.26
1.654LysAsn: 1.654 ± 0.2
3.279LysPro: 3.279 ± 0.512
1.19LysGln: 1.19 ± 0.204
5.368LysArg: 5.368 ± 1.014
4.701LysSer: 4.701 ± 1.005
4.033LysThr: 4.033 ± 0.312
3.511LysVal: 3.511 ± 0.285
0.522LysTrp: 0.522 ± 0.124
1.828LysTyr: 1.828 ± 0.221
0.0LysXaa: 0.0 ± 0.0
Leu
6.268LeuAla: 6.268 ± 0.436
1.799LeuCys: 1.799 ± 0.314
5.02LeuAsp: 5.02 ± 0.427
5.281LeuGlu: 5.281 ± 0.46
3.366LeuPhe: 3.366 ± 0.683
5.194LeuGly: 5.194 ± 0.423
1.828LeuHis: 1.828 ± 0.327
2.699LeuIle: 2.699 ± 0.341
5.716LeuLys: 5.716 ± 0.485
6.616LeuLeu: 6.616 ± 0.661
2.612LeuMet: 2.612 ± 0.273
2.205LeuAsn: 2.205 ± 0.255
3.627LeuPro: 3.627 ± 0.384
1.48LeuGln: 1.48 ± 0.176
7.022LeuArg: 7.022 ± 0.599
6.848LeuSer: 6.848 ± 0.55
5.136LeuThr: 5.136 ± 0.459
5.833LeuVal: 5.833 ± 0.473
1.045LeuTrp: 1.045 ± 0.184
2.554LeuTyr: 2.554 ± 0.255
0.0LeuXaa: 0.0 ± 0.0
Met
3.221MetAla: 3.221 ± 0.353
0.812MetCys: 0.812 ± 0.174
1.915MetAsp: 1.915 ± 0.242
1.625MetGlu: 1.625 ± 0.247
1.103MetPhe: 1.103 ± 0.215
2.583MetGly: 2.583 ± 0.267
0.638MetHis: 0.638 ± 0.137
0.696MetIle: 0.696 ± 0.148
0.812MetLys: 0.812 ± 0.152
2.176MetLeu: 2.176 ± 0.3
0.812MetMet: 0.812 ± 0.168
0.377MetAsn: 0.377 ± 0.11
1.48MetPro: 1.48 ± 0.227
0.638MetGln: 0.638 ± 0.13
2.408MetArg: 2.408 ± 0.273
2.641MetSer: 2.641 ± 0.277
2.031MetThr: 2.031 ± 0.204
2.234MetVal: 2.234 ± 0.257
0.638MetTrp: 0.638 ± 0.155
0.958MetTyr: 0.958 ± 0.216
0.0MetXaa: 0.0 ± 0.0
Asn
2.002AsnAla: 2.002 ± 0.233
0.493AsnCys: 0.493 ± 0.125
0.9AsnAsp: 0.9 ± 0.167
0.842AsnGlu: 0.842 ± 0.138
0.638AsnPhe: 0.638 ± 0.136
1.654AsnGly: 1.654 ± 0.235
0.348AsnHis: 0.348 ± 0.098
1.48AsnIle: 1.48 ± 0.257
0.9AsnLys: 0.9 ± 0.16
2.583AsnLeu: 2.583 ± 0.333
0.9AsnMet: 0.9 ± 0.192
0.754AsnAsn: 0.754 ± 0.212
2.321AsnPro: 2.321 ± 0.385
0.58AsnGln: 0.58 ± 0.106
1.596AsnArg: 1.596 ± 0.217
1.654AsnSer: 1.654 ± 0.227
1.364AsnThr: 1.364 ± 0.254
2.408AsnVal: 2.408 ± 0.312
0.464AsnTrp: 0.464 ± 0.102
0.783AsnTyr: 0.783 ± 0.158
0.0AsnXaa: 0.0 ± 0.0
Pro
6.558ProAla: 6.558 ± 0.987
1.074ProCys: 1.074 ± 0.193
3.685ProAsp: 3.685 ± 0.372
4.643ProGlu: 4.643 ± 0.398
1.973ProPhe: 1.973 ± 0.237
4.062ProGly: 4.062 ± 0.461
1.683ProHis: 1.683 ± 0.241
1.451ProIle: 1.451 ± 0.193
3.772ProLys: 3.772 ± 0.618
3.656ProLeu: 3.656 ± 0.39
1.19ProMet: 1.19 ± 0.182
1.132ProAsn: 1.132 ± 0.195
4.033ProPro: 4.033 ± 0.703
1.625ProGln: 1.625 ± 0.211
4.266ProArg: 4.266 ± 0.544
4.962ProSer: 4.962 ± 0.519
2.873ProThr: 2.873 ± 0.474
6.703ProVal: 6.703 ± 0.827
0.9ProTrp: 0.9 ± 0.195
1.393ProTyr: 1.393 ± 0.209
0.0ProXaa: 0.0 ± 0.0
Gln
2.321GlnAla: 2.321 ± 0.232
0.522GlnCys: 0.522 ± 0.124
1.654GlnAsp: 1.654 ± 0.276
1.973GlnGlu: 1.973 ± 0.578
0.696GlnPhe: 0.696 ± 0.133
1.886GlnGly: 1.886 ± 0.242
0.551GlnHis: 0.551 ± 0.148
0.987GlnIle: 0.987 ± 0.16
1.364GlnLys: 1.364 ± 0.202
1.944GlnLeu: 1.944 ± 0.299
0.551GlnMet: 0.551 ± 0.134
0.667GlnAsn: 0.667 ± 0.113
1.219GlnPro: 1.219 ± 0.188
2.234GlnGln: 2.234 ± 1.279
2.292GlnArg: 2.292 ± 0.531
1.915GlnSer: 1.915 ± 0.284
2.06GlnThr: 2.06 ± 0.309
1.857GlnVal: 1.857 ± 0.312
0.406GlnTrp: 0.406 ± 0.103
0.667GlnTyr: 0.667 ± 0.132
0.0GlnXaa: 0.0 ± 0.0
Arg
5.658ArgAla: 5.658 ± 0.451
1.277ArgCys: 1.277 ± 0.229
4.585ArgAsp: 4.585 ± 0.51
4.701ArgGlu: 4.701 ± 0.41
2.263ArgPhe: 2.263 ± 0.37
6.181ArgGly: 6.181 ± 0.611
1.567ArgHis: 1.567 ± 0.26
2.408ArgIle: 2.408 ± 0.295
5.542ArgLys: 5.542 ± 1.077
6.094ArgLeu: 6.094 ± 0.427
2.06ArgMet: 2.06 ± 0.276
2.147ArgAsn: 2.147 ± 0.327
4.701ArgPro: 4.701 ± 0.601
1.944ArgGln: 1.944 ± 0.282
7.341ArgArg: 7.341 ± 0.708
4.527ArgSer: 4.527 ± 0.778
4.266ArgThr: 4.266 ± 0.408
5.281ArgVal: 5.281 ± 0.478
1.161ArgTrp: 1.161 ± 0.226
2.728ArgTyr: 2.728 ± 0.453
0.0ArgXaa: 0.0 ± 0.0
Ser
6.21SerAla: 6.21 ± 0.649
1.364SerCys: 1.364 ± 0.199
4.991SerAsp: 4.991 ± 0.343
4.179SerGlu: 4.179 ± 0.368
3.192SerPhe: 3.192 ± 0.367
5.136SerGly: 5.136 ± 0.428
1.567SerHis: 1.567 ± 0.26
2.321SerIle: 2.321 ± 0.246
3.221SerLys: 3.221 ± 0.365
7.225SerLeu: 7.225 ± 0.666
2.176SerMet: 2.176 ± 0.319
1.712SerAsn: 1.712 ± 0.257
6.674SerPro: 6.674 ± 1.791
2.205SerGln: 2.205 ± 0.328
4.991SerArg: 4.991 ± 0.501
5.513SerSer: 5.513 ± 0.505
3.308SerThr: 3.308 ± 0.356
6.529SerVal: 6.529 ± 0.529
1.132SerTrp: 1.132 ± 0.186
1.828SerTyr: 1.828 ± 0.223
0.0SerXaa: 0.0 ± 0.0
Thr
5.6ThrAla: 5.6 ± 0.671
1.103ThrCys: 1.103 ± 0.16
3.772ThrAsp: 3.772 ± 0.334
2.728ThrGlu: 2.728 ± 0.272
2.466ThrPhe: 2.466 ± 0.262
5.513ThrGly: 5.513 ± 0.744
0.609ThrHis: 0.609 ± 0.117
2.147ThrIle: 2.147 ± 0.257
2.205ThrLys: 2.205 ± 0.322
4.614ThrLeu: 4.614 ± 0.451
1.857ThrMet: 1.857 ± 0.221
1.335ThrAsn: 1.335 ± 0.175
3.714ThrPro: 3.714 ± 0.481
1.683ThrGln: 1.683 ± 0.243
3.308ThrArg: 3.308 ± 0.317
2.931ThrSer: 2.931 ± 0.319
2.118ThrThr: 2.118 ± 0.522
6.123ThrVal: 6.123 ± 0.449
0.58ThrTrp: 0.58 ± 0.187
1.248ThrTyr: 1.248 ± 0.242
0.0ThrXaa: 0.0 ± 0.0
Val
5.716ValAla: 5.716 ± 0.473
2.031ValCys: 2.031 ± 0.242
4.295ValAsp: 4.295 ± 0.403
4.062ValGlu: 4.062 ± 0.409
2.902ValPhe: 2.902 ± 0.285
4.585ValGly: 4.585 ± 0.512
1.915ValHis: 1.915 ± 0.239
2.437ValIle: 2.437 ± 0.253
6.036ValLys: 6.036 ± 0.692
7.08ValLeu: 7.08 ± 0.509
2.466ValMet: 2.466 ± 0.31
2.35ValAsn: 2.35 ± 0.261
4.585ValPro: 4.585 ± 0.496
2.118ValGln: 2.118 ± 0.245
7.08ValArg: 7.08 ± 0.669
6.645ValSer: 6.645 ± 0.515
4.73ValThr: 4.73 ± 0.406
6.848ValVal: 6.848 ± 0.575
1.248ValTrp: 1.248 ± 0.212
2.525ValTyr: 2.525 ± 0.295
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.213
0.261TrpCys: 0.261 ± 0.085
0.987TrpAsp: 0.987 ± 0.163
0.754TrpGlu: 0.754 ± 0.193
0.638TrpPhe: 0.638 ± 0.139
1.045TrpGly: 1.045 ± 0.196
0.319TrpHis: 0.319 ± 0.135
0.551TrpIle: 0.551 ± 0.175
0.871TrpLys: 0.871 ± 0.159
1.335TrpLeu: 1.335 ± 0.185
0.377TrpMet: 0.377 ± 0.1
0.667TrpAsn: 0.667 ± 0.154
0.58TrpPro: 0.58 ± 0.134
0.232TrpGln: 0.232 ± 0.08
0.929TrpArg: 0.929 ± 0.159
0.987TrpSer: 0.987 ± 0.231
1.248TrpThr: 1.248 ± 0.213
0.871TrpVal: 0.871 ± 0.205
0.174TrpTrp: 0.174 ± 0.067
0.435TrpTyr: 0.435 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.466TyrAla: 2.466 ± 0.335
0.638TyrCys: 0.638 ± 0.149
2.35TyrAsp: 2.35 ± 0.248
1.48TyrGlu: 1.48 ± 0.211
0.9TyrPhe: 0.9 ± 0.178
2.292TyrGly: 2.292 ± 0.226
0.522TyrHis: 0.522 ± 0.11
1.306TyrIle: 1.306 ± 0.196
1.828TyrLys: 1.828 ± 0.208
2.466TyrLeu: 2.466 ± 0.28
0.696TyrMet: 0.696 ± 0.143
0.609TyrAsn: 0.609 ± 0.149
1.944TyrPro: 1.944 ± 0.242
0.871TyrGln: 0.871 ± 0.135
2.002TyrArg: 2.002 ± 0.403
2.96TyrSer: 2.96 ± 0.318
1.451TyrThr: 1.451 ± 0.182
2.786TyrVal: 2.786 ± 0.343
0.203TyrTrp: 0.203 ± 0.087
1.741TyrTyr: 1.741 ± 0.749
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 135 proteins (34463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski