Amino acid dipepetide frequency for Wheat dwarf virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.208AlaAla: 5.208 ± 0.918
1.042AlaCys: 1.042 ± 0.906
8.333AlaAsp: 8.333 ± 2.539
3.125AlaGlu: 3.125 ± 0.464
1.042AlaPhe: 1.042 ± 0.854
2.083AlaGly: 2.083 ± 1.812
0.0AlaHis: 0.0 ± 0.0
1.042AlaIle: 1.042 ± 0.854
6.25AlaLys: 6.25 ± 2.068
6.25AlaLeu: 6.25 ± 0.928
0.0AlaMet: 0.0 ± 0.0
0.0AlaAsn: 0.0 ± 0.0
3.125AlaPro: 3.125 ± 1.163
1.042AlaGln: 1.042 ± 0.854
4.167AlaArg: 4.167 ± 1.572
7.292AlaSer: 7.292 ± 0.881
3.125AlaThr: 3.125 ± 0.464
7.292AlaVal: 7.292 ± 1.451
2.083AlaTrp: 2.083 ± 1.393
3.125AlaTyr: 3.125 ± 2.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.042CysAla: 1.042 ± 0.906
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
2.083CysPhe: 2.083 ± 0.747
1.042CysGly: 1.042 ± 0.854
4.167CysHis: 4.167 ± 1.57
4.167CysIle: 4.167 ± 1.572
1.042CysLys: 1.042 ± 0.906
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
2.083CysAsn: 2.083 ± 0.785
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
2.083CysThr: 2.083 ± 1.163
2.083CysVal: 2.083 ± 1.812
0.0CysTrp: 0.0 ± 0.0
2.083CysTyr: 2.083 ± 1.812
0.0CysXaa: 0.0 ± 0.0
Asp
4.167AspAla: 4.167 ± 1.206
3.125AspCys: 3.125 ± 1.163
2.083AspAsp: 2.083 ± 0.785
2.083AspGlu: 2.083 ± 0.747
4.167AspPhe: 4.167 ± 2.168
5.208AspGly: 5.208 ± 1.551
0.0AspHis: 0.0 ± 0.0
3.125AspIle: 3.125 ± 1.424
2.083AspLys: 2.083 ± 1.163
2.083AspLeu: 2.083 ± 1.163
3.125AspMet: 3.125 ± 1.389
1.042AspAsn: 1.042 ± 0.906
5.208AspPro: 5.208 ± 1.982
4.167AspGln: 4.167 ± 2.194
2.083AspArg: 2.083 ± 0.785
6.25AspSer: 6.25 ± 2.976
2.083AspThr: 2.083 ± 0.785
4.167AspVal: 4.167 ± 0.733
1.042AspTrp: 1.042 ± 0.854
5.208AspTyr: 5.208 ± 1.604
0.0AspXaa: 0.0 ± 0.0
Glu
1.042GluAla: 1.042 ± 0.906
0.0GluCys: 0.0 ± 0.0
3.125GluAsp: 3.125 ± 1.389
3.125GluGlu: 3.125 ± 1.163
4.167GluPhe: 4.167 ± 1.57
1.042GluGly: 1.042 ± 0.854
2.083GluHis: 2.083 ± 0.785
1.042GluIle: 1.042 ± 1.168
0.0GluLys: 0.0 ± 0.0
2.083GluLeu: 2.083 ± 0.785
0.0GluMet: 0.0 ± 0.0
1.042GluAsn: 1.042 ± 0.854
5.208GluPro: 5.208 ± 0.918
1.042GluGln: 1.042 ± 0.872
1.042GluArg: 1.042 ± 0.872
11.458GluSer: 11.458 ± 4.365
2.083GluThr: 2.083 ± 0.785
3.125GluVal: 3.125 ± 0.464
6.25GluTrp: 6.25 ± 1.634
2.083GluTyr: 2.083 ± 0.785
0.0GluXaa: 0.0 ± 0.0
Phe
4.167PheAla: 4.167 ± 0.733
1.042PheCys: 1.042 ± 0.906
0.0PheAsp: 0.0 ± 0.0
5.208PheGlu: 5.208 ± 0.918
1.042PhePhe: 1.042 ± 0.854
2.083PheGly: 2.083 ± 1.377
2.083PheHis: 2.083 ± 0.785
2.083PheIle: 2.083 ± 0.785
2.083PheLys: 2.083 ± 0.747
5.208PheLeu: 5.208 ± 1.604
0.0PheMet: 0.0 ± 0.0
3.125PheAsn: 3.125 ± 0.464
6.25PhePro: 6.25 ± 2.355
0.0PheGln: 0.0 ± 0.0
2.083PheArg: 2.083 ± 0.785
0.0PheSer: 0.0 ± 0.0
5.208PheThr: 5.208 ± 2.223
4.167PheVal: 4.167 ± 2.266
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
3.125GlyAla: 3.125 ± 1.424
0.0GlyCys: 0.0 ± 0.0
4.167GlyAsp: 4.167 ± 2.832
2.083GlyGlu: 2.083 ± 1.708
0.0GlyPhe: 0.0 ± 0.0
2.083GlyGly: 2.083 ± 0.747
0.0GlyHis: 0.0 ± 0.0
3.125GlyIle: 3.125 ± 0.464
8.333GlyLys: 8.333 ± 4.534
4.167GlyLeu: 4.167 ± 2.336
0.0GlyMet: 0.0 ± 0.0
2.083GlyAsn: 2.083 ± 1.393
2.083GlyPro: 2.083 ± 0.747
1.042GlyGln: 1.042 ± 0.872
4.167GlyArg: 4.167 ± 0.733
4.167GlySer: 4.167 ± 0.842
4.167GlyThr: 4.167 ± 0.733
2.083GlyVal: 2.083 ± 1.393
0.0GlyTrp: 0.0 ± 0.0
1.042GlyTyr: 1.042 ± 1.168
0.0GlyXaa: 0.0 ± 0.0
His
3.125HisAla: 3.125 ± 0.464
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
4.167HisGlu: 4.167 ± 1.57
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.042HisLys: 1.042 ± 0.854
6.25HisLeu: 6.25 ± 2.355
0.0HisMet: 0.0 ± 0.0
1.042HisAsn: 1.042 ± 0.854
2.083HisPro: 2.083 ± 0.785
0.0HisGln: 0.0 ± 0.0
4.167HisArg: 4.167 ± 1.181
0.0HisSer: 0.0 ± 0.0
1.042HisThr: 1.042 ± 0.906
2.083HisVal: 2.083 ± 0.785
1.042HisTrp: 1.042 ± 0.906
1.042HisTyr: 1.042 ± 0.854
0.0HisXaa: 0.0 ± 0.0
Ile
5.208IleAla: 5.208 ± 1.604
1.042IleCys: 1.042 ± 0.854
1.042IleAsp: 1.042 ± 0.854
6.25IleGlu: 6.25 ± 2.355
3.125IlePhe: 3.125 ± 0.464
3.125IleGly: 3.125 ± 2.039
0.0IleHis: 0.0 ± 0.0
3.125IleIle: 3.125 ± 1.389
1.042IleLys: 1.042 ± 0.906
5.208IleLeu: 5.208 ± 1.604
0.0IleMet: 0.0 ± 0.0
0.0IleAsn: 0.0 ± 0.0
2.083IlePro: 2.083 ± 1.708
4.167IleGln: 4.167 ± 1.206
5.208IleArg: 5.208 ± 0.914
1.042IleSer: 1.042 ± 0.872
6.25IleThr: 6.25 ± 0.928
3.125IleVal: 3.125 ± 1.424
0.0IleTrp: 0.0 ± 0.0
1.042IleTyr: 1.042 ± 0.906
0.0IleXaa: 0.0 ± 0.0
Lys
3.125LysAla: 3.125 ± 1.429
1.042LysCys: 1.042 ± 0.854
9.375LysAsp: 9.375 ± 1.799
2.083LysGlu: 2.083 ± 0.785
3.125LysPhe: 3.125 ± 1.424
4.167LysGly: 4.167 ± 3.623
0.0LysHis: 0.0 ± 0.0
1.042LysIle: 1.042 ± 0.906
3.125LysLys: 3.125 ± 2.039
3.125LysLeu: 3.125 ± 0.464
1.042LysMet: 1.042 ± 0.854
3.125LysAsn: 3.125 ± 0.464
1.042LysPro: 1.042 ± 0.906
5.208LysGln: 5.208 ± 1.306
4.167LysArg: 4.167 ± 2.267
3.125LysSer: 3.125 ± 1.424
2.083LysThr: 2.083 ± 0.747
2.083LysVal: 2.083 ± 1.812
1.042LysTrp: 1.042 ± 0.906
6.25LysTyr: 6.25 ± 2.778
0.0LysXaa: 0.0 ± 0.0
Leu
3.125LeuAla: 3.125 ± 1.163
2.083LeuCys: 2.083 ± 1.163
1.042LeuAsp: 1.042 ± 0.906
6.25LeuGlu: 6.25 ± 2.846
5.208LeuPhe: 5.208 ± 1.604
1.042LeuGly: 1.042 ± 0.854
4.167LeuHis: 4.167 ± 1.57
3.125LeuIle: 3.125 ± 2.039
4.167LeuLys: 4.167 ± 1.572
4.167LeuLeu: 4.167 ± 0.842
2.083LeuMet: 2.083 ± 1.278
3.125LeuAsn: 3.125 ± 0.464
3.125LeuPro: 3.125 ± 1.429
0.0LeuGln: 0.0 ± 0.0
7.292LeuArg: 7.292 ± 1.644
3.125LeuSer: 3.125 ± 0.464
2.083LeuThr: 2.083 ± 0.785
7.292LeuVal: 7.292 ± 1.197
0.0LeuTrp: 0.0 ± 0.0
7.292LeuTyr: 7.292 ± 0.881
0.0LeuXaa: 0.0 ± 0.0
Met
2.083MetAla: 2.083 ± 0.785
2.083MetCys: 2.083 ± 0.785
4.167MetAsp: 4.167 ± 1.527
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.042MetIle: 1.042 ± 0.854
2.083MetLys: 2.083 ± 0.785
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.042MetAsn: 1.042 ± 0.906
1.042MetPro: 1.042 ± 0.906
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
1.042MetThr: 1.042 ± 0.854
3.125MetVal: 3.125 ± 0.464
0.0MetTrp: 0.0 ± 0.0
2.083MetTyr: 2.083 ± 1.708
0.0MetXaa: 0.0 ± 0.0
Asn
2.083AsnAla: 2.083 ± 1.708
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
2.083AsnGlu: 2.083 ± 0.785
0.0AsnPhe: 0.0 ± 0.0
1.042AsnGly: 1.042 ± 1.168
0.0AsnHis: 0.0 ± 0.0
7.292AsnIle: 7.292 ± 1.588
3.125AsnLys: 3.125 ± 0.464
4.167AsnLeu: 4.167 ± 1.206
0.0AsnMet: 0.0 ± 0.0
1.042AsnAsn: 1.042 ± 0.906
4.167AsnPro: 4.167 ± 2.168
3.125AsnGln: 3.125 ± 0.464
1.042AsnArg: 1.042 ± 0.906
2.083AsnSer: 2.083 ± 0.747
5.208AsnThr: 5.208 ± 1.306
2.083AsnVal: 2.083 ± 1.708
2.083AsnTrp: 2.083 ± 0.747
2.083AsnTyr: 2.083 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
3.125ProAla: 3.125 ± 1.429
1.042ProCys: 1.042 ± 0.854
5.208ProAsp: 5.208 ± 1.522
2.083ProGlu: 2.083 ± 0.785
5.208ProPhe: 5.208 ± 2.089
5.208ProGly: 5.208 ± 1.604
4.167ProHis: 4.167 ± 1.57
3.125ProIle: 3.125 ± 0.464
2.083ProLys: 2.083 ± 0.747
2.083ProLeu: 2.083 ± 0.785
0.0ProMet: 0.0 ± 0.0
4.167ProAsn: 4.167 ± 1.572
2.083ProPro: 2.083 ± 1.393
4.167ProGln: 4.167 ± 1.57
6.25ProArg: 6.25 ± 2.164
2.083ProSer: 2.083 ± 1.393
1.042ProThr: 1.042 ± 0.854
4.167ProVal: 4.167 ± 0.842
1.042ProTrp: 1.042 ± 0.906
1.042ProTyr: 1.042 ± 0.872
0.0ProXaa: 0.0 ± 0.0
Gln
5.208GlnAla: 5.208 ± 1.306
2.083GlnCys: 2.083 ± 0.785
0.0GlnAsp: 0.0 ± 0.0
2.083GlnGlu: 2.083 ± 1.745
2.083GlnPhe: 2.083 ± 0.785
3.125GlnGly: 3.125 ± 1.429
0.0GlnHis: 0.0 ± 0.0
2.083GlnIle: 2.083 ± 0.785
0.0GlnLys: 0.0 ± 0.0
0.0GlnLeu: 0.0 ± 0.0
2.083GlnMet: 2.083 ± 0.709
2.083GlnAsn: 2.083 ± 0.785
0.0GlnPro: 0.0 ± 0.0
2.083GlnGln: 2.083 ± 1.301
3.125GlnArg: 3.125 ± 1.218
1.042GlnSer: 1.042 ± 0.854
1.042GlnThr: 1.042 ± 0.906
2.083GlnVal: 2.083 ± 0.785
0.0GlnTrp: 0.0 ± 0.0
1.042GlnTyr: 1.042 ± 1.168
0.0GlnXaa: 0.0 ± 0.0
Arg
4.167ArgAla: 4.167 ± 0.842
0.0ArgCys: 0.0 ± 0.0
6.25ArgAsp: 6.25 ± 2.355
4.167ArgGlu: 4.167 ± 1.57
5.208ArgPhe: 5.208 ± 0.918
3.125ArgGly: 3.125 ± 1.424
4.167ArgHis: 4.167 ± 0.733
0.0ArgIle: 0.0 ± 0.0
6.25ArgLys: 6.25 ± 1.636
3.125ArgLeu: 3.125 ± 1.423
3.125ArgMet: 3.125 ± 1.054
0.0ArgAsn: 0.0 ± 0.0
1.042ArgPro: 1.042 ± 1.168
0.0ArgGln: 0.0 ± 0.0
2.083ArgArg: 2.083 ± 1.393
2.083ArgSer: 2.083 ± 0.785
6.25ArgThr: 6.25 ± 3.425
5.208ArgVal: 5.208 ± 2.082
1.042ArgTrp: 1.042 ± 0.906
2.083ArgTyr: 2.083 ± 1.812
0.0ArgXaa: 0.0 ± 0.0
Ser
4.167SerAla: 4.167 ± 1.181
0.0SerCys: 0.0 ± 0.0
8.333SerAsp: 8.333 ± 1.684
1.042SerGlu: 1.042 ± 0.854
3.125SerPhe: 3.125 ± 1.218
2.083SerGly: 2.083 ± 1.812
2.083SerHis: 2.083 ± 1.163
6.25SerIle: 6.25 ± 0.928
4.167SerLys: 4.167 ± 1.206
9.375SerLeu: 9.375 ± 2.672
2.083SerMet: 2.083 ± 0.785
1.042SerAsn: 1.042 ± 0.854
6.25SerPro: 6.25 ± 2.355
1.042SerGln: 1.042 ± 0.854
4.167SerArg: 4.167 ± 1.181
14.583SerSer: 14.583 ± 1.403
2.083SerThr: 2.083 ± 1.163
2.083SerVal: 2.083 ± 1.163
4.167SerTrp: 4.167 ± 0.733
1.042SerTyr: 1.042 ± 0.872
0.0SerXaa: 0.0 ± 0.0
Thr
5.208ThrAla: 5.208 ± 2.089
3.125ThrCys: 3.125 ± 2.717
1.042ThrAsp: 1.042 ± 0.906
2.083ThrGlu: 2.083 ± 1.393
3.125ThrPhe: 3.125 ± 1.163
2.083ThrGly: 2.083 ± 0.747
2.083ThrHis: 2.083 ± 0.747
3.125ThrIle: 3.125 ± 1.163
2.083ThrLys: 2.083 ± 0.785
3.125ThrLeu: 3.125 ± 1.163
1.042ThrMet: 1.042 ± 0.906
5.208ThrAsn: 5.208 ± 2.082
11.458ThrPro: 11.458 ± 1.525
0.0ThrGln: 0.0 ± 0.0
2.083ThrArg: 2.083 ± 0.747
5.208ThrSer: 5.208 ± 2.126
4.167ThrThr: 4.167 ± 0.733
3.125ThrVal: 3.125 ± 1.424
0.0ThrTrp: 0.0 ± 0.0
5.208ThrTyr: 5.208 ± 2.089
0.0ThrXaa: 0.0 ± 0.0
Val
4.167ValAla: 4.167 ± 1.206
3.125ValCys: 3.125 ± 0.464
6.25ValAsp: 6.25 ± 1.636
0.0ValGlu: 0.0 ± 0.0
2.083ValPhe: 2.083 ± 2.335
5.208ValGly: 5.208 ± 2.362
1.042ValHis: 1.042 ± 0.854
1.042ValIle: 1.042 ± 0.854
2.083ValLys: 2.083 ± 1.812
3.125ValLeu: 3.125 ± 0.464
0.0ValMet: 0.0 ± 0.0
6.25ValAsn: 6.25 ± 2.357
1.042ValPro: 1.042 ± 0.906
3.125ValGln: 3.125 ± 0.464
4.167ValArg: 4.167 ± 1.57
6.25ValSer: 6.25 ± 2.97
5.208ValThr: 5.208 ± 0.886
5.208ValVal: 5.208 ± 3.677
2.083ValTrp: 2.083 ± 2.335
6.25ValTyr: 6.25 ± 2.976
0.0ValXaa: 0.0 ± 0.0
Trp
1.042TrpAla: 1.042 ± 0.854
1.042TrpCys: 1.042 ± 0.906
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
2.083TrpGly: 2.083 ± 0.785
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
5.208TrpLys: 5.208 ± 0.914
4.167TrpLeu: 4.167 ± 1.646
2.083TrpMet: 2.083 ± 1.163
1.042TrpAsn: 1.042 ± 0.906
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.042TrpArg: 1.042 ± 1.168
3.125TrpSer: 3.125 ± 0.464
1.042TrpThr: 1.042 ± 0.906
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.042TyrAla: 1.042 ± 1.168
0.0TyrCys: 0.0 ± 0.0
2.083TyrAsp: 2.083 ± 0.747
3.125TyrGlu: 3.125 ± 1.389
1.042TyrPhe: 1.042 ± 0.906
2.083TyrGly: 2.083 ± 1.377
1.042TyrHis: 1.042 ± 0.906
6.25TyrIle: 6.25 ± 2.355
3.125TyrLys: 3.125 ± 2.717
3.125TyrLeu: 3.125 ± 0.464
2.083TyrMet: 2.083 ± 1.708
4.167TyrAsn: 4.167 ± 1.494
2.083TyrPro: 2.083 ± 0.785
1.042TyrGln: 1.042 ± 1.168
1.042TyrArg: 1.042 ± 0.906
6.25TyrSer: 6.25 ± 2.355
7.292TyrThr: 7.292 ± 1.451
3.125TyrVal: 3.125 ± 2.717
0.0TyrTrp: 0.0 ± 0.0
1.042TyrTyr: 1.042 ± 0.854
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski