Amino acid dipepetide frequency for Ranid herpesvirus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.684AlaAla: 4.684 ± 0.289
2.103AlaCys: 2.103 ± 0.196
2.968AlaAsp: 2.968 ± 0.216
2.834AlaGlu: 2.834 ± 0.177
3.252AlaPhe: 3.252 ± 0.204
2.476AlaGly: 2.476 ± 0.164
1.7AlaHis: 1.7 ± 0.186
3.923AlaIle: 3.923 ± 0.243
3.222AlaLys: 3.222 ± 0.207
7.503AlaLeu: 7.503 ± 0.336
1.462AlaMet: 1.462 ± 0.169
3.147AlaAsn: 3.147 ± 0.304
2.685AlaPro: 2.685 ± 0.225
2.252AlaGln: 2.252 ± 0.178
3.237AlaArg: 3.237 ± 0.172
4.341AlaSer: 4.341 ± 0.271
3.908AlaThr: 3.908 ± 0.258
4.505AlaVal: 4.505 ± 0.267
0.716AlaTrp: 0.716 ± 0.103
2.193AlaTyr: 2.193 ± 0.141
0.0AlaXaa: 0.0 ± 0.0
Cys
1.879CysAla: 1.879 ± 0.187
0.656CysCys: 0.656 ± 0.117
1.417CysAsp: 1.417 ± 0.153
1.492CysGlu: 1.492 ± 0.168
1.507CysPhe: 1.507 ± 0.167
1.328CysGly: 1.328 ± 0.158
0.656CysHis: 0.656 ± 0.103
1.328CysIle: 1.328 ± 0.146
1.357CysLys: 1.357 ± 0.173
2.61CysLeu: 2.61 ± 0.211
0.686CysMet: 0.686 ± 0.111
1.402CysAsn: 1.402 ± 0.147
1.626CysPro: 1.626 ± 0.189
0.835CysGln: 0.835 ± 0.092
1.104CysArg: 1.104 ± 0.159
2.148CysSer: 2.148 ± 0.2
1.969CysThr: 1.969 ± 0.203
2.387CysVal: 2.387 ± 0.21
0.313CysTrp: 0.313 ± 0.072
1.521CysTyr: 1.521 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
2.968AspAla: 2.968 ± 0.191
1.462AspCys: 1.462 ± 0.157
2.506AspAsp: 2.506 ± 0.287
3.311AspGlu: 3.311 ± 0.325
2.357AspPhe: 2.357 ± 0.186
2.655AspGly: 2.655 ± 0.181
1.089AspHis: 1.089 ± 0.122
2.282AspIle: 2.282 ± 0.184
2.387AspLys: 2.387 ± 0.218
4.758AspLeu: 4.758 ± 0.294
1.193AspMet: 1.193 ± 0.125
1.939AspAsn: 1.939 ± 0.166
2.222AspPro: 2.222 ± 0.229
1.924AspGln: 1.924 ± 0.203
2.64AspArg: 2.64 ± 0.217
3.028AspSer: 3.028 ± 0.227
2.506AspThr: 2.506 ± 0.177
3.833AspVal: 3.833 ± 0.266
0.731AspTrp: 0.731 ± 0.095
2.208AspTyr: 2.208 ± 0.215
0.0AspXaa: 0.0 ± 0.0
Glu
3.386GluAla: 3.386 ± 0.255
1.507GluCys: 1.507 ± 0.152
2.998GluAsp: 2.998 ± 0.232
3.759GluGlu: 3.759 ± 0.454
1.835GluPhe: 1.835 ± 0.162
2.208GluGly: 2.208 ± 0.185
1.477GluHis: 1.477 ± 0.141
3.252GluIle: 3.252 ± 0.31
3.341GluLys: 3.341 ± 0.235
5.295GluLeu: 5.295 ± 0.298
1.313GluMet: 1.313 ± 0.134
3.222GluAsn: 3.222 ± 0.272
2.476GluPro: 2.476 ± 0.178
1.939GluGln: 1.939 ± 0.156
2.789GluArg: 2.789 ± 0.212
3.923GluSer: 3.923 ± 0.288
4.221GluThr: 4.221 ± 0.303
2.58GluVal: 2.58 ± 0.189
0.835GluTrp: 0.835 ± 0.115
1.954GluTyr: 1.954 ± 0.19
0.0GluXaa: 0.0 ± 0.0
Phe
2.595PheAla: 2.595 ± 0.208
1.357PheCys: 1.357 ± 0.183
2.342PheAsp: 2.342 ± 0.162
2.267PheGlu: 2.267 ± 0.192
1.999PhePhe: 1.999 ± 0.193
2.088PheGly: 2.088 ± 0.177
1.074PheHis: 1.074 ± 0.129
2.968PheIle: 2.968 ± 0.201
3.117PheLys: 3.117 ± 0.222
4.057PheLeu: 4.057 ± 0.306
1.342PheMet: 1.342 ± 0.156
2.879PheAsn: 2.879 ± 0.185
1.73PhePro: 1.73 ± 0.184
1.402PheGln: 1.402 ± 0.156
2.103PheArg: 2.103 ± 0.233
3.475PheSer: 3.475 ± 0.233
3.461PheThr: 3.461 ± 0.214
3.207PheVal: 3.207 ± 0.24
0.612PheTrp: 0.612 ± 0.12
2.193PheTyr: 2.193 ± 0.188
0.0PheXaa: 0.0 ± 0.0
Gly
2.759GlyAla: 2.759 ± 0.245
1.253GlyCys: 1.253 ± 0.161
2.312GlyAsp: 2.312 ± 0.163
2.387GlyGlu: 2.387 ± 0.171
2.551GlyPhe: 2.551 ± 0.196
2.521GlyGly: 2.521 ± 0.256
1.089GlyHis: 1.089 ± 0.107
2.64GlyIle: 2.64 ± 0.193
2.745GlyLys: 2.745 ± 0.2
4.743GlyLeu: 4.743 ± 0.26
1.119GlyMet: 1.119 ± 0.13
2.327GlyAsn: 2.327 ± 0.194
1.715GlyPro: 1.715 ± 0.166
1.477GlyGln: 1.477 ± 0.141
2.178GlyArg: 2.178 ± 0.151
3.356GlySer: 3.356 ± 0.248
2.7GlyThr: 2.7 ± 0.21
3.326GlyVal: 3.326 ± 0.211
0.955GlyTrp: 0.955 ± 0.147
1.805GlyTyr: 1.805 ± 0.163
0.0GlyXaa: 0.0 ± 0.0
His
1.641HisAla: 1.641 ± 0.161
0.462HisCys: 0.462 ± 0.081
1.208HisAsp: 1.208 ± 0.131
1.432HisGlu: 1.432 ± 0.129
1.178HisPhe: 1.178 ± 0.127
0.97HisGly: 0.97 ± 0.112
0.791HisHis: 0.791 ± 0.141
1.566HisIle: 1.566 ± 0.155
1.357HisLys: 1.357 ± 0.122
2.327HisLeu: 2.327 ± 0.191
0.671HisMet: 0.671 ± 0.1
1.417HisAsn: 1.417 ± 0.127
1.462HisPro: 1.462 ± 0.145
0.805HisGln: 0.805 ± 0.124
1.134HisArg: 1.134 ± 0.158
1.775HisSer: 1.775 ± 0.151
1.686HisThr: 1.686 ± 0.167
2.058HisVal: 2.058 ± 0.203
0.358HisTrp: 0.358 ± 0.074
1.134HisTyr: 1.134 ± 0.135
0.0HisXaa: 0.0 ± 0.0
Ile
3.908IleAla: 3.908 ± 0.243
1.462IleCys: 1.462 ± 0.158
2.685IleAsp: 2.685 ± 0.219
3.117IleGlu: 3.117 ± 0.197
2.446IlePhe: 2.446 ± 0.18
2.461IleGly: 2.461 ± 0.222
1.372IleHis: 1.372 ± 0.13
3.55IleIle: 3.55 ± 0.226
3.729IleLys: 3.729 ± 0.244
5.743IleLeu: 5.743 ± 0.276
1.73IleMet: 1.73 ± 0.142
3.997IleAsn: 3.997 ± 0.23
2.774IlePro: 2.774 ± 0.196
1.745IleGln: 1.745 ± 0.141
2.595IleArg: 2.595 ± 0.204
4.594IleSer: 4.594 ± 0.295
3.744IleThr: 3.744 ± 0.268
3.968IleVal: 3.968 ± 0.192
0.656IleTrp: 0.656 ± 0.104
2.416IleTyr: 2.416 ± 0.2
0.0IleXaa: 0.0 ± 0.0
Lys
3.371LysAla: 3.371 ± 0.256
1.671LysCys: 1.671 ± 0.158
2.938LysAsp: 2.938 ± 0.229
3.252LysGlu: 3.252 ± 0.26
1.596LysPhe: 1.596 ± 0.177
2.416LysGly: 2.416 ± 0.188
1.969LysHis: 1.969 ± 0.177
3.625LysIle: 3.625 ± 0.251
3.461LysLys: 3.461 ± 0.318
5.071LysLeu: 5.071 ± 0.302
1.313LysMet: 1.313 ± 0.139
3.222LysAsn: 3.222 ± 0.235
3.356LysPro: 3.356 ± 0.224
1.984LysGln: 1.984 ± 0.15
3.669LysArg: 3.669 ± 0.218
4.102LysSer: 4.102 ± 0.236
4.788LysThr: 4.788 ± 0.347
2.685LysVal: 2.685 ± 0.227
0.791LysTrp: 0.791 ± 0.12
2.133LysTyr: 2.133 ± 0.179
0.0LysXaa: 0.0 ± 0.0
Leu
6.116LeuAla: 6.116 ± 0.33
3.073LeuCys: 3.073 ± 0.223
3.893LeuAsp: 3.893 ± 0.223
5.579LeuGlu: 5.579 ± 0.38
4.176LeuPhe: 4.176 ± 0.285
4.132LeuGly: 4.132 ± 0.23
2.819LeuHis: 2.819 ± 0.206
6.25LeuIle: 6.25 ± 0.267
6.951LeuLys: 6.951 ± 0.415
10.173LeuLeu: 10.173 ± 0.424
2.566LeuMet: 2.566 ± 0.194
5.653LeuAsn: 5.653 ± 0.306
4.743LeuPro: 4.743 ± 0.312
3.819LeuGln: 3.819 ± 0.261
4.669LeuArg: 4.669 ± 0.27
7.861LeuSer: 7.861 ± 0.332
6.175LeuThr: 6.175 ± 0.28
4.907LeuVal: 4.907 ± 0.262
1.074LeuTrp: 1.074 ± 0.159
3.938LeuTyr: 3.938 ± 0.259
0.0LeuXaa: 0.0 ± 0.0
Met
1.7MetAla: 1.7 ± 0.163
0.865MetCys: 0.865 ± 0.108
1.044MetAsp: 1.044 ± 0.123
1.283MetGlu: 1.283 ± 0.128
1.149MetPhe: 1.149 ± 0.137
1.402MetGly: 1.402 ± 0.146
0.552MetHis: 0.552 ± 0.079
1.536MetIle: 1.536 ± 0.119
1.357MetLys: 1.357 ± 0.147
2.566MetLeu: 2.566 ± 0.166
0.731MetMet: 0.731 ± 0.099
1.268MetAsn: 1.268 ± 0.136
0.984MetPro: 0.984 ± 0.138
0.791MetGln: 0.791 ± 0.099
1.402MetArg: 1.402 ± 0.154
1.686MetSer: 1.686 ± 0.148
1.521MetThr: 1.521 ± 0.152
1.447MetVal: 1.447 ± 0.169
0.343MetTrp: 0.343 ± 0.068
1.432MetTyr: 1.432 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
3.923AsnAla: 3.923 ± 0.236
1.238AsnCys: 1.238 ± 0.165
2.909AsnAsp: 2.909 ± 0.26
3.341AsnGlu: 3.341 ± 0.226
2.342AsnPhe: 2.342 ± 0.19
3.565AsnGly: 3.565 ± 0.253
1.357AsnHis: 1.357 ± 0.139
3.028AsnIle: 3.028 ± 0.214
3.088AsnLys: 3.088 ± 0.253
4.758AsnLeu: 4.758 ± 0.242
1.119AsnMet: 1.119 ± 0.13
2.879AsnAsn: 2.879 ± 0.258
2.864AsnPro: 2.864 ± 0.218
1.85AsnGln: 1.85 ± 0.166
2.909AsnArg: 2.909 ± 0.208
3.52AsnSer: 3.52 ± 0.234
3.789AsnThr: 3.789 ± 0.263
4.206AsnVal: 4.206 ± 0.246
0.567AsnTrp: 0.567 ± 0.098
2.401AsnTyr: 2.401 ± 0.222
0.0AsnXaa: 0.0 ± 0.0
Pro
2.625ProAla: 2.625 ± 0.192
1.387ProCys: 1.387 ± 0.196
2.208ProAsp: 2.208 ± 0.189
2.282ProGlu: 2.282 ± 0.207
2.461ProPhe: 2.461 ± 0.238
1.954ProGly: 1.954 ± 0.22
1.253ProHis: 1.253 ± 0.126
2.774ProIle: 2.774 ± 0.228
2.416ProLys: 2.416 ± 0.247
5.057ProLeu: 5.057 ± 0.271
1.104ProMet: 1.104 ± 0.129
2.446ProAsn: 2.446 ± 0.186
2.864ProPro: 2.864 ± 0.306
2.088ProGln: 2.088 ± 0.208
2.133ProArg: 2.133 ± 0.211
4.087ProSer: 4.087 ± 0.265
3.207ProThr: 3.207 ± 0.24
2.998ProVal: 2.998 ± 0.213
0.582ProTrp: 0.582 ± 0.102
1.924ProTyr: 1.924 ± 0.212
0.0ProXaa: 0.0 ± 0.0
Gln
1.865GlnAla: 1.865 ± 0.159
0.701GlnCys: 0.701 ± 0.093
1.596GlnAsp: 1.596 ± 0.202
1.76GlnGlu: 1.76 ± 0.181
1.73GlnPhe: 1.73 ± 0.174
1.059GlnGly: 1.059 ± 0.106
0.925GlnHis: 0.925 ± 0.127
1.939GlnIle: 1.939 ± 0.171
1.805GlnLys: 1.805 ± 0.164
3.296GlnLeu: 3.296 ± 0.222
0.999GlnMet: 0.999 ± 0.112
2.67GlnAsn: 2.67 ± 0.194
1.745GlnPro: 1.745 ± 0.163
1.402GlnGln: 1.402 ± 0.192
2.103GlnArg: 2.103 ± 0.193
3.013GlnSer: 3.013 ± 0.238
2.67GlnThr: 2.67 ± 0.233
1.521GlnVal: 1.521 ± 0.135
0.358GlnTrp: 0.358 ± 0.075
1.432GlnTyr: 1.432 ± 0.146
0.0GlnXaa: 0.0 ± 0.0
Arg
3.162ArgAla: 3.162 ± 0.198
1.402ArgCys: 1.402 ± 0.137
2.267ArgAsp: 2.267 ± 0.201
2.357ArgGlu: 2.357 ± 0.218
2.625ArgPhe: 2.625 ± 0.211
2.461ArgGly: 2.461 ± 0.205
1.313ArgHis: 1.313 ± 0.158
3.192ArgIle: 3.192 ± 0.226
2.968ArgLys: 2.968 ± 0.232
5.4ArgLeu: 5.4 ± 0.294
1.238ArgMet: 1.238 ± 0.129
2.58ArgAsn: 2.58 ± 0.201
2.148ArgPro: 2.148 ± 0.178
1.641ArgGln: 1.641 ± 0.164
2.64ArgArg: 2.64 ± 0.21
3.505ArgSer: 3.505 ± 0.216
2.968ArgThr: 2.968 ± 0.225
3.088ArgVal: 3.088 ± 0.237
0.641ArgTrp: 0.641 ± 0.111
2.327ArgTyr: 2.327 ± 0.206
0.0ArgXaa: 0.0 ± 0.0
Ser
4.699SerAla: 4.699 ± 0.334
1.879SerCys: 1.879 ± 0.184
3.819SerAsp: 3.819 ± 0.259
3.759SerGlu: 3.759 ± 0.258
3.505SerPhe: 3.505 ± 0.254
3.804SerGly: 3.804 ± 0.265
1.611SerHis: 1.611 ± 0.143
4.639SerIle: 4.639 ± 0.234
4.162SerLys: 4.162 ± 0.227
7.204SerLeu: 7.204 ± 0.373
1.507SerMet: 1.507 ± 0.129
4.221SerAsn: 4.221 ± 0.354
3.61SerPro: 3.61 ± 0.29
2.431SerGln: 2.431 ± 0.173
3.446SerArg: 3.446 ± 0.258
6.727SerSer: 6.727 ± 0.423
5.31SerThr: 5.31 ± 0.277
5.37SerVal: 5.37 ± 0.275
0.686SerTrp: 0.686 ± 0.105
3.013SerTyr: 3.013 ± 0.24
0.0SerXaa: 0.0 ± 0.0
Thr
4.355ThrAla: 4.355 ± 0.293
2.103ThrCys: 2.103 ± 0.227
3.326ThrAsp: 3.326 ± 0.273
3.744ThrGlu: 3.744 ± 0.382
3.505ThrPhe: 3.505 ± 0.25
2.819ThrGly: 2.819 ± 0.189
1.79ThrHis: 1.79 ± 0.132
3.64ThrIle: 3.64 ± 0.238
3.267ThrLys: 3.267 ± 0.23
6.772ThrLeu: 6.772 ± 0.28
1.76ThrMet: 1.76 ± 0.156
3.431ThrAsn: 3.431 ± 0.232
3.461ThrPro: 3.461 ± 0.23
2.431ThrGln: 2.431 ± 0.249
2.789ThrArg: 2.789 ± 0.208
5.459ThrSer: 5.459 ± 0.377
4.52ThrThr: 4.52 ± 0.412
3.997ThrVal: 3.997 ± 0.227
0.731ThrTrp: 0.731 ± 0.106
2.73ThrTyr: 2.73 ± 0.229
0.0ThrXaa: 0.0 ± 0.0
Val
4.162ValAla: 4.162 ± 0.248
2.118ValCys: 2.118 ± 0.235
2.849ValAsp: 2.849 ± 0.219
3.819ValGlu: 3.819 ± 0.3
3.192ValPhe: 3.192 ± 0.201
2.998ValGly: 2.998 ± 0.181
1.432ValHis: 1.432 ± 0.142
3.416ValIle: 3.416 ± 0.204
3.431ValLys: 3.431 ± 0.252
5.981ValLeu: 5.981 ± 0.327
1.596ValMet: 1.596 ± 0.166
3.475ValAsn: 3.475 ± 0.22
3.326ValPro: 3.326 ± 0.239
2.043ValGln: 2.043 ± 0.154
3.252ValArg: 3.252 ± 0.246
5.444ValSer: 5.444 ± 0.273
3.923ValThr: 3.923 ± 0.283
3.997ValVal: 3.997 ± 0.275
0.925ValTrp: 0.925 ± 0.143
2.715ValTyr: 2.715 ± 0.192
0.0ValXaa: 0.0 ± 0.0
Trp
0.537TrpAla: 0.537 ± 0.081
0.343TrpCys: 0.343 ± 0.071
0.358TrpAsp: 0.358 ± 0.058
0.462TrpGlu: 0.462 ± 0.083
0.82TrpPhe: 0.82 ± 0.127
0.447TrpGly: 0.447 ± 0.086
0.283TrpHis: 0.283 ± 0.06
0.656TrpIle: 0.656 ± 0.101
0.791TrpLys: 0.791 ± 0.119
1.387TrpLeu: 1.387 ± 0.155
0.433TrpMet: 0.433 ± 0.067
0.805TrpAsn: 0.805 ± 0.113
0.477TrpPro: 0.477 ± 0.093
0.462TrpGln: 0.462 ± 0.08
0.805TrpArg: 0.805 ± 0.114
0.865TrpSer: 0.865 ± 0.13
0.701TrpThr: 0.701 ± 0.107
0.984TrpVal: 0.984 ± 0.109
0.134TrpTrp: 0.134 ± 0.048
0.716TrpTyr: 0.716 ± 0.106
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.774TyrAla: 2.774 ± 0.198
1.178TyrCys: 1.178 ± 0.15
2.357TyrAsp: 2.357 ± 0.191
2.073TyrGlu: 2.073 ± 0.147
2.043TyrPhe: 2.043 ± 0.21
2.193TyrGly: 2.193 ± 0.174
0.88TyrHis: 0.88 ± 0.129
2.491TyrIle: 2.491 ± 0.196
2.476TyrLys: 2.476 ± 0.187
3.863TyrLeu: 3.863 ± 0.268
1.163TyrMet: 1.163 ± 0.133
2.67TyrAsn: 2.67 ± 0.202
1.581TyrPro: 1.581 ± 0.199
1.268TyrGln: 1.268 ± 0.132
2.327TyrArg: 2.327 ± 0.239
2.491TyrSer: 2.491 ± 0.222
2.864TyrThr: 2.864 ± 0.245
3.028TyrVal: 3.028 ± 0.204
0.462TyrTrp: 0.462 ± 0.101
2.178TyrTyr: 2.178 ± 0.228
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 186 proteins (67043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski