Amino acid dipepetide frequency for Kouleothrix aurantiaca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.886AlaAla: 17.886 ± 0.142
1.055AlaCys: 1.055 ± 0.022
6.417AlaAsp: 6.417 ± 0.066
7.469AlaGlu: 7.469 ± 0.08
3.888AlaPhe: 3.888 ± 0.043
10.26AlaGly: 10.26 ± 0.099
2.598AlaHis: 2.598 ± 0.04
6.195AlaIle: 6.195 ± 0.073
2.569AlaLys: 2.569 ± 0.043
16.044AlaLeu: 16.044 ± 0.143
2.854AlaMet: 2.854 ± 0.041
3.228AlaAsn: 3.228 ± 0.05
6.764AlaPro: 6.764 ± 0.076
5.859AlaGln: 5.859 ± 0.068
9.197AlaArg: 9.197 ± 0.085
6.132AlaSer: 6.132 ± 0.065
6.661AlaThr: 6.661 ± 0.069
7.92AlaVal: 7.92 ± 0.067
1.836AlaTrp: 1.836 ± 0.035
2.928AlaTyr: 2.928 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.016CysAla: 1.016 ± 0.024
0.127CysCys: 0.127 ± 0.01
0.479CysAsp: 0.479 ± 0.017
0.414CysGlu: 0.414 ± 0.016
0.311CysPhe: 0.311 ± 0.012
0.895CysGly: 0.895 ± 0.025
0.206CysHis: 0.206 ± 0.011
0.356CysIle: 0.356 ± 0.014
0.187CysLys: 0.187 ± 0.011
0.696CysLeu: 0.696 ± 0.019
0.157CysMet: 0.157 ± 0.008
0.206CysAsn: 0.206 ± 0.011
0.496CysPro: 0.496 ± 0.018
0.308CysGln: 0.308 ± 0.013
0.515CysArg: 0.515 ± 0.018
0.413CysSer: 0.413 ± 0.018
0.435CysThr: 0.435 ± 0.016
0.546CysVal: 0.546 ± 0.016
0.148CysTrp: 0.148 ± 0.01
0.275CysTyr: 0.275 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.776AspAla: 6.776 ± 0.068
0.38AspCys: 0.38 ± 0.015
3.148AspAsp: 3.148 ± 0.052
3.418AspGlu: 3.418 ± 0.052
1.792AspPhe: 1.792 ± 0.036
4.714AspGly: 4.714 ± 0.068
1.069AspHis: 1.069 ± 0.028
2.568AspIle: 2.568 ± 0.041
1.152AspLys: 1.152 ± 0.032
5.552AspLeu: 5.552 ± 0.051
1.172AspMet: 1.172 ± 0.028
1.245AspAsn: 1.245 ± 0.027
3.118AspPro: 3.118 ± 0.038
1.94AspGln: 1.94 ± 0.034
3.315AspArg: 3.315 ± 0.044
2.202AspSer: 2.202 ± 0.036
2.959AspThr: 2.959 ± 0.044
3.904AspVal: 3.904 ± 0.052
0.897AspTrp: 0.897 ± 0.025
1.538AspTyr: 1.538 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
6.371GluAla: 6.371 ± 0.073
0.362GluCys: 0.362 ± 0.016
2.163GluAsp: 2.163 ± 0.039
2.734GluGlu: 2.734 ± 0.045
1.654GluPhe: 1.654 ± 0.034
3.366GluGly: 3.366 ± 0.047
1.512GluHis: 1.512 ± 0.03
2.787GluIle: 2.787 ± 0.05
1.308GluLys: 1.308 ± 0.033
6.404GluLeu: 6.404 ± 0.07
1.233GluMet: 1.233 ± 0.027
1.359GluAsn: 1.359 ± 0.031
2.711GluPro: 2.711 ± 0.043
3.458GluGln: 3.458 ± 0.047
5.527GluArg: 5.527 ± 0.06
2.155GluSer: 2.155 ± 0.038
2.782GluThr: 2.782 ± 0.04
3.518GluVal: 3.518 ± 0.05
0.839GluTrp: 0.839 ± 0.02
1.349GluTyr: 1.349 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.313PheAla: 4.313 ± 0.052
0.358PheCys: 0.358 ± 0.013
2.169PheAsp: 2.169 ± 0.04
1.781PheGlu: 1.781 ± 0.033
1.423PhePhe: 1.423 ± 0.036
3.253PheGly: 3.253 ± 0.05
0.675PheHis: 0.675 ± 0.02
1.432PheIle: 1.432 ± 0.032
0.74PheLys: 0.74 ± 0.021
3.301PheLeu: 3.301 ± 0.053
0.623PheMet: 0.623 ± 0.021
1.053PheAsn: 1.053 ± 0.028
1.539PhePro: 1.539 ± 0.03
1.183PheGln: 1.183 ± 0.028
2.083PheArg: 2.083 ± 0.034
2.031PheSer: 2.031 ± 0.043
2.062PheThr: 2.062 ± 0.033
2.657PheVal: 2.657 ± 0.04
0.625PheTrp: 0.625 ± 0.017
1.074PheTyr: 1.074 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.493GlyAla: 9.493 ± 0.083
0.754GlyCys: 0.754 ± 0.02
4.235GlyAsp: 4.235 ± 0.053
4.354GlyGlu: 4.354 ± 0.052
2.868GlyPhe: 2.868 ± 0.045
6.908GlyGly: 6.908 ± 0.081
1.67GlyHis: 1.67 ± 0.031
4.064GlyIle: 4.064 ± 0.054
2.577GlyLys: 2.577 ± 0.042
8.045GlyLeu: 8.045 ± 0.091
2.233GlyMet: 2.233 ± 0.039
2.21GlyAsn: 2.21 ± 0.043
3.166GlyPro: 3.166 ± 0.041
3.519GlyGln: 3.519 ± 0.044
5.411GlyArg: 5.411 ± 0.061
4.327GlySer: 4.327 ± 0.058
4.753GlyThr: 4.753 ± 0.061
6.177GlyVal: 6.177 ± 0.061
1.575GlyTrp: 1.575 ± 0.031
2.467GlyTyr: 2.467 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.588HisAla: 2.588 ± 0.047
0.222HisCys: 0.222 ± 0.013
1.266HisAsp: 1.266 ± 0.028
1.175HisGlu: 1.175 ± 0.025
0.807HisPhe: 0.807 ± 0.021
1.811HisGly: 1.811 ± 0.036
0.588HisHis: 0.588 ± 0.018
1.136HisIle: 1.136 ± 0.025
0.425HisLys: 0.425 ± 0.015
2.08HisLeu: 2.08 ± 0.031
0.479HisMet: 0.479 ± 0.016
0.658HisAsn: 0.658 ± 0.02
1.422HisPro: 1.422 ± 0.028
0.756HisGln: 0.756 ± 0.02
1.32HisArg: 1.32 ± 0.027
1.128HisSer: 1.128 ± 0.027
1.236HisThr: 1.236 ± 0.026
1.433HisVal: 1.433 ± 0.031
0.357HisTrp: 0.357 ± 0.015
0.681HisTyr: 0.681 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.874IleAla: 6.874 ± 0.067
0.468IleCys: 0.468 ± 0.019
3.364IleAsp: 3.364 ± 0.045
3.055IleGlu: 3.055 ± 0.046
1.582IlePhe: 1.582 ± 0.031
4.571IleGly: 4.571 ± 0.052
1.012IleHis: 1.012 ± 0.023
2.427IleIle: 2.427 ± 0.042
1.227IleLys: 1.227 ± 0.032
4.025IleLeu: 4.025 ± 0.05
0.892IleMet: 0.892 ± 0.025
1.518IleAsn: 1.518 ± 0.032
2.417IlePro: 2.417 ± 0.039
1.596IleGln: 1.596 ± 0.028
2.848IleArg: 2.848 ± 0.042
2.822IleSer: 2.822 ± 0.041
3.07IleThr: 3.07 ± 0.05
3.98IleVal: 3.98 ± 0.053
0.673IleTrp: 0.673 ± 0.018
1.369IleTyr: 1.369 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
2.384LysAla: 2.384 ± 0.046
0.124LysCys: 0.124 ± 0.009
1.153LysAsp: 1.153 ± 0.027
1.215LysGlu: 1.215 ± 0.027
0.649LysPhe: 0.649 ± 0.022
1.625LysGly: 1.625 ± 0.034
0.559LysHis: 0.559 ± 0.018
1.304LysIle: 1.304 ± 0.03
0.746LysLys: 0.746 ± 0.025
2.614LysLeu: 2.614 ± 0.048
0.525LysMet: 0.525 ± 0.019
0.761LysAsn: 0.761 ± 0.023
1.463LysPro: 1.463 ± 0.027
1.134LysGln: 1.134 ± 0.024
1.78LysArg: 1.78 ± 0.036
1.152LysSer: 1.152 ± 0.03
1.44LysThr: 1.44 ± 0.03
1.694LysVal: 1.694 ± 0.034
0.269LysTrp: 0.269 ± 0.011
0.603LysTyr: 0.603 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.681LeuAla: 15.681 ± 0.145
0.923LeuCys: 0.923 ± 0.023
5.872LeuAsp: 5.872 ± 0.063
5.355LeuGlu: 5.355 ± 0.062
3.646LeuPhe: 3.646 ± 0.054
8.983LeuGly: 8.983 ± 0.086
2.411LeuHis: 2.411 ± 0.042
5.142LeuIle: 5.142 ± 0.065
2.507LeuLys: 2.507 ± 0.042
12.9LeuLeu: 12.9 ± 0.145
2.098LeuMet: 2.098 ± 0.041
2.95LeuAsn: 2.95 ± 0.043
6.495LeuPro: 6.495 ± 0.068
3.728LeuGln: 3.728 ± 0.046
8.427LeuArg: 8.427 ± 0.079
5.659LeuSer: 5.659 ± 0.063
5.521LeuThr: 5.521 ± 0.062
7.687LeuVal: 7.687 ± 0.07
1.448LeuTrp: 1.448 ± 0.032
2.525LeuTyr: 2.525 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.549MetAla: 2.549 ± 0.041
0.142MetCys: 0.142 ± 0.009
0.9MetAsp: 0.9 ± 0.022
0.895MetGlu: 0.895 ± 0.024
0.685MetPhe: 0.685 ± 0.019
1.465MetGly: 1.465 ± 0.029
0.514MetHis: 0.514 ± 0.018
1.123MetIle: 1.123 ± 0.025
0.558MetLys: 0.558 ± 0.017
2.718MetLeu: 2.718 ± 0.042
0.474MetMet: 0.474 ± 0.019
0.708MetAsn: 0.708 ± 0.019
1.478MetPro: 1.478 ± 0.025
0.989MetGln: 0.989 ± 0.027
1.781MetArg: 1.781 ± 0.033
1.236MetSer: 1.236 ± 0.029
1.263MetThr: 1.263 ± 0.027
1.474MetVal: 1.474 ± 0.033
0.234MetTrp: 0.234 ± 0.012
0.433MetTyr: 0.433 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.173AsnAla: 3.173 ± 0.046
0.223AsnCys: 0.223 ± 0.011
1.583AsnAsp: 1.583 ± 0.033
1.327AsnGlu: 1.327 ± 0.031
0.904AsnPhe: 0.904 ± 0.026
2.694AsnGly: 2.694 ± 0.053
0.541AsnHis: 0.541 ± 0.018
1.426AsnIle: 1.426 ± 0.035
0.649AsnLys: 0.649 ± 0.021
2.748AsnLeu: 2.748 ± 0.041
0.558AsnMet: 0.558 ± 0.018
0.966AsnAsn: 0.966 ± 0.032
1.898AsnPro: 1.898 ± 0.032
1.09AsnGln: 1.09 ± 0.025
1.687AsnArg: 1.687 ± 0.036
1.477AsnSer: 1.477 ± 0.033
1.801AsnThr: 1.801 ± 0.041
1.957AsnVal: 1.957 ± 0.037
0.444AsnTrp: 0.444 ± 0.016
0.79AsnTyr: 0.79 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.775ProAla: 7.775 ± 0.089
0.349ProCys: 0.349 ± 0.014
3.56ProAsp: 3.56 ± 0.046
3.456ProGlu: 3.456 ± 0.043
1.999ProPhe: 1.999 ± 0.035
4.506ProGly: 4.506 ± 0.053
1.163ProHis: 1.163 ± 0.029
2.591ProIle: 2.591 ± 0.035
1.103ProLys: 1.103 ± 0.029
5.557ProLeu: 5.557 ± 0.058
1.025ProMet: 1.025 ± 0.022
1.749ProAsn: 1.749 ± 0.032
3.275ProPro: 3.275 ± 0.055
2.069ProGln: 2.069 ± 0.037
3.212ProArg: 3.212 ± 0.042
2.944ProSer: 2.944 ± 0.045
3.253ProThr: 3.253 ± 0.057
3.632ProVal: 3.632 ± 0.047
0.782ProTrp: 0.782 ± 0.022
1.358ProTyr: 1.358 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.368GlnAla: 5.368 ± 0.065
0.225GlnCys: 0.225 ± 0.012
1.374GlnAsp: 1.374 ± 0.028
1.852GlnGlu: 1.852 ± 0.031
1.403GlnPhe: 1.403 ± 0.031
2.818GlnGly: 2.818 ± 0.035
1.147GlnHis: 1.147 ± 0.026
2.451GlnIle: 2.451 ± 0.039
0.975GlnLys: 0.975 ± 0.027
4.725GlnLeu: 4.725 ± 0.058
0.896GlnMet: 0.896 ± 0.02
1.137GlnAsn: 1.137 ± 0.03
2.754GlnPro: 2.754 ± 0.045
2.341GlnGln: 2.341 ± 0.043
3.702GlnArg: 3.702 ± 0.053
2.071GlnSer: 2.071 ± 0.036
2.083GlnThr: 2.083 ± 0.036
2.909GlnVal: 2.909 ± 0.039
0.559GlnTrp: 0.559 ± 0.018
0.941GlnTyr: 0.941 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.34ArgAla: 9.34 ± 0.088
0.61ArgCys: 0.61 ± 0.021
3.897ArgAsp: 3.897 ± 0.052
4.215ArgGlu: 4.215 ± 0.051
2.564ArgPhe: 2.564 ± 0.036
4.898ArgGly: 4.898 ± 0.056
1.537ArgHis: 1.537 ± 0.033
3.446ArgIle: 3.446 ± 0.047
1.66ArgLys: 1.66 ± 0.035
7.728ArgLeu: 7.728 ± 0.069
1.719ArgMet: 1.719 ± 0.034
1.821ArgAsn: 1.821 ± 0.034
3.511ArgPro: 3.511 ± 0.047
3.068ArgGln: 3.068 ± 0.041
5.814ArgArg: 5.814 ± 0.073
3.431ArgSer: 3.431 ± 0.046
3.663ArgThr: 3.663 ± 0.05
4.907ArgVal: 4.907 ± 0.055
1.388ArgTrp: 1.388 ± 0.026
2.279ArgTyr: 2.279 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.369SerAla: 6.369 ± 0.069
0.395SerCys: 0.395 ± 0.017
2.795SerAsp: 2.795 ± 0.047
2.509SerGlu: 2.509 ± 0.04
2.062SerPhe: 2.062 ± 0.032
4.877SerGly: 4.877 ± 0.063
0.928SerHis: 0.928 ± 0.026
2.566SerIle: 2.566 ± 0.044
1.184SerLys: 1.184 ± 0.023
4.919SerLeu: 4.919 ± 0.064
1.19SerMet: 1.19 ± 0.025
1.494SerAsn: 1.494 ± 0.036
2.782SerPro: 2.782 ± 0.04
1.915SerGln: 1.915 ± 0.033
2.971SerArg: 2.971 ± 0.037
3.069SerSer: 3.069 ± 0.056
3.092SerThr: 3.092 ± 0.045
3.53SerVal: 3.53 ± 0.053
0.909SerTrp: 0.909 ± 0.026
1.6SerTyr: 1.6 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.019ThrAla: 6.019 ± 0.08
0.426ThrCys: 0.426 ± 0.017
2.667ThrAsp: 2.667 ± 0.043
2.434ThrGlu: 2.434 ± 0.04
2.122ThrPhe: 2.122 ± 0.037
4.313ThrGly: 4.313 ± 0.051
1.126ThrHis: 1.126 ± 0.026
3.412ThrIle: 3.412 ± 0.051
1.122ThrLys: 1.122 ± 0.031
6.89ThrLeu: 6.89 ± 0.07
1.15ThrMet: 1.15 ± 0.027
1.678ThrAsn: 1.678 ± 0.037
4.04ThrPro: 4.04 ± 0.057
1.961ThrGln: 1.961 ± 0.032
3.397ThrArg: 3.397 ± 0.045
3.06ThrSer: 3.06 ± 0.05
3.41ThrThr: 3.41 ± 0.048
4.216ThrVal: 4.216 ± 0.058
0.774ThrTrp: 0.774 ± 0.024
1.476ThrTyr: 1.476 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.084ValAla: 9.084 ± 0.079
0.654ValCys: 0.654 ± 0.02
3.388ValAsp: 3.388 ± 0.045
3.793ValGlu: 3.793 ± 0.047
2.493ValPhe: 2.493 ± 0.037
5.452ValGly: 5.452 ± 0.062
1.264ValHis: 1.264 ± 0.028
3.509ValIle: 3.509 ± 0.048
1.552ValLys: 1.552 ± 0.033
8.243ValLeu: 8.243 ± 0.071
1.479ValMet: 1.479 ± 0.027
1.881ValAsn: 1.881 ± 0.038
3.996ValPro: 3.996 ± 0.052
2.813ValGln: 2.813 ± 0.04
5.087ValArg: 5.087 ± 0.058
3.639ValSer: 3.639 ± 0.048
3.772ValThr: 3.772 ± 0.061
5.786ValVal: 5.786 ± 0.074
0.992ValTrp: 0.992 ± 0.026
1.805ValTyr: 1.805 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.626TrpAla: 1.626 ± 0.03
0.14TrpCys: 0.14 ± 0.009
0.787TrpAsp: 0.787 ± 0.022
0.756TrpGlu: 0.756 ± 0.022
0.544TrpPhe: 0.544 ± 0.016
1.074TrpGly: 1.074 ± 0.027
0.386TrpHis: 0.386 ± 0.017
0.603TrpIle: 0.603 ± 0.021
0.381TrpLys: 0.381 ± 0.014
2.059TrpLeu: 2.059 ± 0.039
0.36TrpMet: 0.36 ± 0.014
0.502TrpAsn: 0.502 ± 0.019
0.755TrpPro: 0.755 ± 0.021
0.886TrpGln: 0.886 ± 0.024
1.35TrpArg: 1.35 ± 0.033
0.871TrpSer: 0.871 ± 0.023
0.686TrpThr: 0.686 ± 0.023
0.965TrpVal: 0.965 ± 0.023
0.317TrpTrp: 0.317 ± 0.015
0.449TrpTyr: 0.449 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.075TyrAla: 3.075 ± 0.045
0.245TyrCys: 0.245 ± 0.011
1.642TyrAsp: 1.642 ± 0.038
1.387TyrGlu: 1.387 ± 0.028
0.979TyrPhe: 0.979 ± 0.023
2.325TyrGly: 2.325 ± 0.036
0.663TyrHis: 0.663 ± 0.019
1.254TyrIle: 1.254 ± 0.026
0.572TyrLys: 0.572 ± 0.018
2.713TyrLeu: 2.713 ± 0.039
0.503TyrMet: 0.503 ± 0.015
0.809TyrAsn: 0.809 ± 0.022
1.277TyrPro: 1.277 ± 0.032
1.116TyrGln: 1.116 ± 0.028
2.071TyrArg: 2.071 ± 0.034
1.339TyrSer: 1.339 ± 0.028
1.75TyrThr: 1.75 ± 0.033
1.789TyrVal: 1.789 ± 0.033
0.43TyrTrp: 0.43 ± 0.018
0.797TyrTyr: 0.797 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7836 proteins (1774083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski