Amino acid dipepetide frequency for Gramella salexigens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.586AlaAla: 4.586 ± 0.085	0.527AlaCys: 0.527 ± 0.027	3.579AlaAsp: 3.579 ± 0.125	4.683AlaGlu: 4.683 ± 0.09	3.023AlaPhe: 3.023 ± 0.071	4.774AlaGly: 4.774 ± 0.096	1.075AlaHis: 1.075 ± 0.039	5.176AlaIle: 5.176 ± 0.11	4.476AlaLys: 4.476 ± 0.086	5.79AlaLeu: 5.79 ± 0.099	1.581AlaMet: 1.581 ± 0.051	3.204AlaAsn: 3.204 ± 0.077	2.059AlaPro: 2.059 ± 0.08	2.23AlaGln: 2.23 ± 0.046	2.4AlaArg: 2.4 ± 0.053	4.293AlaSer: 4.293 ± 0.106	3.303AlaThr: 3.303 ± 0.106	4.225AlaVal: 4.225 ± 0.081	0.611AlaTrp: 0.611 ± 0.031	2.444AlaTyr: 2.444 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.387CysAla: 0.387 ± 0.028	0.079CysCys: 0.079 ± 0.009	0.458CysAsp: 0.458 ± 0.026	0.513CysGlu: 0.513 ± 0.031	0.359CysPhe: 0.359 ± 0.023	0.601CysGly: 0.601 ± 0.037	0.133CysHis: 0.133 ± 0.013	0.533CysIle: 0.533 ± 0.026	0.428CysLys: 0.428 ± 0.02	0.602CysLeu: 0.602 ± 0.026	0.133CysMet: 0.133 ± 0.011	0.366CysAsn: 0.366 ± 0.022	0.328CysPro: 0.328 ± 0.028	0.191CysGln: 0.191 ± 0.018	0.209CysArg: 0.209 ± 0.018	0.564CysSer: 0.564 ± 0.03	0.373CysThr: 0.373 ± 0.027	0.379CysVal: 0.379 ± 0.024	0.053CysTrp: 0.053 ± 0.007	0.252CysTyr: 0.252 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.824AspAla: 3.824 ± 0.132	0.403AspCys: 0.403 ± 0.028	3.151AspAsp: 3.151 ± 0.091	4.344AspGlu: 4.344 ± 0.078	3.796AspPhe: 3.796 ± 0.08	3.711AspGly: 3.711 ± 0.103	1.167AspHis: 1.167 ± 0.035	4.503AspIle: 4.503 ± 0.079	4.316AspLys: 4.316 ± 0.081	6.03AspLeu: 6.03 ± 0.083	1.179AspMet: 1.179 ± 0.031	3.146AspAsn: 3.146 ± 0.135	2.317AspPro: 2.317 ± 0.082	1.818AspGln: 1.818 ± 0.042	2.173AspArg: 2.173 ± 0.056	3.697AspSer: 3.697 ± 0.145	2.723AspThr: 2.723 ± 0.078	3.459AspVal: 3.459 ± 0.081	0.731AspTrp: 0.731 ± 0.03	2.968AspTyr: 2.968 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	4.897GluAla: 4.897 ± 0.092	0.347GluCys: 0.347 ± 0.025	4.487GluAsp: 4.487 ± 0.083	6.257GluGlu: 6.257 ± 0.115	3.483GluPhe: 3.483 ± 0.057	4.174GluGly: 4.174 ± 0.083	1.242GluHis: 1.242 ± 0.039	6.244GluIle: 6.244 ± 0.099	6.565GluLys: 6.565 ± 0.105	6.972GluLeu: 6.972 ± 0.105	1.834GluMet: 1.834 ± 0.057	5.116GluAsn: 5.116 ± 0.083	1.852GluPro: 1.852 ± 0.05	2.212GluGln: 2.212 ± 0.053	2.799GluArg: 2.799 ± 0.064	3.749GluSer: 3.749 ± 0.071	3.573GluThr: 3.573 ± 0.065	4.87GluVal: 4.87 ± 0.081	0.677GluTrp: 0.677 ± 0.03	2.727GluTyr: 2.727 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.902PheAla: 2.902 ± 0.058	0.385PheCys: 0.385 ± 0.021	3.219PheAsp: 3.219 ± 0.062	3.69PheGlu: 3.69 ± 0.066	2.597PhePhe: 2.597 ± 0.068	3.656PheGly: 3.656 ± 0.079	0.86PheHis: 0.86 ± 0.031	3.794PheIle: 3.794 ± 0.08	3.723PheLys: 3.723 ± 0.082	4.691PheLeu: 4.691 ± 0.09	1.114PheMet: 1.114 ± 0.037	3.104PheAsn: 3.104 ± 0.068	1.712PhePro: 1.712 ± 0.048	1.604PheGln: 1.604 ± 0.041	1.943PheArg: 1.943 ± 0.053	3.991PheSer: 3.991 ± 0.084	2.827PheThr: 2.827 ± 0.067	2.759PheVal: 2.759 ± 0.065	0.575PheTrp: 0.575 ± 0.028	2.013PheTyr: 2.013 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.234GlyAla: 4.234 ± 0.096	0.551GlyCys: 0.551 ± 0.033	3.966GlyAsp: 3.966 ± 0.108	4.41GlyGlu: 4.41 ± 0.074	3.677GlyPhe: 3.677 ± 0.075	4.728GlyGly: 4.728 ± 0.105	1.128GlyHis: 1.128 ± 0.04	5.514GlyIle: 5.514 ± 0.1	5.121GlyLys: 5.121 ± 0.093	5.962GlyLeu: 5.962 ± 0.096	1.729GlyMet: 1.729 ± 0.054	3.629GlyAsn: 3.629 ± 0.078	1.472GlyPro: 1.472 ± 0.047	1.845GlyGln: 1.845 ± 0.066	2.28GlyArg: 2.28 ± 0.055	4.271GlySer: 4.271 ± 0.092	3.868GlyThr: 3.868 ± 0.132	4.354GlyVal: 4.354 ± 0.085	0.75GlyTrp: 0.75 ± 0.03	2.704GlyTyr: 2.704 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.929HisAla: 0.929 ± 0.04	0.157HisCys: 0.157 ± 0.015	0.88HisAsp: 0.88 ± 0.034	1.132HisGlu: 1.132 ± 0.037	1.047HisPhe: 1.047 ± 0.034	1.102HisGly: 1.102 ± 0.034	0.457HisHis: 0.457 ± 0.024	1.281HisIle: 1.281 ± 0.044	1.21HisLys: 1.21 ± 0.038	1.739HisLeu: 1.739 ± 0.051	0.328HisMet: 0.328 ± 0.019	0.867HisAsn: 0.867 ± 0.033	0.945HisPro: 0.945 ± 0.036	0.633HisGln: 0.633 ± 0.029	0.761HisArg: 0.761 ± 0.027	1.161HisSer: 1.161 ± 0.034	0.852HisThr: 0.852 ± 0.035	0.846HisVal: 0.846 ± 0.034	0.204HisTrp: 0.204 ± 0.016	0.787HisTyr: 0.787 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.342IleAla: 5.342 ± 0.094	0.601IleCys: 0.601 ± 0.029	4.85IleAsp: 4.85 ± 0.102	5.35IleGlu: 5.35 ± 0.093	3.78IlePhe: 3.78 ± 0.084	5.141IleGly: 5.141 ± 0.082	1.307IleHis: 1.307 ± 0.038	5.723IleIle: 5.723 ± 0.115	5.544IleLys: 5.544 ± 0.099	7.219IleLeu: 7.219 ± 0.125	1.339IleMet: 1.339 ± 0.044	4.292IleAsn: 4.292 ± 0.078	3.289IlePro: 3.289 ± 0.063	2.533IleGln: 2.533 ± 0.055	2.866IleArg: 2.866 ± 0.058	5.927IleSer: 5.927 ± 0.106	4.372IleThr: 4.372 ± 0.159	4.164IleVal: 4.164 ± 0.081	0.747IleTrp: 0.747 ± 0.029	2.813IleTyr: 2.813 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	5.037LysAla: 5.037 ± 0.086	0.32LysCys: 0.32 ± 0.02	4.665LysAsp: 4.665 ± 0.095	6.446LysGlu: 6.446 ± 0.117	3.223LysPhe: 3.223 ± 0.067	4.297LysGly: 4.297 ± 0.076	1.262LysHis: 1.262 ± 0.041	5.968LysIle: 5.968 ± 0.088	6.771LysLys: 6.771 ± 0.123	7.045LysLeu: 7.045 ± 0.109	1.989LysMet: 1.989 ± 0.056	4.745LysAsn: 4.745 ± 0.08	2.585LysPro: 2.585 ± 0.052	2.382LysGln: 2.382 ± 0.057	3.012LysArg: 3.012 ± 0.069	4.485LysSer: 4.485 ± 0.082	4.034LysThr: 4.034 ± 0.077	4.487LysVal: 4.487 ± 0.077	0.743LysTrp: 0.743 ± 0.027	2.89LysTyr: 2.89 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.711LeuAla: 5.711 ± 0.103	0.637LeuCys: 0.637 ± 0.027	5.495LeuAsp: 5.495 ± 0.094	6.712LeuGlu: 6.712 ± 0.103	4.505LeuPhe: 4.505 ± 0.089	5.874LeuGly: 5.874 ± 0.096	1.498LeuHis: 1.498 ± 0.045	7.244LeuIle: 7.244 ± 0.135	8.176LeuLys: 8.176 ± 0.122	8.39LeuLeu: 8.39 ± 0.156	2.258LeuMet: 2.258 ± 0.06	5.601LeuAsn: 5.601 ± 0.091	3.443LeuPro: 3.443 ± 0.068	2.939LeuGln: 2.939 ± 0.059	3.626LeuArg: 3.626 ± 0.08	6.853LeuSer: 6.853 ± 0.093	4.605LeuThr: 4.605 ± 0.093	5.254LeuVal: 5.254 ± 0.09	0.831LeuTrp: 0.831 ± 0.035	3.084LeuTyr: 3.084 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	1.665MetAla: 1.665 ± 0.052	0.121MetCys: 0.121 ± 0.013	1.394MetAsp: 1.394 ± 0.036	1.665MetGlu: 1.665 ± 0.047	0.866MetPhe: 0.866 ± 0.032	1.497MetGly: 1.497 ± 0.054	0.373MetHis: 0.373 ± 0.021	1.626MetIle: 1.626 ± 0.046	2.232MetLys: 2.232 ± 0.06	2.012MetLeu: 2.012 ± 0.057	0.595MetMet: 0.595 ± 0.03	1.3MetAsn: 1.3 ± 0.039	0.823MetPro: 0.823 ± 0.032	0.844MetGln: 0.844 ± 0.035	0.949MetArg: 0.949 ± 0.033	1.379MetSer: 1.379 ± 0.042	1.008MetThr: 1.008 ± 0.038	1.375MetVal: 1.375 ± 0.042	0.143MetTrp: 0.143 ± 0.014	0.663MetTyr: 0.663 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.468AsnAla: 3.468 ± 0.072	0.47AsnCys: 0.47 ± 0.045	3.236AsnAsp: 3.236 ± 0.088	3.948AsnGlu: 3.948 ± 0.071	3.226AsnPhe: 3.226 ± 0.069	3.74AsnGly: 3.74 ± 0.097	0.949AsnHis: 0.949 ± 0.033	4.546AsnIle: 4.546 ± 0.078	3.918AsnLys: 3.918 ± 0.067	5.365AsnLeu: 5.365 ± 0.101	1.357AsnMet: 1.357 ± 0.042	3.225AsnAsn: 3.225 ± 0.075	2.64AsnPro: 2.64 ± 0.06	1.846AsnGln: 1.846 ± 0.045	2.288AsnArg: 2.288 ± 0.06	4.144AsnSer: 4.144 ± 0.076	3.048AsnThr: 3.048 ± 0.084	3.103AsnVal: 3.103 ± 0.114	0.771AsnTrp: 0.771 ± 0.032	2.769AsnTyr: 2.769 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	2.22ProAla: 2.22 ± 0.06	0.195ProCys: 0.195 ± 0.015	2.412ProAsp: 2.412 ± 0.078	3.639ProGlu: 3.639 ± 0.069	1.783ProPhe: 1.783 ± 0.05	2.373ProGly: 2.373 ± 0.058	0.618ProHis: 0.618 ± 0.029	2.28ProIle: 2.28 ± 0.05	2.335ProLys: 2.335 ± 0.048	2.913ProLeu: 2.913 ± 0.059	0.697ProMet: 0.697 ± 0.032	1.954ProAsn: 1.954 ± 0.053	0.83ProPro: 0.83 ± 0.033	1.196ProGln: 1.196 ± 0.033	1.029ProArg: 1.029 ± 0.035	2.173ProSer: 2.173 ± 0.062	1.68ProThr: 1.68 ± 0.056	3.024ProVal: 3.024 ± 0.083	0.32ProTrp: 0.32 ± 0.022	1.379ProTyr: 1.379 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.059GlnAla: 2.059 ± 0.06	0.136GlnCys: 0.136 ± 0.013	1.815GlnAsp: 1.815 ± 0.049	2.537GlnGlu: 2.537 ± 0.05	1.52GlnPhe: 1.52 ± 0.049	1.806GlnGly: 1.806 ± 0.054	0.545GlnHis: 0.545 ± 0.027	2.485GlnIle: 2.485 ± 0.05	2.677GlnLys: 2.677 ± 0.063	3.206GlnLeu: 3.206 ± 0.066	0.763GlnMet: 0.763 ± 0.032	2.126GlnAsn: 2.126 ± 0.051	1.069GlnPro: 1.069 ± 0.035	1.223GlnGln: 1.223 ± 0.043	1.331GlnArg: 1.331 ± 0.049	1.757GlnSer: 1.757 ± 0.046	1.736GlnThr: 1.736 ± 0.11	1.839GlnVal: 1.839 ± 0.046	0.317GlnTrp: 0.317 ± 0.02	1.124GlnTyr: 1.124 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.13ArgAla: 2.13 ± 0.05	0.195ArgCys: 0.195 ± 0.015	2.194ArgAsp: 2.194 ± 0.056	2.87ArgGlu: 2.87 ± 0.075	2.051ArgPhe: 2.051 ± 0.055	2.09ArgGly: 2.09 ± 0.057	0.725ArgHis: 0.725 ± 0.029	3.178ArgIle: 3.178 ± 0.066	3.247ArgLys: 3.247 ± 0.065	3.652ArgLeu: 3.652 ± 0.078	0.911ArgMet: 0.911 ± 0.029	2.481ArgAsn: 2.481 ± 0.062	1.181ArgPro: 1.181 ± 0.04	1.181ArgGln: 1.181 ± 0.045	1.509ArgArg: 1.509 ± 0.053	2.416ArgSer: 2.416 ± 0.055	1.888ArgThr: 1.888 ± 0.05	2.184ArgVal: 2.184 ± 0.064	0.41ArgTrp: 0.41 ± 0.021	1.546ArgTyr: 1.546 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.08SerAla: 4.08 ± 0.101	0.587SerCys: 0.587 ± 0.031	3.848SerAsp: 3.848 ± 0.102	4.898SerGlu: 4.898 ± 0.076	3.762SerPhe: 3.762 ± 0.07	5.11SerGly: 5.11 ± 0.132	1.112SerHis: 1.112 ± 0.036	5.14SerIle: 5.14 ± 0.118	4.63SerLys: 4.63 ± 0.089	6.35SerLeu: 6.35 ± 0.105	1.366SerMet: 1.366 ± 0.043	3.63SerAsn: 3.63 ± 0.065	2.142SerPro: 2.142 ± 0.049	2.128SerGln: 2.128 ± 0.055	2.655SerArg: 2.655 ± 0.053	4.341SerSer: 4.341 ± 0.086	3.27SerThr: 3.27 ± 0.06	4.137SerVal: 4.137 ± 0.089	0.71SerTrp: 0.71 ± 0.036	2.658SerTyr: 2.658 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.656ThrAla: 3.656 ± 0.142	0.376ThrCys: 0.376 ± 0.037	3.3ThrAsp: 3.3 ± 0.21	3.583ThrGlu: 3.583 ± 0.068	2.431ThrPhe: 2.431 ± 0.079	4.412ThrGly: 4.412 ± 0.077	0.904ThrHis: 0.904 ± 0.031	3.716ThrIle: 3.716 ± 0.103	3.124ThrLys: 3.124 ± 0.066	4.264ThrLeu: 4.264 ± 0.076	0.882ThrMet: 0.882 ± 0.035	2.76ThrAsn: 2.76 ± 0.071	2.362ThrPro: 2.362 ± 0.06	1.694ThrGln: 1.694 ± 0.079	1.912ThrArg: 1.912 ± 0.046	3.726ThrSer: 3.726 ± 0.079	2.826ThrThr: 2.826 ± 0.12	3.373ThrVal: 3.373 ± 0.183	0.493ThrTrp: 0.493 ± 0.028	2.259ThrTyr: 2.259 ± 0.089	0.0ThrXaa: 0.0 ± 0.0
Val	3.995ValAla: 3.995 ± 0.086	0.479ValCys: 0.479 ± 0.031	3.586ValAsp: 3.586 ± 0.076	4.207ValGlu: 4.207 ± 0.067	3.049ValPhe: 3.049 ± 0.062	3.815ValGly: 3.815 ± 0.09	0.989ValHis: 0.989 ± 0.036	4.94ValIle: 4.94 ± 0.085	4.236ValLys: 4.236 ± 0.078	5.71ValLeu: 5.71 ± 0.086	1.438ValMet: 1.438 ± 0.05	3.421ValAsn: 3.421 ± 0.091	2.188ValPro: 2.188 ± 0.057	1.855ValGln: 1.855 ± 0.053	2.09ValArg: 2.09 ± 0.052	4.174ValSer: 4.174 ± 0.074	3.419ValThr: 3.419 ± 0.181	3.85ValVal: 3.85 ± 0.081	0.523ValTrp: 0.523 ± 0.026	2.305ValTyr: 2.305 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.589TrpAla: 0.589 ± 0.029	0.077TrpCys: 0.077 ± 0.01	0.628TrpAsp: 0.628 ± 0.027	0.706TrpGlu: 0.706 ± 0.027	0.587TrpPhe: 0.587 ± 0.022	0.579TrpGly: 0.579 ± 0.026	0.214TrpHis: 0.214 ± 0.016	0.731TrpIle: 0.731 ± 0.03	0.863TrpLys: 0.863 ± 0.032	0.931TrpLeu: 0.931 ± 0.038	0.328TrpMet: 0.328 ± 0.019	0.68TrpAsn: 0.68 ± 0.026	0.275TrpPro: 0.275 ± 0.021	0.351TrpGln: 0.351 ± 0.018	0.425TrpArg: 0.425 ± 0.025	0.573TrpSer: 0.573 ± 0.025	0.494TrpThr: 0.494 ± 0.027	0.582TrpVal: 0.582 ± 0.032	0.147TrpTrp: 0.147 ± 0.013	0.467TrpTyr: 0.467 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.332TyrAla: 2.332 ± 0.068	0.3TyrCys: 0.3 ± 0.022	2.291TyrAsp: 2.291 ± 0.053	2.487TyrGlu: 2.487 ± 0.06	2.391TyrPhe: 2.391 ± 0.059	2.71TyrGly: 2.71 ± 0.084	0.761TyrHis: 0.761 ± 0.028	2.577TyrIle: 2.577 ± 0.051	2.793TyrLys: 2.793 ± 0.061	3.894TyrLeu: 3.894 ± 0.084	0.706TyrMet: 0.706 ± 0.031	2.41TyrAsn: 2.41 ± 0.063	1.54TyrPro: 1.54 ± 0.05	1.366TyrGln: 1.366 ± 0.04	1.786TyrArg: 1.786 ± 0.052	2.882TyrSer: 2.882 ± 0.073	2.153TyrThr: 2.153 ± 0.082	2.003TyrVal: 2.003 ± 0.054	0.472TyrTrp: 0.472 ± 0.022	1.797TyrTyr: 1.797 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2591 proteins (899170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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