Amino acid dipepetide frequency for Rubritalea squalenifaciens DSM 18772

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.331AlaAla: 8.331 ± 0.099	0.973AlaCys: 0.973 ± 0.03	4.954AlaAsp: 4.954 ± 0.071	5.938AlaGlu: 5.938 ± 0.093	3.207AlaPhe: 3.207 ± 0.055	6.757AlaGly: 6.757 ± 0.106	1.681AlaHis: 1.681 ± 0.035	4.963AlaIle: 4.963 ± 0.076	5.025AlaLys: 5.025 ± 0.083	8.58AlaLeu: 8.58 ± 0.104	2.19AlaMet: 2.19 ± 0.052	3.013AlaAsn: 3.013 ± 0.063	3.38AlaPro: 3.38 ± 0.063	2.951AlaGln: 2.951 ± 0.047	3.97AlaArg: 3.97 ± 0.065	5.69AlaSer: 5.69 ± 0.086	4.646AlaThr: 4.646 ± 0.072	5.589AlaVal: 5.589 ± 0.076	1.191AlaTrp: 1.191 ± 0.031	2.516AlaTyr: 2.516 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.85CysAla: 0.85 ± 0.026	0.205CysCys: 0.205 ± 0.014	0.604CysAsp: 0.604 ± 0.023	0.657CysGlu: 0.657 ± 0.026	0.404CysPhe: 0.404 ± 0.018	0.953CysGly: 0.953 ± 0.03	0.323CysHis: 0.323 ± 0.018	0.609CysIle: 0.609 ± 0.023	0.43CysLys: 0.43 ± 0.018	1.11CysLeu: 1.11 ± 0.033	0.265CysMet: 0.265 ± 0.014	0.275CysAsn: 0.275 ± 0.016	0.506CysPro: 0.506 ± 0.023	0.345CysGln: 0.345 ± 0.018	0.53CysArg: 0.53 ± 0.022	0.754CysSer: 0.754 ± 0.025	0.564CysThr: 0.564 ± 0.023	0.688CysVal: 0.688 ± 0.022	0.159CysTrp: 0.159 ± 0.011	0.336CysTyr: 0.336 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.827AspAla: 4.827 ± 0.075	0.524AspCys: 0.524 ± 0.022	3.212AspAsp: 3.212 ± 0.061	4.076AspGlu: 4.076 ± 0.066	2.658AspPhe: 2.658 ± 0.047	5.305AspGly: 5.305 ± 0.112	1.414AspHis: 1.414 ± 0.036	3.119AspIle: 3.119 ± 0.059	3.113AspLys: 3.113 ± 0.055	5.639AspLeu: 5.639 ± 0.069	1.209AspMet: 1.209 ± 0.03	1.985AspAsn: 1.985 ± 0.046	3.027AspPro: 3.027 ± 0.053	2.184AspGln: 2.184 ± 0.041	2.713AspArg: 2.713 ± 0.055	3.788AspSer: 3.788 ± 0.074	3.106AspThr: 3.106 ± 0.056	3.483AspVal: 3.483 ± 0.059	1.035AspTrp: 1.035 ± 0.03	2.192AspTyr: 2.192 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.963GluAla: 5.963 ± 0.09	0.55GluCys: 0.55 ± 0.02	3.764GluAsp: 3.764 ± 0.063	4.989GluGlu: 4.989 ± 0.09	2.398GluPhe: 2.398 ± 0.041	4.79GluGly: 4.79 ± 0.068	1.532GluHis: 1.532 ± 0.039	4.052GluIle: 4.052 ± 0.062	4.518GluLys: 4.518 ± 0.083	6.611GluLeu: 6.611 ± 0.09	1.84GluMet: 1.84 ± 0.051	2.74GluAsn: 2.74 ± 0.049	2.307GluPro: 2.307 ± 0.05	2.764GluGln: 2.764 ± 0.052	3.63GluArg: 3.63 ± 0.076	3.912GluSer: 3.912 ± 0.065	3.363GluThr: 3.363 ± 0.053	4.735GluVal: 4.735 ± 0.075	0.978GluTrp: 0.978 ± 0.026	1.942GluTyr: 1.942 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.042PheAla: 3.042 ± 0.051	0.534PheCys: 0.534 ± 0.022	2.513PheAsp: 2.513 ± 0.041	2.45PheGlu: 2.45 ± 0.044	1.61PhePhe: 1.61 ± 0.038	3.11PheGly: 3.11 ± 0.06	0.899PheHis: 0.899 ± 0.028	2.186PheIle: 2.186 ± 0.05	1.854PheLys: 1.854 ± 0.039	3.555PheLeu: 3.555 ± 0.064	0.875PheMet: 0.875 ± 0.025	1.435PheAsn: 1.435 ± 0.039	1.611PhePro: 1.611 ± 0.036	1.248PheGln: 1.248 ± 0.03	1.885PheArg: 1.885 ± 0.038	3.01PheSer: 3.01 ± 0.059	2.564PheThr: 2.564 ± 0.043	2.403PheVal: 2.403 ± 0.045	0.594PheTrp: 0.594 ± 0.022	1.381PheTyr: 1.381 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.969GlyAla: 5.969 ± 0.092	0.847GlyCys: 0.847 ± 0.031	4.584GlyAsp: 4.584 ± 0.069	4.927GlyGlu: 4.927 ± 0.071	3.181GlyPhe: 3.181 ± 0.05	6.431GlyGly: 6.431 ± 0.118	1.699GlyHis: 1.699 ± 0.036	4.36GlyIle: 4.36 ± 0.076	4.951GlyLys: 4.951 ± 0.079	6.864GlyLeu: 6.864 ± 0.079	1.963GlyMet: 1.963 ± 0.043	3.053GlyAsn: 3.053 ± 0.077	2.17GlyPro: 2.17 ± 0.044	2.588GlyGln: 2.588 ± 0.05	3.473GlyArg: 3.473 ± 0.05	5.462GlySer: 5.462 ± 0.124	4.511GlyThr: 4.511 ± 0.099	5.389GlyVal: 5.389 ± 0.086	1.284GlyTrp: 1.284 ± 0.034	2.64GlyTyr: 2.64 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.861HisAla: 1.861 ± 0.042	0.334HisCys: 0.334 ± 0.018	1.284HisAsp: 1.284 ± 0.035	1.309HisGlu: 1.309 ± 0.033	1.121HisPhe: 1.121 ± 0.03	1.865HisGly: 1.865 ± 0.041	0.695HisHis: 0.695 ± 0.028	1.226HisIle: 1.226 ± 0.036	1.003HisLys: 1.003 ± 0.03	2.35HisLeu: 2.35 ± 0.049	0.458HisMet: 0.458 ± 0.019	0.717HisAsn: 0.717 ± 0.022	1.277HisPro: 1.277 ± 0.036	0.866HisGln: 0.866 ± 0.026	1.216HisArg: 1.216 ± 0.034	1.405HisSer: 1.405 ± 0.037	1.196HisThr: 1.196 ± 0.032	1.356HisVal: 1.356 ± 0.037	0.368HisTrp: 0.368 ± 0.02	0.906HisTyr: 0.906 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.063IleAla: 5.063 ± 0.071	0.683IleCys: 0.683 ± 0.024	3.667IleAsp: 3.667 ± 0.056	3.675IleGlu: 3.675 ± 0.062	2.032IlePhe: 2.032 ± 0.042	4.077IleGly: 4.077 ± 0.068	1.346IleHis: 1.346 ± 0.037	3.18IleIle: 3.18 ± 0.059	2.737IleLys: 2.737 ± 0.055	5.237IleLeu: 5.237 ± 0.084	1.038IleMet: 1.038 ± 0.029	2.097IleAsn: 2.097 ± 0.048	2.935IlePro: 2.935 ± 0.054	1.999IleGln: 1.999 ± 0.044	2.944IleArg: 2.944 ± 0.054	4.112IleSer: 4.112 ± 0.066	3.719IleThr: 3.719 ± 0.065	3.461IleVal: 3.461 ± 0.056	0.65IleTrp: 0.65 ± 0.024	1.784IleTyr: 1.784 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.998LysAla: 4.998 ± 0.085	0.398LysCys: 0.398 ± 0.016	3.301LysAsp: 3.301 ± 0.054	4.069LysGlu: 4.069 ± 0.077	1.798LysPhe: 1.798 ± 0.041	3.773LysGly: 3.773 ± 0.062	1.381LysHis: 1.381 ± 0.035	3.045LysIle: 3.045 ± 0.048	3.924LysLys: 3.924 ± 0.095	5.658LysLeu: 5.658 ± 0.086	1.475LysMet: 1.475 ± 0.038	2.117LysAsn: 2.117 ± 0.047	2.742LysPro: 2.742 ± 0.057	2.293LysGln: 2.293 ± 0.05	3.01LysArg: 3.01 ± 0.059	3.311LysSer: 3.311 ± 0.052	2.972LysThr: 2.972 ± 0.043	3.968LysVal: 3.968 ± 0.075	0.879LysTrp: 0.879 ± 0.028	1.501LysTyr: 1.501 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.851LeuAla: 8.851 ± 0.091	1.159LeuCys: 1.159 ± 0.035	5.725LeuAsp: 5.725 ± 0.066	6.403LeuGlu: 6.403 ± 0.09	3.496LeuPhe: 3.496 ± 0.059	6.971LeuGly: 6.971 ± 0.084	2.035LeuHis: 2.035 ± 0.042	5.323LeuIle: 5.323 ± 0.077	5.575LeuLys: 5.575 ± 0.084	9.43LeuLeu: 9.43 ± 0.119	2.238LeuMet: 2.238 ± 0.046	3.616LeuAsn: 3.616 ± 0.058	4.849LeuPro: 4.849 ± 0.069	3.302LeuGln: 3.302 ± 0.053	5.01LeuArg: 5.01 ± 0.074	7.259LeuSer: 7.259 ± 0.091	5.794LeuThr: 5.794 ± 0.078	6.323LeuVal: 6.323 ± 0.077	1.169LeuTrp: 1.169 ± 0.031	2.629LeuTyr: 2.629 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.22MetAla: 2.22 ± 0.044	0.211MetCys: 0.211 ± 0.012	1.336MetAsp: 1.336 ± 0.034	1.573MetGlu: 1.573 ± 0.04	0.686MetPhe: 0.686 ± 0.024	1.649MetGly: 1.649 ± 0.033	0.493MetHis: 0.493 ± 0.022	1.273MetIle: 1.273 ± 0.034	1.809MetLys: 1.809 ± 0.044	2.259MetLeu: 2.259 ± 0.046	0.621MetMet: 0.621 ± 0.024	0.995MetAsn: 0.995 ± 0.027	1.192MetPro: 1.192 ± 0.032	0.855MetGln: 0.855 ± 0.028	1.468MetArg: 1.468 ± 0.036	1.582MetSer: 1.582 ± 0.035	1.296MetThr: 1.296 ± 0.032	1.511MetVal: 1.511 ± 0.036	0.233MetTrp: 0.233 ± 0.013	0.416MetTyr: 0.416 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.127AsnAla: 3.127 ± 0.05	0.31AsnCys: 0.31 ± 0.017	2.09AsnAsp: 2.09 ± 0.052	2.186AsnGlu: 2.186 ± 0.043	1.456AsnPhe: 1.456 ± 0.033	3.349AsnGly: 3.349 ± 0.084	0.933AsnHis: 0.933 ± 0.026	2.047AsnIle: 2.047 ± 0.045	1.909AsnLys: 1.909 ± 0.044	3.593AsnLeu: 3.593 ± 0.057	0.736AsnMet: 0.736 ± 0.022	1.546AsnAsn: 1.546 ± 0.051	2.27AsnPro: 2.27 ± 0.048	1.484AsnGln: 1.484 ± 0.035	1.843AsnArg: 1.843 ± 0.038	2.56AsnSer: 2.56 ± 0.064	2.2AsnThr: 2.2 ± 0.066	2.169AsnVal: 2.169 ± 0.043	0.602AsnTrp: 0.602 ± 0.021	1.248AsnTyr: 1.248 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.944ProAla: 3.944 ± 0.07	0.41ProCys: 0.41 ± 0.019	3.061ProAsp: 3.061 ± 0.052	4.171ProGlu: 4.171 ± 0.073	1.688ProPhe: 1.688 ± 0.037	3.236ProGly: 3.236 ± 0.057	1.027ProHis: 1.027 ± 0.031	2.094ProIle: 2.094 ± 0.043	2.43ProLys: 2.43 ± 0.053	3.936ProLeu: 3.936 ± 0.064	1.036ProMet: 1.036 ± 0.029	1.771ProAsn: 1.771 ± 0.039	1.649ProPro: 1.649 ± 0.042	1.616ProGln: 1.616 ± 0.039	1.852ProArg: 1.852 ± 0.043	3.178ProSer: 3.178 ± 0.058	2.348ProThr: 2.348 ± 0.044	3.329ProVal: 3.329 ± 0.061	0.588ProTrp: 0.588 ± 0.022	1.268ProTyr: 1.268 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.401GlnAla: 3.401 ± 0.047	0.292GlnCys: 0.292 ± 0.014	1.905GlnAsp: 1.905 ± 0.04	2.54GlnGlu: 2.54 ± 0.05	1.282GlnPhe: 1.282 ± 0.034	2.498GlnGly: 2.498 ± 0.046	0.816GlnHis: 0.816 ± 0.025	2.063GlnIle: 2.063 ± 0.038	2.07GlnLys: 2.07 ± 0.049	3.695GlnLeu: 3.695 ± 0.058	0.88GlnMet: 0.88 ± 0.024	1.321GlnAsn: 1.321 ± 0.032	1.586GlnPro: 1.586 ± 0.038	1.703GlnGln: 1.703 ± 0.047	2.012GlnArg: 2.012 ± 0.042	2.252GlnSer: 2.252 ± 0.046	1.914GlnThr: 1.914 ± 0.042	2.436GlnVal: 2.436 ± 0.042	0.665GlnTrp: 0.665 ± 0.025	1.051GlnTyr: 1.051 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.733ArgAla: 3.733 ± 0.065	0.489ArgCys: 0.489 ± 0.018	2.862ArgAsp: 2.862 ± 0.05	3.827ArgGlu: 3.827 ± 0.074	2.162ArgPhe: 2.162 ± 0.046	3.274ArgGly: 3.274 ± 0.057	1.113ArgHis: 1.113 ± 0.033	3.102ArgIle: 3.102 ± 0.045	3.145ArgLys: 3.145 ± 0.055	4.885ArgLeu: 4.885 ± 0.067	1.518ArgMet: 1.518 ± 0.038	1.95ArgAsn: 1.95 ± 0.04	1.976ArgPro: 1.976 ± 0.048	1.775ArgGln: 1.775 ± 0.037	3.061ArgArg: 3.061 ± 0.065	3.075ArgSer: 3.075 ± 0.048	2.409ArgThr: 2.409 ± 0.045	3.407ArgVal: 3.407 ± 0.059	0.767ArgTrp: 0.767 ± 0.025	1.778ArgTyr: 1.778 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.383SerAla: 5.383 ± 0.077	0.804SerCys: 0.804 ± 0.024	3.798SerAsp: 3.798 ± 0.076	4.138SerGlu: 4.138 ± 0.056	2.845SerPhe: 2.845 ± 0.06	5.885SerGly: 5.885 ± 0.121	1.494SerHis: 1.494 ± 0.034	3.958SerIle: 3.958 ± 0.062	3.545SerLys: 3.545 ± 0.056	6.859SerLeu: 6.859 ± 0.081	1.534SerMet: 1.534 ± 0.035	2.481SerAsn: 2.481 ± 0.055	3.235SerPro: 3.235 ± 0.06	2.392SerGln: 2.392 ± 0.049	3.119SerArg: 3.119 ± 0.05	5.192SerSer: 5.192 ± 0.106	3.943SerThr: 3.943 ± 0.074	4.329SerVal: 4.329 ± 0.065	1.031SerTrp: 1.031 ± 0.031	2.341SerTyr: 2.341 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.838ThrAla: 4.838 ± 0.088	0.493ThrCys: 0.493 ± 0.022	3.219ThrAsp: 3.219 ± 0.071	3.195ThrGlu: 3.195 ± 0.049	2.192ThrPhe: 2.192 ± 0.045	4.671ThrGly: 4.671 ± 0.081	1.267ThrHis: 1.267 ± 0.032	3.408ThrIle: 3.408 ± 0.075	2.651ThrLys: 2.651 ± 0.047	6.004ThrLeu: 6.004 ± 0.099	1.142ThrMet: 1.142 ± 0.03	2.114ThrAsn: 2.114 ± 0.053	3.143ThrPro: 3.143 ± 0.055	1.912ThrGln: 1.912 ± 0.042	2.454ThrArg: 2.454 ± 0.047	3.898ThrSer: 3.898 ± 0.084	3.454ThrThr: 3.454 ± 0.083	4.072ThrVal: 4.072 ± 0.089	0.819ThrTrp: 0.819 ± 0.029	1.804ThrTyr: 1.804 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	5.71ValAla: 5.71 ± 0.086	0.807ValCys: 0.807 ± 0.024	4.033ValAsp: 4.033 ± 0.067	4.44ValGlu: 4.44 ± 0.071	2.593ValPhe: 2.593 ± 0.054	4.4ValGly: 4.4 ± 0.068	1.371ValHis: 1.371 ± 0.034	4.1ValIle: 4.1 ± 0.06	3.531ValLys: 3.531 ± 0.066	6.17ValLeu: 6.17 ± 0.086	1.603ValMet: 1.603 ± 0.041	2.592ValAsn: 2.592 ± 0.056	2.857ValPro: 2.857 ± 0.05	2.068ValGln: 2.068 ± 0.042	3.363ValArg: 3.363 ± 0.056	4.792ValSer: 4.792 ± 0.061	4.173ValThr: 4.173 ± 0.083	4.691ValVal: 4.691 ± 0.084	0.869ValTrp: 0.869 ± 0.031	1.98ValTyr: 1.98 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.951TrpAla: 0.951 ± 0.032	0.185TrpCys: 0.185 ± 0.014	0.848TrpAsp: 0.848 ± 0.027	0.849TrpGlu: 0.849 ± 0.025	0.55TrpPhe: 0.55 ± 0.022	0.98TrpGly: 0.98 ± 0.034	0.426TrpHis: 0.426 ± 0.021	0.834TrpIle: 0.834 ± 0.027	0.974TrpLys: 0.974 ± 0.029	1.522TrpLeu: 1.522 ± 0.038	0.465TrpMet: 0.465 ± 0.017	0.708TrpAsn: 0.708 ± 0.025	0.48TrpPro: 0.48 ± 0.019	0.643TrpGln: 0.643 ± 0.023	0.813TrpArg: 0.813 ± 0.026	0.997TrpSer: 0.997 ± 0.032	0.735TrpThr: 0.735 ± 0.024	0.99TrpVal: 0.99 ± 0.029	0.264TrpTrp: 0.264 ± 0.015	0.405TrpTyr: 0.405 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.054	0.355TyrCys: 0.355 ± 0.019	1.849TyrAsp: 1.849 ± 0.047	1.97TyrGlu: 1.97 ± 0.039	1.403TyrPhe: 1.403 ± 0.036	2.371TyrGly: 2.371 ± 0.041	0.869TyrHis: 0.869 ± 0.03	1.492TyrIle: 1.492 ± 0.034	1.422TyrLys: 1.422 ± 0.039	3.202TyrLeu: 3.202 ± 0.052	0.592TyrMet: 0.592 ± 0.023	1.133TyrAsn: 1.133 ± 0.03	1.438TyrPro: 1.438 ± 0.036	1.392TyrGln: 1.392 ± 0.034	1.943TyrArg: 1.943 ± 0.041	2.075TyrSer: 2.075 ± 0.045	1.843TyrThr: 1.843 ± 0.044	1.815TyrVal: 1.815 ± 0.035	0.475TyrTrp: 0.475 ± 0.018	1.198TyrTyr: 1.198 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3805 proteins (1291566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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