Amino acid dipepetide frequency for Nostoc azollae (strain 0708) (Anabaena azollae (strain 0708))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.104AlaAla: 7.104 ± 0.117
0.846AlaCys: 0.846 ± 0.03
3.804AlaAsp: 3.804 ± 0.073
5.013AlaGlu: 5.013 ± 0.083
2.712AlaPhe: 2.712 ± 0.065
5.27AlaGly: 5.27 ± 0.087
1.271AlaHis: 1.271 ± 0.043
6.441AlaIle: 6.441 ± 0.088
4.204AlaLys: 4.204 ± 0.08
8.127AlaLeu: 8.127 ± 0.1
1.632AlaMet: 1.632 ± 0.05
3.362AlaAsn: 3.362 ± 0.075
2.608AlaPro: 2.608 ± 0.057
3.645AlaGln: 3.645 ± 0.075
3.274AlaArg: 3.274 ± 0.055
4.351AlaSer: 4.351 ± 0.067
4.423AlaThr: 4.423 ± 0.078
5.62AlaVal: 5.62 ± 0.085
0.955AlaTrp: 0.955 ± 0.036
2.252AlaTyr: 2.252 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.647CysAla: 0.647 ± 0.025
0.171CysCys: 0.171 ± 0.013
0.586CysAsp: 0.586 ± 0.023
0.541CysGlu: 0.541 ± 0.026
0.421CysPhe: 0.421 ± 0.022
0.8CysGly: 0.8 ± 0.037
0.29CysHis: 0.29 ± 0.019
0.638CysIle: 0.638 ± 0.025
0.38CysLys: 0.38 ± 0.019
1.252CysLeu: 1.252 ± 0.04
0.217CysMet: 0.217 ± 0.015
0.44CysAsn: 0.44 ± 0.024
0.592CysPro: 0.592 ± 0.024
0.647CysGln: 0.647 ± 0.03
0.507CysArg: 0.507 ± 0.023
0.715CysSer: 0.715 ± 0.033
0.509CysThr: 0.509 ± 0.024
0.589CysVal: 0.589 ± 0.026
0.155CysTrp: 0.155 ± 0.013
0.371CysTyr: 0.371 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.41AspAla: 3.41 ± 0.06
0.518AspCys: 0.518 ± 0.022
2.064AspAsp: 2.064 ± 0.06
2.735AspGlu: 2.735 ± 0.062
2.246AspPhe: 2.246 ± 0.055
3.028AspGly: 3.028 ± 0.066
0.893AspHis: 0.893 ± 0.033
3.705AspIle: 3.705 ± 0.067
2.389AspLys: 2.389 ± 0.046
5.606AspLeu: 5.606 ± 0.081
0.901AspMet: 0.901 ± 0.034
1.976AspAsn: 1.976 ± 0.048
2.119AspPro: 2.119 ± 0.052
1.838AspGln: 1.838 ± 0.049
2.501AspArg: 2.501 ± 0.055
2.786AspSer: 2.786 ± 0.056
2.414AspThr: 2.414 ± 0.053
2.911AspVal: 2.911 ± 0.059
0.824AspTrp: 0.824 ± 0.029
1.817AspTyr: 1.817 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.996GluAla: 4.996 ± 0.08
0.503GluCys: 0.503 ± 0.027
2.638GluAsp: 2.638 ± 0.059
4.171GluGlu: 4.171 ± 0.078
2.41GluPhe: 2.41 ± 0.054
3.24GluGly: 3.24 ± 0.063
1.046GluHis: 1.046 ± 0.035
5.31GluIle: 5.31 ± 0.093
3.761GluLys: 3.761 ± 0.068
7.093GluLeu: 7.093 ± 0.103
1.458GluMet: 1.458 ± 0.038
2.913GluAsn: 2.913 ± 0.063
2.269GluPro: 2.269 ± 0.05
3.267GluGln: 3.267 ± 0.064
3.3GluArg: 3.3 ± 0.059
3.241GluSer: 3.241 ± 0.066
3.596GluThr: 3.596 ± 0.069
4.516GluVal: 4.516 ± 0.08
0.746GluTrp: 0.746 ± 0.028
1.878GluTyr: 1.878 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
2.817PheAla: 2.817 ± 0.055
0.555PheCys: 0.555 ± 0.026
2.118PheAsp: 2.118 ± 0.045
1.916PheGlu: 1.916 ± 0.049
1.556PhePhe: 1.556 ± 0.047
2.891PheGly: 2.891 ± 0.067
0.876PheHis: 0.876 ± 0.024
2.557PheIle: 2.557 ± 0.062
1.588PheLys: 1.588 ± 0.041
4.245PheLeu: 4.245 ± 0.088
0.837PheMet: 0.837 ± 0.03
1.76PheAsn: 1.76 ± 0.049
1.888PhePro: 1.888 ± 0.043
1.69PheGln: 1.69 ± 0.039
1.744PheArg: 1.744 ± 0.041
2.95PheSer: 2.95 ± 0.065
2.382PheThr: 2.382 ± 0.05
2.276PheVal: 2.276 ± 0.05
0.709PheTrp: 0.709 ± 0.03
1.263PheTyr: 1.263 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.696GlyAla: 4.696 ± 0.092
0.86GlyCys: 0.86 ± 0.031
3.253GlyAsp: 3.253 ± 0.057
4.046GlyGlu: 4.046 ± 0.065
2.886GlyPhe: 2.886 ± 0.056
4.754GlyGly: 4.754 ± 0.101
1.284GlyHis: 1.284 ± 0.039
5.563GlyIle: 5.563 ± 0.087
4.339GlyLys: 4.339 ± 0.077
7.05GlyLeu: 7.05 ± 0.106
1.603GlyMet: 1.603 ± 0.051
2.893GlyAsn: 2.893 ± 0.06
1.38GlyPro: 1.38 ± 0.043
2.787GlyGln: 2.787 ± 0.061
3.187GlyArg: 3.187 ± 0.065
3.993GlySer: 3.993 ± 0.071
3.79GlyThr: 3.79 ± 0.066
5.026GlyVal: 5.026 ± 0.078
1.101GlyTrp: 1.101 ± 0.035
2.385GlyTyr: 2.385 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.067HisAla: 1.067 ± 0.042
0.263HisCys: 0.263 ± 0.017
0.775HisAsp: 0.775 ± 0.028
0.93HisGlu: 0.93 ± 0.036
0.937HisPhe: 0.937 ± 0.031
1.165HisGly: 1.165 ± 0.034
0.647HisHis: 0.647 ± 0.033
1.343HisIle: 1.343 ± 0.039
0.836HisLys: 0.836 ± 0.03
2.445HisLeu: 2.445 ± 0.061
0.281HisMet: 0.281 ± 0.018
0.842HisAsn: 0.842 ± 0.031
1.362HisPro: 1.362 ± 0.038
1.255HisGln: 1.255 ± 0.041
1.165HisArg: 1.165 ± 0.038
1.223HisSer: 1.223 ± 0.039
1.038HisThr: 1.038 ± 0.033
0.939HisVal: 0.939 ± 0.038
0.338HisTrp: 0.338 ± 0.021
0.699HisTyr: 0.699 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.68IleAla: 6.68 ± 0.088
0.848IleCys: 0.848 ± 0.033
3.682IleAsp: 3.682 ± 0.071
4.211IleGlu: 4.211 ± 0.086
2.987IlePhe: 2.987 ± 0.064
4.878IleGly: 4.878 ± 0.074
1.397IleHis: 1.397 ± 0.04
4.531IleIle: 4.531 ± 0.083
3.372IleLys: 3.372 ± 0.064
7.59IleLeu: 7.59 ± 0.086
1.142IleMet: 1.142 ± 0.039
3.439IleAsn: 3.439 ± 0.069
3.909IlePro: 3.909 ± 0.073
3.244IleGln: 3.244 ± 0.069
3.18IleArg: 3.18 ± 0.064
5.077IleSer: 5.077 ± 0.088
4.43IleThr: 4.43 ± 0.083
4.407IleVal: 4.407 ± 0.068
0.944IleTrp: 0.944 ± 0.036
2.205IleTyr: 2.205 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
3.87LysAla: 3.87 ± 0.082
0.351LysCys: 0.351 ± 0.02
2.172LysAsp: 2.172 ± 0.056
2.962LysGlu: 2.962 ± 0.06
1.887LysPhe: 1.887 ± 0.041
2.9LysGly: 2.9 ± 0.063
0.846LysHis: 0.846 ± 0.03
4.055LysIle: 4.055 ± 0.071
2.455LysLys: 2.455 ± 0.059
5.892LysLeu: 5.892 ± 0.087
1.108LysMet: 1.108 ± 0.035
2.239LysAsn: 2.239 ± 0.05
2.597LysPro: 2.597 ± 0.056
2.666LysGln: 2.666 ± 0.049
2.42LysArg: 2.42 ± 0.059
3.245LysSer: 3.245 ± 0.061
3.022LysThr: 3.022 ± 0.059
3.427LysVal: 3.427 ± 0.067
0.571LysTrp: 0.571 ± 0.028
1.598LysTyr: 1.598 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
9.222LeuAla: 9.222 ± 0.106
1.039LeuCys: 1.039 ± 0.035
5.088LeuAsp: 5.088 ± 0.074
7.563LeuGlu: 7.563 ± 0.108
3.786LeuPhe: 3.786 ± 0.076
8.102LeuGly: 8.102 ± 0.099
2.053LeuHis: 2.053 ± 0.052
7.292LeuIle: 7.292 ± 0.09
5.518LeuLys: 5.518 ± 0.092
11.695LeuLeu: 11.695 ± 0.14
2.333LeuMet: 2.333 ± 0.057
4.634LeuAsn: 4.634 ± 0.076
5.805LeuPro: 5.805 ± 0.099
5.931LeuGln: 5.931 ± 0.084
5.443LeuArg: 5.443 ± 0.08
7.384LeuSer: 7.384 ± 0.099
6.687LeuThr: 6.687 ± 0.092
7.561LeuVal: 7.561 ± 0.09
1.367LeuTrp: 1.367 ± 0.041
2.658LeuTyr: 2.658 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.795MetAla: 1.795 ± 0.048
0.17MetCys: 0.17 ± 0.013
0.792MetAsp: 0.792 ± 0.031
1.165MetGlu: 1.165 ± 0.034
0.639MetPhe: 0.639 ± 0.027
1.529MetGly: 1.529 ± 0.046
0.291MetHis: 0.291 ± 0.016
1.386MetIle: 1.386 ± 0.042
1.018MetLys: 1.018 ± 0.032
2.234MetLeu: 2.234 ± 0.057
0.53MetMet: 0.53 ± 0.029
0.957MetAsn: 0.957 ± 0.036
0.961MetPro: 0.961 ± 0.038
0.964MetGln: 0.964 ± 0.033
1.043MetArg: 1.043 ± 0.034
1.435MetSer: 1.435 ± 0.04
1.432MetThr: 1.432 ± 0.036
1.471MetVal: 1.471 ± 0.041
0.165MetTrp: 0.165 ± 0.012
0.427MetTyr: 0.427 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.784AsnAla: 2.784 ± 0.061
0.527AsnCys: 0.527 ± 0.022
1.568AsnAsp: 1.568 ± 0.044
1.9AsnGlu: 1.9 ± 0.049
1.966AsnPhe: 1.966 ± 0.045
2.469AsnGly: 2.469 ± 0.054
1.058AsnHis: 1.058 ± 0.039
3.211AsnIle: 3.211 ± 0.06
1.96AsnLys: 1.96 ± 0.049
5.598AsnLeu: 5.598 ± 0.101
0.79AsnMet: 0.79 ± 0.031
2.126AsnAsn: 2.126 ± 0.054
2.767AsnPro: 2.767 ± 0.054
2.771AsnGln: 2.771 ± 0.068
2.341AsnArg: 2.341 ± 0.054
3.149AsnSer: 3.149 ± 0.068
2.496AsnThr: 2.496 ± 0.05
2.295AsnVal: 2.295 ± 0.049
0.737AsnTrp: 0.737 ± 0.027
1.644AsnTyr: 1.644 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
3.089ProAla: 3.089 ± 0.063
0.372ProCys: 0.372 ± 0.019
2.687ProAsp: 2.687 ± 0.052
3.81ProGlu: 3.81 ± 0.063
1.599ProPhe: 1.599 ± 0.042
3.17ProGly: 3.17 ± 0.067
1.0ProHis: 1.0 ± 0.032
3.33ProIle: 3.33 ± 0.063
2.239ProLys: 2.239 ± 0.045
4.613ProLeu: 4.613 ± 0.073
0.788ProMet: 0.788 ± 0.028
2.204ProAsn: 2.204 ± 0.059
2.204ProPro: 2.204 ± 0.058
2.513ProGln: 2.513 ± 0.056
1.756ProArg: 1.756 ± 0.047
2.781ProSer: 2.781 ± 0.06
3.006ProThr: 3.006 ± 0.065
3.309ProVal: 3.309 ± 0.066
0.668ProTrp: 0.668 ± 0.031
1.414ProTyr: 1.414 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
4.456GlnAla: 4.456 ± 0.082
0.398GlnCys: 0.398 ± 0.021
2.014GlnAsp: 2.014 ± 0.047
3.821GlnGlu: 3.821 ± 0.078
1.616GlnPhe: 1.616 ± 0.04
3.189GlnGly: 3.189 ± 0.061
0.909GlnHis: 0.909 ± 0.034
3.772GlnIle: 3.772 ± 0.07
2.935GlnLys: 2.935 ± 0.066
5.765GlnLeu: 5.765 ± 0.093
1.106GlnMet: 1.106 ± 0.031
2.128GlnAsn: 2.128 ± 0.042
2.574GlnPro: 2.574 ± 0.05
3.497GlnGln: 3.497 ± 0.084
2.703GlnArg: 2.703 ± 0.062
2.783GlnSer: 2.783 ± 0.063
2.906GlnThr: 2.906 ± 0.059
3.925GlnVal: 3.925 ± 0.07
0.643GlnTrp: 0.643 ± 0.026
1.26GlnTyr: 1.26 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.984ArgAla: 2.984 ± 0.06
0.51ArgCys: 0.51 ± 0.022
2.364ArgAsp: 2.364 ± 0.053
3.295ArgGlu: 3.295 ± 0.068
1.958ArgPhe: 1.958 ± 0.046
2.849ArgGly: 2.849 ± 0.054
0.96ArgHis: 0.96 ± 0.033
3.422ArgIle: 3.422 ± 0.058
2.389ArgLys: 2.389 ± 0.053
5.623ArgLeu: 5.623 ± 0.081
1.086ArgMet: 1.086 ± 0.03
2.208ArgAsn: 2.208 ± 0.052
1.966ArgPro: 1.966 ± 0.047
2.97ArgGln: 2.97 ± 0.066
2.915ArgArg: 2.915 ± 0.064
3.033ArgSer: 3.033 ± 0.053
2.513ArgThr: 2.513 ± 0.049
3.291ArgVal: 3.291 ± 0.072
0.707ArgTrp: 0.707 ± 0.033
1.781ArgTyr: 1.781 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.203SerAla: 4.203 ± 0.079
0.703SerCys: 0.703 ± 0.028
2.819SerAsp: 2.819 ± 0.057
3.705SerGlu: 3.705 ± 0.067
2.4SerPhe: 2.4 ± 0.049
4.535SerGly: 4.535 ± 0.072
1.357SerHis: 1.357 ± 0.037
4.083SerIle: 4.083 ± 0.078
2.753SerLys: 2.753 ± 0.05
7.588SerLeu: 7.588 ± 0.101
1.325SerMet: 1.325 ± 0.037
2.641SerAsn: 2.641 ± 0.052
3.284SerPro: 3.284 ± 0.06
3.687SerGln: 3.687 ± 0.065
3.163SerArg: 3.163 ± 0.054
4.377SerSer: 4.377 ± 0.086
3.589SerThr: 3.589 ± 0.066
4.014SerVal: 4.014 ± 0.078
0.915SerTrp: 0.915 ± 0.031
1.968SerTyr: 1.968 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.858ThrAla: 4.858 ± 0.079
0.507ThrCys: 0.507 ± 0.024
2.91ThrAsp: 2.91 ± 0.07
3.5ThrGlu: 3.5 ± 0.06
2.13ThrPhe: 2.13 ± 0.045
4.442ThrGly: 4.442 ± 0.069
1.055ThrHis: 1.055 ± 0.039
3.855ThrIle: 3.855 ± 0.068
2.651ThrLys: 2.651 ± 0.053
6.263ThrLeu: 6.263 ± 0.083
0.909ThrMet: 0.909 ± 0.033
2.449ThrAsn: 2.449 ± 0.055
3.507ThrPro: 3.507 ± 0.065
2.941ThrGln: 2.941 ± 0.068
2.384ThrArg: 2.384 ± 0.045
3.538ThrSer: 3.538 ± 0.065
3.575ThrThr: 3.575 ± 0.071
4.075ThrVal: 4.075 ± 0.06
0.68ThrTrp: 0.68 ± 0.032
1.638ThrTyr: 1.638 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
5.498ValAla: 5.498 ± 0.085
0.718ValCys: 0.718 ± 0.027
3.397ValAsp: 3.397 ± 0.065
4.43ValGlu: 4.43 ± 0.078
2.575ValPhe: 2.575 ± 0.055
4.672ValGly: 4.672 ± 0.068
1.138ValHis: 1.138 ± 0.035
4.96ValIle: 4.96 ± 0.082
3.596ValLys: 3.596 ± 0.064
6.918ValLeu: 6.918 ± 0.091
1.501ValMet: 1.501 ± 0.039
3.056ValAsn: 3.056 ± 0.055
2.814ValPro: 2.814 ± 0.059
2.841ValGln: 2.841 ± 0.063
3.234ValArg: 3.234 ± 0.067
4.28ValSer: 4.28 ± 0.076
3.951ValThr: 3.951 ± 0.062
4.871ValVal: 4.871 ± 0.071
0.819ValTrp: 0.819 ± 0.028
1.862ValTyr: 1.862 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.765TrpAla: 0.765 ± 0.031
0.169TrpCys: 0.169 ± 0.013
0.584TrpAsp: 0.584 ± 0.027
0.98TrpGlu: 0.98 ± 0.036
0.646TrpPhe: 0.646 ± 0.03
0.952TrpGly: 0.952 ± 0.035
0.364TrpHis: 0.364 ± 0.022
0.848TrpIle: 0.848 ± 0.035
0.592TrpLys: 0.592 ± 0.027
1.808TrpLeu: 1.808 ± 0.05
0.325TrpMet: 0.325 ± 0.018
0.592TrpAsn: 0.592 ± 0.024
0.302TrpPro: 0.302 ± 0.02
1.165TrpGln: 1.165 ± 0.039
0.738TrpArg: 0.738 ± 0.027
0.757TrpSer: 0.757 ± 0.033
0.566TrpThr: 0.566 ± 0.025
0.997TrpVal: 0.997 ± 0.034
0.226TrpTrp: 0.226 ± 0.016
0.414TrpTyr: 0.414 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.976TyrAla: 1.976 ± 0.049
0.441TyrCys: 0.441 ± 0.023
1.363TyrAsp: 1.363 ± 0.038
1.66TyrGlu: 1.66 ± 0.05
1.26TyrPhe: 1.26 ± 0.037
2.039TyrGly: 2.039 ± 0.049
0.815TyrHis: 0.815 ± 0.029
1.852TyrIle: 1.852 ± 0.051
1.309TyrLys: 1.309 ± 0.039
3.755TyrLeu: 3.755 ± 0.067
0.532TyrMet: 0.532 ± 0.025
1.3TyrAsn: 1.3 ± 0.036
1.645TyrPro: 1.645 ± 0.05
2.079TyrGln: 2.079 ± 0.048
1.823TyrArg: 1.823 ± 0.047
2.012TyrSer: 2.012 ± 0.051
1.541TyrThr: 1.541 ± 0.045
1.613TyrVal: 1.613 ± 0.038
0.52TyrTrp: 0.52 ± 0.023
1.187TyrTyr: 1.187 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3646 proteins (942988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski