Amino acid dipepetide frequency for Butyrivibrio sp. M55

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.079AlaAla: 6.079 ± 0.105	0.984AlaCys: 0.984 ± 0.029	4.887AlaAsp: 4.887 ± 0.081	5.378AlaGlu: 5.378 ± 0.075	3.095AlaPhe: 3.095 ± 0.058	5.461AlaGly: 5.461 ± 0.076	0.987AlaHis: 0.987 ± 0.028	5.449AlaIle: 5.449 ± 0.085	5.147AlaLys: 5.147 ± 0.08	6.483AlaLeu: 6.483 ± 0.091	2.222AlaMet: 2.222 ± 0.051	2.94AlaAsn: 2.94 ± 0.053	1.888AlaPro: 1.888 ± 0.047	1.945AlaGln: 1.945 ± 0.047	2.578AlaArg: 2.578 ± 0.048	4.486AlaSer: 4.486 ± 0.07	3.514AlaThr: 3.514 ± 0.067	5.614AlaVal: 5.614 ± 0.088	0.537AlaTrp: 0.537 ± 0.023	2.723AlaTyr: 2.723 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.032	0.237CysCys: 0.237 ± 0.017	0.975CysAsp: 0.975 ± 0.033	0.9CysGlu: 0.9 ± 0.033	0.647CysPhe: 0.647 ± 0.026	1.385CysGly: 1.385 ± 0.044	0.23CysHis: 0.23 ± 0.014	1.126CysIle: 1.126 ± 0.034	0.908CysLys: 0.908 ± 0.03	1.0CysLeu: 1.0 ± 0.026	0.426CysMet: 0.426 ± 0.022	0.618CysAsn: 0.618 ± 0.024	0.517CysPro: 0.517 ± 0.021	0.273CysGln: 0.273 ± 0.015	0.533CysArg: 0.533 ± 0.025	0.831CysSer: 0.831 ± 0.027	0.66CysThr: 0.66 ± 0.029	0.98CysVal: 0.98 ± 0.03	0.105CysTrp: 0.105 ± 0.01	0.578CysTyr: 0.578 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.845AspAla: 4.845 ± 0.075	0.735AspCys: 0.735 ± 0.026	4.165AspAsp: 4.165 ± 0.072	5.743AspGlu: 5.743 ± 0.072	2.992AspPhe: 2.992 ± 0.055	4.709AspGly: 4.709 ± 0.085	0.843AspHis: 0.843 ± 0.026	5.633AspIle: 5.633 ± 0.062	5.189AspLys: 5.189 ± 0.075	4.438AspLeu: 4.438 ± 0.068	1.987AspMet: 1.987 ± 0.041	3.27AspAsn: 3.27 ± 0.073	1.837AspPro: 1.837 ± 0.041	1.134AspGln: 1.134 ± 0.035	2.586AspArg: 2.586 ± 0.058	3.831AspSer: 3.831 ± 0.069	3.095AspThr: 3.095 ± 0.061	4.418AspVal: 4.418 ± 0.072	0.556AspTrp: 0.556 ± 0.021	3.27AspTyr: 3.27 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	5.409GluAla: 5.409 ± 0.088	0.829GluCys: 0.829 ± 0.025	4.69GluAsp: 4.69 ± 0.082	6.507GluGlu: 6.507 ± 0.116	2.897GluPhe: 2.897 ± 0.053	4.271GluGly: 4.271 ± 0.071	1.231GluHis: 1.231 ± 0.035	5.647GluIle: 5.647 ± 0.078	7.095GluLys: 7.095 ± 0.085	6.627GluLeu: 6.627 ± 0.085	2.214GluMet: 2.214 ± 0.045	4.365GluAsn: 4.365 ± 0.072	1.726GluPro: 1.726 ± 0.042	2.342GluGln: 2.342 ± 0.091	2.993GluArg: 2.993 ± 0.117	3.721GluSer: 3.721 ± 0.066	3.428GluThr: 3.428 ± 0.055	4.382GluVal: 4.382 ± 0.072	0.63GluTrp: 0.63 ± 0.02	3.525GluTyr: 3.525 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.095PheAla: 3.095 ± 0.057	0.721PheCys: 0.721 ± 0.027	3.1PheAsp: 3.1 ± 0.051	2.844PheGlu: 2.844 ± 0.051	2.31PhePhe: 2.31 ± 0.061	3.191PheGly: 3.191 ± 0.059	0.637PheHis: 0.637 ± 0.023	3.447PheIle: 3.447 ± 0.064	2.683PheLys: 2.683 ± 0.048	3.825PheLeu: 3.825 ± 0.066	1.359PheMet: 1.359 ± 0.037	1.835PheAsn: 1.835 ± 0.043	1.325PhePro: 1.325 ± 0.037	0.838PheGln: 0.838 ± 0.025	1.526PheArg: 1.526 ± 0.035	3.097PheSer: 3.097 ± 0.058	2.331PheThr: 2.331 ± 0.046	3.231PheVal: 3.231 ± 0.062	0.429PheTrp: 0.429 ± 0.021	1.915PheTyr: 1.915 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.807GlyAla: 4.807 ± 0.076	1.186GlyCys: 1.186 ± 0.035	4.032GlyAsp: 4.032 ± 0.071	4.481GlyGlu: 4.481 ± 0.065	3.22GlyPhe: 3.22 ± 0.057	4.391GlyGly: 4.391 ± 0.077	1.108GlyHis: 1.108 ± 0.032	6.099GlyIle: 6.099 ± 0.08	5.797GlyLys: 5.797 ± 0.083	5.343GlyLeu: 5.343 ± 0.072	2.198GlyMet: 2.198 ± 0.046	3.476GlyAsn: 3.476 ± 0.059	1.225GlyPro: 1.225 ± 0.037	1.663GlyGln: 1.663 ± 0.042	2.705GlyArg: 2.705 ± 0.056	4.006GlySer: 4.006 ± 0.067	3.836GlyThr: 3.836 ± 0.064	4.867GlyVal: 4.867 ± 0.073	0.575GlyTrp: 0.575 ± 0.025	3.414GlyTyr: 3.414 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.926HisAla: 0.926 ± 0.028	0.258HisCys: 0.258 ± 0.016	0.968HisAsp: 0.968 ± 0.026	1.007HisGlu: 1.007 ± 0.032	0.722HisPhe: 0.722 ± 0.027	1.151HisGly: 1.151 ± 0.035	0.317HisHis: 0.317 ± 0.025	1.29HisIle: 1.29 ± 0.03	0.993HisLys: 0.993 ± 0.032	1.162HisLeu: 1.162 ± 0.033	0.504HisMet: 0.504 ± 0.021	0.786HisAsn: 0.786 ± 0.028	0.71HisPro: 0.71 ± 0.026	0.378HisGln: 0.378 ± 0.021	0.63HisArg: 0.63 ± 0.024	0.891HisSer: 0.891 ± 0.028	0.754HisThr: 0.754 ± 0.026	1.013HisVal: 1.013 ± 0.031	0.119HisTrp: 0.119 ± 0.01	0.691HisTyr: 0.691 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.131IleAla: 6.131 ± 0.079	1.359IleCys: 1.359 ± 0.031	5.209IleAsp: 5.209 ± 0.068	5.334IleGlu: 5.334 ± 0.07	3.167IlePhe: 3.167 ± 0.063	5.172IleGly: 5.172 ± 0.082	1.172IleHis: 1.172 ± 0.034	6.152IleIle: 6.152 ± 0.087	5.627IleLys: 5.627 ± 0.078	6.547IleLeu: 6.547 ± 0.092	2.162IleMet: 2.162 ± 0.046	3.658IleAsn: 3.658 ± 0.062	2.937IlePro: 2.937 ± 0.052	1.79IleGln: 1.79 ± 0.039	3.241IleArg: 3.241 ± 0.056	5.505IleSer: 5.505 ± 0.071	4.434IleThr: 4.434 ± 0.063	5.476IleVal: 5.476 ± 0.077	0.571IleTrp: 0.571 ± 0.022	3.14IleTyr: 3.14 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.418LysAla: 5.418 ± 0.083	0.842LysCys: 0.842 ± 0.03	5.168LysAsp: 5.168 ± 0.067	7.258LysGlu: 7.258 ± 0.095	2.57LysPhe: 2.57 ± 0.049	4.412LysGly: 4.412 ± 0.066	1.087LysHis: 1.087 ± 0.03	5.552LysIle: 5.552 ± 0.069	7.282LysLys: 7.282 ± 0.086	5.951LysLeu: 5.951 ± 0.072	2.277LysMet: 2.277 ± 0.04	4.345LysAsn: 4.345 ± 0.061	1.975LysPro: 1.975 ± 0.046	2.028LysGln: 2.028 ± 0.052	3.143LysArg: 3.143 ± 0.056	4.063LysSer: 4.063 ± 0.061	3.934LysThr: 3.934 ± 0.068	4.869LysVal: 4.869 ± 0.076	0.684LysTrp: 0.684 ± 0.028	3.482LysTyr: 3.482 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	5.922LeuAla: 5.922 ± 0.076	1.303LeuCys: 1.303 ± 0.04	5.069LeuAsp: 5.069 ± 0.077	5.388LeuGlu: 5.388 ± 0.085	3.887LeuPhe: 3.887 ± 0.07	5.563LeuGly: 5.563 ± 0.07	1.299LeuHis: 1.299 ± 0.039	6.161LeuIle: 6.161 ± 0.104	6.271LeuLys: 6.271 ± 0.083	7.228LeuLeu: 7.228 ± 0.111	2.496LeuMet: 2.496 ± 0.055	3.842LeuAsn: 3.842 ± 0.063	2.818LeuPro: 2.818 ± 0.058	2.109LeuGln: 2.109 ± 0.05	3.24LeuArg: 3.24 ± 0.056	6.339LeuSer: 6.339 ± 0.084	4.442LeuThr: 4.442 ± 0.074	5.213LeuVal: 5.213 ± 0.074	0.64LeuTrp: 0.64 ± 0.03	3.233LeuTyr: 3.233 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.251MetAla: 2.251 ± 0.043	0.392MetCys: 0.392 ± 0.019	1.872MetAsp: 1.872 ± 0.038	1.972MetGlu: 1.972 ± 0.045	1.108MetPhe: 1.108 ± 0.034	1.967MetGly: 1.967 ± 0.048	0.485MetHis: 0.485 ± 0.021	2.364MetIle: 2.364 ± 0.051	2.279MetLys: 2.279 ± 0.04	2.589MetLeu: 2.589 ± 0.06	0.918MetMet: 0.918 ± 0.03	1.682MetAsn: 1.682 ± 0.037	1.04MetPro: 1.04 ± 0.031	0.947MetGln: 0.947 ± 0.031	1.208MetArg: 1.208 ± 0.038	1.994MetSer: 1.994 ± 0.041	1.631MetThr: 1.631 ± 0.04	1.904MetVal: 1.904 ± 0.039	0.225MetTrp: 0.225 ± 0.013	1.019MetTyr: 1.019 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.511AsnAla: 3.511 ± 0.066	0.641AsnCys: 0.641 ± 0.024	2.939AsnAsp: 2.939 ± 0.054	3.352AsnGlu: 3.352 ± 0.056	1.814AsnPhe: 1.814 ± 0.046	3.754AsnGly: 3.754 ± 0.072	0.741AsnHis: 0.741 ± 0.026	4.223AsnIle: 4.223 ± 0.059	3.45AsnLys: 3.45 ± 0.066	3.826AsnLeu: 3.826 ± 0.065	1.57AsnMet: 1.57 ± 0.036	2.68AsnAsn: 2.68 ± 0.075	1.993AsnPro: 1.993 ± 0.05	1.146AsnGln: 1.146 ± 0.038	1.989AsnArg: 1.989 ± 0.045	2.943AsnSer: 2.943 ± 0.055	2.555AsnThr: 2.555 ± 0.049	3.439AsnVal: 3.439 ± 0.058	0.431AsnTrp: 0.431 ± 0.023	2.163AsnTyr: 2.163 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.047ProAla: 2.047 ± 0.045	0.368ProCys: 0.368 ± 0.021	2.366ProAsp: 2.366 ± 0.052	2.833ProGlu: 2.833 ± 0.06	1.495ProPhe: 1.495 ± 0.036	2.03ProGly: 2.03 ± 0.051	0.462ProHis: 0.462 ± 0.02	2.15ProIle: 2.15 ± 0.045	1.949ProLys: 1.949 ± 0.046	2.34ProLeu: 2.34 ± 0.052	0.825ProMet: 0.825 ± 0.025	1.266ProAsn: 1.266 ± 0.037	0.592ProPro: 0.592 ± 0.03	0.894ProGln: 0.894 ± 0.035	0.916ProArg: 0.916 ± 0.036	1.758ProSer: 1.758 ± 0.041	1.407ProThr: 1.407 ± 0.041	2.635ProVal: 2.635 ± 0.049	0.248ProTrp: 0.248 ± 0.015	1.392ProTyr: 1.392 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.861GlnAla: 1.861 ± 0.056	0.287GlnCys: 0.287 ± 0.016	1.424GlnAsp: 1.424 ± 0.042	1.861GlnGlu: 1.861 ± 0.06	0.98GlnPhe: 0.98 ± 0.029	1.46GlnGly: 1.46 ± 0.035	0.377GlnHis: 0.377 ± 0.016	2.148GlnIle: 2.148 ± 0.049	2.141GlnLys: 2.141 ± 0.041	2.139GlnLeu: 2.139 ± 0.047	0.881GlnMet: 0.881 ± 0.034	1.429GlnAsn: 1.429 ± 0.041	0.748GlnPro: 0.748 ± 0.035	0.917GlnGln: 0.917 ± 0.042	1.119GlnArg: 1.119 ± 0.044	1.372GlnSer: 1.372 ± 0.041	1.384GlnThr: 1.384 ± 0.04	1.555GlnVal: 1.555 ± 0.036	0.21GlnTrp: 0.21 ± 0.014	1.09GlnTyr: 1.09 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.559ArgAla: 2.559 ± 0.05	0.511ArgCys: 0.511 ± 0.02	2.427ArgAsp: 2.427 ± 0.054	3.244ArgGlu: 3.244 ± 0.13	1.783ArgPhe: 1.783 ± 0.039	2.252ArgGly: 2.252 ± 0.049	0.663ArgHis: 0.663 ± 0.028	3.239ArgIle: 3.239 ± 0.054	3.257ArgLys: 3.257 ± 0.049	3.245ArgLeu: 3.245 ± 0.06	1.27ArgMet: 1.27 ± 0.034	2.045ArgAsn: 2.045 ± 0.045	1.11ArgPro: 1.11 ± 0.037	1.182ArgGln: 1.182 ± 0.032	1.821ArgArg: 1.821 ± 0.054	1.963ArgSer: 1.963 ± 0.047	1.939ArgThr: 1.939 ± 0.042	2.498ArgVal: 2.498 ± 0.047	0.318ArgTrp: 0.318 ± 0.017	1.843ArgTyr: 1.843 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.423SerAla: 4.423 ± 0.081	0.788SerCys: 0.788 ± 0.027	4.362SerAsp: 4.362 ± 0.069	4.723SerGlu: 4.723 ± 0.076	3.199SerPhe: 3.199 ± 0.058	4.994SerGly: 4.994 ± 0.07	0.949SerHis: 0.949 ± 0.03	4.564SerIle: 4.564 ± 0.074	4.353SerLys: 4.353 ± 0.062	4.915SerLeu: 4.915 ± 0.063	1.745SerMet: 1.745 ± 0.044	2.805SerAsn: 2.805 ± 0.061	1.619SerPro: 1.619 ± 0.034	1.57SerGln: 1.57 ± 0.037	2.348SerArg: 2.348 ± 0.048	4.15SerSer: 4.15 ± 0.08	3.003SerThr: 3.003 ± 0.053	4.696SerVal: 4.696 ± 0.071	0.512SerTrp: 0.512 ± 0.025	2.692SerTyr: 2.692 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.9ThrAla: 3.9 ± 0.065	0.634ThrCys: 0.634 ± 0.027	3.559ThrAsp: 3.559 ± 0.059	3.613ThrGlu: 3.613 ± 0.059	2.265ThrPhe: 2.265 ± 0.044	4.296ThrGly: 4.296 ± 0.066	0.763ThrHis: 0.763 ± 0.03	3.916ThrIle: 3.916 ± 0.056	3.302ThrLys: 3.302 ± 0.054	4.337ThrLeu: 4.337 ± 0.07	1.335ThrMet: 1.335 ± 0.031	2.099ThrAsn: 2.099 ± 0.048	1.968ThrPro: 1.968 ± 0.053	1.315ThrGln: 1.315 ± 0.037	1.758ThrArg: 1.758 ± 0.041	3.159ThrSer: 3.159 ± 0.057	2.83ThrThr: 2.83 ± 0.057	4.133ThrVal: 4.133 ± 0.067	0.436ThrTrp: 0.436 ± 0.018	2.149ThrTyr: 2.149 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.962ValAla: 4.962 ± 0.064	1.101ValCys: 1.101 ± 0.036	4.311ValAsp: 4.311 ± 0.071	4.339ValGlu: 4.339 ± 0.07	3.257ValPhe: 3.257 ± 0.067	4.365ValGly: 4.365 ± 0.066	1.013ValHis: 1.013 ± 0.03	5.68ValIle: 5.68 ± 0.073	4.914ValLys: 4.914 ± 0.078	6.204ValLeu: 6.204 ± 0.076	1.986ValMet: 1.986 ± 0.048	3.188ValAsn: 3.188 ± 0.056	2.407ValPro: 2.407 ± 0.046	1.558ValGln: 1.558 ± 0.038	2.631ValArg: 2.631 ± 0.054	4.916ValSer: 4.916 ± 0.07	3.988ValThr: 3.988 ± 0.062	5.017ValVal: 5.017 ± 0.078	0.507ValTrp: 0.507 ± 0.026	2.884ValTyr: 2.884 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.486TrpAla: 0.486 ± 0.021	0.117TrpCys: 0.117 ± 0.011	0.503TrpAsp: 0.503 ± 0.02	0.551TrpGlu: 0.551 ± 0.023	0.391TrpPhe: 0.391 ± 0.019	0.643TrpGly: 0.643 ± 0.025	0.184TrpHis: 0.184 ± 0.013	0.629TrpIle: 0.629 ± 0.023	0.628TrpLys: 0.628 ± 0.026	0.764TrpLeu: 0.764 ± 0.028	0.277TrpMet: 0.277 ± 0.016	0.51TrpAsn: 0.51 ± 0.025	0.165TrpPro: 0.165 ± 0.013	0.275TrpGln: 0.275 ± 0.017	0.31TrpArg: 0.31 ± 0.017	0.461TrpSer: 0.461 ± 0.019	0.357TrpThr: 0.357 ± 0.018	0.475TrpVal: 0.475 ± 0.021	0.088TrpTrp: 0.088 ± 0.009	0.384TrpTyr: 0.384 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.768TyrAla: 2.768 ± 0.049	0.631TyrCys: 0.631 ± 0.025	3.248TyrAsp: 3.248 ± 0.07	3.203TyrGlu: 3.203 ± 0.057	1.938TyrPhe: 1.938 ± 0.04	2.96TyrGly: 2.96 ± 0.046	0.721TyrHis: 0.721 ± 0.03	3.318TyrIle: 3.318 ± 0.06	3.075TyrLys: 3.075 ± 0.053	3.5TyrLeu: 3.5 ± 0.062	1.196TyrMet: 1.196 ± 0.03	2.324TyrAsn: 2.324 ± 0.051	1.372TyrPro: 1.372 ± 0.039	1.08TyrGln: 1.08 ± 0.028	1.896TyrArg: 1.896 ± 0.042	2.924TyrSer: 2.924 ± 0.057	2.245TyrThr: 2.245 ± 0.048	2.812TyrVal: 2.812 ± 0.053	0.376TyrTrp: 0.376 ± 0.019	2.124TyrTyr: 2.124 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3341 proteins (1100749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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