Amino acid dipepetide frequency for Salmonella phage vB_SnwM_CGG4-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.199AlaAla: 5.199 ± 0.395
0.418AlaCys: 0.418 ± 0.078
4.163AlaAsp: 4.163 ± 0.257
4.621AlaGlu: 4.621 ± 0.366
2.151AlaPhe: 2.151 ± 0.204
4.9AlaGly: 4.9 ± 0.418
0.916AlaHis: 0.916 ± 0.13
4.442AlaIle: 4.442 ± 0.295
5.279AlaLys: 5.279 ± 0.347
5.597AlaLeu: 5.597 ± 0.389
1.574AlaMet: 1.574 ± 0.201
3.068AlaAsn: 3.068 ± 0.22
2.251AlaPro: 2.251 ± 0.215
2.211AlaGln: 2.211 ± 0.233
2.789AlaArg: 2.789 ± 0.231
4.044AlaSer: 4.044 ± 0.287
3.745AlaThr: 3.745 ± 0.45
4.94AlaVal: 4.94 ± 0.345
1.056AlaTrp: 1.056 ± 0.147
2.271AlaTyr: 2.271 ± 0.231
0.0AlaXaa: 0.0 ± 0.0
Cys
0.578CysAla: 0.578 ± 0.129
0.1CysCys: 0.1 ± 0.054
0.617CysAsp: 0.617 ± 0.104
0.976CysGlu: 0.976 ± 0.164
0.398CysPhe: 0.398 ± 0.089
0.717CysGly: 0.717 ± 0.127
0.319CysHis: 0.319 ± 0.081
0.578CysIle: 0.578 ± 0.107
0.717CysLys: 0.717 ± 0.13
0.737CysLeu: 0.737 ± 0.138
0.199CysMet: 0.199 ± 0.06
0.458CysAsn: 0.458 ± 0.101
0.498CysPro: 0.498 ± 0.102
0.279CysGln: 0.279 ± 0.074
0.598CysArg: 0.598 ± 0.109
0.876CysSer: 0.876 ± 0.136
0.578CysThr: 0.578 ± 0.097
0.518CysVal: 0.518 ± 0.107
0.159CysTrp: 0.159 ± 0.058
0.398CysTyr: 0.398 ± 0.089
0.0CysXaa: 0.0 ± 0.0
Asp
4.442AspAla: 4.442 ± 0.329
0.598AspCys: 0.598 ± 0.11
3.765AspAsp: 3.765 ± 0.34
4.701AspGlu: 4.701 ± 0.329
3.287AspPhe: 3.287 ± 0.28
4.701AspGly: 4.701 ± 0.318
0.777AspHis: 0.777 ± 0.121
5.179AspIle: 5.179 ± 0.361
4.322AspLys: 4.322 ± 0.295
4.701AspLeu: 4.701 ± 0.27
1.972AspMet: 1.972 ± 0.222
3.346AspAsn: 3.346 ± 0.227
2.311AspPro: 2.311 ± 0.218
1.374AspGln: 1.374 ± 0.147
2.012AspArg: 2.012 ± 0.184
3.964AspSer: 3.964 ± 0.289
3.605AspThr: 3.605 ± 0.305
3.486AspVal: 3.486 ± 0.298
1.275AspTrp: 1.275 ± 0.192
2.988AspTyr: 2.988 ± 0.257
0.0AspXaa: 0.0 ± 0.0
Glu
4.92GluAla: 4.92 ± 0.34
0.817GluCys: 0.817 ± 0.134
4.442GluAsp: 4.442 ± 0.306
5.438GluGlu: 5.438 ± 0.395
3.486GluPhe: 3.486 ± 0.281
3.685GluGly: 3.685 ± 0.288
1.335GluHis: 1.335 ± 0.159
6.095GluIle: 6.095 ± 0.417
5.239GluLys: 5.239 ± 0.356
7.51GluLeu: 7.51 ± 0.398
2.012GluMet: 2.012 ± 0.229
4.024GluAsn: 4.024 ± 0.266
1.813GluPro: 1.813 ± 0.235
2.43GluGln: 2.43 ± 0.236
2.709GluArg: 2.709 ± 0.267
3.466GluSer: 3.466 ± 0.291
4.183GluThr: 4.183 ± 0.285
5.02GluVal: 5.02 ± 0.271
0.956GluTrp: 0.956 ± 0.146
3.028GluTyr: 3.028 ± 0.253
0.0GluXaa: 0.0 ± 0.0
Phe
2.53PheAla: 2.53 ± 0.225
0.498PheCys: 0.498 ± 0.108
3.366PheAsp: 3.366 ± 0.269
3.346PheGlu: 3.346 ± 0.229
1.394PhePhe: 1.394 ± 0.185
2.888PheGly: 2.888 ± 0.228
0.617PheHis: 0.617 ± 0.123
3.227PheIle: 3.227 ± 0.265
4.044PheLys: 4.044 ± 0.357
2.37PheLeu: 2.37 ± 0.207
1.414PheMet: 1.414 ± 0.155
2.809PheAsn: 2.809 ± 0.221
1.135PhePro: 1.135 ± 0.158
1.414PheGln: 1.414 ± 0.171
1.534PheArg: 1.534 ± 0.143
2.829PheSer: 2.829 ± 0.204
2.749PheThr: 2.749 ± 0.251
2.749PheVal: 2.749 ± 0.249
0.637PheTrp: 0.637 ± 0.099
1.673PheTyr: 1.673 ± 0.206
0.0PheXaa: 0.0 ± 0.0
Gly
4.123GlyAla: 4.123 ± 0.282
0.518GlyCys: 0.518 ± 0.105
4.024GlyAsp: 4.024 ± 0.306
4.004GlyGlu: 4.004 ± 0.243
2.888GlyPhe: 2.888 ± 0.242
4.083GlyGly: 4.083 ± 0.583
1.056GlyHis: 1.056 ± 0.178
4.502GlyIle: 4.502 ± 0.279
4.522GlyLys: 4.522 ± 0.355
5.02GlyLeu: 5.02 ± 0.356
1.872GlyMet: 1.872 ± 0.241
3.426GlyAsn: 3.426 ± 0.307
2.012GlyPro: 2.012 ± 0.534
2.311GlyGln: 2.311 ± 0.237
2.669GlyArg: 2.669 ± 0.243
4.123GlySer: 4.123 ± 0.296
4.083GlyThr: 4.083 ± 0.348
4.024GlyVal: 4.024 ± 0.282
1.036GlyTrp: 1.036 ± 0.133
2.988GlyTyr: 2.988 ± 0.256
0.0GlyXaa: 0.0 ± 0.0
His
0.976HisAla: 0.976 ± 0.137
0.139HisCys: 0.139 ± 0.062
0.976HisAsp: 0.976 ± 0.141
1.215HisGlu: 1.215 ± 0.142
1.076HisPhe: 1.076 ± 0.168
1.135HisGly: 1.135 ± 0.164
0.319HisHis: 0.319 ± 0.081
1.374HisIle: 1.374 ± 0.174
1.335HisLys: 1.335 ± 0.196
1.374HisLeu: 1.374 ± 0.153
0.398HisMet: 0.398 ± 0.09
0.777HisAsn: 0.777 ± 0.127
0.876HisPro: 0.876 ± 0.135
0.578HisGln: 0.578 ± 0.118
0.617HisArg: 0.617 ± 0.121
1.076HisSer: 1.076 ± 0.158
1.016HisThr: 1.016 ± 0.139
1.135HisVal: 1.135 ± 0.161
0.279HisTrp: 0.279 ± 0.079
0.697HisTyr: 0.697 ± 0.102
0.0HisXaa: 0.0 ± 0.0
Ile
4.721IleAla: 4.721 ± 0.291
0.797IleCys: 0.797 ± 0.128
5.199IleAsp: 5.199 ± 0.308
5.119IleGlu: 5.119 ± 0.385
2.789IlePhe: 2.789 ± 0.24
3.884IleGly: 3.884 ± 0.298
1.374IleHis: 1.374 ± 0.171
5.298IleIle: 5.298 ± 0.306
6.135IleLys: 6.135 ± 0.506
4.462IleLeu: 4.462 ± 0.283
1.892IleMet: 1.892 ± 0.224
5.318IleAsn: 5.318 ± 0.347
2.829IlePro: 2.829 ± 0.234
2.53IleGln: 2.53 ± 0.224
3.785IleArg: 3.785 ± 0.278
5.159IleSer: 5.159 ± 0.299
4.342IleThr: 4.342 ± 0.245
4.701IleVal: 4.701 ± 0.302
0.896IleTrp: 0.896 ± 0.155
2.888IleTyr: 2.888 ± 0.205
0.0IleXaa: 0.0 ± 0.0
Lys
5.577LysAla: 5.577 ± 0.369
0.637LysCys: 0.637 ± 0.127
4.681LysAsp: 4.681 ± 0.345
5.259LysGlu: 5.259 ± 0.424
3.187LysPhe: 3.187 ± 0.299
3.924LysGly: 3.924 ± 0.277
1.753LysHis: 1.753 ± 0.195
6.095LysIle: 6.095 ± 0.374
4.82LysLys: 4.82 ± 0.362
5.836LysLeu: 5.836 ± 0.366
2.55LysMet: 2.55 ± 0.228
4.163LysAsn: 4.163 ± 0.292
2.151LysPro: 2.151 ± 0.192
2.848LysGln: 2.848 ± 0.289
3.486LysArg: 3.486 ± 0.285
4.9LysSer: 4.9 ± 0.313
4.283LysThr: 4.283 ± 0.299
4.044LysVal: 4.044 ± 0.293
1.215LysTrp: 1.215 ± 0.147
3.486LysTyr: 3.486 ± 0.287
0.0LysXaa: 0.0 ± 0.0
Leu
4.92LeuAla: 4.92 ± 0.328
0.817LeuCys: 0.817 ± 0.146
5.139LeuAsp: 5.139 ± 0.341
5.518LeuGlu: 5.518 ± 0.337
3.147LeuPhe: 3.147 ± 0.283
3.884LeuGly: 3.884 ± 0.271
1.355LeuHis: 1.355 ± 0.15
5.199LeuIle: 5.199 ± 0.263
5.896LeuLys: 5.896 ± 0.332
4.442LeuLeu: 4.442 ± 0.306
2.251LeuMet: 2.251 ± 0.215
4.82LeuAsn: 4.82 ± 0.314
2.988LeuPro: 2.988 ± 0.258
2.47LeuGln: 2.47 ± 0.227
3.466LeuArg: 3.466 ± 0.281
4.94LeuSer: 4.94 ± 0.31
4.581LeuThr: 4.581 ± 0.376
5.0LeuVal: 5.0 ± 0.312
0.837LeuTrp: 0.837 ± 0.139
2.948LeuTyr: 2.948 ± 0.225
0.0LeuXaa: 0.0 ± 0.0
Met
2.111MetAla: 2.111 ± 0.179
0.259MetCys: 0.259 ± 0.066
1.594MetAsp: 1.594 ± 0.224
1.952MetGlu: 1.952 ± 0.208
1.135MetPhe: 1.135 ± 0.155
1.175MetGly: 1.175 ± 0.161
0.339MetHis: 0.339 ± 0.086
2.131MetIle: 2.131 ± 0.231
2.908MetLys: 2.908 ± 0.246
2.072MetLeu: 2.072 ± 0.211
0.717MetMet: 0.717 ± 0.138
1.753MetAsn: 1.753 ± 0.178
0.598MetPro: 0.598 ± 0.099
0.996MetGln: 0.996 ± 0.163
1.195MetArg: 1.195 ± 0.155
2.311MetSer: 2.311 ± 0.214
1.733MetThr: 1.733 ± 0.182
1.195MetVal: 1.195 ± 0.166
0.319MetTrp: 0.319 ± 0.068
1.016MetTyr: 1.016 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
3.227AsnAla: 3.227 ± 0.21
0.578AsnCys: 0.578 ± 0.107
3.287AsnAsp: 3.287 ± 0.248
4.283AsnGlu: 4.283 ± 0.325
2.829AsnPhe: 2.829 ± 0.182
4.083AsnGly: 4.083 ± 0.331
1.135AsnHis: 1.135 ± 0.176
4.303AsnIle: 4.303 ± 0.311
4.462AsnLys: 4.462 ± 0.303
4.083AsnLeu: 4.083 ± 0.29
1.693AsnMet: 1.693 ± 0.201
3.307AsnAsn: 3.307 ± 0.3
2.43AsnPro: 2.43 ± 0.233
2.111AsnGln: 2.111 ± 0.216
2.609AsnArg: 2.609 ± 0.216
3.824AsnSer: 3.824 ± 0.299
2.948AsnThr: 2.948 ± 0.246
3.307AsnVal: 3.307 ± 0.323
0.817AsnTrp: 0.817 ± 0.119
2.35AsnTyr: 2.35 ± 0.263
0.0AsnXaa: 0.0 ± 0.0
Pro
2.51ProAla: 2.51 ± 0.262
0.438ProCys: 0.438 ± 0.091
2.251ProAsp: 2.251 ± 0.215
3.227ProGlu: 3.227 ± 0.259
1.315ProPhe: 1.315 ± 0.156
2.749ProGly: 2.749 ± 0.29
0.677ProHis: 0.677 ± 0.119
2.131ProIle: 2.131 ± 0.207
2.032ProLys: 2.032 ± 0.208
2.35ProLeu: 2.35 ± 0.237
0.677ProMet: 0.677 ± 0.125
1.932ProAsn: 1.932 ± 0.178
0.936ProPro: 0.936 ± 0.156
1.016ProGln: 1.016 ± 0.244
1.235ProArg: 1.235 ± 0.153
2.291ProSer: 2.291 ± 0.191
1.992ProThr: 1.992 ± 0.257
2.809ProVal: 2.809 ± 0.234
0.518ProTrp: 0.518 ± 0.116
1.374ProTyr: 1.374 ± 0.156
0.0ProXaa: 0.0 ± 0.0
Gln
2.111GlnAla: 2.111 ± 0.244
0.359GlnCys: 0.359 ± 0.1
1.693GlnAsp: 1.693 ± 0.185
2.53GlnGlu: 2.53 ± 0.225
1.733GlnPhe: 1.733 ± 0.225
2.709GlnGly: 2.709 ± 0.471
0.558GlnHis: 0.558 ± 0.124
2.709GlnIle: 2.709 ± 0.252
2.151GlnLys: 2.151 ± 0.241
2.908GlnLeu: 2.908 ± 0.231
1.016GlnMet: 1.016 ± 0.14
1.335GlnAsn: 1.335 ± 0.162
1.135GlnPro: 1.135 ± 0.161
1.016GlnGln: 1.016 ± 0.139
1.793GlnArg: 1.793 ± 0.174
1.912GlnSer: 1.912 ± 0.199
2.072GlnThr: 2.072 ± 0.215
2.251GlnVal: 2.251 ± 0.213
0.598GlnTrp: 0.598 ± 0.132
1.494GlnTyr: 1.494 ± 0.184
0.0GlnXaa: 0.0 ± 0.0
Arg
2.729ArgAla: 2.729 ± 0.241
0.558ArgCys: 0.558 ± 0.103
2.689ArgAsp: 2.689 ± 0.229
3.267ArgGlu: 3.267 ± 0.292
1.613ArgPhe: 1.613 ± 0.183
2.669ArgGly: 2.669 ± 0.236
0.697ArgHis: 0.697 ± 0.113
3.486ArgIle: 3.486 ± 0.262
3.466ArgLys: 3.466 ± 0.228
2.908ArgLeu: 2.908 ± 0.222
1.076ArgMet: 1.076 ± 0.149
2.331ArgAsn: 2.331 ± 0.229
1.235ArgPro: 1.235 ± 0.129
1.673ArgGln: 1.673 ± 0.183
2.171ArgArg: 2.171 ± 0.22
2.49ArgSer: 2.49 ± 0.226
2.311ArgThr: 2.311 ± 0.24
2.689ArgVal: 2.689 ± 0.263
0.717ArgTrp: 0.717 ± 0.138
1.972ArgTyr: 1.972 ± 0.187
0.0ArgXaa: 0.0 ± 0.0
Ser
4.024SerAla: 4.024 ± 0.267
0.757SerCys: 0.757 ± 0.114
3.924SerAsp: 3.924 ± 0.306
3.944SerGlu: 3.944 ± 0.278
3.267SerPhe: 3.267 ± 0.256
4.781SerGly: 4.781 ± 0.319
0.976SerHis: 0.976 ± 0.141
4.601SerIle: 4.601 ± 0.336
4.9SerLys: 4.9 ± 0.373
4.86SerLeu: 4.86 ± 0.283
1.494SerMet: 1.494 ± 0.178
3.864SerAsn: 3.864 ± 0.341
2.092SerPro: 2.092 ± 0.211
2.111SerGln: 2.111 ± 0.205
2.749SerArg: 2.749 ± 0.216
4.542SerSer: 4.542 ± 0.302
3.745SerThr: 3.745 ± 0.319
4.661SerVal: 4.661 ± 0.337
0.817SerTrp: 0.817 ± 0.121
2.888SerTyr: 2.888 ± 0.287
0.0SerXaa: 0.0 ± 0.0
Thr
3.824ThrAla: 3.824 ± 0.357
0.598ThrCys: 0.598 ± 0.113
2.928ThrAsp: 2.928 ± 0.266
4.123ThrGlu: 4.123 ± 0.303
2.271ThrPhe: 2.271 ± 0.246
4.303ThrGly: 4.303 ± 0.351
1.096ThrHis: 1.096 ± 0.157
4.143ThrIle: 4.143 ± 0.315
3.486ThrLys: 3.486 ± 0.274
4.183ThrLeu: 4.183 ± 0.32
1.414ThrMet: 1.414 ± 0.174
3.426ThrAsn: 3.426 ± 0.273
2.948ThrPro: 2.948 ± 0.307
1.833ThrGln: 1.833 ± 0.245
2.609ThrArg: 2.609 ± 0.195
3.984ThrSer: 3.984 ± 0.321
3.366ThrThr: 3.366 ± 0.314
4.342ThrVal: 4.342 ± 0.375
0.697ThrTrp: 0.697 ± 0.113
2.311ThrTyr: 2.311 ± 0.198
0.0ThrXaa: 0.0 ± 0.0
Val
3.805ValAla: 3.805 ± 0.294
0.578ValCys: 0.578 ± 0.112
4.382ValAsp: 4.382 ± 0.293
5.418ValGlu: 5.418 ± 0.344
2.908ValPhe: 2.908 ± 0.261
3.486ValGly: 3.486 ± 0.295
1.016ValHis: 1.016 ± 0.153
4.641ValIle: 4.641 ± 0.282
5.358ValLys: 5.358 ± 0.341
4.641ValLeu: 4.641 ± 0.282
1.534ValMet: 1.534 ± 0.167
3.585ValAsn: 3.585 ± 0.355
2.291ValPro: 2.291 ± 0.187
2.669ValGln: 2.669 ± 0.269
2.47ValArg: 2.47 ± 0.232
4.542ValSer: 4.542 ± 0.296
3.685ValThr: 3.685 ± 0.292
4.402ValVal: 4.402 ± 0.285
0.757ValTrp: 0.757 ± 0.151
2.868ValTyr: 2.868 ± 0.211
0.0ValXaa: 0.0 ± 0.0
Trp
0.677TrpAla: 0.677 ± 0.135
0.299TrpCys: 0.299 ± 0.066
1.036TrpAsp: 1.036 ± 0.138
0.837TrpGlu: 0.837 ± 0.143
0.558TrpPhe: 0.558 ± 0.107
0.657TrpGly: 0.657 ± 0.115
0.279TrpHis: 0.279 ± 0.083
0.936TrpIle: 0.936 ± 0.155
1.115TrpLys: 1.115 ± 0.162
1.335TrpLeu: 1.335 ± 0.177
0.538TrpMet: 0.538 ± 0.106
1.155TrpAsn: 1.155 ± 0.146
0.378TrpPro: 0.378 ± 0.093
0.498TrpGln: 0.498 ± 0.094
0.717TrpArg: 0.717 ± 0.128
0.797TrpSer: 0.797 ± 0.124
0.478TrpThr: 0.478 ± 0.097
1.076TrpVal: 1.076 ± 0.145
0.359TrpTrp: 0.359 ± 0.091
0.837TrpTyr: 0.837 ± 0.131
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.629TyrAla: 2.629 ± 0.231
0.538TyrCys: 0.538 ± 0.117
2.649TyrAsp: 2.649 ± 0.216
2.829TyrGlu: 2.829 ± 0.235
1.793TyrPhe: 1.793 ± 0.197
2.868TyrGly: 2.868 ± 0.269
0.777TyrHis: 0.777 ± 0.142
3.048TyrIle: 3.048 ± 0.248
2.709TyrLys: 2.709 ± 0.271
3.227TyrLeu: 3.227 ± 0.296
1.195TyrMet: 1.195 ± 0.131
2.769TyrAsn: 2.769 ± 0.237
1.554TyrPro: 1.554 ± 0.155
1.713TyrGln: 1.713 ± 0.171
1.534TyrArg: 1.534 ± 0.171
2.928TyrSer: 2.928 ± 0.22
2.39TyrThr: 2.39 ± 0.229
2.689TyrVal: 2.689 ± 0.196
0.617TyrTrp: 0.617 ± 0.111
1.753TyrTyr: 1.753 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 259 proteins (50204 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski