Amino acid dipepetide frequency for Rhizobiales bacterium PAR1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.585AlaAla: 16.585 ± 0.159
1.025AlaCys: 1.025 ± 0.033
6.142AlaAsp: 6.142 ± 0.078
7.899AlaGlu: 7.899 ± 0.097
4.971AlaPhe: 4.971 ± 0.068
10.841AlaGly: 10.841 ± 0.136
2.227AlaHis: 2.227 ± 0.042
7.277AlaIle: 7.277 ± 0.082
5.264AlaLys: 5.264 ± 0.083
14.366AlaLeu: 14.366 ± 0.122
3.921AlaMet: 3.921 ± 0.061
3.161AlaAsn: 3.161 ± 0.057
5.806AlaPro: 5.806 ± 0.086
3.765AlaGln: 3.765 ± 0.062
8.728AlaArg: 8.728 ± 0.113
6.829AlaSer: 6.829 ± 0.082
6.361AlaThr: 6.361 ± 0.09
8.31AlaVal: 8.31 ± 0.096
1.246AlaTrp: 1.246 ± 0.038
2.6AlaTyr: 2.6 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.855CysAla: 0.855 ± 0.027
0.104CysCys: 0.104 ± 0.008
0.517CysAsp: 0.517 ± 0.02
0.405CysGlu: 0.405 ± 0.019
0.311CysPhe: 0.311 ± 0.015
0.904CysGly: 0.904 ± 0.03
0.265CysHis: 0.265 ± 0.015
0.359CysIle: 0.359 ± 0.018
0.217CysLys: 0.217 ± 0.014
0.83CysLeu: 0.83 ± 0.028
0.152CysMet: 0.152 ± 0.011
0.206CysAsn: 0.206 ± 0.014
0.47CysPro: 0.47 ± 0.019
0.228CysGln: 0.228 ± 0.014
0.603CysArg: 0.603 ± 0.022
0.418CysSer: 0.418 ± 0.017
0.405CysThr: 0.405 ± 0.018
0.569CysVal: 0.569 ± 0.023
0.106CysTrp: 0.106 ± 0.008
0.168CysTyr: 0.168 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.28AspAla: 6.28 ± 0.085
0.466AspCys: 0.466 ± 0.02
2.438AspAsp: 2.438 ± 0.051
3.023AspGlu: 3.023 ± 0.056
2.207AspPhe: 2.207 ± 0.042
4.451AspGly: 4.451 ± 0.082
1.153AspHis: 1.153 ± 0.036
3.157AspIle: 3.157 ± 0.055
1.873AspLys: 1.873 ± 0.043
5.716AspLeu: 5.716 ± 0.068
1.195AspMet: 1.195 ± 0.031
1.13AspAsn: 1.13 ± 0.036
3.17AspPro: 3.17 ± 0.05
1.486AspGln: 1.486 ± 0.043
3.654AspArg: 3.654 ± 0.055
1.922AspSer: 1.922 ± 0.046
2.358AspThr: 2.358 ± 0.085
3.753AspVal: 3.753 ± 0.064
0.781AspTrp: 0.781 ± 0.026
1.257AspTyr: 1.257 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
8.595GluAla: 8.595 ± 0.097
0.381GluCys: 0.381 ± 0.017
2.455GluAsp: 2.455 ± 0.05
2.901GluGlu: 2.901 ± 0.051
1.817GluPhe: 1.817 ± 0.046
4.371GluGly: 4.371 ± 0.059
1.114GluHis: 1.114 ± 0.032
3.79GluIle: 3.79 ± 0.063
2.716GluLys: 2.716 ± 0.054
4.549GluLeu: 4.549 ± 0.061
1.634GluMet: 1.634 ± 0.034
1.635GluAsn: 1.635 ± 0.04
2.726GluPro: 2.726 ± 0.053
1.63GluGln: 1.63 ± 0.042
4.482GluArg: 4.482 ± 0.065
2.449GluSer: 2.449 ± 0.04
3.714GluThr: 3.714 ± 0.061
3.885GluVal: 3.885 ± 0.06
0.629GluTrp: 0.629 ± 0.023
0.873GluTyr: 0.873 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.795PheAla: 4.795 ± 0.078
0.424PheCys: 0.424 ± 0.018
2.508PheAsp: 2.508 ± 0.044
2.278PheGlu: 2.278 ± 0.051
1.523PhePhe: 1.523 ± 0.039
3.999PheGly: 3.999 ± 0.065
0.768PheHis: 0.768 ± 0.023
1.891PheIle: 1.891 ± 0.045
1.22PheLys: 1.22 ± 0.032
3.713PheLeu: 3.713 ± 0.06
0.88PheMet: 0.88 ± 0.028
1.11PheAsn: 1.11 ± 0.029
1.802PhePro: 1.802 ± 0.043
1.034PheGln: 1.034 ± 0.031
2.432PheArg: 2.432 ± 0.048
2.414PheSer: 2.414 ± 0.039
2.079PheThr: 2.079 ± 0.042
2.972PheVal: 2.972 ± 0.051
0.567PheTrp: 0.567 ± 0.023
0.869PheTyr: 0.869 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.84GlyAla: 9.84 ± 0.124
0.87GlyCys: 0.87 ± 0.031
3.895GlyAsp: 3.895 ± 0.079
4.792GlyGlu: 4.792 ± 0.065
3.982GlyPhe: 3.982 ± 0.057
7.477GlyGly: 7.477 ± 0.164
1.82GlyHis: 1.82 ± 0.046
5.108GlyIle: 5.108 ± 0.066
4.04GlyLys: 4.04 ± 0.06
9.381GlyLeu: 9.381 ± 0.086
2.513GlyMet: 2.513 ± 0.05
2.192GlyAsn: 2.192 ± 0.084
3.397GlyPro: 3.397 ± 0.051
2.922GlyGln: 2.922 ± 0.057
5.467GlyArg: 5.467 ± 0.066
4.522GlySer: 4.522 ± 0.093
4.69GlyThr: 4.69 ± 0.078
6.196GlyVal: 6.196 ± 0.08
1.285GlyTrp: 1.285 ± 0.034
2.273GlyTyr: 2.273 ± 0.047
0.001GlyXaa: 0.001 ± 0.001
His
2.425HisAla: 2.425 ± 0.042
0.206HisCys: 0.206 ± 0.012
1.064HisAsp: 1.064 ± 0.035
1.052HisGlu: 1.052 ± 0.029
0.874HisPhe: 0.874 ± 0.028
1.789HisGly: 1.789 ± 0.036
0.548HisHis: 0.548 ± 0.026
0.982HisIle: 0.982 ± 0.027
0.515HisLys: 0.515 ± 0.023
2.095HisLeu: 2.095 ± 0.043
0.429HisMet: 0.429 ± 0.017
0.463HisAsn: 0.463 ± 0.02
1.263HisPro: 1.263 ± 0.036
0.564HisGln: 0.564 ± 0.022
1.27HisArg: 1.27 ± 0.031
0.893HisSer: 0.893 ± 0.031
0.772HisThr: 0.772 ± 0.027
1.488HisVal: 1.488 ± 0.034
0.303HisTrp: 0.303 ± 0.015
0.518HisTyr: 0.518 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
8.164IleAla: 8.164 ± 0.09
0.494IleCys: 0.494 ± 0.019
3.46IleAsp: 3.46 ± 0.058
3.875IleGlu: 3.875 ± 0.051
1.964IlePhe: 1.964 ± 0.043
5.525IleGly: 5.525 ± 0.068
0.981IleHis: 0.981 ± 0.029
2.636IleIle: 2.636 ± 0.049
1.695IleLys: 1.695 ± 0.04
5.15IleLeu: 5.15 ± 0.067
1.06IleMet: 1.06 ± 0.031
1.489IleAsn: 1.489 ± 0.041
2.685IlePro: 2.685 ± 0.049
1.271IleGln: 1.271 ± 0.034
3.703IleArg: 3.703 ± 0.053
3.114IleSer: 3.114 ± 0.063
3.224IleThr: 3.224 ± 0.063
4.497IleVal: 4.497 ± 0.066
0.568IleTrp: 0.568 ± 0.022
1.056IleTyr: 1.056 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
5.369LysAla: 5.369 ± 0.085
0.158LysCys: 0.158 ± 0.011
1.961LysAsp: 1.961 ± 0.045
1.737LysGlu: 1.737 ± 0.042
1.165LysPhe: 1.165 ± 0.034
3.276LysGly: 3.276 ± 0.062
0.672LysHis: 0.672 ± 0.022
2.124LysIle: 2.124 ± 0.045
1.649LysLys: 1.649 ± 0.047
3.855LysLeu: 3.855 ± 0.065
0.974LysMet: 0.974 ± 0.026
1.081LysAsn: 1.081 ± 0.035
2.565LysPro: 2.565 ± 0.045
1.003LysGln: 1.003 ± 0.027
2.648LysArg: 2.648 ± 0.047
2.164LysSer: 2.164 ± 0.046
2.28LysThr: 2.28 ± 0.042
2.83LysVal: 2.83 ± 0.049
0.377LysTrp: 0.377 ± 0.018
0.64LysTyr: 0.64 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.455LeuAla: 14.455 ± 0.126
0.831LeuCys: 0.831 ± 0.029
5.892LeuAsp: 5.892 ± 0.072
5.201LeuGlu: 5.201 ± 0.059
3.762LeuPhe: 3.762 ± 0.064
8.962LeuGly: 8.962 ± 0.091
1.799LeuHis: 1.799 ± 0.041
5.557LeuIle: 5.557 ± 0.073
4.19LeuLys: 4.19 ± 0.063
9.118LeuLeu: 9.118 ± 0.106
2.549LeuMet: 2.549 ± 0.052
2.571LeuAsn: 2.571 ± 0.048
5.589LeuPro: 5.589 ± 0.077
2.508LeuGln: 2.508 ± 0.046
6.313LeuArg: 6.313 ± 0.081
6.323LeuSer: 6.323 ± 0.083
5.714LeuThr: 5.714 ± 0.089
7.925LeuVal: 7.925 ± 0.082
1.059LeuTrp: 1.059 ± 0.03
1.937LeuTyr: 1.937 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.355MetAla: 3.355 ± 0.056
0.168MetCys: 0.168 ± 0.012
1.056MetAsp: 1.056 ± 0.028
1.05MetGlu: 1.05 ± 0.033
0.716MetPhe: 0.716 ± 0.021
2.008MetGly: 2.008 ± 0.041
0.441MetHis: 0.441 ± 0.019
1.688MetIle: 1.688 ± 0.039
1.104MetLys: 1.104 ± 0.029
2.715MetLeu: 2.715 ± 0.048
0.79MetMet: 0.79 ± 0.026
0.791MetAsn: 0.791 ± 0.025
1.705MetPro: 1.705 ± 0.04
0.834MetGln: 0.834 ± 0.022
2.024MetArg: 2.024 ± 0.047
1.768MetSer: 1.768 ± 0.04
1.771MetThr: 1.771 ± 0.04
1.818MetVal: 1.818 ± 0.042
0.178MetTrp: 0.178 ± 0.012
0.294MetTyr: 0.294 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.409AsnAla: 3.409 ± 0.054
0.243AsnCys: 0.243 ± 0.014
1.27AsnAsp: 1.27 ± 0.058
1.302AsnGlu: 1.302 ± 0.039
1.002AsnPhe: 1.002 ± 0.038
2.399AsnGly: 2.399 ± 0.056
0.474AsnHis: 0.474 ± 0.021
1.442AsnIle: 1.442 ± 0.043
0.797AsnLys: 0.797 ± 0.029
2.707AsnLeu: 2.707 ± 0.057
0.591AsnMet: 0.591 ± 0.022
0.711AsnAsn: 0.711 ± 0.026
1.913AsnPro: 1.913 ± 0.043
0.705AsnGln: 0.705 ± 0.027
1.852AsnArg: 1.852 ± 0.037
1.179AsnSer: 1.179 ± 0.035
1.392AsnThr: 1.392 ± 0.055
1.886AsnVal: 1.886 ± 0.047
0.424AsnTrp: 0.424 ± 0.022
0.633AsnTyr: 0.633 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.267ProAla: 6.267 ± 0.092
0.306ProCys: 0.306 ± 0.017
3.263ProAsp: 3.263 ± 0.055
3.858ProGlu: 3.858 ± 0.055
2.11ProPhe: 2.11 ± 0.049
4.557ProGly: 4.557 ± 0.057
1.071ProHis: 1.071 ± 0.028
2.59ProIle: 2.59 ± 0.052
2.16ProLys: 2.16 ± 0.05
4.756ProLeu: 4.756 ± 0.078
1.412ProMet: 1.412 ± 0.034
1.491ProAsn: 1.491 ± 0.039
2.542ProPro: 2.542 ± 0.064
1.542ProGln: 1.542 ± 0.036
2.863ProArg: 2.863 ± 0.057
2.617ProSer: 2.617 ± 0.044
2.527ProThr: 2.527 ± 0.052
4.377ProVal: 4.377 ± 0.065
0.601ProTrp: 0.601 ± 0.022
1.159ProTyr: 1.159 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.714GlnAla: 3.714 ± 0.06
0.2GlnCys: 0.2 ± 0.014
1.292GlnAsp: 1.292 ± 0.032
1.346GlnGlu: 1.346 ± 0.035
1.043GlnPhe: 1.043 ± 0.031
2.394GlnGly: 2.394 ± 0.045
0.602GlnHis: 0.602 ± 0.021
1.789GlnIle: 1.789 ± 0.039
1.226GlnLys: 1.226 ± 0.034
2.52GlnLeu: 2.52 ± 0.051
0.793GlnMet: 0.793 ± 0.025
0.899GlnAsn: 0.899 ± 0.028
1.592GlnPro: 1.592 ± 0.041
1.119GlnGln: 1.119 ± 0.035
2.262GlnArg: 2.262 ± 0.053
1.641GlnSer: 1.641 ± 0.041
1.645GlnThr: 1.645 ± 0.043
2.113GlnVal: 2.113 ± 0.043
0.33GlnTrp: 0.33 ± 0.018
0.532GlnTyr: 0.532 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.115ArgAla: 8.115 ± 0.096
0.45ArgCys: 0.45 ± 0.021
3.564ArgAsp: 3.564 ± 0.059
4.074ArgGlu: 4.074 ± 0.065
3.039ArgPhe: 3.039 ± 0.054
4.614ArgGly: 4.614 ± 0.063
1.501ArgHis: 1.501 ± 0.04
4.073ArgIle: 4.073 ± 0.058
2.49ArgLys: 2.49 ± 0.041
7.59ArgLeu: 7.59 ± 0.086
1.825ArgMet: 1.825 ± 0.041
1.773ArgAsn: 1.773 ± 0.04
3.228ArgPro: 3.228 ± 0.059
2.422ArgGln: 2.422 ± 0.042
4.819ArgArg: 4.819 ± 0.067
3.315ArgSer: 3.315 ± 0.057
3.139ArgThr: 3.139 ± 0.051
4.626ArgVal: 4.626 ± 0.07
0.851ArgTrp: 0.851 ± 0.03
1.546ArgTyr: 1.546 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.362SerAla: 6.362 ± 0.082
0.372SerCys: 0.372 ± 0.017
2.617SerAsp: 2.617 ± 0.057
2.859SerGlu: 2.859 ± 0.052
2.279SerPhe: 2.279 ± 0.045
5.623SerGly: 5.623 ± 0.092
1.036SerHis: 1.036 ± 0.033
3.051SerIle: 3.051 ± 0.058
1.758SerLys: 1.758 ± 0.042
5.597SerLeu: 5.597 ± 0.082
1.354SerMet: 1.354 ± 0.034
1.344SerAsn: 1.344 ± 0.041
2.836SerPro: 2.836 ± 0.052
1.51SerGln: 1.51 ± 0.04
3.424SerArg: 3.424 ± 0.055
2.774SerSer: 2.774 ± 0.05
2.848SerThr: 2.848 ± 0.05
3.861SerVal: 3.861 ± 0.055
0.676SerTrp: 0.676 ± 0.023
1.172SerTyr: 1.172 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.08ThrAla: 6.08 ± 0.077
0.469ThrCys: 0.469 ± 0.021
2.495ThrAsp: 2.495 ± 0.054
2.656ThrGlu: 2.656 ± 0.053
2.227ThrPhe: 2.227 ± 0.042
5.254ThrGly: 5.254 ± 0.121
1.029ThrHis: 1.029 ± 0.029
3.212ThrIle: 3.212 ± 0.063
1.775ThrLys: 1.775 ± 0.041
6.374ThrLeu: 6.374 ± 0.093
1.341ThrMet: 1.341 ± 0.034
1.389ThrAsn: 1.389 ± 0.046
3.283ThrPro: 3.283 ± 0.055
1.345ThrGln: 1.345 ± 0.033
3.605ThrArg: 3.605 ± 0.059
2.87ThrSer: 2.87 ± 0.059
2.994ThrThr: 2.994 ± 0.065
3.981ThrVal: 3.981 ± 0.081
0.555ThrTrp: 0.555 ± 0.019
1.263ThrTyr: 1.263 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.007ValAla: 9.007 ± 0.093
0.541ValCys: 0.541 ± 0.02
3.79ValAsp: 3.79 ± 0.063
4.497ValGlu: 4.497 ± 0.07
2.876ValPhe: 2.876 ± 0.054
5.428ValGly: 5.428 ± 0.078
1.317ValHis: 1.317 ± 0.035
4.475ValIle: 4.475 ± 0.07
2.703ValLys: 2.703 ± 0.058
7.531ValLeu: 7.531 ± 0.091
2.149ValMet: 2.149 ± 0.05
1.97ValAsn: 1.97 ± 0.047
3.712ValPro: 3.712 ± 0.056
2.008ValGln: 2.008 ± 0.043
4.284ValArg: 4.284 ± 0.062
4.374ValSer: 4.374 ± 0.06
4.59ValThr: 4.59 ± 0.071
5.641ValVal: 5.641 ± 0.076
0.736ValTrp: 0.736 ± 0.024
1.308ValTyr: 1.308 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.101TrpAla: 1.101 ± 0.032
0.128TrpCys: 0.128 ± 0.01
0.546TrpAsp: 0.546 ± 0.021
0.481TrpGlu: 0.481 ± 0.019
0.533TrpPhe: 0.533 ± 0.02
0.837TrpGly: 0.837 ± 0.03
0.295TrpHis: 0.295 ± 0.017
0.556TrpIle: 0.556 ± 0.021
0.502TrpLys: 0.502 ± 0.02
1.451TrpLeu: 1.451 ± 0.036
0.321TrpMet: 0.321 ± 0.016
0.409TrpAsn: 0.409 ± 0.019
0.685TrpPro: 0.685 ± 0.024
0.514TrpGln: 0.514 ± 0.023
1.0TrpArg: 1.0 ± 0.027
0.669TrpSer: 0.669 ± 0.024
0.638TrpThr: 0.638 ± 0.018
0.701TrpVal: 0.701 ± 0.023
0.198TrpTrp: 0.198 ± 0.014
0.236TrpTyr: 0.236 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.551TyrAla: 2.551 ± 0.052
0.255TyrCys: 0.255 ± 0.016
1.244TyrAsp: 1.244 ± 0.034
1.061TyrGlu: 1.061 ± 0.03
0.874TyrPhe: 0.874 ± 0.027
1.954TyrGly: 1.954 ± 0.046
0.402TyrHis: 0.402 ± 0.019
0.853TyrIle: 0.853 ± 0.025
0.637TyrLys: 0.637 ± 0.024
2.242TyrLeu: 2.242 ± 0.046
0.391TyrMet: 0.391 ± 0.017
0.513TyrAsn: 0.513 ± 0.022
1.1TyrPro: 1.1 ± 0.034
0.642TyrGln: 0.642 ± 0.023
1.618TyrArg: 1.618 ± 0.033
1.097TyrSer: 1.097 ± 0.028
1.053TyrThr: 1.053 ± 0.028
1.51TyrVal: 1.51 ± 0.035
0.335TyrTrp: 0.335 ± 0.017
0.525TyrTyr: 0.525 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3826 proteins (1256189 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski