Amino acid dipepetide frequency for Neglecta sp. 59

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.497AlaAla: 10.497 ± 0.16	1.615AlaCys: 1.615 ± 0.049	4.619AlaAsp: 4.619 ± 0.086	6.267AlaGlu: 6.267 ± 0.102	3.708AlaPhe: 3.708 ± 0.075	7.987AlaGly: 7.987 ± 0.107	1.409AlaHis: 1.409 ± 0.038	4.41AlaIle: 4.41 ± 0.075	4.433AlaLys: 4.433 ± 0.072	10.048AlaLeu: 10.048 ± 0.117	2.697AlaMet: 2.697 ± 0.058	2.344AlaAsn: 2.344 ± 0.057	3.568AlaPro: 3.568 ± 0.078	3.812AlaGln: 3.812 ± 0.074	4.651AlaArg: 4.651 ± 0.09	4.248AlaSer: 4.248 ± 0.074	3.309AlaThr: 3.309 ± 0.071	7.376AlaVal: 7.376 ± 0.103	0.856AlaTrp: 0.856 ± 0.033	2.967AlaTyr: 2.967 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.582CysAla: 1.582 ± 0.044	0.393CysCys: 0.393 ± 0.021	0.816CysAsp: 0.816 ± 0.032	0.862CysGlu: 0.862 ± 0.031	0.728CysPhe: 0.728 ± 0.028	1.835CysGly: 1.835 ± 0.046	0.344CysHis: 0.344 ± 0.019	0.886CysIle: 0.886 ± 0.031	0.792CysLys: 0.792 ± 0.03	1.428CysLeu: 1.428 ± 0.041	0.414CysMet: 0.414 ± 0.022	0.458CysAsn: 0.458 ± 0.022	0.894CysPro: 0.894 ± 0.038	0.568CysGln: 0.568 ± 0.026	1.11CysArg: 1.11 ± 0.034	0.92CysSer: 0.92 ± 0.032	0.89CysThr: 0.89 ± 0.033	1.082CysVal: 1.082 ± 0.035	0.195CysTrp: 0.195 ± 0.015	0.513CysTyr: 0.513 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.119AspAla: 4.119 ± 0.069	0.894AspCys: 0.894 ± 0.032	2.307AspAsp: 2.307 ± 0.056	3.683AspGlu: 3.683 ± 0.075	2.827AspPhe: 2.827 ± 0.054	4.575AspGly: 4.575 ± 0.092	0.707AspHis: 0.707 ± 0.024	3.725AspIle: 3.725 ± 0.069	3.007AspLys: 3.007 ± 0.056	4.533AspLeu: 4.533 ± 0.075	1.768AspMet: 1.768 ± 0.045	1.684AspAsn: 1.684 ± 0.053	2.254AspPro: 2.254 ± 0.059	1.145AspGln: 1.145 ± 0.035	2.688AspArg: 2.688 ± 0.062	3.015AspSer: 3.015 ± 0.058	2.887AspThr: 2.887 ± 0.061	3.355AspVal: 3.355 ± 0.062	0.614AspTrp: 0.614 ± 0.028	2.06AspTyr: 2.06 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.648GluAla: 6.648 ± 0.103	0.728GluCys: 0.728 ± 0.029	3.912GluAsp: 3.912 ± 0.076	6.762GluGlu: 6.762 ± 0.121	2.342GluPhe: 2.342 ± 0.053	5.295GluGly: 5.295 ± 0.086	1.131GluHis: 1.131 ± 0.04	4.66GluIle: 4.66 ± 0.09	5.93GluLys: 5.93 ± 0.081	6.613GluLeu: 6.613 ± 0.093	2.179GluMet: 2.179 ± 0.049	3.539GluAsn: 3.539 ± 0.064	2.469GluPro: 2.469 ± 0.056	3.147GluGln: 3.147 ± 0.077	3.99GluArg: 3.99 ± 0.077	3.659GluSer: 3.659 ± 0.073	3.588GluThr: 3.588 ± 0.072	4.036GluVal: 4.036 ± 0.076	0.623GluTrp: 0.623 ± 0.03	2.558GluTyr: 2.558 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.592PheAla: 3.592 ± 0.062	0.891PheCys: 0.891 ± 0.034	2.481PheAsp: 2.481 ± 0.055	2.375PheGlu: 2.375 ± 0.056	2.004PhePhe: 2.004 ± 0.055	3.187PheGly: 3.187 ± 0.059	0.806PheHis: 0.806 ± 0.029	2.264PheIle: 2.264 ± 0.052	1.551PheLys: 1.551 ± 0.051	4.114PheLeu: 4.114 ± 0.087	0.985PheMet: 0.985 ± 0.032	1.233PheAsn: 1.233 ± 0.036	1.78PhePro: 1.78 ± 0.044	1.59PheGln: 1.59 ± 0.044	1.947PheArg: 1.947 ± 0.051	3.274PheSer: 3.274 ± 0.065	2.6PheThr: 2.6 ± 0.056	2.5PheVal: 2.5 ± 0.056	0.49PheTrp: 0.49 ± 0.025	1.528PheTyr: 1.528 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	6.532GlyAla: 6.532 ± 0.098	1.38GlyCys: 1.38 ± 0.048	3.914GlyAsp: 3.914 ± 0.08	5.981GlyGlu: 5.981 ± 0.097	3.432GlyPhe: 3.432 ± 0.074	6.027GlyGly: 6.027 ± 0.108	1.364GlyHis: 1.364 ± 0.041	4.819GlyIle: 4.819 ± 0.081	5.304GlyLys: 5.304 ± 0.068	7.411GlyLeu: 7.411 ± 0.116	2.648GlyMet: 2.648 ± 0.058	2.572GlyAsn: 2.572 ± 0.062	1.958GlyPro: 1.958 ± 0.052	2.79GlyGln: 2.79 ± 0.056	4.538GlyArg: 4.538 ± 0.084	4.115GlySer: 4.115 ± 0.071	4.135GlyThr: 4.135 ± 0.075	5.592GlyVal: 5.592 ± 0.079	0.898GlyTrp: 0.898 ± 0.034	3.101GlyTyr: 3.101 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.189HisAla: 1.189 ± 0.035	0.365HisCys: 0.365 ± 0.02	0.825HisAsp: 0.825 ± 0.029	0.965HisGlu: 0.965 ± 0.031	0.826HisPhe: 0.826 ± 0.031	1.299HisGly: 1.299 ± 0.038	0.381HisHis: 0.381 ± 0.022	1.232HisIle: 1.232 ± 0.035	0.9HisLys: 0.9 ± 0.034	1.519HisLeu: 1.519 ± 0.043	0.497HisMet: 0.497 ± 0.027	0.669HisAsn: 0.669 ± 0.028	0.946HisPro: 0.946 ± 0.038	0.582HisGln: 0.582 ± 0.028	0.975HisArg: 0.975 ± 0.035	1.029HisSer: 1.029 ± 0.034	1.005HisThr: 1.005 ± 0.035	1.074HisVal: 1.074 ± 0.04	0.224HisTrp: 0.224 ± 0.017	0.677HisTyr: 0.677 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.025IleAla: 5.025 ± 0.076	1.065IleCys: 1.065 ± 0.037	3.217IleAsp: 3.217 ± 0.068	3.564IleGlu: 3.564 ± 0.069	2.169IlePhe: 2.169 ± 0.052	4.081IleGly: 4.081 ± 0.069	1.023IleHis: 1.023 ± 0.032	3.219IleIle: 3.219 ± 0.087	2.901IleLys: 2.901 ± 0.064	5.438IleLeu: 5.438 ± 0.085	1.402IleMet: 1.402 ± 0.038	2.032IleAsn: 2.032 ± 0.052	2.782IlePro: 2.782 ± 0.052	1.92IleGln: 1.92 ± 0.046	3.015IleArg: 3.015 ± 0.057	3.957IleSer: 3.957 ± 0.072	3.469IleThr: 3.469 ± 0.065	3.711IleVal: 3.711 ± 0.079	0.516IleTrp: 0.516 ± 0.024	1.82IleTyr: 1.82 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.544LysAla: 5.544 ± 0.085	0.618LysCys: 0.618 ± 0.028	2.909LysAsp: 2.909 ± 0.055	4.8LysGlu: 4.8 ± 0.083	1.589LysPhe: 1.589 ± 0.04	4.023LysGly: 4.023 ± 0.067	0.816LysHis: 0.816 ± 0.034	3.287LysIle: 3.287 ± 0.059	4.243LysLys: 4.243 ± 0.076	4.997LysLeu: 4.997 ± 0.077	1.576LysMet: 1.576 ± 0.047	2.378LysAsn: 2.378 ± 0.054	2.355LysPro: 2.355 ± 0.058	1.969LysGln: 1.969 ± 0.044	3.274LysArg: 3.274 ± 0.053	2.931LysSer: 2.931 ± 0.061	3.082LysThr: 3.082 ± 0.054	3.27LysVal: 3.27 ± 0.08	0.609LysTrp: 0.609 ± 0.023	1.938LysTyr: 1.938 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	8.648LeuAla: 8.648 ± 0.099	2.187LeuCys: 2.187 ± 0.057	5.061LeuAsp: 5.061 ± 0.073	7.17LeuGlu: 7.17 ± 0.1	4.091LeuPhe: 4.091 ± 0.086	7.141LeuGly: 7.141 ± 0.11	1.877LeuHis: 1.877 ± 0.043	4.569LeuIle: 4.569 ± 0.08	4.756LeuLys: 4.756 ± 0.074	10.921LeuLeu: 10.921 ± 0.15	2.406LeuMet: 2.406 ± 0.052	2.973LeuAsn: 2.973 ± 0.063	4.875LeuPro: 4.875 ± 0.092	3.637LeuGln: 3.637 ± 0.063	5.572LeuArg: 5.572 ± 0.089	6.922LeuSer: 6.922 ± 0.098	5.234LeuThr: 5.234 ± 0.074	5.814LeuVal: 5.814 ± 0.08	1.067LeuTrp: 1.067 ± 0.038	3.423LeuTyr: 3.423 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.775MetAla: 2.775 ± 0.063	0.338MetCys: 0.338 ± 0.021	1.712MetAsp: 1.712 ± 0.04	2.574MetGlu: 2.574 ± 0.058	0.9MetPhe: 0.9 ± 0.031	2.296MetGly: 2.296 ± 0.055	0.368MetHis: 0.368 ± 0.02	1.319MetIle: 1.319 ± 0.038	1.921MetLys: 1.921 ± 0.047	2.655MetLeu: 2.655 ± 0.057	0.748MetMet: 0.748 ± 0.031	1.168MetAsn: 1.168 ± 0.036	1.251MetPro: 1.251 ± 0.036	1.003MetGln: 1.003 ± 0.03	1.409MetArg: 1.409 ± 0.042	1.467MetSer: 1.467 ± 0.038	1.397MetThr: 1.397 ± 0.045	1.795MetVal: 1.795 ± 0.051	0.238MetTrp: 0.238 ± 0.017	0.705MetTyr: 0.705 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.882AsnAla: 2.882 ± 0.064	0.559AsnCys: 0.559 ± 0.029	1.525AsnAsp: 1.525 ± 0.052	1.935AsnGlu: 1.935 ± 0.05	1.41AsnPhe: 1.41 ± 0.04	2.964AsnGly: 2.964 ± 0.074	0.643AsnHis: 0.643 ± 0.028	2.315AsnIle: 2.315 ± 0.051	1.617AsnLys: 1.617 ± 0.044	3.324AsnLeu: 3.324 ± 0.07	1.009AsnMet: 1.009 ± 0.032	1.19AsnAsn: 1.19 ± 0.041	2.037AsnPro: 2.037 ± 0.045	1.138AsnGln: 1.138 ± 0.035	2.022AsnArg: 2.022 ± 0.051	1.959AsnSer: 1.959 ± 0.049	1.835AsnThr: 1.835 ± 0.048	2.161AsnVal: 2.161 ± 0.046	0.395AsnTrp: 0.395 ± 0.02	1.181AsnTyr: 1.181 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.329ProAla: 4.329 ± 0.083	0.647ProCys: 0.647 ± 0.028	2.529ProAsp: 2.529 ± 0.052	4.252ProGlu: 4.252 ± 0.068	1.811ProPhe: 1.811 ± 0.049	3.396ProGly: 3.396 ± 0.071	0.758ProHis: 0.758 ± 0.029	1.888ProIle: 1.888 ± 0.047	1.992ProLys: 1.992 ± 0.048	3.692ProLeu: 3.692 ± 0.087	1.08ProMet: 1.08 ± 0.033	1.195ProAsn: 1.195 ± 0.035	1.83ProPro: 1.83 ± 0.072	1.908ProGln: 1.908 ± 0.054	1.815ProArg: 1.815 ± 0.05	2.229ProSer: 2.229 ± 0.058	1.801ProThr: 1.801 ± 0.054	3.549ProVal: 3.549 ± 0.069	0.446ProTrp: 0.446 ± 0.023	1.612ProTyr: 1.612 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	4.031GlnAla: 4.031 ± 0.076	0.451GlnCys: 0.451 ± 0.022	1.668GlnAsp: 1.668 ± 0.04	3.136GlnGlu: 3.136 ± 0.063	1.17GlnPhe: 1.17 ± 0.03	3.013GlnGly: 3.013 ± 0.059	0.56GlnHis: 0.56 ± 0.027	2.069GlnIle: 2.069 ± 0.049	2.662GlnLys: 2.662 ± 0.057	2.958GlnLeu: 2.958 ± 0.062	1.119GlnMet: 1.119 ± 0.037	1.546GlnAsn: 1.546 ± 0.043	1.418GlnPro: 1.418 ± 0.043	1.65GlnGln: 1.65 ± 0.056	2.323GlnArg: 2.323 ± 0.056	1.861GlnSer: 1.861 ± 0.047	1.63GlnThr: 1.63 ± 0.035	2.639GlnVal: 2.639 ± 0.057	0.465GlnTrp: 0.465 ± 0.021	1.358GlnTyr: 1.358 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	4.349ArgAla: 4.349 ± 0.073	0.838ArgCys: 0.838 ± 0.031	2.641ArgAsp: 2.641 ± 0.062	4.929ArgGlu: 4.929 ± 0.085	2.361ArgPhe: 2.361 ± 0.043	3.464ArgGly: 3.464 ± 0.062	1.051ArgHis: 1.051 ± 0.035	3.102ArgIle: 3.102 ± 0.058	3.324ArgLys: 3.324 ± 0.074	5.804ArgLeu: 5.804 ± 0.103	1.609ArgMet: 1.609 ± 0.037	1.794ArgAsn: 1.794 ± 0.049	2.128ArgPro: 2.128 ± 0.058	2.603ArgGln: 2.603 ± 0.056	3.805ArgArg: 3.805 ± 0.089	2.404ArgSer: 2.404 ± 0.055	2.464ArgThr: 2.464 ± 0.051	3.634ArgVal: 3.634 ± 0.054	0.618ArgTrp: 0.618 ± 0.032	2.028ArgTyr: 2.028 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.059SerAla: 5.059 ± 0.093	0.84SerCys: 0.84 ± 0.032	2.651SerAsp: 2.651 ± 0.058	3.185SerGlu: 3.185 ± 0.076	2.699SerPhe: 2.699 ± 0.059	5.293SerGly: 5.293 ± 0.091	1.029SerHis: 1.029 ± 0.03	3.294SerIle: 3.294 ± 0.067	2.591SerLys: 2.591 ± 0.056	6.062SerLeu: 6.062 ± 0.09	1.659SerMet: 1.659 ± 0.043	1.587SerAsn: 1.587 ± 0.046	2.693SerPro: 2.693 ± 0.057	2.288SerGln: 2.288 ± 0.058	3.333SerArg: 3.333 ± 0.064	3.363SerSer: 3.363 ± 0.078	2.744SerThr: 2.744 ± 0.066	4.004SerVal: 4.004 ± 0.073	0.59SerTrp: 0.59 ± 0.028	2.09SerTyr: 2.09 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.146ThrAla: 5.146 ± 0.079	0.705ThrCys: 0.705 ± 0.03	2.838ThrAsp: 2.838 ± 0.061	3.379ThrGlu: 3.379 ± 0.064	1.97ThrPhe: 1.97 ± 0.055	4.779ThrGly: 4.779 ± 0.085	0.915ThrHis: 0.915 ± 0.036	3.019ThrIle: 3.019 ± 0.071	2.271ThrLys: 2.271 ± 0.054	5.099ThrLeu: 5.099 ± 0.083	1.318ThrMet: 1.318 ± 0.041	1.552ThrAsn: 1.552 ± 0.056	2.669ThrPro: 2.669 ± 0.055	1.688ThrGln: 1.688 ± 0.051	2.322ThrArg: 2.322 ± 0.053	2.47ThrSer: 2.47 ± 0.051	2.373ThrThr: 2.373 ± 0.067	4.468ThrVal: 4.468 ± 0.087	0.45ThrTrp: 0.45 ± 0.026	1.629ThrTyr: 1.629 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.957ValAla: 4.957 ± 0.084	1.361ValCys: 1.361 ± 0.039	3.614ValAsp: 3.614 ± 0.076	4.702ValGlu: 4.702 ± 0.074	3.152ValPhe: 3.152 ± 0.056	4.2ValGly: 4.2 ± 0.079	1.039ValHis: 1.039 ± 0.035	3.676ValIle: 3.676 ± 0.074	3.678ValLys: 3.678 ± 0.073	7.412ValLeu: 7.412 ± 0.099	1.804ValMet: 1.804 ± 0.048	2.344ValAsn: 2.344 ± 0.057	3.102ValPro: 3.102 ± 0.062	2.41ValGln: 2.41 ± 0.046	3.606ValArg: 3.606 ± 0.065	4.671ValSer: 4.671 ± 0.075	3.985ValThr: 3.985 ± 0.094	4.619ValVal: 4.619 ± 0.075	0.694ValTrp: 0.694 ± 0.026	2.409ValTyr: 2.409 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.995TrpAla: 0.995 ± 0.036	0.196TrpCys: 0.196 ± 0.016	0.579TrpAsp: 0.579 ± 0.029	0.904TrpGlu: 0.904 ± 0.032	0.437TrpPhe: 0.437 ± 0.022	0.855TrpGly: 0.855 ± 0.034	0.228TrpHis: 0.228 ± 0.015	0.487TrpIle: 0.487 ± 0.024	0.592TrpLys: 0.592 ± 0.026	1.031TrpLeu: 1.031 ± 0.042	0.282TrpMet: 0.282 ± 0.019	0.418TrpAsn: 0.418 ± 0.025	0.297TrpPro: 0.297 ± 0.019	0.526TrpGln: 0.526 ± 0.027	0.538TrpArg: 0.538 ± 0.026	0.449TrpSer: 0.449 ± 0.023	0.456TrpThr: 0.456 ± 0.023	0.649TrpVal: 0.649 ± 0.028	0.138TrpTrp: 0.138 ± 0.014	0.428TrpTyr: 0.428 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.921TyrAla: 2.921 ± 0.064	0.636TyrCys: 0.636 ± 0.026	2.028TyrAsp: 2.028 ± 0.05	2.384TyrGlu: 2.384 ± 0.053	1.566TyrPhe: 1.566 ± 0.044	2.802TyrGly: 2.802 ± 0.063	0.729TyrHis: 0.729 ± 0.03	2.086TyrIle: 2.086 ± 0.05	1.747TyrLys: 1.747 ± 0.049	3.285TyrLeu: 3.285 ± 0.07	0.84TyrMet: 0.84 ± 0.027	1.422TyrAsn: 1.422 ± 0.04	1.453TyrPro: 1.453 ± 0.045	1.352TyrGln: 1.352 ± 0.04	2.02TyrArg: 2.02 ± 0.051	2.111TyrSer: 2.111 ± 0.047	2.175TyrThr: 2.175 ± 0.053	2.108TyrVal: 2.108 ± 0.049	0.359TyrTrp: 0.359 ± 0.021	1.416TyrTyr: 1.416 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3248 proteins (899311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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