Amino acid dipepetide frequency for Syntrophotalea acetylenivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.139AlaAla: 10.139 ± 0.149	1.237AlaCys: 1.237 ± 0.04	5.091AlaAsp: 5.091 ± 0.081	6.943AlaGlu: 6.943 ± 0.093	3.453AlaPhe: 3.453 ± 0.073	7.905AlaGly: 7.905 ± 0.112	1.615AlaHis: 1.615 ± 0.045	5.173AlaIle: 5.173 ± 0.081	3.866AlaLys: 3.866 ± 0.076	11.047AlaLeu: 11.047 ± 0.136	2.428AlaMet: 2.428 ± 0.058	2.58AlaAsn: 2.58 ± 0.055	3.355AlaPro: 3.355 ± 0.065	3.282AlaGln: 3.282 ± 0.063	5.431AlaArg: 5.431 ± 0.096	4.914AlaSer: 4.914 ± 0.088	4.387AlaThr: 4.387 ± 0.073	6.96AlaVal: 6.96 ± 0.098	0.893AlaTrp: 0.893 ± 0.033	2.131AlaTyr: 2.131 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.015CysAla: 1.015 ± 0.037	0.291CysCys: 0.291 ± 0.019	0.722CysAsp: 0.722 ± 0.032	0.68CysGlu: 0.68 ± 0.029	0.482CysPhe: 0.482 ± 0.022	1.423CysGly: 1.423 ± 0.046	0.44CysHis: 0.44 ± 0.028	0.561CysIle: 0.561 ± 0.025	0.469CysLys: 0.469 ± 0.026	1.38CysLeu: 1.38 ± 0.039	0.245CysMet: 0.245 ± 0.015	0.418CysAsn: 0.418 ± 0.021	0.809CysPro: 0.809 ± 0.036	0.572CysGln: 0.572 ± 0.026	1.044CysArg: 1.044 ± 0.036	0.866CysSer: 0.866 ± 0.03	0.512CysThr: 0.512 ± 0.024	0.693CysVal: 0.693 ± 0.031	0.173CysTrp: 0.173 ± 0.015	0.429CysTyr: 0.429 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.138AspAla: 4.138 ± 0.069	0.808AspCys: 0.808 ± 0.03	2.675AspAsp: 2.675 ± 0.061	3.508AspGlu: 3.508 ± 0.063	2.543AspPhe: 2.543 ± 0.053	4.1AspGly: 4.1 ± 0.081	1.265AspHis: 1.265 ± 0.037	3.402AspIle: 3.402 ± 0.063	2.301AspLys: 2.301 ± 0.057	6.701AspLeu: 6.701 ± 0.092	1.279AspMet: 1.279 ± 0.038	1.743AspAsn: 1.743 ± 0.042	2.729AspPro: 2.729 ± 0.055	2.258AspGln: 2.258 ± 0.055	3.628AspArg: 3.628 ± 0.075	2.962AspSer: 2.962 ± 0.059	2.263AspThr: 2.263 ± 0.055	3.169AspVal: 3.169 ± 0.066	0.75AspTrp: 0.75 ± 0.033	1.888AspTyr: 1.888 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.247GluAla: 6.247 ± 0.1	0.547GluCys: 0.547 ± 0.027	3.039GluAsp: 3.039 ± 0.063	5.296GluGlu: 5.296 ± 0.112	2.225GluPhe: 2.225 ± 0.046	4.63GluGly: 4.63 ± 0.069	1.284GluHis: 1.284 ± 0.037	4.215GluIle: 4.215 ± 0.08	3.785GluLys: 3.785 ± 0.074	7.523GluLeu: 7.523 ± 0.093	1.752GluMet: 1.752 ± 0.048	2.099GluAsn: 2.099 ± 0.051	2.303GluPro: 2.303 ± 0.049	3.693GluGln: 3.693 ± 0.065	4.411GluArg: 4.411 ± 0.067	3.185GluSer: 3.185 ± 0.07	3.357GluThr: 3.357 ± 0.061	4.969GluVal: 4.969 ± 0.083	0.568GluTrp: 0.568 ± 0.027	1.48GluTyr: 1.48 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.6PheAla: 3.6 ± 0.071	0.648PheCys: 0.648 ± 0.031	2.597PheAsp: 2.597 ± 0.059	2.247PheGlu: 2.247 ± 0.055	1.977PhePhe: 1.977 ± 0.06	3.275PheGly: 3.275 ± 0.069	0.875PheHis: 0.875 ± 0.033	2.129PheIle: 2.129 ± 0.057	1.568PheLys: 1.568 ± 0.044	4.203PheLeu: 4.203 ± 0.083	0.896PheMet: 0.896 ± 0.036	1.448PheAsn: 1.448 ± 0.043	1.677PhePro: 1.677 ± 0.046	1.25PheGln: 1.25 ± 0.039	2.191PheArg: 2.191 ± 0.049	2.918PheSer: 2.918 ± 0.062	1.954PheThr: 1.954 ± 0.049	2.645PheVal: 2.645 ± 0.06	0.496PheTrp: 0.496 ± 0.025	1.13PheTyr: 1.13 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.308GlyAla: 6.308 ± 0.101	1.269GlyCys: 1.269 ± 0.042	4.044GlyAsp: 4.044 ± 0.083	4.864GlyGlu: 4.864 ± 0.068	3.223GlyPhe: 3.223 ± 0.064	6.064GlyGly: 6.064 ± 0.123	1.76GlyHis: 1.76 ± 0.05	4.863GlyIle: 4.863 ± 0.089	3.984GlyLys: 3.984 ± 0.075	8.737GlyLeu: 8.737 ± 0.108	2.123GlyMet: 2.123 ± 0.052	2.343GlyAsn: 2.343 ± 0.055	2.523GlyPro: 2.523 ± 0.055	3.316GlyGln: 3.316 ± 0.06	5.164GlyArg: 5.164 ± 0.076	4.383GlySer: 4.383 ± 0.08	3.866GlyThr: 3.866 ± 0.077	5.627GlyVal: 5.627 ± 0.084	0.911GlyTrp: 0.911 ± 0.034	2.526GlyTyr: 2.526 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.454HisAla: 1.454 ± 0.044	0.377HisCys: 0.377 ± 0.02	1.022HisAsp: 1.022 ± 0.032	1.031HisGlu: 1.031 ± 0.036	1.076HisPhe: 1.076 ± 0.038	1.68HisGly: 1.68 ± 0.039	0.666HisHis: 0.666 ± 0.031	1.154HisIle: 1.154 ± 0.035	0.763HisLys: 0.763 ± 0.031	2.544HisLeu: 2.544 ± 0.065	0.418HisMet: 0.418 ± 0.022	0.704HisAsn: 0.704 ± 0.029	1.381HisPro: 1.381 ± 0.039	0.916HisGln: 0.916 ± 0.037	1.489HisArg: 1.489 ± 0.05	1.198HisSer: 1.198 ± 0.038	0.888HisThr: 0.888 ± 0.033	1.101HisVal: 1.101 ± 0.035	0.286HisTrp: 0.286 ± 0.018	0.657HisTyr: 0.657 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.387IleAla: 5.387 ± 0.077	0.831IleCys: 0.831 ± 0.03	4.032IleAsp: 4.032 ± 0.068	3.99IleGlu: 3.99 ± 0.068	2.162IlePhe: 2.162 ± 0.056	4.526IleGly: 4.526 ± 0.092	1.174IleHis: 1.174 ± 0.039	3.054IleIle: 3.054 ± 0.076	2.389IleLys: 2.389 ± 0.055	5.557IleLeu: 5.557 ± 0.103	1.101IleMet: 1.101 ± 0.037	2.086IleAsn: 2.086 ± 0.054	2.734IlePro: 2.734 ± 0.052	1.67IleGln: 1.67 ± 0.044	3.198IleArg: 3.198 ± 0.06	3.53IleSer: 3.53 ± 0.066	2.829IleThr: 2.829 ± 0.047	3.963IleVal: 3.963 ± 0.075	0.473IleTrp: 0.473 ± 0.019	1.509IleTyr: 1.509 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.1LysAla: 4.1 ± 0.077	0.391LysCys: 0.391 ± 0.024	2.426LysAsp: 2.426 ± 0.059	3.389LysGlu: 3.389 ± 0.073	1.183LysPhe: 1.183 ± 0.041	3.387LysGly: 3.387 ± 0.064	0.835LysHis: 0.835 ± 0.031	2.744LysIle: 2.744 ± 0.063	2.802LysLys: 2.802 ± 0.08	4.197LysLeu: 4.197 ± 0.075	1.093LysMet: 1.093 ± 0.037	1.661LysAsn: 1.661 ± 0.042	1.995LysPro: 1.995 ± 0.053	1.927LysGln: 1.927 ± 0.049	2.735LysArg: 2.735 ± 0.059	2.336LysSer: 2.336 ± 0.055	2.448LysThr: 2.448 ± 0.057	3.483LysVal: 3.483 ± 0.075	0.365LysTrp: 0.365 ± 0.021	1.093LysTyr: 1.093 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	12.218LeuAla: 12.218 ± 0.146	1.44LeuCys: 1.44 ± 0.043	6.043LeuAsp: 6.043 ± 0.1	7.136LeuGlu: 7.136 ± 0.099	4.622LeuPhe: 4.622 ± 0.085	8.189LeuGly: 8.189 ± 0.124	2.264LeuHis: 2.264 ± 0.058	5.666LeuIle: 5.666 ± 0.093	5.085LeuLys: 5.085 ± 0.084	14.079LeuLeu: 14.079 ± 0.21	2.349LeuMet: 2.349 ± 0.047	3.312LeuAsn: 3.312 ± 0.06	5.906LeuPro: 5.906 ± 0.084	5.294LeuGln: 5.294 ± 0.094	7.02LeuArg: 7.02 ± 0.098	7.083LeuSer: 7.083 ± 0.106	5.67LeuThr: 5.67 ± 0.089	8.045LeuVal: 8.045 ± 0.123	1.132LeuTrp: 1.132 ± 0.036	2.571LeuTyr: 2.571 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.676MetAla: 2.676 ± 0.059	0.165MetCys: 0.165 ± 0.014	1.21MetAsp: 1.21 ± 0.037	1.585MetGlu: 1.585 ± 0.046	0.678MetPhe: 0.678 ± 0.027	1.642MetGly: 1.642 ± 0.039	0.397MetHis: 0.397 ± 0.024	1.241MetIle: 1.241 ± 0.038	1.282MetLys: 1.282 ± 0.04	2.372MetLeu: 2.372 ± 0.054	0.535MetMet: 0.535 ± 0.033	0.845MetAsn: 0.845 ± 0.029	1.104MetPro: 1.104 ± 0.035	0.899MetGln: 0.899 ± 0.035	1.304MetArg: 1.304 ± 0.043	1.362MetSer: 1.362 ± 0.041	1.421MetThr: 1.421 ± 0.037	1.892MetVal: 1.892 ± 0.05	0.121MetTrp: 0.121 ± 0.012	0.355MetTyr: 0.355 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.462AsnAla: 2.462 ± 0.06	0.451AsnCys: 0.451 ± 0.026	1.686AsnAsp: 1.686 ± 0.047	1.628AsnGlu: 1.628 ± 0.048	1.224AsnPhe: 1.224 ± 0.04	2.324AsnGly: 2.324 ± 0.053	0.674AsnHis: 0.674 ± 0.026	2.091AsnIle: 2.091 ± 0.052	1.331AsnLys: 1.331 ± 0.041	3.82AsnLeu: 3.82 ± 0.077	0.696AsnMet: 0.696 ± 0.027	1.12AsnAsn: 1.12 ± 0.039	1.925AsnPro: 1.925 ± 0.046	1.19AsnGln: 1.19 ± 0.034	2.253AsnArg: 2.253 ± 0.056	1.727AsnSer: 1.727 ± 0.048	1.347AsnThr: 1.347 ± 0.042	1.974AsnVal: 1.974 ± 0.05	0.374AsnTrp: 0.374 ± 0.024	0.977AsnTyr: 0.977 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.318ProAla: 4.318 ± 0.08	0.557ProCys: 0.557 ± 0.027	2.646ProAsp: 2.646 ± 0.052	3.744ProGlu: 3.744 ± 0.065	1.94ProPhe: 1.94 ± 0.054	3.814ProGly: 3.814 ± 0.059	0.946ProHis: 0.946 ± 0.033	2.119ProIle: 2.119 ± 0.051	1.712ProLys: 1.712 ± 0.049	5.177ProLeu: 5.177 ± 0.099	0.995ProMet: 0.995 ± 0.029	1.222ProAsn: 1.222 ± 0.038	1.897ProPro: 1.897 ± 0.052	1.9ProGln: 1.9 ± 0.045	2.236ProArg: 2.236 ± 0.058	2.368ProSer: 2.368 ± 0.051	2.075ProThr: 2.075 ± 0.044	3.751ProVal: 3.751 ± 0.058	0.56ProTrp: 0.56 ± 0.026	1.175ProTyr: 1.175 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.375GlnAla: 4.375 ± 0.08	0.391GlnCys: 0.391 ± 0.02	1.884GlnAsp: 1.884 ± 0.052	2.948GlnGlu: 2.948 ± 0.069	1.228GlnPhe: 1.228 ± 0.041	3.223GlnGly: 3.223 ± 0.056	0.846GlnHis: 0.846 ± 0.034	2.343GlnIle: 2.343 ± 0.051	2.108GlnLys: 2.108 ± 0.048	4.667GlnLeu: 4.667 ± 0.086	0.955GlnMet: 0.955 ± 0.033	1.216GlnAsn: 1.216 ± 0.04	1.841GlnPro: 1.841 ± 0.049	2.75GlnGln: 2.75 ± 0.068	3.088GlnArg: 3.088 ± 0.064	2.033GlnSer: 2.033 ± 0.047	1.964GlnThr: 1.964 ± 0.054	3.465GlnVal: 3.465 ± 0.063	0.403GlnTrp: 0.403 ± 0.021	0.8GlnTyr: 0.8 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.576ArgAla: 4.576 ± 0.084	0.88ArgCys: 0.88 ± 0.031	3.116ArgAsp: 3.116 ± 0.066	4.204ArgGlu: 4.204 ± 0.075	2.804ArgPhe: 2.804 ± 0.059	3.879ArgGly: 3.879 ± 0.073	1.55ArgHis: 1.55 ± 0.048	3.978ArgIle: 3.978 ± 0.078	2.942ArgLys: 2.942 ± 0.057	7.788ArgLeu: 7.788 ± 0.12	1.533ArgMet: 1.533 ± 0.04	2.033ArgAsn: 2.033 ± 0.047	2.663ArgPro: 2.663 ± 0.053	3.559ArgGln: 3.559 ± 0.068	4.574ArgArg: 4.574 ± 0.078	3.565ArgSer: 3.565 ± 0.074	2.755ArgThr: 2.755 ± 0.055	3.974ArgVal: 3.974 ± 0.069	0.823ArgTrp: 0.823 ± 0.031	2.084ArgTyr: 2.084 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.943SerAla: 4.943 ± 0.072	0.84SerCys: 0.84 ± 0.03	3.03SerAsp: 3.03 ± 0.059	3.433SerGlu: 3.433 ± 0.053	2.61SerPhe: 2.61 ± 0.06	5.166SerGly: 5.166 ± 0.091	1.232SerHis: 1.232 ± 0.039	3.041SerIle: 3.041 ± 0.065	2.203SerLys: 2.203 ± 0.048	6.782SerLeu: 6.782 ± 0.092	1.37SerMet: 1.37 ± 0.039	1.723SerAsn: 1.723 ± 0.048	2.685SerPro: 2.685 ± 0.057	2.23SerGln: 2.23 ± 0.057	3.618SerArg: 3.618 ± 0.068	3.454SerSer: 3.454 ± 0.07	2.586SerThr: 2.586 ± 0.064	3.674SerVal: 3.674 ± 0.062	0.707SerTrp: 0.707 ± 0.026	1.598SerTyr: 1.598 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.751ThrAla: 4.751 ± 0.081	0.58ThrCys: 0.58 ± 0.026	2.674ThrAsp: 2.674 ± 0.048	3.001ThrGlu: 3.001 ± 0.057	1.906ThrPhe: 1.906 ± 0.05	4.441ThrGly: 4.441 ± 0.079	0.841ThrHis: 0.841 ± 0.033	2.887ThrIle: 2.887 ± 0.057	1.591ThrLys: 1.591 ± 0.047	6.042ThrLeu: 6.042 ± 0.087	1.083ThrMet: 1.083 ± 0.034	1.386ThrAsn: 1.386 ± 0.042	2.554ThrPro: 2.554 ± 0.054	1.276ThrGln: 1.276 ± 0.039	2.551ThrArg: 2.551 ± 0.05	2.594ThrSer: 2.594 ± 0.051	2.478ThrThr: 2.478 ± 0.06	4.002ThrVal: 4.002 ± 0.068	0.423ThrTrp: 0.423 ± 0.024	1.169ThrTyr: 1.169 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.313ValAla: 7.313 ± 0.089	0.96ValCys: 0.96 ± 0.038	4.139ValAsp: 4.139 ± 0.07	5.017ValGlu: 5.017 ± 0.078	2.723ValPhe: 2.723 ± 0.058	5.309ValGly: 5.309 ± 0.082	1.239ValHis: 1.239 ± 0.039	3.863ValIle: 3.863 ± 0.076	3.087ValLys: 3.087 ± 0.069	7.795ValLeu: 7.795 ± 0.119	1.558ValMet: 1.558 ± 0.043	2.239ValAsn: 2.239 ± 0.044	3.251ValPro: 3.251 ± 0.058	2.425ValGln: 2.425 ± 0.052	4.187ValArg: 4.187 ± 0.08	4.249ValSer: 4.249 ± 0.074	3.904ValThr: 3.904 ± 0.075	5.84ValVal: 5.84 ± 0.107	0.647ValTrp: 0.647 ± 0.027	1.709ValTyr: 1.709 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.772TrpAla: 0.772 ± 0.029	0.146TrpCys: 0.146 ± 0.014	0.534TrpAsp: 0.534 ± 0.025	0.595TrpGlu: 0.595 ± 0.029	0.424TrpPhe: 0.424 ± 0.026	0.761TrpGly: 0.761 ± 0.032	0.261TrpHis: 0.261 ± 0.014	0.533TrpIle: 0.533 ± 0.025	0.468TrpLys: 0.468 ± 0.024	1.328TrpLeu: 1.328 ± 0.041	0.23TrpMet: 0.23 ± 0.016	0.326TrpAsn: 0.326 ± 0.019	0.477TrpPro: 0.477 ± 0.029	0.843TrpGln: 0.843 ± 0.033	0.752TrpArg: 0.752 ± 0.033	0.604TrpSer: 0.604 ± 0.032	0.411TrpThr: 0.411 ± 0.024	0.657TrpVal: 0.657 ± 0.03	0.155TrpTrp: 0.155 ± 0.014	0.279TrpTyr: 0.279 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.037TyrAla: 2.037 ± 0.05	0.414TyrCys: 0.414 ± 0.023	1.5TyrAsp: 1.5 ± 0.043	1.367TyrGlu: 1.367 ± 0.042	1.242TyrPhe: 1.242 ± 0.04	2.163TyrGly: 2.163 ± 0.054	0.644TyrHis: 0.644 ± 0.028	1.137TyrIle: 1.137 ± 0.037	0.858TyrLys: 0.858 ± 0.033	3.387TyrLeu: 3.387 ± 0.069	0.443TyrMet: 0.443 ± 0.023	0.769TyrAsn: 0.769 ± 0.035	1.342TyrPro: 1.342 ± 0.044	1.28TyrGln: 1.28 ± 0.039	2.406TyrArg: 2.406 ± 0.053	1.593TyrSer: 1.593 ± 0.046	1.114TyrThr: 1.114 ± 0.033	1.568TyrVal: 1.568 ± 0.041	0.297TyrTrp: 0.297 ± 0.019	0.85TyrTyr: 0.85 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2762 proteins (882519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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