Amino acid dipepetide frequency for Riemerella columbipharyngis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.897AlaAla: 3.897 ± 0.103
0.512AlaCys: 0.512 ± 0.032
3.375AlaAsp: 3.375 ± 0.066
4.521AlaGlu: 4.521 ± 0.102
3.058AlaPhe: 3.058 ± 0.07
4.007AlaGly: 4.007 ± 0.085
1.111AlaHis: 1.111 ± 0.046
4.612AlaIle: 4.612 ± 0.112
5.504AlaLys: 5.504 ± 0.096
5.983AlaLeu: 5.983 ± 0.112
1.734AlaMet: 1.734 ± 0.06
3.171AlaAsn: 3.171 ± 0.081
1.673AlaPro: 1.673 ± 0.055
2.609AlaGln: 2.609 ± 0.075
2.107AlaArg: 2.107 ± 0.061
3.631AlaSer: 3.631 ± 0.095
3.043AlaThr: 3.043 ± 0.068
4.126AlaVal: 4.126 ± 0.084
0.544AlaTrp: 0.544 ± 0.029
2.643AlaTyr: 2.643 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.455CysAla: 0.455 ± 0.027
0.106CysCys: 0.106 ± 0.015
0.403CysAsp: 0.403 ± 0.027
0.49CysGlu: 0.49 ± 0.025
0.463CysPhe: 0.463 ± 0.032
0.64CysGly: 0.64 ± 0.033
0.166CysHis: 0.166 ± 0.017
0.648CysIle: 0.648 ± 0.031
0.532CysLys: 0.532 ± 0.03
0.693CysLeu: 0.693 ± 0.034
0.186CysMet: 0.186 ± 0.018
0.389CysAsn: 0.389 ± 0.027
0.378CysPro: 0.378 ± 0.031
0.235CysGln: 0.235 ± 0.02
0.347CysArg: 0.347 ± 0.026
0.548CysSer: 0.548 ± 0.034
0.424CysThr: 0.424 ± 0.025
0.445CysVal: 0.445 ± 0.027
0.059CysTrp: 0.059 ± 0.008
0.311CysTyr: 0.311 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.495AspAla: 3.495 ± 0.076
0.387AspCys: 0.387 ± 0.026
2.752AspAsp: 2.752 ± 0.078
3.975AspGlu: 3.975 ± 0.092
3.85AspPhe: 3.85 ± 0.088
3.298AspGly: 3.298 ± 0.081
0.709AspHis: 0.709 ± 0.034
4.678AspIle: 4.678 ± 0.084
5.004AspLys: 5.004 ± 0.116
4.907AspLeu: 4.907 ± 0.091
1.164AspMet: 1.164 ± 0.042
3.171AspAsn: 3.171 ± 0.07
1.415AspPro: 1.415 ± 0.047
1.202AspGln: 1.202 ± 0.05
2.044AspArg: 2.044 ± 0.056
2.983AspSer: 2.983 ± 0.074
2.707AspThr: 2.707 ± 0.066
3.015AspVal: 3.015 ± 0.062
0.698AspTrp: 0.698 ± 0.035
2.907AspTyr: 2.907 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.476GluAla: 4.476 ± 0.101
0.395GluCys: 0.395 ± 0.022
3.572GluAsp: 3.572 ± 0.085
5.512GluGlu: 5.512 ± 0.138
2.81GluPhe: 2.81 ± 0.069
3.727GluGly: 3.727 ± 0.087
1.217GluHis: 1.217 ± 0.044
5.955GluIle: 5.955 ± 0.117
7.211GluLys: 7.211 ± 0.12
6.164GluLeu: 6.164 ± 0.117
1.806GluMet: 1.806 ± 0.055
4.891GluAsn: 4.891 ± 0.114
1.497GluPro: 1.497 ± 0.052
2.776GluGln: 2.776 ± 0.07
2.882GluArg: 2.882 ± 0.082
3.018GluSer: 3.018 ± 0.067
3.314GluThr: 3.314 ± 0.081
4.391GluVal: 4.391 ± 0.1
0.751GluTrp: 0.751 ± 0.032
2.579GluTyr: 2.579 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.811PheAla: 2.811 ± 0.076
0.504PheCys: 0.504 ± 0.028
2.958PheAsp: 2.958 ± 0.077
3.059PheGlu: 3.059 ± 0.073
2.874PhePhe: 2.874 ± 0.084
3.472PheGly: 3.472 ± 0.086
0.791PheHis: 0.791 ± 0.035
4.06PheIle: 4.06 ± 0.095
3.272PheLys: 3.272 ± 0.081
4.841PheLeu: 4.841 ± 0.118
1.255PheMet: 1.255 ± 0.047
2.846PheAsn: 2.846 ± 0.069
1.731PhePro: 1.731 ± 0.059
1.675PheGln: 1.675 ± 0.049
2.145PheArg: 2.145 ± 0.058
4.206PheSer: 4.206 ± 0.107
2.584PheThr: 2.584 ± 0.062
3.122PheVal: 3.122 ± 0.077
0.596PheTrp: 0.596 ± 0.034
2.312PheTyr: 2.312 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
3.903GlyAla: 3.903 ± 0.097
0.549GlyCys: 0.549 ± 0.032
3.285GlyAsp: 3.285 ± 0.078
3.756GlyGlu: 3.756 ± 0.087
3.312GlyPhe: 3.312 ± 0.08
4.337GlyGly: 4.337 ± 0.1
1.05GlyHis: 1.05 ± 0.044
5.533GlyIle: 5.533 ± 0.106
5.879GlyLys: 5.879 ± 0.093
5.48GlyLeu: 5.48 ± 0.099
1.511GlyMet: 1.511 ± 0.053
3.54GlyAsn: 3.54 ± 0.092
1.037GlyPro: 1.037 ± 0.042
1.867GlyGln: 1.867 ± 0.064
2.433GlyArg: 2.433 ± 0.068
3.476GlySer: 3.476 ± 0.081
3.468GlyThr: 3.468 ± 0.081
4.399GlyVal: 4.399 ± 0.099
0.744GlyTrp: 0.744 ± 0.032
3.021GlyTyr: 3.021 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
0.816HisAla: 0.816 ± 0.039
0.235HisCys: 0.235 ± 0.021
0.644HisAsp: 0.644 ± 0.031
0.805HisGlu: 0.805 ± 0.037
1.173HisPhe: 1.173 ± 0.053
0.903HisGly: 0.903 ± 0.039
0.485HisHis: 0.485 ± 0.032
1.522HisIle: 1.522 ± 0.041
1.252HisLys: 1.252 ± 0.047
1.83HisLeu: 1.83 ± 0.055
0.309HisMet: 0.309 ± 0.023
1.013HisAsn: 1.013 ± 0.04
0.824HisPro: 0.824 ± 0.029
0.762HisGln: 0.762 ± 0.034
0.864HisArg: 0.864 ± 0.036
1.161HisSer: 1.161 ± 0.042
0.924HisThr: 0.924 ± 0.046
0.458HisVal: 0.458 ± 0.03
0.213HisTrp: 0.213 ± 0.021
0.953HisTyr: 0.953 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.209IleAla: 5.209 ± 0.085
0.666IleCys: 0.666 ± 0.034
4.777IleAsp: 4.777 ± 0.084
5.53IleGlu: 5.53 ± 0.113
4.007IlePhe: 4.007 ± 0.102
4.939IleGly: 4.939 ± 0.103
1.287IleHis: 1.287 ± 0.039
6.328IleIle: 6.328 ± 0.124
6.905IleLys: 6.905 ± 0.113
7.291IleLeu: 7.291 ± 0.133
1.532IleMet: 1.532 ± 0.045
4.678IleAsn: 4.678 ± 0.093
3.487IlePro: 3.487 ± 0.077
2.701IleGln: 2.701 ± 0.069
2.85IleArg: 2.85 ± 0.065
5.995IleSer: 5.995 ± 0.1
4.212IleThr: 4.212 ± 0.086
4.502IleVal: 4.502 ± 0.083
0.676IleTrp: 0.676 ± 0.035
2.968IleTyr: 2.968 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.453LysAla: 5.453 ± 0.102
0.455LysCys: 0.455 ± 0.03
5.089LysAsp: 5.089 ± 0.093
6.914LysGlu: 6.914 ± 0.117
3.396LysPhe: 3.396 ± 0.075
5.096LysGly: 5.096 ± 0.094
1.417LysHis: 1.417 ± 0.051
7.929LysIle: 7.929 ± 0.109
8.435LysLys: 8.435 ± 0.131
6.737LysLeu: 6.737 ± 0.123
2.568LysMet: 2.568 ± 0.055
6.349LysAsn: 6.349 ± 0.109
2.637LysPro: 2.637 ± 0.064
2.946LysGln: 2.946 ± 0.077
3.226LysArg: 3.226 ± 0.078
5.133LysSer: 5.133 ± 0.094
4.98LysThr: 4.98 ± 0.087
4.958LysVal: 4.958 ± 0.098
0.821LysTrp: 0.821 ± 0.043
3.692LysTyr: 3.692 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
5.594LeuAla: 5.594 ± 0.103
0.808LeuCys: 0.808 ± 0.04
4.892LeuAsp: 4.892 ± 0.094
6.09LeuGlu: 6.09 ± 0.112
4.598LeuPhe: 4.598 ± 0.116
5.984LeuGly: 5.984 ± 0.12
1.486LeuHis: 1.486 ± 0.052
6.205LeuIle: 6.205 ± 0.103
8.323LeuLys: 8.323 ± 0.122
8.024LeuLeu: 8.024 ± 0.13
2.36LeuMet: 2.36 ± 0.062
5.193LeuAsn: 5.193 ± 0.102
3.413LeuPro: 3.413 ± 0.067
3.019LeuGln: 3.019 ± 0.07
3.436LeuArg: 3.436 ± 0.073
7.239LeuSer: 7.239 ± 0.111
4.294LeuThr: 4.294 ± 0.081
5.085LeuVal: 5.085 ± 0.083
0.791LeuTrp: 0.791 ± 0.036
3.378LeuTyr: 3.378 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.75MetAla: 1.75 ± 0.051
0.141MetCys: 0.141 ± 0.014
1.213MetAsp: 1.213 ± 0.046
1.572MetGlu: 1.572 ± 0.056
0.948MetPhe: 0.948 ± 0.041
1.654MetGly: 1.654 ± 0.053
0.349MetHis: 0.349 ± 0.028
1.761MetIle: 1.761 ± 0.069
2.766MetLys: 2.766 ± 0.065
2.211MetLeu: 2.211 ± 0.065
0.781MetMet: 0.781 ± 0.036
1.497MetAsn: 1.497 ± 0.051
0.981MetPro: 0.981 ± 0.041
0.815MetGln: 0.815 ± 0.039
0.962MetArg: 0.962 ± 0.043
1.481MetSer: 1.481 ± 0.049
1.133MetThr: 1.133 ± 0.042
1.463MetVal: 1.463 ± 0.053
0.157MetTrp: 0.157 ± 0.016
0.658MetTyr: 0.658 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.757AsnAla: 3.757 ± 0.077
0.397AsnCys: 0.397 ± 0.024
2.861AsnAsp: 2.861 ± 0.07
3.681AsnGlu: 3.681 ± 0.079
3.202AsnPhe: 3.202 ± 0.082
3.825AsnGly: 3.825 ± 0.094
1.119AsnHis: 1.119 ± 0.042
5.59AsnIle: 5.59 ± 0.098
4.822AsnLys: 4.822 ± 0.088
5.283AsnLeu: 5.283 ± 0.096
1.292AsnMet: 1.292 ± 0.047
3.701AsnAsn: 3.701 ± 0.094
2.814AsnPro: 2.814 ± 0.059
2.156AsnGln: 2.156 ± 0.062
2.299AsnArg: 2.299 ± 0.059
3.399AsnSer: 3.399 ± 0.079
3.439AsnThr: 3.439 ± 0.093
3.175AsnVal: 3.175 ± 0.079
0.66AsnTrp: 0.66 ± 0.032
2.739AsnTyr: 2.739 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.884ProAla: 1.884 ± 0.056
0.259ProCys: 0.259 ± 0.021
1.929ProAsp: 1.929 ± 0.059
2.653ProGlu: 2.653 ± 0.07
1.742ProPhe: 1.742 ± 0.055
1.54ProGly: 1.54 ± 0.043
0.629ProHis: 0.629 ± 0.029
2.595ProIle: 2.595 ± 0.067
3.251ProLys: 3.251 ± 0.08
2.787ProLeu: 2.787 ± 0.062
0.816ProMet: 0.816 ± 0.035
2.241ProAsn: 2.241 ± 0.066
0.864ProPro: 0.864 ± 0.046
1.327ProGln: 1.327 ± 0.046
0.991ProArg: 0.991 ± 0.044
2.092ProSer: 2.092 ± 0.055
1.769ProThr: 1.769 ± 0.049
2.118ProVal: 2.118 ± 0.06
0.275ProTrp: 0.275 ± 0.025
1.679ProTyr: 1.679 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.073GlnAla: 2.073 ± 0.059
0.251GlnCys: 0.251 ± 0.018
1.753GlnAsp: 1.753 ± 0.053
2.613GlnGlu: 2.613 ± 0.063
1.505GlnPhe: 1.505 ± 0.055
2.011GlnGly: 2.011 ± 0.061
0.522GlnHis: 0.522 ± 0.025
2.842GlnIle: 2.842 ± 0.068
3.588GlnLys: 3.588 ± 0.087
3.05GlnLeu: 3.05 ± 0.074
0.962GlnMet: 0.962 ± 0.043
2.513GlnAsn: 2.513 ± 0.076
1.042GlnPro: 1.042 ± 0.047
1.378GlnGln: 1.378 ± 0.058
1.439GlnArg: 1.439 ± 0.052
2.073GlnSer: 2.073 ± 0.059
1.745GlnThr: 1.745 ± 0.054
1.863GlnVal: 1.863 ± 0.056
0.394GlnTrp: 0.394 ± 0.023
1.574GlnTyr: 1.574 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
2.2ArgAla: 2.2 ± 0.067
0.251ArgCys: 0.251 ± 0.022
1.969ArgAsp: 1.969 ± 0.054
2.742ArgGlu: 2.742 ± 0.076
1.953ArgPhe: 1.953 ± 0.055
2.2ArgGly: 2.2 ± 0.065
0.711ArgHis: 0.711 ± 0.036
3.122ArgIle: 3.122 ± 0.066
3.448ArgLys: 3.448 ± 0.076
3.615ArgLeu: 3.615 ± 0.079
1.015ArgMet: 1.015 ± 0.039
2.461ArgAsn: 2.461 ± 0.071
1.151ArgPro: 1.151 ± 0.047
1.369ArgGln: 1.369 ± 0.05
1.734ArgArg: 1.734 ± 0.06
1.833ArgSer: 1.833 ± 0.055
1.833ArgThr: 1.833 ± 0.055
2.301ArgVal: 2.301 ± 0.06
0.418ArgTrp: 0.418 ± 0.027
1.705ArgTyr: 1.705 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.783SerAla: 3.783 ± 0.084
0.621SerCys: 0.621 ± 0.031
3.532SerAsp: 3.532 ± 0.07
4.174SerGlu: 4.174 ± 0.082
3.524SerPhe: 3.524 ± 0.082
4.457SerGly: 4.457 ± 0.104
1.047SerHis: 1.047 ± 0.041
4.923SerIle: 4.923 ± 0.094
4.936SerLys: 4.936 ± 0.08
5.766SerLeu: 5.766 ± 0.105
1.338SerMet: 1.338 ± 0.047
3.344SerAsn: 3.344 ± 0.086
2.185SerPro: 2.185 ± 0.056
2.22SerGln: 2.22 ± 0.063
2.176SerArg: 2.176 ± 0.061
3.825SerSer: 3.825 ± 0.085
3.018SerThr: 3.018 ± 0.066
4.207SerVal: 4.207 ± 0.089
0.631SerTrp: 0.631 ± 0.035
2.726SerTyr: 2.726 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
3.405ThrAla: 3.405 ± 0.091
0.309ThrCys: 0.309 ± 0.02
3.034ThrAsp: 3.034 ± 0.073
3.568ThrGlu: 3.568 ± 0.069
2.371ThrPhe: 2.371 ± 0.061
3.476ThrGly: 3.476 ± 0.08
0.965ThrHis: 0.965 ± 0.038
3.999ThrIle: 3.999 ± 0.075
4.066ThrLys: 4.066 ± 0.083
5.085ThrLeu: 5.085 ± 0.091
1.06ThrMet: 1.06 ± 0.04
2.702ThrAsn: 2.702 ± 0.074
2.462ThrPro: 2.462 ± 0.06
1.948ThrGln: 1.948 ± 0.057
1.574ThrArg: 1.574 ± 0.049
2.96ThrSer: 2.96 ± 0.076
2.754ThrThr: 2.754 ± 0.084
2.93ThrVal: 2.93 ± 0.064
0.455ThrTrp: 0.455 ± 0.027
2.052ThrTyr: 2.052 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
3.717ValAla: 3.717 ± 0.091
0.556ValCys: 0.556 ± 0.031
3.178ValAsp: 3.178 ± 0.084
4.095ValGlu: 4.095 ± 0.09
3.163ValPhe: 3.163 ± 0.086
3.717ValGly: 3.717 ± 0.1
0.927ValHis: 0.927 ± 0.038
4.379ValIle: 4.379 ± 0.095
4.755ValLys: 4.755 ± 0.086
5.766ValLeu: 5.766 ± 0.109
1.457ValMet: 1.457 ± 0.053
3.253ValAsn: 3.253 ± 0.077
2.105ValPro: 2.105 ± 0.058
1.836ValGln: 1.836 ± 0.056
2.206ValArg: 2.206 ± 0.067
4.138ValSer: 4.138 ± 0.089
2.718ValThr: 2.718 ± 0.072
4.143ValVal: 4.143 ± 0.103
0.557ValTrp: 0.557 ± 0.031
2.568ValTyr: 2.568 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.655TrpAla: 0.655 ± 0.033
0.085TrpCys: 0.085 ± 0.012
0.604TrpAsp: 0.604 ± 0.031
0.692TrpGlu: 0.692 ± 0.04
0.514TrpPhe: 0.514 ± 0.028
0.626TrpGly: 0.626 ± 0.034
0.195TrpHis: 0.195 ± 0.019
0.772TrpIle: 0.772 ± 0.03
0.858TrpLys: 0.858 ± 0.037
0.877TrpLeu: 0.877 ± 0.033
0.311TrpMet: 0.311 ± 0.022
0.701TrpAsn: 0.701 ± 0.039
0.157TrpPro: 0.157 ± 0.015
0.418TrpGln: 0.418 ± 0.025
0.408TrpArg: 0.408 ± 0.028
0.511TrpSer: 0.511 ± 0.03
0.475TrpThr: 0.475 ± 0.028
0.652TrpVal: 0.652 ± 0.032
0.115TrpTrp: 0.115 ± 0.014
0.411TrpTyr: 0.411 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.528TyrAla: 2.528 ± 0.066
0.429TyrCys: 0.429 ± 0.028
2.542TyrAsp: 2.542 ± 0.072
2.501TyrGlu: 2.501 ± 0.061
2.653TyrPhe: 2.653 ± 0.069
2.672TyrGly: 2.672 ± 0.071
0.964TyrHis: 0.964 ± 0.043
3.085TyrIle: 3.085 ± 0.068
3.423TyrLys: 3.423 ± 0.078
3.823TyrLeu: 3.823 ± 0.083
0.836TyrMet: 0.836 ± 0.038
2.555TyrAsn: 2.555 ± 0.065
1.59TyrPro: 1.59 ± 0.051
1.931TyrGln: 1.931 ± 0.061
1.907TyrArg: 1.907 ± 0.059
2.733TyrSer: 2.733 ± 0.085
2.341TyrThr: 2.341 ± 0.074
1.884TyrVal: 1.884 ± 0.052
0.482TyrTrp: 0.482 ± 0.028
2.171TyrTyr: 2.171 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2118 proteins (624644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski