Amino acid dipepetide frequency for Flavobacterium tiangeerense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.606AlaAla: 4.606 ± 0.122
0.537AlaCys: 0.537 ± 0.041
3.309AlaAsp: 3.309 ± 0.098
3.652AlaGlu: 3.652 ± 0.109
3.409AlaPhe: 3.409 ± 0.091
4.145AlaGly: 4.145 ± 0.13
1.064AlaHis: 1.064 ± 0.047
5.722AlaIle: 5.722 ± 0.119
5.119AlaLys: 5.119 ± 0.134
6.444AlaLeu: 6.444 ± 0.118
1.579AlaMet: 1.579 ± 0.067
3.687AlaAsn: 3.687 ± 0.104
1.852AlaPro: 1.852 ± 0.068
2.617AlaGln: 2.617 ± 0.072
1.945AlaArg: 1.945 ± 0.076
4.214AlaSer: 4.214 ± 0.109
4.29AlaThr: 4.29 ± 0.111
4.407AlaVal: 4.407 ± 0.115
0.563AlaTrp: 0.563 ± 0.034
2.261AlaTyr: 2.261 ± 0.069
0.002AlaXaa: 0.002 ± 0.002
Cys
0.422CysAla: 0.422 ± 0.027
0.084CysCys: 0.084 ± 0.014
0.372CysAsp: 0.372 ± 0.031
0.43CysGlu: 0.43 ± 0.031
0.438CysPhe: 0.438 ± 0.034
0.607CysGly: 0.607 ± 0.037
0.179CysHis: 0.179 ± 0.021
0.587CysIle: 0.587 ± 0.034
0.515CysLys: 0.515 ± 0.036
0.623CysLeu: 0.623 ± 0.033
0.175CysMet: 0.175 ± 0.021
0.497CysAsn: 0.497 ± 0.039
0.344CysPro: 0.344 ± 0.044
0.27CysGln: 0.27 ± 0.026
0.185CysArg: 0.185 ± 0.023
0.539CysSer: 0.539 ± 0.039
0.447CysThr: 0.447 ± 0.035
0.402CysVal: 0.402 ± 0.029
0.048CysTrp: 0.048 ± 0.011
0.304CysTyr: 0.304 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.713AspAla: 3.713 ± 0.102
0.412AspCys: 0.412 ± 0.032
2.476AspAsp: 2.476 ± 0.077
3.154AspGlu: 3.154 ± 0.08
3.711AspPhe: 3.711 ± 0.09
3.097AspGly: 3.097 ± 0.092
0.776AspHis: 0.776 ± 0.041
4.057AspIle: 4.057 ± 0.097
4.324AspLys: 4.324 ± 0.117
5.348AspLeu: 5.348 ± 0.111
0.951AspMet: 0.951 ± 0.046
2.997AspAsn: 2.997 ± 0.081
1.525AspPro: 1.525 ± 0.057
1.647AspGln: 1.647 ± 0.057
1.635AspArg: 1.635 ± 0.06
2.93AspSer: 2.93 ± 0.092
2.691AspThr: 2.691 ± 0.077
3.427AspVal: 3.427 ± 0.091
0.658AspTrp: 0.658 ± 0.043
2.554AspTyr: 2.554 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
4.133GluAla: 4.133 ± 0.117
0.338GluCys: 0.338 ± 0.028
3.093GluAsp: 3.093 ± 0.095
4.417GluGlu: 4.417 ± 0.135
2.944GluPhe: 2.944 ± 0.084
3.208GluGly: 3.208 ± 0.074
1.008GluHis: 1.008 ± 0.045
5.957GluIle: 5.957 ± 0.116
6.132GluLys: 6.132 ± 0.155
5.891GluLeu: 5.891 ± 0.123
1.679GluMet: 1.679 ± 0.059
4.918GluAsn: 4.918 ± 0.107
1.46GluPro: 1.46 ± 0.054
2.275GluGln: 2.275 ± 0.072
2.241GluArg: 2.241 ± 0.077
3.423GluSer: 3.423 ± 0.072
3.648GluThr: 3.648 ± 0.084
4.019GluVal: 4.019 ± 0.105
0.613GluTrp: 0.613 ± 0.035
2.279GluTyr: 2.279 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.24PheAla: 3.24 ± 0.083
0.485PheCys: 0.485 ± 0.028
3.25PheAsp: 3.25 ± 0.086
3.648PheGlu: 3.648 ± 0.092
2.955PhePhe: 2.955 ± 0.105
3.618PheGly: 3.618 ± 0.086
0.811PheHis: 0.811 ± 0.04
4.163PheIle: 4.163 ± 0.111
4.099PheLys: 4.099 ± 0.104
4.867PheLeu: 4.867 ± 0.124
1.118PheMet: 1.118 ± 0.048
3.172PheAsn: 3.172 ± 0.097
1.792PhePro: 1.792 ± 0.074
1.629PheGln: 1.629 ± 0.063
1.559PheArg: 1.559 ± 0.063
4.099PheSer: 4.099 ± 0.105
3.359PheThr: 3.359 ± 0.09
3.13PheVal: 3.13 ± 0.087
0.593PheTrp: 0.593 ± 0.037
2.387PheTyr: 2.387 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
3.89GlyAla: 3.89 ± 0.109
0.555GlyCys: 0.555 ± 0.045
2.989GlyAsp: 2.989 ± 0.079
3.13GlyGlu: 3.13 ± 0.093
3.699GlyPhe: 3.699 ± 0.087
4.129GlyGly: 4.129 ± 0.148
1.05GlyHis: 1.05 ± 0.046
5.585GlyIle: 5.585 ± 0.108
5.05GlyLys: 5.05 ± 0.101
5.571GlyLeu: 5.571 ± 0.102
1.44GlyMet: 1.44 ± 0.052
3.528GlyAsn: 3.528 ± 0.112
1.257GlyPro: 1.257 ± 0.055
1.877GlyGln: 1.877 ± 0.063
1.806GlyArg: 1.806 ± 0.071
3.92GlySer: 3.92 ± 0.119
4.105GlyThr: 4.105 ± 0.123
4.095GlyVal: 4.095 ± 0.109
0.642GlyTrp: 0.642 ± 0.04
2.621GlyTyr: 2.621 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
0.937HisAla: 0.937 ± 0.049
0.175HisCys: 0.175 ± 0.015
0.823HisAsp: 0.823 ± 0.042
0.949HisGlu: 0.949 ± 0.046
1.179HisPhe: 1.179 ± 0.048
0.949HisGly: 0.949 ± 0.052
0.436HisHis: 0.436 ± 0.032
1.227HisIle: 1.227 ± 0.052
1.158HisLys: 1.158 ± 0.063
1.607HisLeu: 1.607 ± 0.059
0.272HisMet: 0.272 ± 0.022
0.915HisAsn: 0.915 ± 0.046
0.76HisPro: 0.76 ± 0.04
0.738HisGln: 0.738 ± 0.038
0.477HisArg: 0.477 ± 0.032
0.973HisSer: 0.973 ± 0.044
0.835HisThr: 0.835 ± 0.04
0.861HisVal: 0.861 ± 0.048
0.169HisTrp: 0.169 ± 0.02
0.778HisTyr: 0.778 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.05IleAla: 6.05 ± 0.132
0.668IleCys: 0.668 ± 0.041
4.95IleAsp: 4.95 ± 0.09
5.626IleGlu: 5.626 ± 0.129
3.852IlePhe: 3.852 ± 0.101
5.29IleGly: 5.29 ± 0.108
1.42IleHis: 1.42 ± 0.058
6.426IleIle: 6.426 ± 0.148
6.321IleLys: 6.321 ± 0.125
7.18IleLeu: 7.18 ± 0.141
1.468IleMet: 1.468 ± 0.057
5.048IleAsn: 5.048 ± 0.112
3.25IlePro: 3.25 ± 0.086
3.041IleGln: 3.041 ± 0.089
2.528IleArg: 2.528 ± 0.079
5.613IleSer: 5.613 ± 0.108
5.239IleThr: 5.239 ± 0.125
5.358IleVal: 5.358 ± 0.114
0.708IleTrp: 0.708 ± 0.033
2.691IleTyr: 2.691 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.173LysAla: 5.173 ± 0.146
0.42LysCys: 0.42 ± 0.031
4.155LysAsp: 4.155 ± 0.098
6.056LysGlu: 6.056 ± 0.122
3.115LysPhe: 3.115 ± 0.086
4.475LysGly: 4.475 ± 0.097
1.179LysHis: 1.179 ± 0.055
7.319LysIle: 7.319 ± 0.132
7.351LysLys: 7.351 ± 0.173
6.939LysLeu: 6.939 ± 0.125
2.267LysMet: 2.267 ± 0.072
6.018LysAsn: 6.018 ± 0.125
2.534LysPro: 2.534 ± 0.08
2.886LysGln: 2.886 ± 0.085
2.609LysArg: 2.609 ± 0.072
4.976LysSer: 4.976 ± 0.112
5.217LysThr: 5.217 ± 0.105
4.801LysVal: 4.801 ± 0.109
0.788LysTrp: 0.788 ± 0.036
3.172LysTyr: 3.172 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
5.99LeuAla: 5.99 ± 0.094
0.72LeuCys: 0.72 ± 0.045
4.747LeuAsp: 4.747 ± 0.106
6.331LeuGlu: 6.331 ± 0.118
5.131LeuPhe: 5.131 ± 0.136
5.652LeuGly: 5.652 ± 0.124
1.551LeuHis: 1.551 ± 0.063
7.142LeuIle: 7.142 ± 0.126
7.882LeuLys: 7.882 ± 0.15
8.91LeuLeu: 8.91 ± 0.179
2.082LeuMet: 2.082 ± 0.065
5.986LeuAsn: 5.986 ± 0.128
3.373LeuPro: 3.373 ± 0.082
3.636LeuGln: 3.636 ± 0.094
2.922LeuArg: 2.922 ± 0.081
6.762LeuSer: 6.762 ± 0.131
4.968LeuThr: 4.968 ± 0.116
5.589LeuVal: 5.589 ± 0.121
0.774LeuTrp: 0.774 ± 0.044
3.298LeuTyr: 3.298 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.545MetAla: 1.545 ± 0.058
0.161MetCys: 0.161 ± 0.018
1.112MetAsp: 1.112 ± 0.054
1.388MetGlu: 1.388 ± 0.049
0.798MetPhe: 0.798 ± 0.041
1.309MetGly: 1.309 ± 0.053
0.438MetHis: 0.438 ± 0.031
1.661MetIle: 1.661 ± 0.063
2.239MetLys: 2.239 ± 0.069
1.824MetLeu: 1.824 ± 0.057
0.569MetMet: 0.569 ± 0.036
1.37MetAsn: 1.37 ± 0.062
0.829MetPro: 0.829 ± 0.049
0.969MetGln: 0.969 ± 0.048
0.792MetArg: 0.792 ± 0.041
1.521MetSer: 1.521 ± 0.062
1.169MetThr: 1.169 ± 0.051
1.319MetVal: 1.319 ± 0.058
0.149MetTrp: 0.149 ± 0.019
0.676MetTyr: 0.676 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
4.091AsnAla: 4.091 ± 0.11
0.515AsnCys: 0.515 ± 0.036
3.138AsnAsp: 3.138 ± 0.08
3.96AsnGlu: 3.96 ± 0.096
3.353AsnPhe: 3.353 ± 0.097
4.141AsnGly: 4.141 ± 0.128
0.959AsnHis: 0.959 ± 0.046
4.914AsnIle: 4.914 ± 0.111
4.658AsnLys: 4.658 ± 0.109
5.835AsnLeu: 5.835 ± 0.114
1.215AsnMet: 1.215 ± 0.051
4.099AsnAsn: 4.099 ± 0.127
2.963AsnPro: 2.963 ± 0.081
2.671AsnGln: 2.671 ± 0.08
1.999AsnArg: 1.999 ± 0.067
4.278AsnSer: 4.278 ± 0.125
3.894AsnThr: 3.894 ± 0.106
3.614AsnVal: 3.614 ± 0.089
0.802AsnTrp: 0.802 ± 0.043
2.965AsnTyr: 2.965 ± 0.088
0.0AsnXaa: 0.0 ± 0.0
Pro
2.049ProAla: 2.049 ± 0.078
0.197ProCys: 0.197 ± 0.02
1.716ProAsp: 1.716 ± 0.068
2.53ProGlu: 2.53 ± 0.077
2.007ProPhe: 2.007 ± 0.071
1.641ProGly: 1.641 ± 0.059
0.491ProHis: 0.491 ± 0.033
2.759ProIle: 2.759 ± 0.07
2.629ProLys: 2.629 ± 0.076
2.93ProLeu: 2.93 ± 0.073
0.71ProMet: 0.71 ± 0.038
2.353ProAsn: 2.353 ± 0.064
0.73ProPro: 0.73 ± 0.044
1.088ProGln: 1.088 ± 0.046
0.835ProArg: 0.835 ± 0.047
2.078ProSer: 2.078 ± 0.075
2.013ProThr: 2.013 ± 0.076
2.331ProVal: 2.331 ± 0.074
0.332ProTrp: 0.332 ± 0.028
1.384ProTyr: 1.384 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
2.184GlnAla: 2.184 ± 0.062
0.191GlnCys: 0.191 ± 0.02
1.86GlnAsp: 1.86 ± 0.067
2.534GlnGlu: 2.534 ± 0.075
1.891GlnPhe: 1.891 ± 0.063
1.84GlnGly: 1.84 ± 0.064
0.591GlnHis: 0.591 ± 0.033
2.953GlnIle: 2.953 ± 0.081
3.419GlnLys: 3.419 ± 0.088
3.711GlnLeu: 3.711 ± 0.102
0.827GlnMet: 0.827 ± 0.048
2.631GlnAsn: 2.631 ± 0.087
1.058GlnPro: 1.058 ± 0.053
1.408GlnGln: 1.408 ± 0.062
1.12GlnArg: 1.12 ± 0.048
2.188GlnSer: 2.188 ± 0.067
1.993GlnThr: 1.993 ± 0.065
2.015GlnVal: 2.015 ± 0.073
0.356GlnTrp: 0.356 ± 0.03
1.521GlnTyr: 1.521 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
1.808ArgAla: 1.808 ± 0.068
0.173ArgCys: 0.173 ± 0.019
1.581ArgAsp: 1.581 ± 0.063
2.041ArgGlu: 2.041 ± 0.069
1.764ArgPhe: 1.764 ± 0.063
1.677ArgGly: 1.677 ± 0.066
0.485ArgHis: 0.485 ± 0.031
2.778ArgIle: 2.778 ± 0.086
2.526ArgLys: 2.526 ± 0.074
3.027ArgLeu: 3.027 ± 0.096
0.79ArgMet: 0.79 ± 0.046
2.029ArgAsn: 2.029 ± 0.071
0.933ArgPro: 0.933 ± 0.048
0.998ArgGln: 0.998 ± 0.045
1.114ArgArg: 1.114 ± 0.052
1.744ArgSer: 1.744 ± 0.066
1.75ArgThr: 1.75 ± 0.055
1.977ArgVal: 1.977 ± 0.054
0.348ArgTrp: 0.348 ± 0.024
1.382ArgTyr: 1.382 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.827SerAla: 3.827 ± 0.096
0.609SerCys: 0.609 ± 0.036
3.3SerAsp: 3.3 ± 0.082
3.777SerGlu: 3.777 ± 0.095
4.069SerPhe: 4.069 ± 0.101
4.387SerGly: 4.387 ± 0.107
1.036SerHis: 1.036 ± 0.053
5.479SerIle: 5.479 ± 0.108
5.288SerLys: 5.288 ± 0.115
5.996SerLeu: 5.996 ± 0.117
1.374SerMet: 1.374 ± 0.061
4.258SerAsn: 4.258 ± 0.123
2.049SerPro: 2.049 ± 0.062
2.434SerGln: 2.434 ± 0.067
2.056SerArg: 2.056 ± 0.067
4.328SerSer: 4.328 ± 0.112
3.63SerThr: 3.63 ± 0.09
3.962SerVal: 3.962 ± 0.086
0.658SerTrp: 0.658 ± 0.035
2.695SerTyr: 2.695 ± 0.083
0.002SerXaa: 0.002 ± 0.002
Thr
4.198ThrAla: 4.198 ± 0.117
0.372ThrCys: 0.372 ± 0.029
3.083ThrAsp: 3.083 ± 0.08
3.437ThrGlu: 3.437 ± 0.085
3.202ThrPhe: 3.202 ± 0.084
3.922ThrGly: 3.922 ± 0.122
0.895ThrHis: 0.895 ± 0.047
5.519ThrIle: 5.519 ± 0.127
4.336ThrLys: 4.336 ± 0.092
5.517ThrLeu: 5.517 ± 0.115
1.046ThrMet: 1.046 ± 0.049
3.564ThrAsn: 3.564 ± 0.117
2.432ThrPro: 2.432 ± 0.067
2.07ThrGln: 2.07 ± 0.067
1.593ThrArg: 1.593 ± 0.059
3.948ThrSer: 3.948 ± 0.113
3.779ThrThr: 3.779 ± 0.108
3.976ThrVal: 3.976 ± 0.101
0.459ThrTrp: 0.459 ± 0.036
2.202ThrTyr: 2.202 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
4.475ValAla: 4.475 ± 0.112
0.447ValCys: 0.447 ± 0.03
3.365ValAsp: 3.365 ± 0.088
3.689ValGlu: 3.689 ± 0.098
3.415ValPhe: 3.415 ± 0.093
3.715ValGly: 3.715 ± 0.091
0.943ValHis: 0.943 ± 0.045
4.978ValIle: 4.978 ± 0.109
4.608ValLys: 4.608 ± 0.105
6.527ValLeu: 6.527 ± 0.133
1.293ValMet: 1.293 ± 0.051
3.6ValAsn: 3.6 ± 0.088
2.104ValPro: 2.104 ± 0.067
2.1ValGln: 2.1 ± 0.067
1.8ValArg: 1.8 ± 0.061
4.451ValSer: 4.451 ± 0.106
3.693ValThr: 3.693 ± 0.097
4.411ValVal: 4.411 ± 0.103
0.547ValTrp: 0.547 ± 0.037
2.279ValTyr: 2.279 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.615TrpAla: 0.615 ± 0.046
0.086TrpCys: 0.086 ± 0.013
0.555TrpAsp: 0.555 ± 0.035
0.587TrpGlu: 0.587 ± 0.039
0.561TrpPhe: 0.561 ± 0.039
0.535TrpGly: 0.535 ± 0.036
0.199TrpHis: 0.199 ± 0.021
0.825TrpIle: 0.825 ± 0.038
0.788TrpLys: 0.788 ± 0.04
0.883TrpLeu: 0.883 ± 0.051
0.272TrpMet: 0.272 ± 0.024
0.762TrpAsn: 0.762 ± 0.047
0.183TrpPro: 0.183 ± 0.022
0.39TrpGln: 0.39 ± 0.027
0.332TrpArg: 0.332 ± 0.027
0.591TrpSer: 0.591 ± 0.033
0.491TrpThr: 0.491 ± 0.032
0.493TrpVal: 0.493 ± 0.036
0.129TrpTrp: 0.129 ± 0.019
0.465TrpTyr: 0.465 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.476TyrAla: 2.476 ± 0.074
0.324TyrCys: 0.324 ± 0.027
2.21TyrAsp: 2.21 ± 0.059
2.339TyrGlu: 2.339 ± 0.067
2.482TyrPhe: 2.482 ± 0.079
2.599TyrGly: 2.599 ± 0.076
0.708TyrHis: 0.708 ± 0.04
2.677TyrIle: 2.677 ± 0.081
3.007TyrLys: 3.007 ± 0.08
3.817TyrLeu: 3.817 ± 0.101
0.708TyrMet: 0.708 ± 0.038
2.633TyrAsn: 2.633 ± 0.092
1.376TyrPro: 1.376 ± 0.052
1.547TyrGln: 1.547 ± 0.063
1.378TyrArg: 1.378 ± 0.058
2.637TyrSer: 2.637 ± 0.067
2.339TyrThr: 2.339 ± 0.08
2.251TyrVal: 2.251 ± 0.068
0.406TyrTrp: 0.406 ± 0.036
1.8TyrTyr: 1.8 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.002XaaMet: 0.002 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.012XaaXaa: 0.012 ± 0.009
Statistics based on 1482 proteins (497200 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski