Amino acid dipepetide frequency for Lactococcus garvieae (strain Lg2) (Enterococcus seriolicida)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.686AlaAla: 6.686 ± 0.168	0.472AlaCys: 0.472 ± 0.034	4.213AlaAsp: 4.213 ± 0.099	5.504AlaGlu: 5.504 ± 0.13	3.579AlaPhe: 3.579 ± 0.081	5.887AlaGly: 5.887 ± 0.114	1.463AlaHis: 1.463 ± 0.054	5.728AlaIle: 5.728 ± 0.121	5.117AlaLys: 5.117 ± 0.095	8.469AlaLeu: 8.469 ± 0.129	2.152AlaMet: 2.152 ± 0.07	3.04AlaAsn: 3.04 ± 0.079	2.328AlaPro: 2.328 ± 0.073	3.627AlaGln: 3.627 ± 0.087	2.97AlaArg: 2.97 ± 0.069	4.607AlaSer: 4.607 ± 0.091	4.416AlaThr: 4.416 ± 0.098	5.591AlaVal: 5.591 ± 0.115	0.726AlaTrp: 0.726 ± 0.039	2.667AlaTyr: 2.667 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	0.398CysAla: 0.398 ± 0.03	0.064CysCys: 0.064 ± 0.013	0.293CysAsp: 0.293 ± 0.024	0.25CysGlu: 0.25 ± 0.021	0.206CysPhe: 0.206 ± 0.021	0.419CysGly: 0.419 ± 0.027	0.128CysHis: 0.128 ± 0.019	0.279CysIle: 0.279 ± 0.025	0.25CysLys: 0.25 ± 0.02	0.462CysLeu: 0.462 ± 0.03	0.115CysMet: 0.115 ± 0.013	0.163CysAsn: 0.163 ± 0.017	0.206CysPro: 0.206 ± 0.02	0.206CysGln: 0.206 ± 0.018	0.202CysArg: 0.202 ± 0.016	0.325CysSer: 0.325 ± 0.028	0.233CysThr: 0.233 ± 0.024	0.293CysVal: 0.293 ± 0.022	0.043CysTrp: 0.043 ± 0.009	0.194CysTyr: 0.194 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.72AspAla: 3.72 ± 0.098	0.234AspCys: 0.234 ± 0.02	2.289AspAsp: 2.289 ± 0.07	4.116AspGlu: 4.116 ± 0.106	3.32AspPhe: 3.32 ± 0.078	3.439AspGly: 3.439 ± 0.082	0.845AspHis: 0.845 ± 0.041	4.16AspIle: 4.16 ± 0.086	4.181AspLys: 4.181 ± 0.107	5.316AspLeu: 5.316 ± 0.108	1.474AspMet: 1.474 ± 0.053	2.432AspAsn: 2.432 ± 0.066	1.584AspPro: 1.584 ± 0.056	1.772AspGln: 1.772 ± 0.064	1.795AspArg: 1.795 ± 0.056	2.841AspSer: 2.841 ± 0.063	2.685AspThr: 2.685 ± 0.077	3.633AspVal: 3.633 ± 0.085	0.648AspTrp: 0.648 ± 0.04	2.45AspTyr: 2.45 ± 0.073	0.0AspXaa: 0.0 ± 0.0
Glu	5.864GluAla: 5.864 ± 0.114	0.268GluCys: 0.268 ± 0.023	3.656GluAsp: 3.656 ± 0.098	6.402GluGlu: 6.402 ± 0.153	2.876GluPhe: 2.876 ± 0.075	3.927GluGly: 3.927 ± 0.103	1.33GluHis: 1.33 ± 0.042	5.893GluIle: 5.893 ± 0.124	6.653GluLys: 6.653 ± 0.117	6.836GluLeu: 6.836 ± 0.142	2.013GluMet: 2.013 ± 0.061	4.43GluAsn: 4.43 ± 0.087	1.564GluPro: 1.564 ± 0.055	2.89GluGln: 2.89 ± 0.091	3.128GluArg: 3.128 ± 0.086	3.205GluSer: 3.205 ± 0.076	3.663GluThr: 3.663 ± 0.087	4.804GluVal: 4.804 ± 0.111	0.559GluTrp: 0.559 ± 0.036	2.12GluTyr: 2.12 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.599PheAla: 3.599 ± 0.085	0.275PheCys: 0.275 ± 0.022	3.034PheAsp: 3.034 ± 0.077	3.205PheGlu: 3.205 ± 0.085	2.301PhePhe: 2.301 ± 0.069	3.492PheGly: 3.492 ± 0.096	0.763PheHis: 0.763 ± 0.039	3.757PheIle: 3.757 ± 0.114	2.525PheLys: 2.525 ± 0.062	4.675PheLeu: 4.675 ± 0.108	1.213PheMet: 1.213 ± 0.053	2.132PheAsn: 2.132 ± 0.062	1.657PhePro: 1.657 ± 0.045	1.506PheGln: 1.506 ± 0.059	1.415PheArg: 1.415 ± 0.055	3.549PheSer: 3.549 ± 0.093	2.8PheThr: 2.8 ± 0.072	3.334PheVal: 3.334 ± 0.081	0.598PheTrp: 0.598 ± 0.033	1.838PheTyr: 1.838 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	5.231GlyAla: 5.231 ± 0.124	0.368GlyCys: 0.368 ± 0.031	3.244GlyAsp: 3.244 ± 0.079	4.094GlyGlu: 4.094 ± 0.099	3.452GlyPhe: 3.452 ± 0.082	4.567GlyGly: 4.567 ± 0.122	1.314GlyHis: 1.314 ± 0.051	5.342GlyIle: 5.342 ± 0.107	4.787GlyLys: 4.787 ± 0.102	6.623GlyLeu: 6.623 ± 0.121	1.889GlyMet: 1.889 ± 0.058	2.811GlyAsn: 2.811 ± 0.085	1.451GlyPro: 1.451 ± 0.054	2.912GlyGln: 2.912 ± 0.072	2.633GlyArg: 2.633 ± 0.077	3.958GlySer: 3.958 ± 0.094	3.979GlyThr: 3.979 ± 0.081	4.717GlyVal: 4.717 ± 0.101	0.714GlyTrp: 0.714 ± 0.038	2.505GlyTyr: 2.505 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.346HisAla: 1.346 ± 0.052	0.11HisCys: 0.11 ± 0.014	0.921HisAsp: 0.921 ± 0.037	1.191HisGlu: 1.191 ± 0.046	0.998HisPhe: 0.998 ± 0.046	1.312HisGly: 1.312 ± 0.052	0.449HisHis: 0.449 ± 0.027	1.309HisIle: 1.309 ± 0.042	1.008HisLys: 1.008 ± 0.038	1.93HisLeu: 1.93 ± 0.059	0.49HisMet: 0.49 ± 0.032	0.731HisAsn: 0.731 ± 0.036	0.907HisPro: 0.907 ± 0.04	0.776HisGln: 0.776 ± 0.04	0.749HisArg: 0.749 ± 0.034	1.014HisSer: 1.014 ± 0.046	0.982HisThr: 0.982 ± 0.049	1.262HisVal: 1.262 ± 0.058	0.19HisTrp: 0.19 ± 0.018	0.827HisTyr: 0.827 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.326IleAla: 6.326 ± 0.129	0.451IleCys: 0.451 ± 0.029	4.14IleAsp: 4.14 ± 0.088	4.835IleGlu: 4.835 ± 0.109	3.766IlePhe: 3.766 ± 0.108	5.094IleGly: 5.094 ± 0.131	1.285IleHis: 1.285 ± 0.054	5.518IleIle: 5.518 ± 0.126	4.59IleLys: 4.59 ± 0.092	7.349IleLeu: 7.349 ± 0.136	1.832IleMet: 1.832 ± 0.07	3.407IleAsn: 3.407 ± 0.069	2.846IlePro: 2.846 ± 0.08	2.502IleGln: 2.502 ± 0.066	2.642IleArg: 2.642 ± 0.077	4.945IleSer: 4.945 ± 0.096	4.121IleThr: 4.121 ± 0.08	5.167IleVal: 5.167 ± 0.108	0.584IleTrp: 0.584 ± 0.033	2.436IleTyr: 2.436 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.447LysAla: 5.447 ± 0.137	0.179LysCys: 0.179 ± 0.017	3.697LysAsp: 3.697 ± 0.089	5.82LysGlu: 5.82 ± 0.12	2.67LysPhe: 2.67 ± 0.069	3.686LysGly: 3.686 ± 0.091	1.127LysHis: 1.127 ± 0.047	5.492LysIle: 5.492 ± 0.104	6.196LysLys: 6.196 ± 0.133	6.072LysLeu: 6.072 ± 0.114	2.431LysMet: 2.431 ± 0.061	4.208LysAsn: 4.208 ± 0.088	2.033LysPro: 2.033 ± 0.067	2.4LysGln: 2.4 ± 0.081	2.951LysArg: 2.951 ± 0.078	3.65LysSer: 3.65 ± 0.085	4.08LysThr: 4.08 ± 0.092	4.899LysVal: 4.899 ± 0.1	0.573LysTrp: 0.573 ± 0.037	2.455LysTyr: 2.455 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	8.565LeuAla: 8.565 ± 0.13	0.433LeuCys: 0.433 ± 0.03	5.33LeuAsp: 5.33 ± 0.109	7.029LeuGlu: 7.029 ± 0.141	4.554LeuPhe: 4.554 ± 0.11	6.447LeuGly: 6.447 ± 0.118	1.71LeuHis: 1.71 ± 0.06	6.969LeuIle: 6.969 ± 0.147	6.491LeuLys: 6.491 ± 0.128	10.129LeuLeu: 10.129 ± 0.2	2.585LeuMet: 2.585 ± 0.069	4.178LeuAsn: 4.178 ± 0.083	4.21LeuPro: 4.21 ± 0.079	3.45LeuGln: 3.45 ± 0.086	3.775LeuArg: 3.775 ± 0.089	7.39LeuSer: 7.39 ± 0.125	5.871LeuThr: 5.871 ± 0.103	6.427LeuVal: 6.427 ± 0.143	0.769LeuTrp: 0.769 ± 0.039	2.921LeuTyr: 2.921 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	2.122MetAla: 2.122 ± 0.069	0.096MetCys: 0.096 ± 0.011	1.429MetAsp: 1.429 ± 0.053	1.584MetGlu: 1.584 ± 0.05	0.968MetPhe: 0.968 ± 0.044	1.758MetGly: 1.758 ± 0.057	0.428MetHis: 0.428 ± 0.03	1.973MetIle: 1.973 ± 0.063	2.301MetLys: 2.301 ± 0.064	2.521MetLeu: 2.521 ± 0.065	0.834MetMet: 0.834 ± 0.045	1.589MetAsn: 1.589 ± 0.056	1.035MetPro: 1.035 ± 0.045	1.028MetGln: 1.028 ± 0.046	1.136MetArg: 1.136 ± 0.043	1.756MetSer: 1.756 ± 0.055	1.976MetThr: 1.976 ± 0.058	1.715MetVal: 1.715 ± 0.06	0.176MetTrp: 0.176 ± 0.021	0.634MetTyr: 0.634 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	3.391AsnAla: 3.391 ± 0.081	0.222AsnCys: 0.222 ± 0.019	2.251AsnAsp: 2.251 ± 0.071	2.779AsnGlu: 2.779 ± 0.065	2.455AsnPhe: 2.455 ± 0.074	3.045AsnGly: 3.045 ± 0.077	0.994AsnHis: 0.994 ± 0.052	3.839AsnIle: 3.839 ± 0.08	3.215AsnLys: 3.215 ± 0.09	4.701AsnLeu: 4.701 ± 0.098	1.317AsnMet: 1.317 ± 0.056	2.264AsnAsn: 2.264 ± 0.077	2.223AsnPro: 2.223 ± 0.066	2.036AsnGln: 2.036 ± 0.061	1.845AsnArg: 1.845 ± 0.057	2.521AsnSer: 2.521 ± 0.079	2.466AsnThr: 2.466 ± 0.064	2.99AsnVal: 2.99 ± 0.077	0.51AsnTrp: 0.51 ± 0.029	1.859AsnTyr: 1.859 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	2.516ProAla: 2.516 ± 0.074	0.131ProCys: 0.131 ± 0.016	1.942ProAsp: 1.942 ± 0.065	3.331ProGlu: 3.331 ± 0.08	1.672ProPhe: 1.672 ± 0.058	2.065ProGly: 2.065 ± 0.061	0.731ProHis: 0.731 ± 0.039	2.223ProIle: 2.223 ± 0.061	2.184ProLys: 2.184 ± 0.055	3.226ProLeu: 3.226 ± 0.071	0.836ProMet: 0.836 ± 0.039	1.53ProAsn: 1.53 ± 0.055	0.611ProPro: 0.611 ± 0.031	1.511ProGln: 1.511 ± 0.049	1.09ProArg: 1.09 ± 0.042	1.99ProSer: 1.99 ± 0.063	1.981ProThr: 1.981 ± 0.062	2.534ProVal: 2.534 ± 0.075	0.353ProTrp: 0.353 ± 0.026	1.253ProTyr: 1.253 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	3.64GlnAla: 3.64 ± 0.09	0.123GlnCys: 0.123 ± 0.014	1.823GlnAsp: 1.823 ± 0.062	3.361GlnGlu: 3.361 ± 0.092	1.483GlnPhe: 1.483 ± 0.051	2.317GlnGly: 2.317 ± 0.073	0.689GlnHis: 0.689 ± 0.034	2.747GlnIle: 2.747 ± 0.07	3.008GlnLys: 3.008 ± 0.088	3.709GlnLeu: 3.709 ± 0.081	1.042GlnMet: 1.042 ± 0.045	1.891GlnAsn: 1.891 ± 0.061	1.285GlnPro: 1.285 ± 0.054	1.427GlnGln: 1.427 ± 0.06	1.543GlnArg: 1.543 ± 0.054	2.072GlnSer: 2.072 ± 0.061	2.179GlnThr: 2.179 ± 0.062	2.802GlnVal: 2.802 ± 0.08	0.355GlnTrp: 0.355 ± 0.024	1.172GlnTyr: 1.172 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	2.835ArgAla: 2.835 ± 0.085	0.172ArgCys: 0.172 ± 0.018	2.013ArgAsp: 2.013 ± 0.056	3.068ArgGlu: 3.068 ± 0.087	1.815ArgPhe: 1.815 ± 0.054	2.361ArgGly: 2.361 ± 0.073	0.801ArgHis: 0.801 ± 0.039	2.764ArgIle: 2.764 ± 0.074	2.938ArgLys: 2.938 ± 0.075	3.755ArgLeu: 3.755 ± 0.079	1.076ArgMet: 1.076 ± 0.046	1.765ArgAsn: 1.765 ± 0.06	1.344ArgPro: 1.344 ± 0.05	1.646ArgGln: 1.646 ± 0.057	1.852ArgArg: 1.852 ± 0.069	1.953ArgSer: 1.953 ± 0.061	2.001ArgThr: 2.001 ± 0.055	2.672ArgVal: 2.672 ± 0.064	0.32ArgTrp: 0.32 ± 0.026	1.477ArgTyr: 1.477 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.071SerAla: 4.071 ± 0.097	0.297SerCys: 0.297 ± 0.023	3.217SerAsp: 3.217 ± 0.082	4.178SerGlu: 4.178 ± 0.088	3.12SerPhe: 3.12 ± 0.085	4.739SerGly: 4.739 ± 0.108	1.166SerHis: 1.166 ± 0.048	4.14SerIle: 4.14 ± 0.094	4.018SerLys: 4.018 ± 0.084	6.219SerLeu: 6.219 ± 0.109	1.518SerMet: 1.518 ± 0.049	2.793SerAsn: 2.793 ± 0.067	1.955SerPro: 1.955 ± 0.069	2.479SerGln: 2.479 ± 0.069	2.475SerArg: 2.475 ± 0.069	3.869SerSer: 3.869 ± 0.091	3.407SerThr: 3.407 ± 0.089	3.84SerVal: 3.84 ± 0.082	0.632SerTrp: 0.632 ± 0.038	2.168SerTyr: 2.168 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.614ThrAla: 4.614 ± 0.104	0.229ThrCys: 0.229 ± 0.02	3.171ThrAsp: 3.171 ± 0.086	3.771ThrGlu: 3.771 ± 0.094	2.708ThrPhe: 2.708 ± 0.073	4.492ThrGly: 4.492 ± 0.1	1.175ThrHis: 1.175 ± 0.045	3.933ThrIle: 3.933 ± 0.089	3.155ThrLys: 3.155 ± 0.076	5.662ThrLeu: 5.662 ± 0.102	1.364ThrMet: 1.364 ± 0.045	2.257ThrAsn: 2.257 ± 0.066	2.457ThrPro: 2.457 ± 0.063	2.077ThrGln: 2.077 ± 0.079	1.985ThrArg: 1.985 ± 0.06	3.528ThrSer: 3.528 ± 0.095	3.247ThrThr: 3.247 ± 0.084	4.364ThrVal: 4.364 ± 0.093	0.581ThrTrp: 0.581 ± 0.036	2.038ThrTyr: 2.038 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	5.729ValAla: 5.729 ± 0.139	0.368ValCys: 0.368 ± 0.024	3.778ValAsp: 3.778 ± 0.085	4.778ValGlu: 4.778 ± 0.103	3.178ValPhe: 3.178 ± 0.088	4.559ValGly: 4.559 ± 0.095	1.198ValHis: 1.198 ± 0.043	4.902ValIle: 4.902 ± 0.102	4.703ValLys: 4.703 ± 0.107	6.899ValLeu: 6.899 ± 0.111	1.756ValMet: 1.756 ± 0.063	3.164ValAsn: 3.164 ± 0.082	2.448ValPro: 2.448 ± 0.059	2.29ValGln: 2.29 ± 0.063	2.507ValArg: 2.507 ± 0.075	4.378ValSer: 4.378 ± 0.077	4.245ValThr: 4.245 ± 0.103	4.829ValVal: 4.829 ± 0.118	0.563ValTrp: 0.563 ± 0.034	2.232ValTyr: 2.232 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.613TrpAla: 0.613 ± 0.034	0.048TrpCys: 0.048 ± 0.01	0.467TrpAsp: 0.467 ± 0.031	0.542TrpGlu: 0.542 ± 0.027	0.52TrpPhe: 0.52 ± 0.029	0.621TrpGly: 0.621 ± 0.031	0.186TrpHis: 0.186 ± 0.018	0.634TrpIle: 0.634 ± 0.034	0.623TrpLys: 0.623 ± 0.033	1.069TrpLeu: 1.069 ± 0.041	0.238TrpMet: 0.238 ± 0.02	0.502TrpAsn: 0.502 ± 0.035	0.201TrpPro: 0.201 ± 0.02	0.455TrpGln: 0.455 ± 0.029	0.414TrpArg: 0.414 ± 0.028	0.639TrpSer: 0.639 ± 0.038	0.575TrpThr: 0.575 ± 0.031	0.588TrpVal: 0.588 ± 0.035	0.147TrpTrp: 0.147 ± 0.014	0.357TrpTyr: 0.357 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.53TyrAla: 2.53 ± 0.07	0.188TyrCys: 0.188 ± 0.019	2.022TyrAsp: 2.022 ± 0.064	2.246TyrGlu: 2.246 ± 0.064	2.028TyrPhe: 2.028 ± 0.063	2.36TyrGly: 2.36 ± 0.063	0.719TyrHis: 0.719 ± 0.038	2.235TyrIle: 2.235 ± 0.061	2.125TyrLys: 2.125 ± 0.061	3.61TyrLeu: 3.61 ± 0.078	0.881TyrMet: 0.881 ± 0.036	1.637TyrAsn: 1.637 ± 0.055	1.369TyrPro: 1.369 ± 0.047	1.676TyrGln: 1.676 ± 0.062	1.522TyrArg: 1.522 ± 0.057	2.111TyrSer: 2.111 ± 0.066	1.902TyrThr: 1.902 ± 0.065	2.045TyrVal: 2.045 ± 0.065	0.398TyrTrp: 0.398 ± 0.028	1.477TyrTyr: 1.477 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1938 proteins (563232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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