Amino acid dipepetide frequency for Hubei noda-like virus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.525AlaAla: 5.525 ± 1.687
1.842AlaCys: 1.842 ± 1.031
3.069AlaAsp: 3.069 ± 1.867
3.069AlaGlu: 3.069 ± 0.524
3.069AlaPhe: 3.069 ± 1.867
2.455AlaGly: 2.455 ± 0.18
0.614AlaHis: 0.614 ± 0.852
4.297AlaIle: 4.297 ± 0.016
4.911AlaLys: 4.911 ± 1.555
7.98AlaLeu: 7.98 ± 3.898
0.614AlaMet: 0.614 ± 0.344
4.297AlaAsn: 4.297 ± 1.18
0.614AlaPro: 0.614 ± 0.344
1.842AlaGln: 1.842 ± 1.359
1.842AlaArg: 1.842 ± 2.555
7.366AlaSer: 7.366 ± 0.656
2.455AlaThr: 2.455 ± 0.18
2.455AlaVal: 2.455 ± 1.375
0.614AlaTrp: 0.614 ± 0.344
3.683AlaTyr: 3.683 ± 0.328
0.0AlaXaa: 0.0 ± 0.0
Cys
2.455CysAla: 2.455 ± 1.375
0.614CysCys: 0.614 ± 0.344
0.0CysAsp: 0.0 ± 0.0
1.228CysGlu: 1.228 ± 1.703
0.614CysPhe: 0.614 ± 0.344
0.614CysGly: 0.614 ± 0.344
0.0CysHis: 0.0 ± 0.0
0.614CysIle: 0.614 ± 0.344
0.614CysLys: 0.614 ± 0.344
1.228CysLeu: 1.228 ± 0.688
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.614CysGln: 0.614 ± 0.344
0.614CysArg: 0.614 ± 0.344
0.614CysSer: 0.614 ± 0.344
1.228CysThr: 1.228 ± 0.688
1.228CysVal: 1.228 ± 0.688
0.0CysTrp: 0.0 ± 0.0
1.842CysTyr: 1.842 ± 1.359
0.0CysXaa: 0.0 ± 0.0
Asp
3.683AspAla: 3.683 ± 1.523
0.0AspCys: 0.0 ± 0.0
1.842AspAsp: 1.842 ± 1.359
3.069AspGlu: 3.069 ± 0.672
1.228AspPhe: 1.228 ± 0.508
3.683AspGly: 3.683 ± 0.867
0.0AspHis: 0.0 ± 0.0
5.525AspIle: 5.525 ± 1.899
2.455AspLys: 2.455 ± 0.18
3.683AspLeu: 3.683 ± 0.328
1.228AspMet: 1.228 ± 0.688
1.228AspAsn: 1.228 ± 0.508
2.455AspPro: 2.455 ± 1.016
1.228AspGln: 1.228 ± 0.508
0.614AspArg: 0.614 ± 0.852
3.683AspSer: 3.683 ± 0.328
3.069AspThr: 3.069 ± 0.524
4.911AspVal: 4.911 ± 0.836
0.614AspTrp: 0.614 ± 0.344
4.297AspTyr: 4.297 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
4.297GluAla: 4.297 ± 0.016
1.842GluCys: 1.842 ± 1.031
1.228GluAsp: 1.228 ± 0.688
2.455GluGlu: 2.455 ± 0.18
1.842GluPhe: 1.842 ± 0.164
4.297GluGly: 4.297 ± 2.375
1.228GluHis: 1.228 ± 0.688
5.525GluIle: 5.525 ± 1.899
4.911GluLys: 4.911 ± 2.75
6.139GluLeu: 6.139 ± 1.047
0.0GluMet: 0.0 ± 0.0
1.842GluAsn: 1.842 ± 1.031
3.683GluPro: 3.683 ± 0.867
1.228GluGln: 1.228 ± 0.508
2.455GluArg: 2.455 ± 1.016
4.297GluSer: 4.297 ± 1.211
2.455GluThr: 2.455 ± 1.375
3.683GluVal: 3.683 ± 2.063
0.0GluTrp: 0.0 ± 0.0
2.455GluTyr: 2.455 ± 0.18
0.0GluXaa: 0.0 ± 0.0
Phe
1.842PheAla: 1.842 ± 1.359
1.228PheCys: 1.228 ± 0.688
3.683PheAsp: 3.683 ± 0.867
2.455PheGlu: 2.455 ± 1.016
1.228PhePhe: 1.228 ± 0.688
0.0PheGly: 0.0 ± 0.0
0.614PheHis: 0.614 ± 0.852
0.614PheIle: 0.614 ± 0.344
3.069PheLys: 3.069 ± 0.524
3.069PheLeu: 3.069 ± 0.524
0.0PheMet: 0.0 ± 0.0
2.455PheAsn: 2.455 ± 0.18
1.842PhePro: 1.842 ± 0.164
0.0PheGln: 0.0 ± 0.0
1.842PheArg: 1.842 ± 1.031
1.842PheSer: 1.842 ± 0.164
3.069PheThr: 3.069 ± 0.672
2.455PheVal: 2.455 ± 0.18
0.0PheTrp: 0.0 ± 0.0
1.842PheTyr: 1.842 ± 1.031
0.0PheXaa: 0.0 ± 0.0
Gly
3.683GlyAla: 3.683 ± 1.523
1.228GlyCys: 1.228 ± 0.508
3.683GlyAsp: 3.683 ± 0.328
3.069GlyGlu: 3.069 ± 1.719
1.228GlyPhe: 1.228 ± 0.508
2.455GlyGly: 2.455 ± 2.211
1.228GlyHis: 1.228 ± 0.688
2.455GlyIle: 2.455 ± 0.18
3.069GlyLys: 3.069 ± 0.524
4.297GlyLeu: 4.297 ± 1.18
0.614GlyMet: 0.614 ± 0.344
4.297GlyAsn: 4.297 ± 2.375
1.228GlyPro: 1.228 ± 0.688
3.683GlyGln: 3.683 ± 0.328
5.525GlyArg: 5.525 ± 1.687
3.683GlySer: 3.683 ± 0.867
3.683GlyThr: 3.683 ± 0.328
3.683GlyVal: 3.683 ± 0.328
0.614GlyTrp: 0.614 ± 0.852
2.455GlyTyr: 2.455 ± 0.18
0.0GlyXaa: 0.0 ± 0.0
His
1.842HisAla: 1.842 ± 1.359
0.0HisCys: 0.0 ± 0.0
0.614HisAsp: 0.614 ± 0.344
0.0HisGlu: 0.0 ± 0.0
0.614HisPhe: 0.614 ± 0.344
1.842HisGly: 1.842 ± 1.031
0.0HisHis: 0.0 ± 0.0
1.228HisIle: 1.228 ± 0.688
1.842HisLys: 1.842 ± 1.031
2.455HisLeu: 2.455 ± 0.18
0.614HisMet: 0.614 ± 0.344
1.228HisAsn: 1.228 ± 0.688
1.842HisPro: 1.842 ± 0.164
0.614HisGln: 0.614 ± 0.852
0.0HisArg: 0.0 ± 0.0
2.455HisSer: 2.455 ± 1.375
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.525IleAla: 5.525 ± 0.703
1.228IleCys: 1.228 ± 0.688
1.842IleAsp: 1.842 ± 0.164
4.297IleGlu: 4.297 ± 2.406
1.842IlePhe: 1.842 ± 1.031
2.455IleGly: 2.455 ± 0.18
0.0IleHis: 0.0 ± 0.0
3.069IleIle: 3.069 ± 1.719
3.069IleLys: 3.069 ± 1.719
4.911IleLeu: 4.911 ± 2.031
0.614IleMet: 0.614 ± 0.344
4.911IleAsn: 4.911 ± 1.555
2.455IlePro: 2.455 ± 1.375
1.228IleGln: 1.228 ± 0.508
5.525IleArg: 5.525 ± 0.492
4.911IleSer: 4.911 ± 1.555
8.594IleThr: 8.594 ± 1.227
5.525IleVal: 5.525 ± 1.899
1.228IleTrp: 1.228 ± 0.508
1.842IleTyr: 1.842 ± 0.164
0.0IleXaa: 0.0 ± 0.0
Lys
3.069LysAla: 3.069 ± 1.719
1.228LysCys: 1.228 ± 0.688
2.455LysAsp: 2.455 ± 1.375
3.683LysGlu: 3.683 ± 2.063
0.614LysPhe: 0.614 ± 0.344
1.842LysGly: 1.842 ± 1.031
1.228LysHis: 1.228 ± 0.688
4.297LysIle: 4.297 ± 1.211
6.139LysLys: 6.139 ± 2.242
4.297LysLeu: 4.297 ± 2.406
0.0LysMet: 0.0 ± 0.0
2.455LysAsn: 2.455 ± 1.016
3.683LysPro: 3.683 ± 0.867
4.297LysGln: 4.297 ± 2.406
5.525LysArg: 5.525 ± 0.703
1.842LysSer: 1.842 ± 1.031
6.139LysThr: 6.139 ± 0.148
0.614LysVal: 0.614 ± 0.344
1.228LysTrp: 1.228 ± 0.688
1.228LysTyr: 1.228 ± 0.688
0.0LysXaa: 0.0 ± 0.0
Leu
2.455LeuAla: 2.455 ± 0.18
0.614LeuCys: 0.614 ± 0.344
6.139LeuAsp: 6.139 ± 2.242
3.683LeuGlu: 3.683 ± 0.328
2.455LeuPhe: 2.455 ± 0.18
6.753LeuGly: 6.753 ± 2.195
1.842LeuHis: 1.842 ± 0.164
3.069LeuIle: 3.069 ± 0.524
3.069LeuLys: 3.069 ± 1.719
3.683LeuLeu: 3.683 ± 0.867
1.228LeuMet: 1.228 ± 0.688
3.683LeuAsn: 3.683 ± 0.328
4.297LeuPro: 4.297 ± 2.375
2.455LeuGln: 2.455 ± 0.18
6.139LeuArg: 6.139 ± 2.539
8.594LeuSer: 8.594 ± 2.359
8.594LeuThr: 8.594 ± 0.032
4.297LeuVal: 4.297 ± 0.016
2.455LeuTrp: 2.455 ± 1.016
4.911LeuTyr: 4.911 ± 0.36
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.614MetPhe: 0.614 ± 0.344
0.614MetGly: 0.614 ± 0.344
0.0MetHis: 0.0 ± 0.0
1.228MetIle: 1.228 ± 0.508
1.228MetLys: 1.228 ± 0.688
1.228MetLeu: 1.228 ± 0.508
0.0MetMet: 0.0 ± 0.0
0.614MetAsn: 0.614 ± 0.852
3.069MetPro: 3.069 ± 0.672
0.0MetGln: 0.0 ± 0.0
0.614MetArg: 0.614 ± 0.344
2.455MetSer: 2.455 ± 1.375
0.614MetThr: 0.614 ± 0.344
1.842MetVal: 1.842 ± 1.031
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.842AsnAla: 1.842 ± 0.164
0.0AsnCys: 0.0 ± 0.0
1.842AsnAsp: 1.842 ± 0.164
2.455AsnGlu: 2.455 ± 1.375
1.228AsnPhe: 1.228 ± 0.688
3.069AsnGly: 3.069 ± 0.524
1.842AsnHis: 1.842 ± 1.031
5.525AsnIle: 5.525 ± 1.687
2.455AsnLys: 2.455 ± 1.375
3.683AsnLeu: 3.683 ± 3.914
1.228AsnMet: 1.228 ± 0.508
1.842AsnAsn: 1.842 ± 0.164
2.455AsnPro: 2.455 ± 1.016
3.069AsnGln: 3.069 ± 1.719
3.683AsnArg: 3.683 ± 1.523
3.069AsnSer: 3.069 ± 0.672
4.911AsnThr: 4.911 ± 3.226
4.297AsnVal: 4.297 ± 2.375
0.0AsnTrp: 0.0 ± 0.0
4.911AsnTyr: 4.911 ± 0.36
0.0AsnXaa: 0.0 ± 0.0
Pro
4.911ProAla: 4.911 ± 2.031
0.614ProCys: 0.614 ± 0.852
3.683ProAsp: 3.683 ± 1.523
3.683ProGlu: 3.683 ± 0.867
2.455ProPhe: 2.455 ± 1.016
4.297ProGly: 4.297 ± 0.016
0.614ProHis: 0.614 ± 0.852
6.139ProIle: 6.139 ± 2.242
1.842ProLys: 1.842 ± 1.031
4.911ProLeu: 4.911 ± 0.836
0.0ProMet: 0.0 ± 0.0
2.455ProAsn: 2.455 ± 2.211
3.069ProPro: 3.069 ± 0.524
1.842ProGln: 1.842 ± 0.164
2.455ProArg: 2.455 ± 1.016
8.594ProSer: 8.594 ± 0.032
3.683ProThr: 3.683 ± 0.867
1.842ProVal: 1.842 ± 0.164
0.614ProTrp: 0.614 ± 0.344
2.455ProTyr: 2.455 ± 1.375
0.0ProXaa: 0.0 ± 0.0
Gln
1.228GlnAla: 1.228 ± 0.508
1.228GlnCys: 1.228 ± 0.688
1.842GlnAsp: 1.842 ± 0.164
0.0GlnGlu: 0.0 ± 0.0
0.614GlnPhe: 0.614 ± 0.852
0.614GlnGly: 0.614 ± 0.344
0.614GlnHis: 0.614 ± 0.344
2.455GlnIle: 2.455 ± 0.18
1.228GlnLys: 1.228 ± 0.508
2.455GlnLeu: 2.455 ± 0.18
0.614GlnMet: 0.614 ± 0.344
2.455GlnAsn: 2.455 ± 1.016
3.683GlnPro: 3.683 ± 0.328
2.455GlnGln: 2.455 ± 1.016
2.455GlnArg: 2.455 ± 0.18
3.683GlnSer: 3.683 ± 2.719
1.228GlnThr: 1.228 ± 0.508
3.683GlnVal: 3.683 ± 0.867
1.228GlnTrp: 1.228 ± 1.703
0.614GlnTyr: 0.614 ± 0.852
0.0GlnXaa: 0.0 ± 0.0
Arg
3.069ArgAla: 3.069 ± 3.062
0.0ArgCys: 0.0 ± 0.0
3.069ArgAsp: 3.069 ± 1.867
2.455ArgGlu: 2.455 ± 0.18
1.842ArgPhe: 1.842 ± 0.164
2.455ArgGly: 2.455 ± 2.211
2.455ArgHis: 2.455 ± 1.375
4.297ArgIle: 4.297 ± 2.406
1.842ArgLys: 1.842 ± 0.164
4.297ArgLeu: 4.297 ± 0.016
0.614ArgMet: 0.614 ± 0.464
3.683ArgAsn: 3.683 ± 0.328
4.297ArgPro: 4.297 ± 1.18
1.228ArgGln: 1.228 ± 0.508
3.683ArgArg: 3.683 ± 0.328
7.98ArgSer: 7.98 ± 5.093
4.297ArgThr: 4.297 ± 1.211
3.683ArgVal: 3.683 ± 1.523
0.614ArgTrp: 0.614 ± 0.344
4.297ArgTyr: 4.297 ± 1.18
0.0ArgXaa: 0.0 ± 0.0
Ser
3.683SerAla: 3.683 ± 0.328
1.228SerCys: 1.228 ± 0.508
4.297SerAsp: 4.297 ± 1.18
6.139SerGlu: 6.139 ± 1.047
3.683SerPhe: 3.683 ± 2.063
4.911SerGly: 4.911 ± 0.836
1.842SerHis: 1.842 ± 1.031
5.525SerIle: 5.525 ± 0.703
5.525SerLys: 5.525 ± 1.899
3.069SerLeu: 3.069 ± 1.867
1.228SerMet: 1.228 ± 0.688
4.297SerAsn: 4.297 ± 0.016
6.753SerPro: 6.753 ± 1.0
3.069SerGln: 3.069 ± 3.062
6.753SerArg: 6.753 ± 2.195
9.208SerSer: 9.208 ± 1.571
7.366SerThr: 7.366 ± 0.539
6.139SerVal: 6.139 ± 1.047
1.842SerTrp: 1.842 ± 0.164
2.455SerTyr: 2.455 ± 0.18
0.0SerXaa: 0.0 ± 0.0
Thr
4.297ThrAla: 4.297 ± 1.18
0.614ThrCys: 0.614 ± 0.852
2.455ThrAsp: 2.455 ± 0.18
2.455ThrGlu: 2.455 ± 0.18
3.069ThrPhe: 3.069 ± 0.672
6.139ThrGly: 6.139 ± 3.734
1.842ThrHis: 1.842 ± 1.031
1.842ThrIle: 1.842 ± 0.164
3.069ThrLys: 3.069 ± 0.524
5.525ThrLeu: 5.525 ± 3.094
1.842ThrMet: 1.842 ± 1.213
5.525ThrAsn: 5.525 ± 0.492
7.98ThrPro: 7.98 ± 0.883
1.842ThrGln: 1.842 ± 0.164
3.683ThrArg: 3.683 ± 0.867
6.139ThrSer: 6.139 ± 0.148
9.208ThrThr: 9.208 ± 0.375
7.366ThrVal: 7.366 ± 0.539
0.0ThrTrp: 0.0 ± 0.0
1.842ThrTyr: 1.842 ± 0.164
0.0ThrXaa: 0.0 ± 0.0
Val
4.911ValAla: 4.911 ± 2.031
0.614ValCys: 0.614 ± 0.344
3.069ValAsp: 3.069 ± 0.524
8.594ValGlu: 8.594 ± 2.422
2.455ValPhe: 2.455 ± 0.18
3.069ValGly: 3.069 ± 1.719
1.228ValHis: 1.228 ± 0.508
4.297ValIle: 4.297 ± 1.18
3.683ValLys: 3.683 ± 2.063
4.911ValLeu: 4.911 ± 0.836
1.228ValMet: 1.228 ± 0.508
3.069ValAsn: 3.069 ± 0.524
3.683ValPro: 3.683 ± 0.867
2.455ValGln: 2.455 ± 2.211
4.297ValArg: 4.297 ± 0.016
3.683ValSer: 3.683 ± 2.063
2.455ValThr: 2.455 ± 1.375
6.139ValVal: 6.139 ± 0.148
0.614ValTrp: 0.614 ± 0.344
0.614ValTyr: 0.614 ± 0.852
0.0ValXaa: 0.0 ± 0.0
Trp
1.842TrpAla: 1.842 ± 1.031
0.0TrpCys: 0.0 ± 0.0
1.228TrpAsp: 1.228 ± 0.508
0.614TrpGlu: 0.614 ± 0.344
0.614TrpPhe: 0.614 ± 0.344
0.614TrpGly: 0.614 ± 0.852
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.842TrpLeu: 1.842 ± 0.164
0.0TrpMet: 0.0 ± 0.0
2.455TrpAsn: 2.455 ± 1.016
0.614TrpPro: 0.614 ± 0.344
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.614TrpSer: 0.614 ± 0.852
0.614TrpThr: 0.614 ± 0.852
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.228TrpTyr: 1.228 ± 0.688
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.455TyrAla: 2.455 ± 1.375
0.0TyrCys: 0.0 ± 0.0
2.455TyrAsp: 2.455 ± 1.016
2.455TyrGlu: 2.455 ± 1.375
1.842TyrPhe: 1.842 ± 1.031
3.683TyrGly: 3.683 ± 0.867
0.0TyrHis: 0.0 ± 0.0
3.069TyrIle: 3.069 ± 1.719
1.842TyrLys: 1.842 ± 0.164
6.753TyrLeu: 6.753 ± 2.586
1.842TyrMet: 1.842 ± 1.359
0.614TyrAsn: 0.614 ± 0.852
2.455TyrPro: 2.455 ± 2.211
1.228TyrGln: 1.228 ± 0.508
2.455TyrArg: 2.455 ± 2.211
4.297TyrSer: 4.297 ± 1.211
3.683TyrThr: 3.683 ± 1.523
1.228TyrVal: 1.228 ± 0.508
0.614TyrTrp: 0.614 ± 0.344
3.069TyrTyr: 3.069 ± 0.672
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski