Amino acid dipepetide frequency for Celeribacter indicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.328AlaAla: 17.328 ± 0.153
1.087AlaCys: 1.087 ± 0.026
6.499AlaAsp: 6.499 ± 0.068
8.878AlaGlu: 8.878 ± 0.099
4.596AlaPhe: 4.596 ± 0.058
11.205AlaGly: 11.205 ± 0.113
2.366AlaHis: 2.366 ± 0.04
5.749AlaIle: 5.749 ± 0.064
3.302AlaLys: 3.302 ± 0.055
14.278AlaLeu: 14.278 ± 0.134
3.745AlaMet: 3.745 ± 0.054
2.32AlaAsn: 2.32 ± 0.037
6.218AlaPro: 6.218 ± 0.077
4.174AlaGln: 4.174 ± 0.054
10.055AlaArg: 10.055 ± 0.105
5.521AlaSer: 5.521 ± 0.072
6.026AlaThr: 6.026 ± 0.067
8.625AlaVal: 8.625 ± 0.091
1.449AlaTrp: 1.449 ± 0.037
2.453AlaTyr: 2.453 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.032CysAla: 1.032 ± 0.027
0.106CysCys: 0.106 ± 0.01
0.603CysAsp: 0.603 ± 0.023
0.472CysGlu: 0.472 ± 0.02
0.336CysPhe: 0.336 ± 0.014
0.921CysGly: 0.921 ± 0.032
0.259CysHis: 0.259 ± 0.012
0.381CysIle: 0.381 ± 0.019
0.179CysLys: 0.179 ± 0.012
0.879CysLeu: 0.879 ± 0.027
0.154CysMet: 0.154 ± 0.011
0.17CysAsn: 0.17 ± 0.011
0.47CysPro: 0.47 ± 0.02
0.205CysGln: 0.205 ± 0.012
0.624CysArg: 0.624 ± 0.021
0.396CysSer: 0.396 ± 0.017
0.42CysThr: 0.42 ± 0.019
0.602CysVal: 0.602 ± 0.019
0.098CysTrp: 0.098 ± 0.009
0.193CysTyr: 0.193 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.796AspAla: 6.796 ± 0.082
0.523AspCys: 0.523 ± 0.021
3.008AspAsp: 3.008 ± 0.058
3.442AspGlu: 3.442 ± 0.054
2.36AspPhe: 2.36 ± 0.044
5.302AspGly: 5.302 ± 0.083
1.375AspHis: 1.375 ± 0.037
2.921AspIle: 2.921 ± 0.047
1.322AspLys: 1.322 ± 0.037
6.726AspLeu: 6.726 ± 0.072
1.591AspMet: 1.591 ± 0.03
1.094AspAsn: 1.094 ± 0.026
3.849AspPro: 3.849 ± 0.058
1.558AspGln: 1.558 ± 0.03
4.845AspArg: 4.845 ± 0.066
2.034AspSer: 2.034 ± 0.04
2.834AspThr: 2.834 ± 0.047
3.94AspVal: 3.94 ± 0.063
1.191AspTrp: 1.191 ± 0.028
1.619AspTyr: 1.619 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
9.096GluAla: 9.096 ± 0.088
0.345GluCys: 0.345 ± 0.019
3.684GluAsp: 3.684 ± 0.057
4.425GluGlu: 4.425 ± 0.076
1.911GluPhe: 1.911 ± 0.038
5.397GluGly: 5.397 ± 0.064
1.151GluHis: 1.151 ± 0.029
4.059GluIle: 4.059 ± 0.061
2.148GluLys: 2.148 ± 0.042
5.475GluLeu: 5.475 ± 0.072
1.87GluMet: 1.87 ± 0.034
1.608GluAsn: 1.608 ± 0.033
2.626GluPro: 2.626 ± 0.054
1.803GluGln: 1.803 ± 0.038
4.909GluArg: 4.909 ± 0.071
2.255GluSer: 2.255 ± 0.039
4.181GluThr: 4.181 ± 0.067
4.526GluVal: 4.526 ± 0.064
0.66GluTrp: 0.66 ± 0.019
1.001GluTyr: 1.001 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.676PheAla: 4.676 ± 0.064
0.412PheCys: 0.412 ± 0.017
2.781PheAsp: 2.781 ± 0.048
2.271PheGlu: 2.271 ± 0.047
1.456PhePhe: 1.456 ± 0.038
3.828PheGly: 3.828 ± 0.057
0.786PheHis: 0.786 ± 0.024
1.502PheIle: 1.502 ± 0.032
0.717PheLys: 0.717 ± 0.023
3.631PheLeu: 3.631 ± 0.055
0.8PheMet: 0.8 ± 0.024
0.915PheAsn: 0.915 ± 0.026
1.643PhePro: 1.643 ± 0.034
0.879PheGln: 0.879 ± 0.023
2.417PheArg: 2.417 ± 0.047
2.126PheSer: 2.126 ± 0.037
2.098PheThr: 2.098 ± 0.039
2.802PheVal: 2.802 ± 0.047
0.556PheTrp: 0.556 ± 0.02
0.916PheTyr: 0.916 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.157GlyAla: 10.157 ± 0.096
0.826GlyCys: 0.826 ± 0.026
4.575GlyAsp: 4.575 ± 0.08
5.421GlyGlu: 5.421 ± 0.067
3.662GlyPhe: 3.662 ± 0.054
7.524GlyGly: 7.524 ± 0.101
1.928GlyHis: 1.928 ± 0.044
4.686GlyIle: 4.686 ± 0.066
2.785GlyLys: 2.785 ± 0.049
9.541GlyLeu: 9.541 ± 0.114
2.571GlyMet: 2.571 ± 0.043
1.88GlyAsn: 1.88 ± 0.043
3.71GlyPro: 3.71 ± 0.054
2.823GlyGln: 2.823 ± 0.05
6.698GlyArg: 6.698 ± 0.085
4.2GlySer: 4.2 ± 0.065
4.961GlyThr: 4.961 ± 0.07
6.321GlyVal: 6.321 ± 0.07
1.466GlyTrp: 1.466 ± 0.032
2.318GlyTyr: 2.318 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.042
0.213HisCys: 0.213 ± 0.014
1.284HisAsp: 1.284 ± 0.035
1.135HisGlu: 1.135 ± 0.035
0.792HisPhe: 0.792 ± 0.026
1.975HisGly: 1.975 ± 0.037
0.558HisHis: 0.558 ± 0.023
0.925HisIle: 0.925 ± 0.026
0.437HisLys: 0.437 ± 0.017
2.075HisLeu: 2.075 ± 0.038
0.507HisMet: 0.507 ± 0.018
0.417HisAsn: 0.417 ± 0.017
1.42HisPro: 1.42 ± 0.032
0.504HisGln: 0.504 ± 0.017
1.552HisArg: 1.552 ± 0.038
0.886HisSer: 0.886 ± 0.022
0.786HisThr: 0.786 ± 0.021
1.598HisVal: 1.598 ± 0.036
0.354HisTrp: 0.354 ± 0.016
0.525HisTyr: 0.525 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.143IleAla: 7.143 ± 0.072
0.545IleCys: 0.545 ± 0.018
3.335IleAsp: 3.335 ± 0.054
3.434IleGlu: 3.434 ± 0.052
1.79IlePhe: 1.79 ± 0.038
4.892IleGly: 4.892 ± 0.072
0.902IleHis: 0.902 ± 0.029
1.854IleIle: 1.854 ± 0.05
0.942IleLys: 0.942 ± 0.028
4.787IleLeu: 4.787 ± 0.063
0.994IleMet: 0.994 ± 0.028
1.079IleAsn: 1.079 ± 0.024
2.429IlePro: 2.429 ± 0.048
0.999IleGln: 0.999 ± 0.03
3.549IleArg: 3.549 ± 0.051
2.904IleSer: 2.904 ± 0.047
2.572IleThr: 2.572 ± 0.045
4.09IleVal: 4.09 ± 0.061
0.706IleTrp: 0.706 ± 0.026
1.141IleTyr: 1.141 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.371LysAla: 3.371 ± 0.057
0.148LysCys: 0.148 ± 0.011
1.463LysAsp: 1.463 ± 0.039
1.405LysGlu: 1.405 ± 0.034
0.823LysPhe: 0.823 ± 0.026
2.355LysGly: 2.355 ± 0.046
0.492LysHis: 0.492 ± 0.019
1.49LysIle: 1.49 ± 0.034
1.019LysLys: 1.019 ± 0.033
2.639LysLeu: 2.639 ± 0.046
0.691LysMet: 0.691 ± 0.022
0.586LysAsn: 0.586 ± 0.021
1.544LysPro: 1.544 ± 0.037
0.734LysGln: 0.734 ± 0.025
2.015LysArg: 2.015 ± 0.047
1.593LysSer: 1.593 ± 0.037
1.736LysThr: 1.736 ± 0.033
2.046LysVal: 2.046 ± 0.043
0.361LysTrp: 0.361 ± 0.016
0.565LysTyr: 0.565 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.776LeuAla: 13.776 ± 0.131
0.984LeuCys: 0.984 ± 0.03
6.219LeuAsp: 6.219 ± 0.074
5.736LeuGlu: 5.736 ± 0.073
3.67LeuPhe: 3.67 ± 0.062
8.882LeuGly: 8.882 ± 0.101
1.973LeuHis: 1.973 ± 0.043
4.947LeuIle: 4.947 ± 0.068
2.792LeuLys: 2.792 ± 0.048
9.873LeuLeu: 9.873 ± 0.131
2.57LeuMet: 2.57 ± 0.049
2.307LeuAsn: 2.307 ± 0.042
5.893LeuPro: 5.893 ± 0.073
2.295LeuGln: 2.295 ± 0.039
7.776LeuArg: 7.776 ± 0.084
7.035LeuSer: 7.035 ± 0.08
5.977LeuThr: 5.977 ± 0.071
7.452LeuVal: 7.452 ± 0.101
1.299LeuTrp: 1.299 ± 0.037
1.979LeuTyr: 1.979 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.297MetAla: 3.297 ± 0.045
0.168MetCys: 0.168 ± 0.011
1.299MetAsp: 1.299 ± 0.031
1.413MetGlu: 1.413 ± 0.03
0.745MetPhe: 0.745 ± 0.024
2.085MetGly: 2.085 ± 0.038
0.418MetHis: 0.418 ± 0.017
1.504MetIle: 1.504 ± 0.032
0.963MetLys: 0.963 ± 0.024
2.51MetLeu: 2.51 ± 0.048
0.755MetMet: 0.755 ± 0.023
0.788MetAsn: 0.788 ± 0.022
1.527MetPro: 1.527 ± 0.033
0.852MetGln: 0.852 ± 0.021
2.009MetArg: 2.009 ± 0.039
1.807MetSer: 1.807 ± 0.038
2.072MetThr: 2.072 ± 0.032
1.745MetVal: 1.745 ± 0.037
0.218MetTrp: 0.218 ± 0.012
0.309MetTyr: 0.309 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.832AsnAla: 2.832 ± 0.042
0.213AsnCys: 0.213 ± 0.013
1.208AsnAsp: 1.208 ± 0.035
1.116AsnGlu: 1.116 ± 0.031
0.854AsnPhe: 0.854 ± 0.025
2.067AsnGly: 2.067 ± 0.037
0.459AsnHis: 0.459 ± 0.017
1.206AsnIle: 1.206 ± 0.032
0.514AsnLys: 0.514 ± 0.018
2.35AsnLeu: 2.35 ± 0.043
0.598AsnMet: 0.598 ± 0.019
0.505AsnAsn: 0.505 ± 0.021
1.613AsnPro: 1.613 ± 0.033
0.561AsnGln: 0.561 ± 0.02
1.702AsnArg: 1.702 ± 0.034
1.004AsnSer: 1.004 ± 0.026
1.157AsnThr: 1.157 ± 0.033
1.653AsnVal: 1.653 ± 0.035
0.389AsnTrp: 0.389 ± 0.02
0.54AsnTyr: 0.54 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
6.297ProAla: 6.297 ± 0.073
0.331ProCys: 0.331 ± 0.017
3.932ProAsp: 3.932 ± 0.059
4.828ProGlu: 4.828 ± 0.064
2.022ProPhe: 2.022 ± 0.042
4.549ProGly: 4.549 ± 0.067
1.092ProHis: 1.092 ± 0.026
2.018ProIle: 2.018 ± 0.038
1.482ProLys: 1.482 ± 0.037
4.95ProLeu: 4.95 ± 0.062
1.252ProMet: 1.252 ± 0.03
1.203ProAsn: 1.203 ± 0.032
2.657ProPro: 2.657 ± 0.053
1.553ProGln: 1.553 ± 0.032
3.24ProArg: 3.24 ± 0.052
2.476ProSer: 2.476 ± 0.044
2.352ProThr: 2.352 ± 0.042
4.585ProVal: 4.585 ± 0.063
0.681ProTrp: 0.681 ± 0.022
1.117ProTyr: 1.117 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
3.573GlnAla: 3.573 ± 0.058
0.181GlnCys: 0.181 ± 0.011
1.519GlnAsp: 1.519 ± 0.035
1.534GlnGlu: 1.534 ± 0.03
0.948GlnPhe: 0.948 ± 0.025
2.381GlnGly: 2.381 ± 0.043
0.466GlnHis: 0.466 ± 0.018
1.943GlnIle: 1.943 ± 0.041
0.929GlnLys: 0.929 ± 0.027
2.473GlnLeu: 2.473 ± 0.045
0.91GlnMet: 0.91 ± 0.026
0.745GlnAsn: 0.745 ± 0.027
1.408GlnPro: 1.408 ± 0.033
0.944GlnGln: 0.944 ± 0.033
2.039GlnArg: 2.039 ± 0.042
1.588GlnSer: 1.588 ± 0.033
1.595GlnThr: 1.595 ± 0.039
2.126GlnVal: 2.126 ± 0.036
0.335GlnTrp: 0.335 ± 0.015
0.542GlnTyr: 0.542 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
9.056ArgAla: 9.056 ± 0.102
0.532ArgCys: 0.532 ± 0.022
4.647ArgAsp: 4.647 ± 0.062
4.702ArgGlu: 4.702 ± 0.07
2.83ArgPhe: 2.83 ± 0.049
5.223ArgGly: 5.223 ± 0.064
1.794ArgHis: 1.794 ± 0.04
4.282ArgIle: 4.282 ± 0.059
2.205ArgLys: 2.205 ± 0.048
8.34ArgLeu: 8.34 ± 0.101
2.06ArgMet: 2.06 ± 0.043
1.813ArgAsn: 1.813 ± 0.035
3.854ArgPro: 3.854 ± 0.058
2.391ArgGln: 2.391 ± 0.047
6.192ArgArg: 6.192 ± 0.087
3.558ArgSer: 3.558 ± 0.051
3.406ArgThr: 3.406 ± 0.049
5.051ArgVal: 5.051 ± 0.063
0.957ArgTrp: 0.957 ± 0.026
1.67ArgTyr: 1.67 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.849SerAla: 5.849 ± 0.056
0.452SerCys: 0.452 ± 0.02
3.082SerAsp: 3.082 ± 0.047
3.059SerGlu: 3.059 ± 0.047
2.207SerPhe: 2.207 ± 0.039
5.41SerGly: 5.41 ± 0.057
1.069SerHis: 1.069 ± 0.029
2.218SerIle: 2.218 ± 0.043
1.245SerLys: 1.245 ± 0.031
5.123SerLeu: 5.123 ± 0.062
1.232SerMet: 1.232 ± 0.031
1.204SerAsn: 1.204 ± 0.027
2.589SerPro: 2.589 ± 0.039
1.451SerGln: 1.451 ± 0.028
3.641SerArg: 3.641 ± 0.055
2.553SerSer: 2.553 ± 0.044
2.491SerThr: 2.491 ± 0.048
3.855SerVal: 3.855 ± 0.059
0.735SerTrp: 0.735 ± 0.024
1.379SerTyr: 1.379 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.274ThrAla: 6.274 ± 0.061
0.463ThrCys: 0.463 ± 0.018
2.947ThrAsp: 2.947 ± 0.046
3.108ThrGlu: 3.108 ± 0.051
1.902ThrPhe: 1.902 ± 0.038
5.688ThrGly: 5.688 ± 0.083
1.067ThrHis: 1.067 ± 0.027
2.615ThrIle: 2.615 ± 0.048
1.22ThrLys: 1.22 ± 0.035
6.267ThrLeu: 6.267 ± 0.064
1.274ThrMet: 1.274 ± 0.028
1.139ThrAsn: 1.139 ± 0.03
3.492ThrPro: 3.492 ± 0.051
1.39ThrGln: 1.39 ± 0.031
3.801ThrArg: 3.801 ± 0.055
2.604ThrSer: 2.604 ± 0.041
2.729ThrThr: 2.729 ± 0.047
4.278ThrVal: 4.278 ± 0.059
0.661ThrTrp: 0.661 ± 0.026
1.199ThrTyr: 1.199 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.176ValAla: 9.176 ± 0.105
0.609ValCys: 0.609 ± 0.022
3.975ValAsp: 3.975 ± 0.059
4.738ValGlu: 4.738 ± 0.057
2.893ValPhe: 2.893 ± 0.05
5.333ValGly: 5.333 ± 0.071
1.319ValHis: 1.319 ± 0.032
4.14ValIle: 4.14 ± 0.061
1.966ValLys: 1.966 ± 0.043
7.683ValLeu: 7.683 ± 0.094
2.05ValMet: 2.05 ± 0.04
1.771ValAsn: 1.771 ± 0.037
3.912ValPro: 3.912 ± 0.06
1.951ValGln: 1.951 ± 0.042
4.543ValArg: 4.543 ± 0.066
4.389ValSer: 4.389 ± 0.058
4.866ValThr: 4.866 ± 0.065
5.649ValVal: 5.649 ± 0.075
0.91ValTrp: 0.91 ± 0.029
1.489ValTyr: 1.489 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.276TrpAla: 1.276 ± 0.034
0.13TrpCys: 0.13 ± 0.009
0.72TrpAsp: 0.72 ± 0.024
0.669TrpGlu: 0.669 ± 0.021
0.565TrpPhe: 0.565 ± 0.02
0.982TrpGly: 0.982 ± 0.033
0.356TrpHis: 0.356 ± 0.017
0.758TrpIle: 0.758 ± 0.023
0.428TrpLys: 0.428 ± 0.019
1.598TrpLeu: 1.598 ± 0.031
0.384TrpMet: 0.384 ± 0.016
0.421TrpAsn: 0.421 ± 0.019
0.679TrpPro: 0.679 ± 0.02
0.53TrpGln: 0.53 ± 0.018
1.162TrpArg: 1.162 ± 0.03
0.802TrpSer: 0.802 ± 0.025
0.785TrpThr: 0.785 ± 0.024
0.84TrpVal: 0.84 ± 0.023
0.203TrpTrp: 0.203 ± 0.014
0.252TrpTyr: 0.252 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.494TyrAla: 2.494 ± 0.04
0.233TyrCys: 0.233 ± 0.014
1.549TyrAsp: 1.549 ± 0.033
1.341TyrGlu: 1.341 ± 0.033
0.847TyrPhe: 0.847 ± 0.024
2.056TyrGly: 2.056 ± 0.042
0.489TyrHis: 0.489 ± 0.017
0.886TyrIle: 0.886 ± 0.023
0.478TyrLys: 0.478 ± 0.02
2.237TyrLeu: 2.237 ± 0.043
0.477TyrMet: 0.477 ± 0.02
0.576TyrAsn: 0.576 ± 0.02
1.086TyrPro: 1.086 ± 0.029
0.579TyrGln: 0.579 ± 0.02
1.795TyrArg: 1.795 ± 0.033
1.114TyrSer: 1.114 ± 0.031
1.077TyrThr: 1.077 ± 0.026
1.577TyrVal: 1.577 ± 0.038
0.314TyrTrp: 0.314 ± 0.017
0.537TyrTyr: 0.537 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4665 proteins (1422014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski