Amino acid dipepetide frequency for Pigeonpox virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.41AlaAla: 1.41 ± 0.164
0.821AlaCys: 0.821 ± 0.101
2.422AlaAsp: 2.422 ± 0.182
1.423AlaGlu: 1.423 ± 0.141
1.355AlaPhe: 1.355 ± 0.127
1.259AlaGly: 1.259 ± 0.146
0.506AlaHis: 0.506 ± 0.082
3.832AlaIle: 3.832 ± 0.26
2.354AlaLys: 2.354 ± 0.173
3.134AlaLeu: 3.134 ± 0.214
0.862AlaMet: 0.862 ± 0.13
2.327AlaAsn: 2.327 ± 0.177
0.671AlaPro: 0.671 ± 0.1
0.383AlaGln: 0.383 ± 0.056
1.3AlaArg: 1.3 ± 0.124
2.587AlaSer: 2.587 ± 0.226
2.313AlaThr: 2.313 ± 0.191
2.477AlaVal: 2.477 ± 0.196
0.205AlaTrp: 0.205 ± 0.06
1.56AlaTyr: 1.56 ± 0.15
0.0AlaXaa: 0.0 ± 0.0
Cys
0.698CysAla: 0.698 ± 0.104
0.616CysCys: 0.616 ± 0.121
1.369CysAsp: 1.369 ± 0.137
1.204CysGlu: 1.204 ± 0.122
0.958CysPhe: 0.958 ± 0.121
1.163CysGly: 1.163 ± 0.133
0.356CysHis: 0.356 ± 0.065
2.573CysIle: 2.573 ± 0.21
1.861CysLys: 1.861 ± 0.201
1.56CysLeu: 1.56 ± 0.183
0.684CysMet: 0.684 ± 0.085
1.642CysAsn: 1.642 ± 0.125
0.849CysPro: 0.849 ± 0.095
0.26CysGln: 0.26 ± 0.067
0.958CysArg: 0.958 ± 0.123
1.451CysSer: 1.451 ± 0.149
1.026CysThr: 1.026 ± 0.098
1.232CysVal: 1.232 ± 0.135
0.151CysTrp: 0.151 ± 0.044
1.423CysTyr: 1.423 ± 0.131
0.0CysXaa: 0.0 ± 0.0
Asp
2.203AspAla: 2.203 ± 0.153
1.068AspCys: 1.068 ± 0.133
4.653AspAsp: 4.653 ± 0.461
3.517AspGlu: 3.517 ± 0.248
2.751AspPhe: 2.751 ± 0.196
2.162AspGly: 2.162 ± 0.186
1.136AspHis: 1.136 ± 0.139
8.308AspIle: 8.308 ± 0.368
5.365AspLys: 5.365 ± 0.27
4.804AspLeu: 4.804 ± 0.295
1.588AspMet: 1.588 ± 0.161
5.269AspAsn: 5.269 ± 0.28
2.012AspPro: 2.012 ± 0.153
0.917AspGln: 0.917 ± 0.101
2.6AspArg: 2.6 ± 0.233
4.161AspSer: 4.161 ± 0.235
3.832AspThr: 3.832 ± 0.237
3.928AspVal: 3.928 ± 0.244
0.37AspTrp: 0.37 ± 0.067
3.736AspTyr: 3.736 ± 0.23
0.0AspXaa: 0.0 ± 0.0
Glu
1.793GluAla: 1.793 ± 0.15
1.177GluCys: 1.177 ± 0.121
3.449GluAsp: 3.449 ± 0.224
3.777GluGlu: 3.777 ± 0.236
2.19GluPhe: 2.19 ± 0.203
1.861GluGly: 1.861 ± 0.144
0.931GluHis: 0.931 ± 0.123
5.748GluIle: 5.748 ± 0.342
4.941GluLys: 4.941 ± 0.247
6.501GluLeu: 6.501 ± 0.335
1.287GluMet: 1.287 ± 0.103
4.092GluAsn: 4.092 ± 0.233
1.355GluPro: 1.355 ± 0.162
1.259GluGln: 1.259 ± 0.115
1.957GluArg: 1.957 ± 0.146
3.818GluSer: 3.818 ± 0.222
3.408GluThr: 3.408 ± 0.195
2.901GluVal: 2.901 ± 0.195
0.411GluTrp: 0.411 ± 0.071
3.887GluTyr: 3.887 ± 0.241
0.0GluXaa: 0.0 ± 0.0
Phe
0.985PheAla: 0.985 ± 0.111
0.999PheCys: 0.999 ± 0.115
2.436PheAsp: 2.436 ± 0.194
2.217PheGlu: 2.217 ± 0.222
1.943PhePhe: 1.943 ± 0.176
1.601PheGly: 1.601 ± 0.138
0.725PheHis: 0.725 ± 0.088
4.763PheIle: 4.763 ± 0.275
3.613PheLys: 3.613 ± 0.222
3.695PheLeu: 3.695 ± 0.265
1.136PheMet: 1.136 ± 0.107
3.435PheAsn: 3.435 ± 0.215
1.478PhePro: 1.478 ± 0.135
0.739PheGln: 0.739 ± 0.109
1.369PheArg: 1.369 ± 0.14
3.818PheSer: 3.818 ± 0.236
2.765PheThr: 2.765 ± 0.163
2.505PheVal: 2.505 ± 0.187
0.342PheTrp: 0.342 ± 0.067
2.368PheTyr: 2.368 ± 0.167
0.0PheXaa: 0.0 ± 0.0
Gly
2.422GlyAla: 2.422 ± 0.25
0.835GlyCys: 0.835 ± 0.104
2.354GlyAsp: 2.354 ± 0.197
1.943GlyGlu: 1.943 ± 0.148
1.957GlyPhe: 1.957 ± 0.166
1.533GlyGly: 1.533 ± 0.172
0.698GlyHis: 0.698 ± 0.088
4.161GlyIle: 4.161 ± 0.232
3.381GlyLys: 3.381 ± 0.216
2.628GlyLeu: 2.628 ± 0.227
0.89GlyMet: 0.89 ± 0.107
3.025GlyAsn: 3.025 ± 0.183
0.807GlyPro: 0.807 ± 0.111
0.671GlyGln: 0.671 ± 0.105
1.697GlyArg: 1.697 ± 0.14
2.669GlySer: 2.669 ± 0.238
2.039GlyThr: 2.039 ± 0.209
2.012GlyVal: 2.012 ± 0.181
0.26GlyTrp: 0.26 ± 0.062
2.628GlyTyr: 2.628 ± 0.187
0.0GlyXaa: 0.0 ± 0.0
His
0.835HisAla: 0.835 ± 0.099
0.424HisCys: 0.424 ± 0.066
1.232HisAsp: 1.232 ± 0.124
0.931HisGlu: 0.931 ± 0.102
0.725HisPhe: 0.725 ± 0.109
1.095HisGly: 1.095 ± 0.124
0.534HisHis: 0.534 ± 0.086
2.149HisIle: 2.149 ± 0.179
1.574HisLys: 1.574 ± 0.16
1.451HisLeu: 1.451 ± 0.138
0.438HisMet: 0.438 ± 0.071
1.3HisAsn: 1.3 ± 0.135
0.835HisPro: 0.835 ± 0.104
0.575HisGln: 0.575 ± 0.091
0.821HisArg: 0.821 ± 0.116
1.328HisSer: 1.328 ± 0.123
0.917HisThr: 0.917 ± 0.092
1.396HisVal: 1.396 ± 0.16
0.151HisTrp: 0.151 ± 0.051
1.341HisTyr: 1.341 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
3.545IleAla: 3.545 ± 0.202
2.094IleCys: 2.094 ± 0.199
6.98IleAsp: 6.98 ± 0.293
6.173IleGlu: 6.173 ± 0.294
4.215IlePhe: 4.215 ± 0.259
3.23IleGly: 3.23 ± 0.164
2.231IleHis: 2.231 ± 0.201
9.334IleIle: 9.334 ± 0.419
9.444IleLys: 9.444 ± 0.424
9.32IleLeu: 9.32 ± 0.403
2.546IleMet: 2.546 ± 0.183
8.554IleAsn: 8.554 ± 0.367
3.682IlePro: 3.682 ± 0.208
1.834IleGln: 1.834 ± 0.178
3.969IleArg: 3.969 ± 0.236
8.458IleSer: 8.458 ± 0.314
6.35IleThr: 6.35 ± 0.328
5.324IleVal: 5.324 ± 0.25
0.493IleTrp: 0.493 ± 0.08
4.968IleTyr: 4.968 ± 0.242
0.0IleXaa: 0.0 ± 0.0
Lys
2.313LysAla: 2.313 ± 0.187
1.766LysCys: 1.766 ± 0.184
5.652LysAsp: 5.652 ± 0.29
5.68LysGlu: 5.68 ± 0.318
3.435LysPhe: 3.435 ± 0.24
2.997LysGly: 2.997 ± 0.21
2.012LysHis: 2.012 ± 0.151
7.637LysIle: 7.637 ± 0.377
7.322LysLys: 7.322 ± 0.362
7.445LysLeu: 7.445 ± 0.338
1.93LysMet: 1.93 ± 0.152
6.487LysAsn: 6.487 ± 0.284
2.245LysPro: 2.245 ± 0.198
2.313LysGln: 2.313 ± 0.151
3.23LysArg: 3.23 ± 0.216
5.776LysSer: 5.776 ± 0.305
4.667LysThr: 4.667 ± 0.237
4.558LysVal: 4.558 ± 0.269
0.616LysTrp: 0.616 ± 0.103
5.721LysTyr: 5.721 ± 0.357
0.0LysXaa: 0.0 ± 0.0
Leu
3.134LeuAla: 3.134 ± 0.228
2.053LeuCys: 2.053 ± 0.187
6.173LeuAsp: 6.173 ± 0.358
6.118LeuGlu: 6.118 ± 0.286
4.051LeuPhe: 4.051 ± 0.228
3.285LeuGly: 3.285 ± 0.235
2.491LeuHis: 2.491 ± 0.262
7.719LeuIle: 7.719 ± 0.377
7.5LeuLys: 7.5 ± 0.383
11.086LeuLeu: 11.086 ± 0.748
2.203LeuMet: 2.203 ± 0.153
4.9LeuAsn: 4.9 ± 0.316
3.134LeuPro: 3.134 ± 0.196
2.313LeuGln: 2.313 ± 0.219
3.463LeuArg: 3.463 ± 0.229
7.377LeuSer: 7.377 ± 0.364
4.407LeuThr: 4.407 ± 0.294
5.037LeuVal: 5.037 ± 0.274
0.37LeuTrp: 0.37 ± 0.07
5.119LeuTyr: 5.119 ± 0.329
0.0LeuXaa: 0.0 ± 0.0
Met
0.985MetAla: 0.985 ± 0.12
0.479MetCys: 0.479 ± 0.078
1.848MetAsp: 1.848 ± 0.171
1.766MetGlu: 1.766 ± 0.174
1.369MetPhe: 1.369 ± 0.148
1.026MetGly: 1.026 ± 0.104
0.438MetHis: 0.438 ± 0.073
1.779MetIle: 1.779 ± 0.139
2.272MetLys: 2.272 ± 0.188
2.737MetLeu: 2.737 ± 0.204
0.794MetMet: 0.794 ± 0.086
1.464MetAsn: 1.464 ± 0.157
0.602MetPro: 0.602 ± 0.097
0.52MetGln: 0.52 ± 0.075
0.835MetArg: 0.835 ± 0.106
1.943MetSer: 1.943 ± 0.133
1.068MetThr: 1.068 ± 0.123
1.451MetVal: 1.451 ± 0.138
0.137MetTrp: 0.137 ± 0.051
1.533MetTyr: 1.533 ± 0.131
0.0MetXaa: 0.0 ± 0.0
Asn
2.067AsnAla: 2.067 ± 0.195
1.204AsnCys: 1.204 ± 0.126
4.311AsnAsp: 4.311 ± 0.227
3.846AsnGlu: 3.846 ± 0.235
2.819AsnPhe: 2.819 ± 0.241
2.86AsnGly: 2.86 ± 0.174
1.519AsnHis: 1.519 ± 0.141
9.758AsnIle: 9.758 ± 0.399
6.419AsnLys: 6.419 ± 0.342
4.845AsnLeu: 4.845 ± 0.275
2.203AsnMet: 2.203 ± 0.21
6.446AsnAsn: 6.446 ± 0.396
2.121AsnPro: 2.121 ± 0.147
1.341AsnGln: 1.341 ± 0.144
3.162AsnArg: 3.162 ± 0.193
5.297AsnSer: 5.297 ± 0.294
5.283AsnThr: 5.283 ± 0.285
3.846AsnVal: 3.846 ± 0.27
0.452AsnTrp: 0.452 ± 0.094
3.641AsnTyr: 3.641 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
0.616ProAla: 0.616 ± 0.105
0.671ProCys: 0.671 ± 0.093
2.19ProAsp: 2.19 ± 0.186
1.902ProGlu: 1.902 ± 0.163
1.396ProPhe: 1.396 ± 0.133
1.259ProGly: 1.259 ± 0.138
0.493ProHis: 0.493 ± 0.089
3.12ProIle: 3.12 ± 0.181
2.505ProLys: 2.505 ± 0.191
3.887ProLeu: 3.887 ± 0.267
0.561ProMet: 0.561 ± 0.098
2.053ProAsn: 2.053 ± 0.154
1.232ProPro: 1.232 ± 0.289
0.671ProGln: 0.671 ± 0.107
1.204ProArg: 1.204 ± 0.137
2.409ProSer: 2.409 ± 0.179
1.245ProThr: 1.245 ± 0.136
1.766ProVal: 1.766 ± 0.174
0.301ProTrp: 0.301 ± 0.05
1.505ProTyr: 1.505 ± 0.135
0.0ProXaa: 0.0 ± 0.0
Gln
0.876GlnAla: 0.876 ± 0.113
0.506GlnCys: 0.506 ± 0.068
1.369GlnAsp: 1.369 ± 0.114
1.314GlnGlu: 1.314 ± 0.132
0.698GlnPhe: 0.698 ± 0.113
0.766GlnGly: 0.766 ± 0.128
0.411GlnHis: 0.411 ± 0.075
1.574GlnIle: 1.574 ± 0.152
1.601GlnLys: 1.601 ± 0.129
2.34GlnLeu: 2.34 ± 0.183
0.52GlnMet: 0.52 ± 0.089
0.958GlnAsn: 0.958 ± 0.114
0.506GlnPro: 0.506 ± 0.088
0.766GlnGln: 0.766 ± 0.114
0.917GlnArg: 0.917 ± 0.142
1.588GlnSer: 1.588 ± 0.157
0.903GlnThr: 0.903 ± 0.107
0.985GlnVal: 0.985 ± 0.123
0.109GlnTrp: 0.109 ± 0.04
1.177GlnTyr: 1.177 ± 0.136
0.0GlnXaa: 0.0 ± 0.0
Arg
1.245ArgAla: 1.245 ± 0.138
1.109ArgCys: 1.109 ± 0.118
2.121ArgAsp: 2.121 ± 0.175
1.93ArgGlu: 1.93 ± 0.171
1.615ArgPhe: 1.615 ± 0.151
1.56ArgGly: 1.56 ± 0.144
0.999ArgHis: 0.999 ± 0.129
3.49ArgIle: 3.49 ± 0.24
2.997ArgLys: 2.997 ± 0.223
3.736ArgLeu: 3.736 ± 0.196
0.876ArgMet: 0.876 ± 0.104
3.367ArgAsn: 3.367 ± 0.205
1.068ArgPro: 1.068 ± 0.145
1.04ArgGln: 1.04 ± 0.13
2.053ArgArg: 2.053 ± 0.228
3.12ArgSer: 3.12 ± 0.217
2.258ArgThr: 2.258 ± 0.151
2.203ArgVal: 2.203 ± 0.205
0.424ArgTrp: 0.424 ± 0.064
2.888ArgTyr: 2.888 ± 0.216
0.0ArgXaa: 0.0 ± 0.0
Ser
2.094SerAla: 2.094 ± 0.231
1.724SerCys: 1.724 ± 0.117
4.79SerAsp: 4.79 ± 0.294
3.545SerGlu: 3.545 ± 0.211
3.394SerPhe: 3.394 ± 0.178
3.175SerGly: 3.175 ± 0.306
1.3SerHis: 1.3 ± 0.151
8.636SerIle: 8.636 ± 0.315
6.857SerLys: 6.857 ± 0.32
6.761SerLeu: 6.761 ± 0.363
1.711SerMet: 1.711 ± 0.139
5.16SerAsn: 5.16 ± 0.329
2.464SerPro: 2.464 ± 0.214
1.314SerGln: 1.314 ± 0.14
3.545SerArg: 3.545 ± 0.217
7.555SerSer: 7.555 ± 0.789
4.161SerThr: 4.161 ± 0.266
4.818SerVal: 4.818 ± 0.258
0.411SerTrp: 0.411 ± 0.078
4.256SerTyr: 4.256 ± 0.244
0.014SerXaa: 0.014 ± 0.011
Thr
2.313ThrAla: 2.313 ± 0.163
1.656ThrCys: 1.656 ± 0.17
3.996ThrAsp: 3.996 ± 0.192
3.189ThrGlu: 3.189 ± 0.228
2.381ThrPhe: 2.381 ± 0.163
2.532ThrGly: 2.532 ± 0.186
0.958ThrHis: 0.958 ± 0.115
5.94ThrIle: 5.94 ± 0.269
4.284ThrLys: 4.284 ± 0.258
4.612ThrLeu: 4.612 ± 0.211
1.218ThrMet: 1.218 ± 0.146
3.476ThrAsn: 3.476 ± 0.196
2.751ThrPro: 2.751 ± 0.259
0.944ThrGln: 0.944 ± 0.118
2.121ThrArg: 2.121 ± 0.169
4.777ThrSer: 4.777 ± 0.306
3.011ThrThr: 3.011 ± 0.263
3.476ThrVal: 3.476 ± 0.284
0.506ThrTrp: 0.506 ± 0.077
2.628ThrTyr: 2.628 ± 0.176
0.0ThrXaa: 0.0 ± 0.0
Val
1.683ValAla: 1.683 ± 0.139
1.437ValCys: 1.437 ± 0.156
3.381ValAsp: 3.381 ± 0.216
2.929ValGlu: 2.929 ± 0.211
2.847ValPhe: 2.847 ± 0.202
1.807ValGly: 1.807 ± 0.186
0.944ValHis: 0.944 ± 0.119
5.83ValIle: 5.83 ± 0.334
4.653ValLys: 4.653 ± 0.294
5.461ValLeu: 5.461 ± 0.214
1.588ValMet: 1.588 ± 0.152
4.407ValAsn: 4.407 ± 0.289
1.67ValPro: 1.67 ± 0.146
0.821ValGln: 0.821 ± 0.099
2.409ValArg: 2.409 ± 0.158
5.009ValSer: 5.009 ± 0.244
3.285ValThr: 3.285 ± 0.209
3.025ValVal: 3.025 ± 0.191
0.233ValTrp: 0.233 ± 0.064
2.956ValTyr: 2.956 ± 0.207
0.0ValXaa: 0.0 ± 0.0
Trp
0.192TrpAla: 0.192 ± 0.073
0.26TrpCys: 0.26 ± 0.069
0.274TrpAsp: 0.274 ± 0.059
0.397TrpGlu: 0.397 ± 0.076
0.328TrpPhe: 0.328 ± 0.074
0.123TrpGly: 0.123 ± 0.048
0.055TrpHis: 0.055 ± 0.029
0.725TrpIle: 0.725 ± 0.098
0.506TrpLys: 0.506 ± 0.09
0.766TrpLeu: 0.766 ± 0.095
0.287TrpMet: 0.287 ± 0.059
0.452TrpAsn: 0.452 ± 0.08
0.151TrpPro: 0.151 ± 0.042
0.123TrpGln: 0.123 ± 0.038
0.233TrpArg: 0.233 ± 0.057
0.301TrpSer: 0.301 ± 0.078
0.397TrpThr: 0.397 ± 0.077
0.397TrpVal: 0.397 ± 0.077
0.041TrpTrp: 0.041 ± 0.029
0.287TrpTyr: 0.287 ± 0.058
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.793TyrAla: 1.793 ± 0.148
1.136TyrCys: 1.136 ± 0.138
3.381TyrAsp: 3.381 ± 0.233
2.943TyrGlu: 2.943 ± 0.186
2.505TyrPhe: 2.505 ± 0.189
3.312TyrGly: 3.312 ± 0.225
1.314TyrHis: 1.314 ± 0.124
5.666TyrIle: 5.666 ± 0.286
4.352TyrLys: 4.352 ± 0.285
5.16TyrLeu: 5.16 ± 0.243
1.711TyrMet: 1.711 ± 0.149
4.626TyrAsn: 4.626 ± 0.248
1.355TyrPro: 1.355 ± 0.142
1.095TyrGln: 1.095 ± 0.121
2.258TyrArg: 2.258 ± 0.168
4.243TyrSer: 4.243 ± 0.228
3.422TyrThr: 3.422 ± 0.203
3.038TyrVal: 3.038 ± 0.191
0.315TyrTrp: 0.315 ± 0.062
3.353TyrTyr: 3.353 ± 0.225
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.014XaaThr: 0.014 ± 0.011
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 222 proteins (73067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski