Amino acid dipepetide frequency for Candidatus Saccharibacteria bacterium RAAC3_TM7_1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.94AlaAla: 8.94 ± 0.243
0.473AlaCys: 0.473 ± 0.05
4.855AlaAsp: 4.855 ± 0.143
5.707AlaGlu: 5.707 ± 0.167
3.163AlaPhe: 3.163 ± 0.119
6.81AlaGly: 6.81 ± 0.178
1.915AlaHis: 1.915 ± 0.085
6.247AlaIle: 6.247 ± 0.164
5.485AlaLys: 5.485 ± 0.164
8.76AlaLeu: 8.76 ± 0.182
2.162AlaMet: 2.162 ± 0.096
3.01AlaAsn: 3.01 ± 0.105
3.026AlaPro: 3.026 ± 0.108
2.967AlaGln: 2.967 ± 0.108
4.906AlaArg: 4.906 ± 0.153
5.465AlaSer: 5.465 ± 0.152
5.625AlaThr: 5.625 ± 0.169
6.38AlaVal: 6.38 ± 0.17
1.012AlaTrp: 1.012 ± 0.066
3.045AlaTyr: 3.045 ± 0.112
0.0AlaXaa: 0.0 ± 0.0
Cys
0.477CysAla: 0.477 ± 0.058
0.051CysCys: 0.051 ± 0.016
0.379CysAsp: 0.379 ± 0.038
0.34CysGlu: 0.34 ± 0.035
0.266CysPhe: 0.266 ± 0.027
0.555CysGly: 0.555 ± 0.051
0.145CysHis: 0.145 ± 0.026
0.317CysIle: 0.317 ± 0.035
0.297CysLys: 0.297 ± 0.037
0.512CysLeu: 0.512 ± 0.037
0.094CysMet: 0.094 ± 0.017
0.203CysAsn: 0.203 ± 0.026
0.375CysPro: 0.375 ± 0.049
0.199CysGln: 0.199 ± 0.034
0.238CysArg: 0.238 ± 0.036
0.383CysSer: 0.383 ± 0.039
0.465CysThr: 0.465 ± 0.055
0.348CysVal: 0.348 ± 0.04
0.117CysTrp: 0.117 ± 0.057
0.254CysTyr: 0.254 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
4.488AspAla: 4.488 ± 0.136
0.297AspCys: 0.297 ± 0.038
3.831AspAsp: 3.831 ± 0.151
4.816AspGlu: 4.816 ± 0.156
2.404AspPhe: 2.404 ± 0.102
4.632AspGly: 4.632 ± 0.143
1.13AspHis: 1.13 ± 0.065
4.097AspIle: 4.097 ± 0.125
3.444AspLys: 3.444 ± 0.127
4.437AspLeu: 4.437 ± 0.141
1.231AspMet: 1.231 ± 0.065
1.966AspAsn: 1.966 ± 0.094
2.236AspPro: 2.236 ± 0.099
2.056AspGln: 2.056 ± 0.086
2.572AspArg: 2.572 ± 0.118
3.061AspSer: 3.061 ± 0.108
3.338AspThr: 3.338 ± 0.127
4.038AspVal: 4.038 ± 0.126
0.629AspTrp: 0.629 ± 0.046
2.279AspTyr: 2.279 ± 0.088
0.0AspXaa: 0.0 ± 0.0
Glu
6.106GluAla: 6.106 ± 0.186
0.309GluCys: 0.309 ± 0.029
2.893GluAsp: 2.893 ± 0.115
3.964GluGlu: 3.964 ± 0.14
2.205GluPhe: 2.205 ± 0.091
3.421GluGly: 3.421 ± 0.128
1.439GluHis: 1.439 ± 0.082
4.066GluIle: 4.066 ± 0.134
4.41GluLys: 4.41 ± 0.146
7.189GluLeu: 7.189 ± 0.188
1.474GluMet: 1.474 ± 0.073
2.166GluAsn: 2.166 ± 0.092
2.06GluPro: 2.06 ± 0.113
2.92GluGln: 2.92 ± 0.121
4.069GluArg: 4.069 ± 0.133
3.112GluSer: 3.112 ± 0.112
3.612GluThr: 3.612 ± 0.121
4.582GluVal: 4.582 ± 0.158
0.606GluTrp: 0.606 ± 0.046
2.127GluTyr: 2.127 ± 0.094
0.0GluXaa: 0.0 ± 0.0
Phe
3.252PheAla: 3.252 ± 0.112
0.199PheCys: 0.199 ± 0.028
2.291PheAsp: 2.291 ± 0.099
2.205PheGlu: 2.205 ± 0.109
1.403PhePhe: 1.403 ± 0.08
3.006PheGly: 3.006 ± 0.125
0.672PheHis: 0.672 ± 0.05
2.459PheIle: 2.459 ± 0.099
1.759PheLys: 1.759 ± 0.087
3.045PheLeu: 3.045 ± 0.119
0.946PheMet: 0.946 ± 0.057
1.478PheAsn: 1.478 ± 0.077
1.263PhePro: 1.263 ± 0.075
1.032PheGln: 1.032 ± 0.063
1.528PheArg: 1.528 ± 0.08
2.65PheSer: 2.65 ± 0.111
2.6PheThr: 2.6 ± 0.103
2.955PheVal: 2.955 ± 0.12
0.477PheTrp: 0.477 ± 0.043
1.251PheTyr: 1.251 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
5.359GlyAla: 5.359 ± 0.168
0.41GlyCys: 0.41 ± 0.042
3.905GlyAsp: 3.905 ± 0.14
4.144GlyGlu: 4.144 ± 0.133
2.983GlyPhe: 2.983 ± 0.109
5.422GlyGly: 5.422 ± 0.191
1.427GlyHis: 1.427 ± 0.078
4.656GlyIle: 4.656 ± 0.153
4.628GlyLys: 4.628 ± 0.139
6.845GlyLeu: 6.845 ± 0.164
1.673GlyMet: 1.673 ± 0.081
2.588GlyAsn: 2.588 ± 0.118
1.65GlyPro: 1.65 ± 0.075
2.392GlyGln: 2.392 ± 0.087
3.643GlyArg: 3.643 ± 0.126
4.828GlySer: 4.828 ± 0.162
4.351GlyThr: 4.351 ± 0.159
5.395GlyVal: 5.395 ± 0.161
0.997GlyTrp: 0.997 ± 0.066
2.815GlyTyr: 2.815 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
1.673HisAla: 1.673 ± 0.079
0.172HisCys: 0.172 ± 0.03
1.31HisAsp: 1.31 ± 0.073
1.482HisGlu: 1.482 ± 0.075
0.86HisPhe: 0.86 ± 0.055
1.458HisGly: 1.458 ± 0.084
0.641HisHis: 0.641 ± 0.055
1.31HisIle: 1.31 ± 0.082
1.048HisLys: 1.048 ± 0.065
2.056HisLeu: 2.056 ± 0.086
0.485HisMet: 0.485 ± 0.046
0.708HisAsn: 0.708 ± 0.052
1.02HisPro: 1.02 ± 0.063
0.833HisGln: 0.833 ± 0.052
1.118HisArg: 1.118 ± 0.07
1.231HisSer: 1.231 ± 0.069
1.173HisThr: 1.173 ± 0.067
1.353HisVal: 1.353 ± 0.072
0.293HisTrp: 0.293 ± 0.036
0.895HisTyr: 0.895 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
6.669IleAla: 6.669 ± 0.164
0.45IleCys: 0.45 ± 0.039
4.324IleAsp: 4.324 ± 0.138
4.124IleGlu: 4.124 ± 0.133
2.099IlePhe: 2.099 ± 0.089
4.718IleGly: 4.718 ± 0.14
1.274IleHis: 1.274 ± 0.069
4.511IleIle: 4.511 ± 0.157
3.256IleLys: 3.256 ± 0.123
5.473IleLeu: 5.473 ± 0.164
1.423IleMet: 1.423 ± 0.073
2.623IleAsn: 2.623 ± 0.1
2.51IlePro: 2.51 ± 0.091
2.087IleGln: 2.087 ± 0.078
3.159IleArg: 3.159 ± 0.1
3.851IleSer: 3.851 ± 0.097
4.191IleThr: 4.191 ± 0.117
5.61IleVal: 5.61 ± 0.153
0.508IleTrp: 0.508 ± 0.043
1.826IleTyr: 1.826 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
5.062LysAla: 5.062 ± 0.161
0.184LysCys: 0.184 ± 0.024
3.467LysAsp: 3.467 ± 0.126
3.765LysGlu: 3.765 ± 0.132
1.646LysPhe: 1.646 ± 0.078
3.385LysGly: 3.385 ± 0.129
1.255LysHis: 1.255 ± 0.063
3.417LysIle: 3.417 ± 0.121
4.656LysLys: 4.656 ± 0.145
5.692LysLeu: 5.692 ± 0.154
1.407LysMet: 1.407 ± 0.067
2.83LysAsn: 2.83 ± 0.117
2.467LysPro: 2.467 ± 0.105
2.713LysGln: 2.713 ± 0.094
3.514LysArg: 3.514 ± 0.106
3.608LysSer: 3.608 ± 0.121
3.948LysThr: 3.948 ± 0.115
3.878LysVal: 3.878 ± 0.143
0.551LysTrp: 0.551 ± 0.047
1.798LysTyr: 1.798 ± 0.093
0.0LysXaa: 0.0 ± 0.0
Leu
9.609LeuAla: 9.609 ± 0.203
0.461LeuCys: 0.461 ± 0.041
5.32LeuAsp: 5.32 ± 0.134
6.047LeuGlu: 6.047 ± 0.177
3.495LeuPhe: 3.495 ± 0.122
6.614LeuGly: 6.614 ± 0.194
2.099LeuHis: 2.099 ± 0.094
5.95LeuIle: 5.95 ± 0.158
5.32LeuLys: 5.32 ± 0.153
9.859LeuLeu: 9.859 ± 0.254
2.107LeuMet: 2.107 ± 0.089
3.151LeuAsn: 3.151 ± 0.113
4.441LeuPro: 4.441 ± 0.133
3.456LeuGln: 3.456 ± 0.113
5.363LeuArg: 5.363 ± 0.142
6.591LeuSer: 6.591 ± 0.151
5.774LeuThr: 5.774 ± 0.127
7.056LeuVal: 7.056 ± 0.207
1.012LeuTrp: 1.012 ± 0.064
2.979LeuTyr: 2.979 ± 0.129
0.0LeuXaa: 0.0 ± 0.0
Met
2.201MetAla: 2.201 ± 0.09
0.133MetCys: 0.133 ± 0.022
1.083MetAsp: 1.083 ± 0.068
1.059MetGlu: 1.059 ± 0.061
0.684MetPhe: 0.684 ± 0.048
1.192MetGly: 1.192 ± 0.072
0.434MetHis: 0.434 ± 0.043
1.47MetIle: 1.47 ± 0.072
1.775MetLys: 1.775 ± 0.089
1.974MetLeu: 1.974 ± 0.082
0.5MetMet: 0.5 ± 0.041
1.196MetAsn: 1.196 ± 0.058
1.11MetPro: 1.11 ± 0.067
0.852MetGln: 0.852 ± 0.059
1.317MetArg: 1.317 ± 0.07
1.712MetSer: 1.712 ± 0.076
1.587MetThr: 1.587 ± 0.073
1.536MetVal: 1.536 ± 0.074
0.164MetTrp: 0.164 ± 0.024
0.715MetTyr: 0.715 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
3.053AsnAla: 3.053 ± 0.102
0.305AsnCys: 0.305 ± 0.037
2.232AsnAsp: 2.232 ± 0.096
2.256AsnGlu: 2.256 ± 0.104
1.243AsnPhe: 1.243 ± 0.073
2.959AsnGly: 2.959 ± 0.126
0.657AsnHis: 0.657 ± 0.049
2.486AsnIle: 2.486 ± 0.088
2.095AsnLys: 2.095 ± 0.097
3.194AsnLeu: 3.194 ± 0.113
0.778AsnMet: 0.778 ± 0.057
1.544AsnAsn: 1.544 ± 0.086
1.853AsnPro: 1.853 ± 0.076
1.388AsnGln: 1.388 ± 0.073
2.001AsnArg: 2.001 ± 0.097
2.22AsnSer: 2.22 ± 0.103
2.279AsnThr: 2.279 ± 0.112
2.764AsnVal: 2.764 ± 0.094
0.516AsnTrp: 0.516 ± 0.052
1.349AsnTyr: 1.349 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
3.464ProAla: 3.464 ± 0.127
0.199ProCys: 0.199 ± 0.032
2.353ProAsp: 2.353 ± 0.096
2.998ProGlu: 2.998 ± 0.099
1.532ProPhe: 1.532 ± 0.084
2.494ProGly: 2.494 ± 0.1
0.966ProHis: 0.966 ± 0.063
2.299ProIle: 2.299 ± 0.102
2.209ProLys: 2.209 ± 0.099
3.757ProLeu: 3.757 ± 0.133
0.711ProMet: 0.711 ± 0.054
1.384ProAsn: 1.384 ± 0.078
1.45ProPro: 1.45 ± 0.091
1.521ProGln: 1.521 ± 0.085
1.876ProArg: 1.876 ± 0.082
3.006ProSer: 3.006 ± 0.113
2.744ProThr: 2.744 ± 0.116
2.994ProVal: 2.994 ± 0.121
0.399ProTrp: 0.399 ± 0.042
1.278ProTyr: 1.278 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
3.835GlnAla: 3.835 ± 0.137
0.18GlnCys: 0.18 ± 0.027
1.689GlnAsp: 1.689 ± 0.078
2.025GlnGlu: 2.025 ± 0.089
1.294GlnPhe: 1.294 ± 0.067
2.041GlnGly: 2.041 ± 0.076
0.77GlnHis: 0.77 ± 0.051
2.224GlnIle: 2.224 ± 0.095
2.467GlnLys: 2.467 ± 0.117
4.159GlnLeu: 4.159 ± 0.129
0.907GlnMet: 0.907 ± 0.059
1.345GlnAsn: 1.345 ± 0.069
1.759GlnPro: 1.759 ± 0.087
1.833GlnGln: 1.833 ± 0.092
2.322GlnArg: 2.322 ± 0.104
2.197GlnSer: 2.197 ± 0.097
2.283GlnThr: 2.283 ± 0.102
2.259GlnVal: 2.259 ± 0.104
0.43GlnTrp: 0.43 ± 0.043
1.341GlnTyr: 1.341 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
4.124ArgAla: 4.124 ± 0.113
0.305ArgCys: 0.305 ± 0.037
3.151ArgAsp: 3.151 ± 0.128
3.557ArgGlu: 3.557 ± 0.107
2.076ArgPhe: 2.076 ± 0.1
3.295ArgGly: 3.295 ± 0.114
1.364ArgHis: 1.364 ± 0.079
3.264ArgIle: 3.264 ± 0.108
3.01ArgLys: 3.01 ± 0.113
5.786ArgLeu: 5.786 ± 0.177
1.446ArgMet: 1.446 ± 0.067
1.904ArgAsn: 1.904 ± 0.087
2.115ArgPro: 2.115 ± 0.085
2.549ArgGln: 2.549 ± 0.1
4.015ArgArg: 4.015 ± 0.152
3.389ArgSer: 3.389 ± 0.125
2.971ArgThr: 2.971 ± 0.116
3.6ArgVal: 3.6 ± 0.124
0.559ArgTrp: 0.559 ± 0.047
2.22ArgTyr: 2.22 ± 0.104
0.0ArgXaa: 0.0 ± 0.0
Ser
5.258SerAla: 5.258 ± 0.154
0.364SerCys: 0.364 ± 0.041
3.89SerAsp: 3.89 ± 0.122
3.788SerGlu: 3.788 ± 0.133
2.611SerPhe: 2.611 ± 0.095
5.313SerGly: 5.313 ± 0.173
1.267SerHis: 1.267 ± 0.069
3.639SerIle: 3.639 ± 0.123
3.393SerLys: 3.393 ± 0.121
6.329SerLeu: 6.329 ± 0.171
1.474SerMet: 1.474 ± 0.072
2.173SerAsn: 2.173 ± 0.09
2.553SerPro: 2.553 ± 0.097
2.416SerGln: 2.416 ± 0.099
3.303SerArg: 3.303 ± 0.137
4.597SerSer: 4.597 ± 0.173
3.604SerThr: 3.604 ± 0.138
4.437SerVal: 4.437 ± 0.135
0.79SerTrp: 0.79 ± 0.061
2.076SerTyr: 2.076 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
5.328ThrAla: 5.328 ± 0.17
0.528ThrCys: 0.528 ± 0.083
3.467ThrAsp: 3.467 ± 0.14
3.096ThrGlu: 3.096 ± 0.098
2.076ThrPhe: 2.076 ± 0.09
4.605ThrGly: 4.605 ± 0.154
1.27ThrHis: 1.27 ± 0.055
4.499ThrIle: 4.499 ± 0.15
3.608ThrLys: 3.608 ± 0.113
6.098ThrLeu: 6.098 ± 0.145
1.337ThrMet: 1.337 ± 0.072
2.451ThrAsn: 2.451 ± 0.1
3.053ThrPro: 3.053 ± 0.11
1.822ThrGln: 1.822 ± 0.101
2.924ThrArg: 2.924 ± 0.097
4.054ThrSer: 4.054 ± 0.136
4.367ThrThr: 4.367 ± 0.166
4.777ThrVal: 4.777 ± 0.152
0.625ThrTrp: 0.625 ± 0.053
2.177ThrTyr: 2.177 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
7.361ValAla: 7.361 ± 0.168
0.481ValCys: 0.481 ± 0.054
3.87ValAsp: 3.87 ± 0.124
4.695ValGlu: 4.695 ± 0.162
2.557ValPhe: 2.557 ± 0.095
5.098ValGly: 5.098 ± 0.137
1.282ValHis: 1.282 ± 0.07
5.258ValIle: 5.258 ± 0.153
4.144ValLys: 4.144 ± 0.14
6.739ValLeu: 6.739 ± 0.173
1.661ValMet: 1.661 ± 0.09
2.525ValAsn: 2.525 ± 0.091
2.854ValPro: 2.854 ± 0.104
2.201ValGln: 2.201 ± 0.083
3.897ValArg: 3.897 ± 0.118
4.625ValSer: 4.625 ± 0.128
4.718ValThr: 4.718 ± 0.145
6.286ValVal: 6.286 ± 0.186
0.797ValTrp: 0.797 ± 0.057
2.244ValTyr: 2.244 ± 0.088
0.0ValXaa: 0.0 ± 0.0
Trp
0.809TrpAla: 0.809 ± 0.069
0.098TrpCys: 0.098 ± 0.021
0.489TrpAsp: 0.489 ± 0.045
0.461TrpGlu: 0.461 ± 0.044
0.461TrpPhe: 0.461 ± 0.044
0.68TrpGly: 0.68 ± 0.069
0.324TrpHis: 0.324 ± 0.042
0.625TrpIle: 0.625 ± 0.048
0.508TrpLys: 0.508 ± 0.045
1.571TrpLeu: 1.571 ± 0.092
0.25TrpMet: 0.25 ± 0.033
0.407TrpAsn: 0.407 ± 0.041
0.422TrpPro: 0.422 ± 0.049
0.747TrpGln: 0.747 ± 0.058
0.778TrpArg: 0.778 ± 0.063
0.649TrpSer: 0.649 ± 0.052
0.547TrpThr: 0.547 ± 0.05
0.614TrpVal: 0.614 ± 0.054
0.246TrpTrp: 0.246 ± 0.036
0.43TrpTyr: 0.43 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.885TyrAla: 2.885 ± 0.104
0.418TyrCys: 0.418 ± 0.07
2.185TyrAsp: 2.185 ± 0.101
2.197TyrGlu: 2.197 ± 0.098
1.415TyrPhe: 1.415 ± 0.067
2.412TyrGly: 2.412 ± 0.085
0.786TyrHis: 0.786 ± 0.059
1.892TyrIle: 1.892 ± 0.084
1.732TyrLys: 1.732 ± 0.074
3.229TyrLeu: 3.229 ± 0.118
0.625TyrMet: 0.625 ± 0.05
1.521TyrAsn: 1.521 ± 0.091
1.419TyrPro: 1.419 ± 0.068
1.38TyrGln: 1.38 ± 0.077
2.154TyrArg: 2.154 ± 0.088
2.044TyrSer: 2.044 ± 0.089
1.986TyrThr: 1.986 ± 0.099
2.431TyrVal: 2.431 ± 0.094
0.387TyrTrp: 0.387 ± 0.04
1.478TyrTyr: 1.478 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 920 proteins (255811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski