Amino acid dipepetide frequency for Prevotella bryantii B14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.014AlaAla: 5.014 ± 0.095	0.935AlaCys: 0.935 ± 0.038	4.268AlaAsp: 4.268 ± 0.062	4.276AlaGlu: 4.276 ± 0.071	2.987AlaPhe: 2.987 ± 0.064	4.646AlaGly: 4.646 ± 0.075	1.405AlaHis: 1.405 ± 0.043	5.23AlaIle: 5.23 ± 0.071	4.697AlaLys: 4.697 ± 0.079	6.144AlaLeu: 6.144 ± 0.089	1.923AlaMet: 1.923 ± 0.045	3.605AlaAsn: 3.605 ± 0.074	2.074AlaPro: 2.074 ± 0.051	2.931AlaGln: 2.931 ± 0.053	2.612AlaArg: 2.612 ± 0.053	4.415AlaSer: 4.415 ± 0.07	3.918AlaThr: 3.918 ± 0.079	4.125AlaVal: 4.125 ± 0.068	0.799AlaTrp: 0.799 ± 0.028	3.021AlaTyr: 3.021 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.708CysAla: 0.708 ± 0.027	0.201CysCys: 0.201 ± 0.016	0.729CysAsp: 0.729 ± 0.028	0.652CysGlu: 0.652 ± 0.028	0.615CysPhe: 0.615 ± 0.025	1.006CysGly: 1.006 ± 0.034	0.314CysHis: 0.314 ± 0.02	1.002CysIle: 1.002 ± 0.035	0.777CysLys: 0.777 ± 0.026	1.021CysLeu: 1.021 ± 0.031	0.361CysMet: 0.361 ± 0.017	0.608CysAsn: 0.608 ± 0.027	0.498CysPro: 0.498 ± 0.025	0.385CysGln: 0.385 ± 0.019	0.488CysArg: 0.488 ± 0.022	0.811CysSer: 0.811 ± 0.032	0.676CysThr: 0.676 ± 0.026	0.704CysVal: 0.704 ± 0.025	0.166CysTrp: 0.166 ± 0.013	0.556CysTyr: 0.556 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.137AspAla: 4.137 ± 0.068	0.677AspCys: 0.677 ± 0.028	3.215AspAsp: 3.215 ± 0.063	4.102AspGlu: 4.102 ± 0.071	3.017AspPhe: 3.017 ± 0.061	4.34AspGly: 4.34 ± 0.091	1.169AspHis: 1.169 ± 0.033	4.653AspIle: 4.653 ± 0.067	4.173AspLys: 4.173 ± 0.071	4.605AspLeu: 4.605 ± 0.077	1.689AspMet: 1.689 ± 0.038	3.283AspAsn: 3.283 ± 0.064	1.792AspPro: 1.792 ± 0.042	1.765AspGln: 1.765 ± 0.042	2.329AspArg: 2.329 ± 0.051	3.366AspSer: 3.366 ± 0.071	2.906AspThr: 2.906 ± 0.061	3.661AspVal: 3.661 ± 0.066	0.903AspTrp: 0.903 ± 0.03	3.128AspTyr: 3.128 ± 0.059	0.002AspXaa: 0.002 ± 0.001
Glu	4.356GluAla: 4.356 ± 0.071	0.656GluCys: 0.656 ± 0.029	3.517GluAsp: 3.517 ± 0.065	4.383GluGlu: 4.383 ± 0.086	2.244GluPhe: 2.244 ± 0.048	3.893GluGly: 3.893 ± 0.071	1.408GluHis: 1.408 ± 0.034	4.229GluIle: 4.229 ± 0.077	4.655GluLys: 4.655 ± 0.085	5.193GluLeu: 5.193 ± 0.089	1.795GluMet: 1.795 ± 0.048	3.636GluAsn: 3.636 ± 0.067	1.688GluPro: 1.688 ± 0.048	2.509GluGln: 2.509 ± 0.055	2.658GluArg: 2.658 ± 0.067	3.065GluSer: 3.065 ± 0.052	3.024GluThr: 3.024 ± 0.049	3.657GluVal: 3.657 ± 0.057	0.803GluTrp: 0.803 ± 0.032	2.703GluTyr: 2.703 ± 0.054	0.002GluXaa: 0.002 ± 0.001
Phe	2.983PheAla: 2.983 ± 0.056	0.644PheCys: 0.644 ± 0.026	2.888PheAsp: 2.888 ± 0.051	2.338PheGlu: 2.338 ± 0.051	2.028PhePhe: 2.028 ± 0.055	3.267PheGly: 3.267 ± 0.062	0.962PheHis: 0.962 ± 0.035	3.056PheIle: 3.056 ± 0.063	2.587PheLys: 2.587 ± 0.057	3.509PheLeu: 3.509 ± 0.078	1.225PheMet: 1.225 ± 0.031	2.431PheAsn: 2.431 ± 0.048	1.484PhePro: 1.484 ± 0.041	1.282PheGln: 1.282 ± 0.035	1.839PheArg: 1.839 ± 0.038	3.126PheSer: 3.126 ± 0.065	2.791PheThr: 2.791 ± 0.055	2.747PheVal: 2.747 ± 0.057	0.585PheTrp: 0.585 ± 0.024	1.855PheTyr: 1.855 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.319GlyAla: 4.319 ± 0.075	0.933GlyCys: 0.933 ± 0.035	3.604GlyAsp: 3.604 ± 0.082	3.777GlyGlu: 3.777 ± 0.065	3.078GlyPhe: 3.078 ± 0.058	4.715GlyGly: 4.715 ± 0.107	1.474GlyHis: 1.474 ± 0.04	5.343GlyIle: 5.343 ± 0.086	5.377GlyLys: 5.377 ± 0.081	5.648GlyLeu: 5.648 ± 0.081	1.964GlyMet: 1.964 ± 0.049	3.842GlyAsn: 3.842 ± 0.077	1.312GlyPro: 1.312 ± 0.039	2.336GlyGln: 2.336 ± 0.048	2.593GlyArg: 2.593 ± 0.054	4.1GlySer: 4.1 ± 0.073	4.222GlyThr: 4.222 ± 0.094	4.631GlyVal: 4.631 ± 0.076	1.03GlyTrp: 1.03 ± 0.037	3.361GlyTyr: 3.361 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.329HisAla: 1.329 ± 0.038	0.336HisCys: 0.336 ± 0.017	1.24HisAsp: 1.24 ± 0.038	1.201HisGlu: 1.201 ± 0.032	1.138HisPhe: 1.138 ± 0.04	1.429HisGly: 1.429 ± 0.039	0.708HisHis: 0.708 ± 0.031	1.748HisIle: 1.748 ± 0.046	1.177HisLys: 1.177 ± 0.036	1.93HisLeu: 1.93 ± 0.055	0.417HisMet: 0.417 ± 0.019	1.101HisAsn: 1.101 ± 0.034	1.048HisPro: 1.048 ± 0.036	0.925HisGln: 0.925 ± 0.034	0.975HisArg: 0.975 ± 0.028	1.217HisSer: 1.217 ± 0.035	1.122HisThr: 1.122 ± 0.035	1.401HisVal: 1.401 ± 0.042	0.282HisTrp: 0.282 ± 0.015	1.093HisTyr: 1.093 ± 0.033	0.002HisXaa: 0.002 ± 0.002
Ile	5.447IleAla: 5.447 ± 0.093	0.993IleCys: 0.993 ± 0.034	4.883IleAsp: 4.883 ± 0.068	4.369IleGlu: 4.369 ± 0.073	2.889IlePhe: 2.889 ± 0.059	4.795IleGly: 4.795 ± 0.087	1.577IleHis: 1.577 ± 0.04	5.188IleIle: 5.188 ± 0.103	4.696IleLys: 4.696 ± 0.075	6.109IleLeu: 6.109 ± 0.095	1.622IleMet: 1.622 ± 0.045	4.012IleAsn: 4.012 ± 0.07	3.11IlePro: 3.11 ± 0.061	2.54IleGln: 2.54 ± 0.053	3.135IleArg: 3.135 ± 0.063	4.858IleSer: 4.858 ± 0.064	4.363IleThr: 4.363 ± 0.067	4.521IleVal: 4.521 ± 0.074	0.823IleTrp: 0.823 ± 0.031	2.866IleTyr: 2.866 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.028LysAla: 5.028 ± 0.079	0.602LysCys: 0.602 ± 0.027	4.245LysAsp: 4.245 ± 0.067	4.848LysGlu: 4.848 ± 0.096	2.411LysPhe: 2.411 ± 0.054	4.463LysGly: 4.463 ± 0.066	1.311LysHis: 1.311 ± 0.041	4.726LysIle: 4.726 ± 0.068	5.516LysLys: 5.516 ± 0.093	5.515LysLeu: 5.515 ± 0.076	2.303LysMet: 2.303 ± 0.046	4.236LysAsn: 4.236 ± 0.068	2.163LysPro: 2.163 ± 0.05	2.652LysGln: 2.652 ± 0.053	2.966LysArg: 2.966 ± 0.058	3.865LysSer: 3.865 ± 0.066	3.708LysThr: 3.708 ± 0.063	4.308LysVal: 4.308 ± 0.067	0.926LysTrp: 0.926 ± 0.03	3.316LysTyr: 3.316 ± 0.064	0.001LysXaa: 0.001 ± 0.001
Leu	6.065LeuAla: 6.065 ± 0.076	1.192LeuCys: 1.192 ± 0.035	4.852LeuAsp: 4.852 ± 0.067	4.483LeuGlu: 4.483 ± 0.077	3.901LeuPhe: 3.901 ± 0.079	5.534LeuGly: 5.534 ± 0.091	2.007LeuHis: 2.007 ± 0.043	5.337LeuIle: 5.337 ± 0.092	6.22LeuLys: 6.22 ± 0.086	7.682LeuLeu: 7.682 ± 0.127	2.41LeuMet: 2.41 ± 0.046	4.673LeuAsn: 4.673 ± 0.084	3.476LeuPro: 3.476 ± 0.061	3.375LeuGln: 3.375 ± 0.055	3.799LeuArg: 3.799 ± 0.067	6.228LeuSer: 6.228 ± 0.096	5.094LeuThr: 5.094 ± 0.067	4.902LeuVal: 4.902 ± 0.084	0.993LeuTrp: 0.993 ± 0.034	3.658LeuTyr: 3.658 ± 0.057	0.002LeuXaa: 0.002 ± 0.002
Met	2.153MetAla: 2.153 ± 0.053	0.277MetCys: 0.277 ± 0.017	1.533MetAsp: 1.533 ± 0.041	1.577MetGlu: 1.577 ± 0.045	0.967MetPhe: 0.967 ± 0.035	1.842MetGly: 1.842 ± 0.046	0.544MetHis: 0.544 ± 0.02	1.765MetIle: 1.765 ± 0.049	2.433MetLys: 2.433 ± 0.044	2.486MetLeu: 2.486 ± 0.055	0.873MetMet: 0.873 ± 0.032	1.644MetAsn: 1.644 ± 0.041	1.142MetPro: 1.142 ± 0.036	1.066MetGln: 1.066 ± 0.036	1.179MetArg: 1.179 ± 0.038	1.668MetSer: 1.668 ± 0.039	1.602MetThr: 1.602 ± 0.042	1.617MetVal: 1.617 ± 0.043	0.258MetTrp: 0.258 ± 0.017	0.866MetTyr: 0.866 ± 0.026	0.001MetXaa: 0.001 ± 0.001
Asn	3.76AsnAla: 3.76 ± 0.07	0.642AsnCys: 0.642 ± 0.033	3.073AsnAsp: 3.073 ± 0.058	2.989AsnGlu: 2.989 ± 0.055	2.442AsnPhe: 2.442 ± 0.055	4.209AsnGly: 4.209 ± 0.078	1.313AsnHis: 1.313 ± 0.041	4.45AsnIle: 4.45 ± 0.068	3.639AsnLys: 3.639 ± 0.064	4.527AsnLeu: 4.527 ± 0.071	1.423AsnMet: 1.423 ± 0.036	3.29AsnAsn: 3.29 ± 0.083	2.436AsnPro: 2.436 ± 0.047	2.098AsnGln: 2.098 ± 0.044	2.487AsnArg: 2.487 ± 0.056	3.298AsnSer: 3.298 ± 0.071	3.25AsnThr: 3.25 ± 0.074	3.317AsnVal: 3.317 ± 0.062	0.769AsnTrp: 0.769 ± 0.032	2.751AsnTyr: 2.751 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.34ProAla: 2.34 ± 0.046	0.352ProCys: 0.352 ± 0.02	2.166ProAsp: 2.166 ± 0.053	2.727ProGlu: 2.727 ± 0.055	1.606ProPhe: 1.606 ± 0.044	2.229ProGly: 2.229 ± 0.05	0.701ProHis: 0.701 ± 0.031	2.471ProIle: 2.471 ± 0.057	2.055ProLys: 2.055 ± 0.051	2.834ProLeu: 2.834 ± 0.053	0.923ProMet: 0.923 ± 0.032	1.868ProAsn: 1.868 ± 0.04	0.582ProPro: 0.582 ± 0.026	1.412ProGln: 1.412 ± 0.037	1.137ProArg: 1.137 ± 0.036	2.27ProSer: 2.27 ± 0.05	2.127ProThr: 2.127 ± 0.047	2.541ProVal: 2.541 ± 0.048	0.468ProTrp: 0.468 ± 0.024	1.718ProTyr: 1.718 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.585GlnAla: 2.585 ± 0.053	0.313GlnCys: 0.313 ± 0.018	1.904GlnAsp: 1.904 ± 0.046	2.437GlnGlu: 2.437 ± 0.057	1.419GlnPhe: 1.419 ± 0.041	2.233GlnGly: 2.233 ± 0.047	0.795GlnHis: 0.795 ± 0.03	2.732GlnIle: 2.732 ± 0.06	2.846GlnLys: 2.846 ± 0.051	3.547GlnLeu: 3.547 ± 0.077	1.153GlnMet: 1.153 ± 0.036	2.152GlnAsn: 2.152 ± 0.049	1.212GlnPro: 1.212 ± 0.043	1.833GlnGln: 1.833 ± 0.055	1.602GlnArg: 1.602 ± 0.041	1.968GlnSer: 1.968 ± 0.054	2.052GlnThr: 2.052 ± 0.047	2.313GlnVal: 2.313 ± 0.053	0.519GlnTrp: 0.519 ± 0.026	1.728GlnTyr: 1.728 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.506ArgAla: 2.506 ± 0.062	0.427ArgCys: 0.427 ± 0.022	2.196ArgAsp: 2.196 ± 0.054	2.594ArgGlu: 2.594 ± 0.053	2.001ArgPhe: 2.001 ± 0.043	2.39ArgGly: 2.39 ± 0.046	0.989ArgHis: 0.989 ± 0.03	3.199ArgIle: 3.199 ± 0.064	3.106ArgLys: 3.106 ± 0.066	3.932ArgLeu: 3.932 ± 0.059	1.314ArgMet: 1.314 ± 0.036	2.304ArgAsn: 2.304 ± 0.049	1.454ArgPro: 1.454 ± 0.04	1.846ArgGln: 1.846 ± 0.048	1.923ArgArg: 1.923 ± 0.053	2.212ArgSer: 2.212 ± 0.055	2.145ArgThr: 2.145 ± 0.045	2.412ArgVal: 2.412 ± 0.051	0.6ArgTrp: 0.6 ± 0.025	2.087ArgTyr: 2.087 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	4.207SerAla: 4.207 ± 0.068	0.798SerCys: 0.798 ± 0.031	3.666SerAsp: 3.666 ± 0.069	3.5SerGlu: 3.5 ± 0.069	3.089SerPhe: 3.089 ± 0.062	4.262SerGly: 4.262 ± 0.074	1.358SerHis: 1.358 ± 0.035	4.731SerIle: 4.731 ± 0.073	3.911SerLys: 3.911 ± 0.062	5.625SerLeu: 5.625 ± 0.08	1.563SerMet: 1.563 ± 0.04	3.198SerAsn: 3.198 ± 0.067	2.076SerPro: 2.076 ± 0.05	2.216SerGln: 2.216 ± 0.045	2.495SerArg: 2.495 ± 0.047	4.424SerSer: 4.424 ± 0.099	3.628SerThr: 3.628 ± 0.073	4.038SerVal: 4.038 ± 0.087	0.935SerTrp: 0.935 ± 0.028	3.068SerTyr: 3.068 ± 0.076	0.002SerXaa: 0.002 ± 0.001
Thr	3.918ThrAla: 3.918 ± 0.073	0.612ThrCys: 0.612 ± 0.023	3.451ThrAsp: 3.451 ± 0.073	3.021ThrGlu: 3.021 ± 0.058	2.606ThrPhe: 2.606 ± 0.06	4.236ThrGly: 4.236 ± 0.086	1.161ThrHis: 1.161 ± 0.033	4.513ThrIle: 4.513 ± 0.081	3.238ThrLys: 3.238 ± 0.058	5.31ThrLeu: 5.31 ± 0.083	1.332ThrMet: 1.332 ± 0.037	2.963ThrAsn: 2.963 ± 0.065	2.631ThrPro: 2.631 ± 0.058	1.931ThrGln: 1.931 ± 0.044	2.142ThrArg: 2.142 ± 0.045	3.843ThrSer: 3.843 ± 0.08	3.613ThrThr: 3.613 ± 0.085	3.7ThrVal: 3.7 ± 0.079	0.74ThrTrp: 0.74 ± 0.025	2.648ThrTyr: 2.648 ± 0.065	0.001ThrXaa: 0.001 ± 0.001
Val	4.367ValAla: 4.367 ± 0.078	0.874ValCys: 0.874 ± 0.034	3.898ValAsp: 3.898 ± 0.059	3.691ValGlu: 3.691 ± 0.061	2.558ValPhe: 2.558 ± 0.049	3.99ValGly: 3.99 ± 0.078	1.163ValHis: 1.163 ± 0.034	4.415ValIle: 4.415 ± 0.064	4.352ValLys: 4.352 ± 0.073	5.235ValLeu: 5.235 ± 0.077	1.657ValMet: 1.657 ± 0.048	3.564ValAsn: 3.564 ± 0.069	2.262ValPro: 2.262 ± 0.049	1.83ValGln: 1.83 ± 0.042	2.529ValArg: 2.529 ± 0.048	4.347ValSer: 4.347 ± 0.077	3.727ValThr: 3.727 ± 0.075	4.186ValVal: 4.186 ± 0.071	0.724ValTrp: 0.724 ± 0.029	2.637ValTyr: 2.637 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.81TrpAla: 0.81 ± 0.029	0.202TrpCys: 0.202 ± 0.016	0.751TrpAsp: 0.751 ± 0.03	0.698TrpGlu: 0.698 ± 0.027	0.528TrpPhe: 0.528 ± 0.024	0.946TrpGly: 0.946 ± 0.032	0.331TrpHis: 0.331 ± 0.02	0.851TrpIle: 0.851 ± 0.028	0.966TrpLys: 0.966 ± 0.032	1.203TrpLeu: 1.203 ± 0.038	0.413TrpMet: 0.413 ± 0.02	0.946TrpAsn: 0.946 ± 0.032	0.315TrpPro: 0.315 ± 0.02	0.563TrpGln: 0.563 ± 0.025	0.541TrpArg: 0.541 ± 0.026	0.797TrpSer: 0.797 ± 0.032	0.748TrpThr: 0.748 ± 0.035	0.682TrpVal: 0.682 ± 0.03	0.227TrpTrp: 0.227 ± 0.018	0.612TrpTyr: 0.612 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.991TyrAla: 2.991 ± 0.058	0.61TyrCys: 0.61 ± 0.026	2.83TyrAsp: 2.83 ± 0.064	2.41TyrGlu: 2.41 ± 0.06	2.101TyrPhe: 2.101 ± 0.045	3.234TyrGly: 3.234 ± 0.069	1.128TyrHis: 1.128 ± 0.031	3.155TyrIle: 3.155 ± 0.055	2.688TyrLys: 2.688 ± 0.06	3.831TyrLeu: 3.831 ± 0.068	1.132TyrMet: 1.132 ± 0.034	2.808TyrAsn: 2.808 ± 0.068	1.77TyrPro: 1.77 ± 0.039	1.848TyrGln: 1.848 ± 0.047	2.21TyrArg: 2.21 ± 0.052	2.912TyrSer: 2.912 ± 0.068	2.894TyrThr: 2.894 ± 0.063	2.539TyrVal: 2.539 ± 0.048	0.58TyrTrp: 0.58 ± 0.022	2.434TyrTyr: 2.434 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 2748 proteins (1019909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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