Amino acid dipepetide frequency for Hollyhock yellow vein mosaic Islamabad virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.346AlaAla: 6.346 ± 2.683
1.813AlaCys: 1.813 ± 1.06
1.813AlaAsp: 1.813 ± 1.122
1.813AlaGlu: 1.813 ± 1.092
1.813AlaPhe: 1.813 ± 1.092
1.813AlaGly: 1.813 ± 0.738
2.72AlaHis: 2.72 ± 1.128
0.907AlaIle: 0.907 ± 0.918
2.72AlaLys: 2.72 ± 1.303
8.16AlaLeu: 8.16 ± 2.229
0.0AlaMet: 0.0 ± 0.0
2.72AlaAsn: 2.72 ± 1.158
1.813AlaPro: 1.813 ± 0.941
3.626AlaGln: 3.626 ± 1.423
7.253AlaArg: 7.253 ± 2.521
6.346AlaSer: 6.346 ± 2.485
4.533AlaThr: 4.533 ± 1.411
3.626AlaVal: 3.626 ± 1.596
1.813AlaTrp: 1.813 ± 0.738
0.907AlaTyr: 0.907 ± 0.62
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.813CysCys: 1.813 ± 1.918
0.0CysAsp: 0.0 ± 0.0
1.813CysGlu: 1.813 ± 1.122
0.907CysPhe: 0.907 ± 1.112
1.813CysGly: 1.813 ± 0.941
0.907CysHis: 0.907 ± 0.918
0.0CysIle: 0.0 ± 0.0
0.907CysLys: 0.907 ± 0.72
0.0CysLeu: 0.0 ± 0.0
1.813CysMet: 1.813 ± 0.998
0.907CysAsn: 0.907 ± 0.62
1.813CysPro: 1.813 ± 1.918
0.0CysGln: 0.0 ± 0.0
0.907CysArg: 0.907 ± 0.62
4.533CysSer: 4.533 ± 2.227
1.813CysThr: 1.813 ± 0.738
1.813CysVal: 1.813 ± 1.439
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.907AspAla: 0.907 ± 0.62
0.0AspCys: 0.0 ± 0.0
1.813AspAsp: 1.813 ± 0.941
2.72AspGlu: 2.72 ± 0.899
1.813AspPhe: 1.813 ± 1.06
2.72AspGly: 2.72 ± 1.861
0.907AspHis: 0.907 ± 1.112
2.72AspIle: 2.72 ± 1.68
0.907AspLys: 0.907 ± 0.72
5.44AspLeu: 5.44 ± 2.103
0.0AspMet: 0.0 ± 0.0
2.72AspAsn: 2.72 ± 1.564
1.813AspPro: 1.813 ± 0.964
1.813AspGln: 1.813 ± 1.241
3.626AspArg: 3.626 ± 1.436
6.346AspSer: 6.346 ± 1.796
2.72AspThr: 2.72 ± 1.82
5.44AspVal: 5.44 ± 1.909
2.72AspTrp: 2.72 ± 1.303
0.907AspTyr: 0.907 ± 0.62
0.0AspXaa: 0.0 ± 0.0
Glu
3.626GluAla: 3.626 ± 1.154
0.0GluCys: 0.0 ± 0.0
0.907GluAsp: 0.907 ± 1.231
4.533GluGlu: 4.533 ± 2.373
3.626GluPhe: 3.626 ± 1.805
5.44GluGly: 5.44 ± 1.523
0.907GluHis: 0.907 ± 1.112
0.907GluIle: 0.907 ± 1.112
1.813GluLys: 1.813 ± 1.241
4.533GluLeu: 4.533 ± 1.888
0.0GluMet: 0.0 ± 0.0
5.44GluAsn: 5.44 ± 1.924
4.533GluPro: 4.533 ± 1.885
3.626GluGln: 3.626 ± 2.033
0.0GluArg: 0.0 ± 0.0
3.626GluSer: 3.626 ± 2.608
2.72GluThr: 2.72 ± 1.4
1.813GluVal: 1.813 ± 0.738
1.813GluTrp: 1.813 ± 0.941
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.907PheCys: 0.907 ± 0.72
4.533PheAsp: 4.533 ± 1.84
0.907PheGlu: 0.907 ± 0.72
1.813PhePhe: 1.813 ± 0.738
0.907PheGly: 0.907 ± 0.72
3.626PheHis: 3.626 ± 1.307
3.626PheIle: 3.626 ± 0.981
3.626PheLys: 3.626 ± 2.184
6.346PheLeu: 6.346 ± 1.885
0.907PheMet: 0.907 ± 0.62
2.72PheAsn: 2.72 ± 2.23
0.907PhePro: 0.907 ± 0.959
1.813PheGln: 1.813 ± 0.941
3.626PheArg: 3.626 ± 2.619
0.907PheSer: 0.907 ± 0.62
3.626PheThr: 3.626 ± 2.203
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
0.907PheTyr: 0.907 ± 0.72
0.0PheXaa: 0.0 ± 0.0
Gly
1.813GlyAla: 1.813 ± 1.241
1.813GlyCys: 1.813 ± 1.06
5.44GlyAsp: 5.44 ± 2.417
5.44GlyGlu: 5.44 ± 1.02
1.813GlyPhe: 1.813 ± 1.267
2.72GlyGly: 2.72 ± 1.158
0.907GlyHis: 0.907 ± 0.62
3.626GlyIle: 3.626 ± 0.981
7.253GlyLys: 7.253 ± 2.555
2.72GlyLeu: 2.72 ± 1.563
1.813GlyMet: 1.813 ± 1.918
0.907GlyAsn: 0.907 ± 1.231
3.626GlyPro: 3.626 ± 1.705
1.813GlyGln: 1.813 ± 1.241
1.813GlyArg: 1.813 ± 1.092
2.72GlySer: 2.72 ± 1.527
1.813GlyThr: 1.813 ± 1.267
1.813GlyVal: 1.813 ± 2.223
0.0GlyTrp: 0.0 ± 0.0
0.907GlyTyr: 0.907 ± 0.959
0.0GlyXaa: 0.0 ± 0.0
His
1.813HisAla: 1.813 ± 1.122
1.813HisCys: 1.813 ± 1.267
1.813HisAsp: 1.813 ± 1.229
1.813HisGlu: 1.813 ± 0.964
2.72HisPhe: 2.72 ± 1.307
1.813HisGly: 1.813 ± 1.267
3.626HisHis: 3.626 ± 2.582
1.813HisIle: 1.813 ± 1.235
1.813HisLys: 1.813 ± 1.446
1.813HisLeu: 1.813 ± 1.241
0.0HisMet: 0.0 ± 0.0
4.533HisAsn: 4.533 ± 1.76
0.907HisPro: 0.907 ± 0.62
0.907HisGln: 0.907 ± 1.112
3.626HisArg: 3.626 ± 2.121
2.72HisSer: 2.72 ± 1.848
2.72HisThr: 2.72 ± 1.319
3.626HisVal: 3.626 ± 2.036
0.0HisTrp: 0.0 ± 0.0
0.907HisTyr: 0.907 ± 0.62
0.0HisXaa: 0.0 ± 0.0
Ile
1.813IleAla: 1.813 ± 1.291
1.813IleCys: 1.813 ± 0.964
1.813IleAsp: 1.813 ± 1.241
0.907IleGlu: 0.907 ± 0.62
2.72IlePhe: 2.72 ± 1.527
1.813IleGly: 1.813 ± 1.439
0.907IleHis: 0.907 ± 1.112
2.72IleIle: 2.72 ± 1.68
6.346IleLys: 6.346 ± 1.885
0.0IleLeu: 0.0 ± 0.0
0.0IleMet: 0.0 ± 0.0
0.907IleAsn: 0.907 ± 1.112
1.813IlePro: 1.813 ± 0.941
3.626IleGln: 3.626 ± 1.215
6.346IleArg: 6.346 ± 2.313
4.533IleSer: 4.533 ± 1.187
3.626IleThr: 3.626 ± 3.197
1.813IleVal: 1.813 ± 0.738
2.72IleTrp: 2.72 ± 1.412
0.907IleTyr: 0.907 ± 0.72
0.0IleXaa: 0.0 ± 0.0
Lys
3.626LysAla: 3.626 ± 1.492
1.813LysCys: 1.813 ± 1.092
2.72LysAsp: 2.72 ± 1.385
4.533LysGlu: 4.533 ± 2.289
1.813LysPhe: 1.813 ± 1.229
5.44LysGly: 5.44 ± 3.045
0.907LysHis: 0.907 ± 0.62
3.626LysIle: 3.626 ± 1.436
2.72LysLys: 2.72 ± 0.899
0.907LysLeu: 0.907 ± 0.62
0.0LysMet: 0.0 ± 0.0
5.44LysAsn: 5.44 ± 2.315
2.72LysPro: 2.72 ± 1.319
0.0LysGln: 0.0 ± 0.0
2.72LysArg: 2.72 ± 1.319
4.533LysSer: 4.533 ± 1.577
2.72LysThr: 2.72 ± 1.053
4.533LysVal: 4.533 ± 1.94
0.907LysTrp: 0.907 ± 0.72
5.44LysTyr: 5.44 ± 1.472
0.0LysXaa: 0.0 ± 0.0
Leu
3.626LeuAla: 3.626 ± 1.816
1.813LeuCys: 1.813 ± 1.241
4.533LeuAsp: 4.533 ± 2.373
4.533LeuGlu: 4.533 ± 1.888
0.0LeuPhe: 0.0 ± 0.0
4.533LeuGly: 4.533 ± 1.894
3.626LeuHis: 3.626 ± 1.848
3.626LeuIle: 3.626 ± 2.054
4.533LeuLys: 4.533 ± 1.577
0.907LeuLeu: 0.907 ± 1.231
2.72LeuMet: 2.72 ± 1.302
5.44LeuAsn: 5.44 ± 1.419
2.72LeuPro: 2.72 ± 1.945
3.626LeuGln: 3.626 ± 1.542
6.346LeuArg: 6.346 ± 1.75
1.813LeuSer: 1.813 ± 1.241
4.533LeuThr: 4.533 ± 2.222
4.533LeuVal: 4.533 ± 1.989
0.907LeuTrp: 0.907 ± 1.112
4.533LeuTyr: 4.533 ± 2.203
0.0LeuXaa: 0.0 ± 0.0
Met
0.907MetAla: 0.907 ± 0.72
0.907MetCys: 0.907 ± 0.72
1.813MetAsp: 1.813 ± 1.229
1.813MetGlu: 1.813 ± 1.241
2.72MetPhe: 2.72 ± 1.563
3.626MetGly: 3.626 ± 2.454
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.72MetLeu: 2.72 ± 1.464
1.813MetMet: 1.813 ± 1.501
1.813MetAsn: 1.813 ± 1.229
1.813MetPro: 1.813 ± 0.941
0.0MetGln: 0.0 ± 0.0
0.907MetArg: 0.907 ± 0.959
0.907MetSer: 0.907 ± 0.72
0.907MetThr: 0.907 ± 1.112
0.0MetVal: 0.0 ± 0.0
0.907MetTrp: 0.907 ± 0.62
1.813MetTyr: 1.813 ± 1.439
0.0MetXaa: 0.0 ± 0.0
Asn
5.44AsnAla: 5.44 ± 2.889
0.0AsnCys: 0.0 ± 0.0
1.813AsnAsp: 1.813 ± 1.241
2.72AsnGlu: 2.72 ± 0.954
0.907AsnPhe: 0.907 ± 0.72
1.813AsnGly: 1.813 ± 1.092
5.44AsnHis: 5.44 ± 2.249
1.813AsnIle: 1.813 ± 0.738
2.72AsnLys: 2.72 ± 1.385
7.253AsnLeu: 7.253 ± 2.915
2.72AsnMet: 2.72 ± 1.432
2.72AsnAsn: 2.72 ± 2.23
2.72AsnPro: 2.72 ± 1.053
2.72AsnGln: 2.72 ± 1.09
3.626AsnArg: 3.626 ± 2.121
2.72AsnSer: 2.72 ± 1.09
0.907AsnThr: 0.907 ± 0.62
4.533AsnVal: 4.533 ± 2.021
0.907AsnTrp: 0.907 ± 0.62
2.72AsnTyr: 2.72 ± 1.307
0.0AsnXaa: 0.0 ± 0.0
Pro
2.72ProAla: 2.72 ± 1.563
2.72ProCys: 2.72 ± 1.307
2.72ProAsp: 2.72 ± 1.307
2.72ProGlu: 2.72 ± 1.128
1.813ProPhe: 1.813 ± 1.092
1.813ProGly: 1.813 ± 1.241
3.626ProHis: 3.626 ± 1.805
5.44ProIle: 5.44 ± 1.192
2.72ProLys: 2.72 ± 1.861
3.626ProLeu: 3.626 ± 1.423
2.72ProMet: 2.72 ± 1.09
2.72ProAsn: 2.72 ± 1.303
2.72ProPro: 2.72 ± 1.128
2.72ProGln: 2.72 ± 2.358
5.44ProArg: 5.44 ± 1.916
5.44ProSer: 5.44 ± 3.08
2.72ProThr: 2.72 ± 1.385
4.533ProVal: 4.533 ± 1.366
0.0ProTrp: 0.0 ± 0.0
0.907ProTyr: 0.907 ± 0.72
0.0ProXaa: 0.0 ± 0.0
Gln
6.346GlnAla: 6.346 ± 1.926
0.907GlnCys: 0.907 ± 0.62
3.626GlnAsp: 3.626 ± 2.033
3.626GlnGlu: 3.626 ± 1.197
2.72GlnPhe: 2.72 ± 1.385
0.907GlnGly: 0.907 ± 0.62
2.72GlnHis: 2.72 ± 1.564
1.813GlnIle: 1.813 ± 1.241
0.907GlnLys: 0.907 ± 0.959
2.72GlnLeu: 2.72 ± 1.293
0.907GlnMet: 0.907 ± 0.918
1.813GlnAsn: 1.813 ± 1.092
3.626GlnPro: 3.626 ± 2.837
1.813GlnGln: 1.813 ± 0.738
3.626GlnArg: 3.626 ± 2.618
5.44GlnSer: 5.44 ± 1.336
0.0GlnThr: 0.0 ± 0.0
4.533GlnVal: 4.533 ± 1.894
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.346ArgAla: 6.346 ± 0.969
1.813ArgCys: 1.813 ± 1.918
4.533ArgAsp: 4.533 ± 1.989
2.72ArgGlu: 2.72 ± 1.535
2.72ArgPhe: 2.72 ± 1.053
3.626ArgGly: 3.626 ± 1.33
2.72ArgHis: 2.72 ± 1.307
2.72ArgIle: 2.72 ± 1.053
2.72ArgLys: 2.72 ± 1.68
4.533ArgLeu: 4.533 ± 2.672
1.813ArgMet: 1.813 ± 1.439
1.813ArgAsn: 1.813 ± 1.52
7.253ArgPro: 7.253 ± 1.862
0.907ArgGln: 0.907 ± 0.959
6.346ArgArg: 6.346 ± 3.325
3.626ArgSer: 3.626 ± 1.274
5.44ArgThr: 5.44 ± 4.68
6.346ArgVal: 6.346 ± 2.121
0.0ArgTrp: 0.0 ± 0.0
1.813ArgTyr: 1.813 ± 1.122
0.0ArgXaa: 0.0 ± 0.0
Ser
5.44SerAla: 5.44 ± 3.055
0.0SerCys: 0.0 ± 0.0
2.72SerAsp: 2.72 ± 0.899
1.813SerGlu: 1.813 ± 0.964
3.626SerPhe: 3.626 ± 1.33
0.907SerGly: 0.907 ± 0.62
0.0SerHis: 0.0 ± 0.0
3.626SerIle: 3.626 ± 2.14
6.346SerLys: 6.346 ± 2.222
2.72SerLeu: 2.72 ± 1.535
1.813SerMet: 1.813 ± 2.462
4.533SerAsn: 4.533 ± 1.84
8.16SerPro: 8.16 ± 1.674
6.346SerGln: 6.346 ± 2.816
5.44SerArg: 5.44 ± 1.283
10.879SerSer: 10.879 ± 5.026
8.16SerThr: 8.16 ± 3.887
4.533SerVal: 4.533 ± 2.242
0.0SerTrp: 0.0 ± 0.0
5.44SerTyr: 5.44 ± 2.423
0.0SerXaa: 0.0 ± 0.0
Thr
3.626ThrAla: 3.626 ± 0.981
1.813ThrCys: 1.813 ± 1.241
0.0ThrAsp: 0.0 ± 0.0
2.72ThrGlu: 2.72 ± 1.412
1.813ThrPhe: 1.813 ± 1.241
4.533ThrGly: 4.533 ± 1.935
3.626ThrHis: 3.626 ± 2.121
0.907ThrIle: 0.907 ± 0.62
3.626ThrLys: 3.626 ± 1.475
3.626ThrLeu: 3.626 ± 1.705
0.907ThrMet: 0.907 ± 0.62
2.72ThrAsn: 2.72 ± 1.09
5.44ThrPro: 5.44 ± 2.164
2.72ThrGln: 2.72 ± 1.725
1.813ThrArg: 1.813 ± 0.738
4.533ThrSer: 4.533 ± 3.714
0.0ThrThr: 0.0 ± 0.0
5.44ThrVal: 5.44 ± 2.303
0.907ThrTrp: 0.907 ± 1.112
1.813ThrTyr: 1.813 ± 0.964
0.0ThrXaa: 0.0 ± 0.0
Val
0.907ValAla: 0.907 ± 0.959
0.0ValCys: 0.0 ± 0.0
3.626ValAsp: 3.626 ± 0.981
0.907ValGlu: 0.907 ± 0.959
2.72ValPhe: 2.72 ± 1.306
2.72ValGly: 2.72 ± 1.307
2.72ValHis: 2.72 ± 1.479
6.346ValIle: 6.346 ± 3.215
4.533ValLys: 4.533 ± 1.995
5.44ValLeu: 5.44 ± 2.106
1.813ValMet: 1.813 ± 1.439
2.72ValAsn: 2.72 ± 0.954
3.626ValPro: 3.626 ± 1.33
7.253ValGln: 7.253 ± 2.529
2.72ValArg: 2.72 ± 2.159
5.44ValSer: 5.44 ± 1.672
2.72ValThr: 2.72 ± 2.159
2.72ValVal: 2.72 ± 1.053
0.0ValTrp: 0.0 ± 0.0
7.253ValTyr: 7.253 ± 2.11
0.0ValXaa: 0.0 ± 0.0
Trp
3.626TrpAla: 3.626 ± 1.705
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.907TrpGlu: 0.907 ± 1.112
0.0TrpPhe: 0.0 ± 0.0
0.907TrpGly: 0.907 ± 0.62
0.907TrpHis: 0.907 ± 0.72
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
1.813TrpMet: 1.813 ± 1.229
0.907TrpAsn: 0.907 ± 1.112
0.0TrpPro: 0.0 ± 0.0
0.907TrpGln: 0.907 ± 0.62
1.813TrpArg: 1.813 ± 1.635
0.907TrpSer: 0.907 ± 0.918
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.907TrpTyr: 0.907 ± 0.62
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.626TyrAla: 3.626 ± 1.993
0.0TyrCys: 0.0 ± 0.0
1.813TyrAsp: 1.813 ± 1.122
0.907TyrGlu: 0.907 ± 0.72
3.626TyrPhe: 3.626 ± 0.981
0.907TyrGly: 0.907 ± 0.62
0.0TyrHis: 0.0 ± 0.0
0.907TyrIle: 0.907 ± 0.62
0.907TyrLys: 0.907 ± 0.62
5.44TyrLeu: 5.44 ± 1.547
0.907TyrMet: 0.907 ± 1.028
2.72TyrAsn: 2.72 ± 0.954
1.813TyrPro: 1.813 ± 1.241
1.813TyrGln: 1.813 ± 0.738
1.813TyrArg: 1.813 ± 1.439
4.533TyrSer: 4.533 ± 1.473
0.907TyrThr: 0.907 ± 1.112
4.533TyrVal: 4.533 ± 1.185
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1104 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski