Amino acid dipepetide frequency for Sphingobium quisquiliarum P25

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.13AlaAla: 19.13 ± 0.186	1.059AlaCys: 1.059 ± 0.028	7.494AlaAsp: 7.494 ± 0.083	7.488AlaGlu: 7.488 ± 0.104	4.305AlaPhe: 4.305 ± 0.058	11.274AlaGly: 11.274 ± 0.099	2.461AlaHis: 2.461 ± 0.042	6.763AlaIle: 6.763 ± 0.096	3.995AlaLys: 3.995 ± 0.066	13.943AlaLeu: 13.943 ± 0.133	4.011AlaMet: 4.011 ± 0.057	2.959AlaAsn: 2.959 ± 0.058	6.188AlaPro: 6.188 ± 0.087	4.783AlaGln: 4.783 ± 0.066	9.938AlaArg: 9.938 ± 0.104	6.645AlaSer: 6.645 ± 0.077	5.625AlaThr: 5.625 ± 0.084	8.351AlaVal: 8.351 ± 0.092	1.571AlaTrp: 1.571 ± 0.034	2.663AlaTyr: 2.663 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.028	0.105CysCys: 0.105 ± 0.009	0.517CysAsp: 0.517 ± 0.021	0.374CysGlu: 0.374 ± 0.019	0.293CysPhe: 0.293 ± 0.016	0.879CysGly: 0.879 ± 0.029	0.198CysHis: 0.198 ± 0.013	0.38CysIle: 0.38 ± 0.02	0.165CysLys: 0.165 ± 0.012	0.736CysLeu: 0.736 ± 0.027	0.162CysMet: 0.162 ± 0.01	0.205CysAsn: 0.205 ± 0.014	0.448CysPro: 0.448 ± 0.019	0.2CysGln: 0.2 ± 0.013	0.556CysArg: 0.556 ± 0.023	0.446CysSer: 0.446 ± 0.02	0.372CysThr: 0.372 ± 0.02	0.558CysVal: 0.558 ± 0.023	0.138CysTrp: 0.138 ± 0.011	0.186CysTyr: 0.186 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.339AspAla: 7.339 ± 0.087	0.454AspCys: 0.454 ± 0.019	3.127AspAsp: 3.127 ± 0.058	3.342AspGlu: 3.342 ± 0.058	2.117AspPhe: 2.117 ± 0.047	5.498AspGly: 5.498 ± 0.079	1.437AspHis: 1.437 ± 0.037	3.197AspIle: 3.197 ± 0.048	1.654AspLys: 1.654 ± 0.046	5.798AspLeu: 5.798 ± 0.068	1.639AspMet: 1.639 ± 0.04	1.364AspAsn: 1.364 ± 0.038	3.799AspPro: 3.799 ± 0.059	1.946AspGln: 1.946 ± 0.04	4.928AspArg: 4.928 ± 0.071	2.319AspSer: 2.319 ± 0.04	2.214AspThr: 2.214 ± 0.044	3.965AspVal: 3.965 ± 0.051	1.064AspTrp: 1.064 ± 0.035	1.702AspTyr: 1.702 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.791GluAla: 7.791 ± 0.091	0.318GluCys: 0.318 ± 0.017	2.93GluAsp: 2.93 ± 0.062	3.387GluGlu: 3.387 ± 0.07	1.454GluPhe: 1.454 ± 0.043	4.774GluGly: 4.774 ± 0.068	1.06GluHis: 1.06 ± 0.032	2.886GluIle: 2.886 ± 0.049	2.074GluLys: 2.074 ± 0.052	4.927GluLeu: 4.927 ± 0.069	1.467GluMet: 1.467 ± 0.038	1.32GluAsn: 1.32 ± 0.034	2.447GluPro: 2.447 ± 0.05	2.283GluGln: 2.283 ± 0.051	5.066GluArg: 5.066 ± 0.088	2.357GluSer: 2.357 ± 0.046	2.884GluThr: 2.884 ± 0.049	3.473GluVal: 3.473 ± 0.055	0.788GluTrp: 0.788 ± 0.026	1.033GluTyr: 1.033 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.663PheAla: 4.663 ± 0.058	0.33PheCys: 0.33 ± 0.015	2.618PheAsp: 2.618 ± 0.047	1.927PheGlu: 1.927 ± 0.043	1.274PhePhe: 1.274 ± 0.039	3.458PheGly: 3.458 ± 0.059	0.799PheHis: 0.799 ± 0.027	1.513PheIle: 1.513 ± 0.036	0.838PheLys: 0.838 ± 0.029	3.27PheLeu: 3.27 ± 0.061	0.783PheMet: 0.783 ± 0.028	1.03PheAsn: 1.03 ± 0.033	1.599PhePro: 1.599 ± 0.039	0.964PheGln: 0.964 ± 0.029	2.312PheArg: 2.312 ± 0.044	2.091PheSer: 2.091 ± 0.045	2.044PheThr: 2.044 ± 0.046	2.337PheVal: 2.337 ± 0.054	0.54PheTrp: 0.54 ± 0.025	0.912PheTyr: 0.912 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.722GlyAla: 9.722 ± 0.095	0.814GlyCys: 0.814 ± 0.028	4.751GlyAsp: 4.751 ± 0.067	4.957GlyGlu: 4.957 ± 0.06	3.593GlyPhe: 3.593 ± 0.049	8.013GlyGly: 8.013 ± 0.104	1.936GlyHis: 1.936 ± 0.045	4.524GlyIle: 4.524 ± 0.057	3.411GlyLys: 3.411 ± 0.061	8.828GlyLeu: 8.828 ± 0.096	2.622GlyMet: 2.622 ± 0.049	2.245GlyAsn: 2.245 ± 0.05	3.7GlyPro: 3.7 ± 0.063	3.167GlyGln: 3.167 ± 0.05	6.735GlyArg: 6.735 ± 0.084	4.811GlySer: 4.811 ± 0.079	4.461GlyThr: 4.461 ± 0.073	6.187GlyVal: 6.187 ± 0.074	1.631GlyTrp: 1.631 ± 0.042	2.337GlyTyr: 2.337 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.448HisAla: 2.448 ± 0.054	0.211HisCys: 0.211 ± 0.015	1.306HisAsp: 1.306 ± 0.031	1.008HisGlu: 1.008 ± 0.025	0.873HisPhe: 0.873 ± 0.029	2.114HisGly: 2.114 ± 0.046	0.6HisHis: 0.6 ± 0.022	1.015HisIle: 1.015 ± 0.036	0.462HisLys: 0.462 ± 0.018	2.049HisLeu: 2.049 ± 0.046	0.564HisMet: 0.564 ± 0.023	0.461HisAsn: 0.461 ± 0.021	1.355HisPro: 1.355 ± 0.034	0.602HisGln: 0.602 ± 0.024	1.548HisArg: 1.548 ± 0.038	1.01HisSer: 1.01 ± 0.031	0.575HisThr: 0.575 ± 0.023	1.656HisVal: 1.656 ± 0.035	0.367HisTrp: 0.367 ± 0.017	0.634HisTyr: 0.634 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.758IleAla: 7.758 ± 0.1	0.466IleCys: 0.466 ± 0.02	3.864IleAsp: 3.864 ± 0.067	3.412IleGlu: 3.412 ± 0.058	1.699IlePhe: 1.699 ± 0.043	5.128IleGly: 5.128 ± 0.071	0.973IleHis: 0.973 ± 0.03	2.38IleIle: 2.38 ± 0.05	1.262IleLys: 1.262 ± 0.036	4.33IleLeu: 4.33 ± 0.069	1.034IleMet: 1.034 ± 0.027	1.36IleAsn: 1.36 ± 0.037	2.329IlePro: 2.329 ± 0.039	1.22IleGln: 1.22 ± 0.034	3.322IleArg: 3.322 ± 0.053	2.85IleSer: 2.85 ± 0.054	2.438IleThr: 2.438 ± 0.047	3.99IleVal: 3.99 ± 0.057	0.659IleTrp: 0.659 ± 0.026	1.083IleTyr: 1.083 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.367LysAla: 4.367 ± 0.077	0.152LysCys: 0.152 ± 0.011	1.701LysAsp: 1.701 ± 0.04	1.324LysGlu: 1.324 ± 0.035	0.747LysPhe: 0.747 ± 0.027	2.8LysGly: 2.8 ± 0.054	0.493LysHis: 0.493 ± 0.019	1.46LysIle: 1.46 ± 0.037	1.104LysLys: 1.104 ± 0.039	3.127LysLeu: 3.127 ± 0.053	0.794LysMet: 0.794 ± 0.027	0.697LysAsn: 0.697 ± 0.025	1.974LysPro: 1.974 ± 0.051	0.934LysGln: 0.934 ± 0.028	2.243LysArg: 2.243 ± 0.045	1.579LysSer: 1.579 ± 0.037	1.528LysThr: 1.528 ± 0.038	2.277LysVal: 2.277 ± 0.043	0.379LysTrp: 0.379 ± 0.018	0.555LysTyr: 0.555 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.622LeuAla: 13.622 ± 0.131	0.876LeuCys: 0.876 ± 0.027	6.09LeuAsp: 6.09 ± 0.089	4.908LeuGlu: 4.908 ± 0.066	3.852LeuPhe: 3.852 ± 0.067	8.069LeuGly: 8.069 ± 0.091	1.954LeuHis: 1.954 ± 0.038	5.217LeuIle: 5.217 ± 0.073	3.133LeuLys: 3.133 ± 0.048	10.26LeuLeu: 10.26 ± 0.144	2.389LeuMet: 2.389 ± 0.047	2.542LeuAsn: 2.542 ± 0.053	5.843LeuPro: 5.843 ± 0.084	2.51LeuGln: 2.51 ± 0.044	7.087LeuArg: 7.087 ± 0.095	6.542LeuSer: 6.542 ± 0.084	5.624LeuThr: 5.624 ± 0.077	6.517LeuVal: 6.517 ± 0.088	1.271LeuTrp: 1.271 ± 0.038	1.991LeuTyr: 1.991 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.538MetAla: 3.538 ± 0.051	0.156MetCys: 0.156 ± 0.012	1.314MetAsp: 1.314 ± 0.04	1.29MetGlu: 1.29 ± 0.035	0.694MetPhe: 0.694 ± 0.027	2.017MetGly: 2.017 ± 0.042	0.486MetHis: 0.486 ± 0.021	1.488MetIle: 1.488 ± 0.033	1.003MetLys: 1.003 ± 0.029	2.901MetLeu: 2.901 ± 0.049	0.788MetMet: 0.788 ± 0.029	0.73MetAsn: 0.73 ± 0.026	1.61MetPro: 1.61 ± 0.036	0.846MetGln: 0.846 ± 0.026	1.89MetArg: 1.89 ± 0.04	1.515MetSer: 1.515 ± 0.037	1.785MetThr: 1.785 ± 0.04	1.647MetVal: 1.647 ± 0.04	0.23MetTrp: 0.23 ± 0.014	0.266MetTyr: 0.266 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.233AsnAla: 3.233 ± 0.064	0.219AsnCys: 0.219 ± 0.013	1.345AsnAsp: 1.345 ± 0.036	1.156AsnGlu: 1.156 ± 0.032	0.906AsnPhe: 0.906 ± 0.029	2.465AsnGly: 2.465 ± 0.051	0.475AsnHis: 0.475 ± 0.019	1.391AsnIle: 1.391 ± 0.037	0.641AsnLys: 0.641 ± 0.023	2.429AsnLeu: 2.429 ± 0.051	0.608AsnMet: 0.608 ± 0.024	0.675AsnAsn: 0.675 ± 0.025	1.681AsnPro: 1.681 ± 0.039	0.798AsnGln: 0.798 ± 0.026	1.908AsnArg: 1.908 ± 0.041	1.315AsnSer: 1.315 ± 0.041	0.9AsnThr: 0.9 ± 0.03	1.84AsnVal: 1.84 ± 0.042	0.409AsnTrp: 0.409 ± 0.016	0.709AsnTyr: 0.709 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.233ProAla: 7.233 ± 0.091	0.332ProCys: 0.332 ± 0.017	3.795ProAsp: 3.795 ± 0.056	3.37ProGlu: 3.37 ± 0.057	1.976ProPhe: 1.976 ± 0.041	5.106ProGly: 5.106 ± 0.074	1.147ProHis: 1.147 ± 0.039	2.329ProIle: 2.329 ± 0.04	1.35ProLys: 1.35 ± 0.036	5.132ProLeu: 5.132 ± 0.065	1.327ProMet: 1.327 ± 0.033	1.261ProAsn: 1.261 ± 0.033	2.892ProPro: 2.892 ± 0.068	1.84ProGln: 1.84 ± 0.044	3.183ProArg: 3.183 ± 0.055	2.929ProSer: 2.929 ± 0.054	2.099ProThr: 2.099 ± 0.047	4.584ProVal: 4.584 ± 0.062	0.695ProTrp: 0.695 ± 0.024	1.11ProTyr: 1.11 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.578GlnAla: 4.578 ± 0.074	0.258GlnCys: 0.258 ± 0.015	1.629GlnAsp: 1.629 ± 0.039	1.497GlnGlu: 1.497 ± 0.034	1.085GlnPhe: 1.085 ± 0.03	2.713GlnGly: 2.713 ± 0.048	0.644GlnHis: 0.644 ± 0.024	1.861GlnIle: 1.861 ± 0.04	0.997GlnLys: 0.997 ± 0.029	3.144GlnLeu: 3.144 ± 0.053	0.916GlnMet: 0.916 ± 0.029	0.765GlnAsn: 0.765 ± 0.027	1.964GlnPro: 1.964 ± 0.037	1.371GlnGln: 1.371 ± 0.04	2.723GlnArg: 2.723 ± 0.045	1.842GlnSer: 1.842 ± 0.042	1.547GlnThr: 1.547 ± 0.04	2.293GlnVal: 2.293 ± 0.047	0.501GlnTrp: 0.501 ± 0.02	0.635GlnTyr: 0.635 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.793ArgAla: 8.793 ± 0.109	0.55ArgCys: 0.55 ± 0.022	4.426ArgAsp: 4.426 ± 0.065	4.143ArgGlu: 4.143 ± 0.071	3.125ArgPhe: 3.125 ± 0.054	5.16ArgGly: 5.16 ± 0.071	1.927ArgHis: 1.927 ± 0.043	4.294ArgIle: 4.294 ± 0.059	2.252ArgLys: 2.252 ± 0.045	8.482ArgLeu: 8.482 ± 0.113	2.028ArgMet: 2.028 ± 0.039	1.888ArgAsn: 1.888 ± 0.044	3.88ArgPro: 3.88 ± 0.057	2.866ArgGln: 2.866 ± 0.047	6.055ArgArg: 6.055 ± 0.1	3.876ArgSer: 3.876 ± 0.062	3.498ArgThr: 3.498 ± 0.05	4.677ArgVal: 4.677 ± 0.07	1.298ArgTrp: 1.298 ± 0.036	1.941ArgTyr: 1.941 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.72SerAla: 6.72 ± 0.085	0.476SerCys: 0.476 ± 0.019	2.999SerAsp: 2.999 ± 0.051	2.547SerGlu: 2.547 ± 0.046	2.287SerPhe: 2.287 ± 0.046	5.695SerGly: 5.695 ± 0.075	1.034SerHis: 1.034 ± 0.03	2.747SerIle: 2.747 ± 0.044	1.422SerLys: 1.422 ± 0.037	5.375SerLeu: 5.375 ± 0.072	1.327SerMet: 1.327 ± 0.031	1.369SerAsn: 1.369 ± 0.035	2.968SerPro: 2.968 ± 0.05	1.59SerGln: 1.59 ± 0.038	3.77SerArg: 3.77 ± 0.062	2.957SerSer: 2.957 ± 0.057	2.446SerThr: 2.446 ± 0.047	3.64SerVal: 3.64 ± 0.067	0.838SerTrp: 0.838 ± 0.027	1.446SerTyr: 1.446 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.853ThrAla: 5.853 ± 0.076	0.368ThrCys: 0.368 ± 0.017	2.573ThrAsp: 2.573 ± 0.048	2.152ThrGlu: 2.152 ± 0.043	1.63ThrPhe: 1.63 ± 0.042	5.185ThrGly: 5.185 ± 0.076	0.947ThrHis: 0.947 ± 0.031	2.706ThrIle: 2.706 ± 0.053	1.181ThrLys: 1.181 ± 0.034	5.461ThrLeu: 5.461 ± 0.074	1.125ThrMet: 1.125 ± 0.032	1.169ThrAsn: 1.169 ± 0.03	3.333ThrPro: 3.333 ± 0.055	1.458ThrGln: 1.458 ± 0.035	3.275ThrArg: 3.275 ± 0.052	2.526ThrSer: 2.526 ± 0.05	2.248ThrThr: 2.248 ± 0.057	3.833ThrVal: 3.833 ± 0.065	0.518ThrTrp: 0.518 ± 0.024	1.015ThrTyr: 1.015 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.696ValAla: 8.696 ± 0.085	0.488ValCys: 0.488 ± 0.02	4.112ValAsp: 4.112 ± 0.054	4.634ValGlu: 4.634 ± 0.067	1.987ValPhe: 1.987 ± 0.044	5.022ValGly: 5.022 ± 0.065	1.387ValHis: 1.387 ± 0.038	3.81ValIle: 3.81 ± 0.056	2.235ValLys: 2.235 ± 0.048	6.22ValLeu: 6.22 ± 0.088	1.723ValMet: 1.723 ± 0.039	1.973ValAsn: 1.973 ± 0.047	3.853ValPro: 3.853 ± 0.067	2.258ValGln: 2.258 ± 0.046	5.221ValArg: 5.221 ± 0.075	3.912ValSer: 3.912 ± 0.065	4.483ValThr: 4.483 ± 0.066	4.77ValVal: 4.77 ± 0.067	0.79ValTrp: 0.79 ± 0.023	1.363ValTyr: 1.363 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.387TrpAla: 1.387 ± 0.036	0.112TrpCys: 0.112 ± 0.01	0.753TrpAsp: 0.753 ± 0.026	0.598TrpGlu: 0.598 ± 0.025	0.528TrpPhe: 0.528 ± 0.021	0.948TrpGly: 0.948 ± 0.03	0.352TrpHis: 0.352 ± 0.016	0.725TrpIle: 0.725 ± 0.023	0.472TrpLys: 0.472 ± 0.019	1.736TrpLeu: 1.736 ± 0.047	0.436TrpMet: 0.436 ± 0.021	0.468TrpAsn: 0.468 ± 0.023	0.741TrpPro: 0.741 ± 0.027	0.594TrpGln: 0.594 ± 0.024	1.402TrpArg: 1.402 ± 0.038	0.866TrpSer: 0.866 ± 0.031	0.843TrpThr: 0.843 ± 0.03	0.815TrpVal: 0.815 ± 0.028	0.248TrpTrp: 0.248 ± 0.015	0.295TrpTyr: 0.295 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.701TyrAla: 2.701 ± 0.045	0.252TyrCys: 0.252 ± 0.014	1.56TyrAsp: 1.56 ± 0.041	1.206TyrGlu: 1.206 ± 0.034	0.878TyrPhe: 0.878 ± 0.03	2.127TyrGly: 2.127 ± 0.046	0.546TyrHis: 0.546 ± 0.019	0.872TyrIle: 0.872 ± 0.024	0.582TyrLys: 0.582 ± 0.023	2.147TyrLeu: 2.147 ± 0.047	0.449TyrMet: 0.449 ± 0.021	0.622TyrAsn: 0.622 ± 0.026	1.086TyrPro: 1.086 ± 0.031	0.735TyrGln: 0.735 ± 0.029	1.996TyrArg: 1.996 ± 0.043	1.264TyrSer: 1.264 ± 0.035	0.943TyrThr: 0.943 ± 0.031	1.527TyrVal: 1.527 ± 0.032	0.383TyrTrp: 0.383 ± 0.019	0.593TyrTyr: 0.593 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3949 proteins (1198606 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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