Amino acid dipepetide frequency for Paralcaligenes ureilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.719AlaAla: 14.719 ± 0.159	1.296AlaCys: 1.296 ± 0.03	5.804AlaAsp: 5.804 ± 0.073	5.201AlaGlu: 5.201 ± 0.075	3.871AlaPhe: 3.871 ± 0.066	9.934AlaGly: 9.934 ± 0.128	2.567AlaHis: 2.567 ± 0.042	6.274AlaIle: 6.274 ± 0.073	3.866AlaLys: 3.866 ± 0.069	13.171AlaLeu: 13.171 ± 0.133	3.305AlaMet: 3.305 ± 0.053	3.049AlaAsn: 3.049 ± 0.064	4.96AlaPro: 4.96 ± 0.077	5.548AlaGln: 5.548 ± 0.078	7.498AlaArg: 7.498 ± 0.079	6.611AlaSer: 6.611 ± 0.077	5.401AlaThr: 5.401 ± 0.068	8.262AlaVal: 8.262 ± 0.092	1.602AlaTrp: 1.602 ± 0.043	2.787AlaTyr: 2.787 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.119CysAla: 1.119 ± 0.028	0.172CysCys: 0.172 ± 0.011	0.552CysAsp: 0.552 ± 0.021	0.489CysGlu: 0.489 ± 0.019	0.337CysPhe: 0.337 ± 0.019	1.055CysGly: 1.055 ± 0.026	0.298CysHis: 0.298 ± 0.014	0.488CysIle: 0.488 ± 0.017	0.28CysLys: 0.28 ± 0.014	1.003CysLeu: 1.003 ± 0.029	0.232CysMet: 0.232 ± 0.013	0.284CysAsn: 0.284 ± 0.014	0.516CysPro: 0.516 ± 0.02	0.277CysGln: 0.277 ± 0.015	0.625CysArg: 0.625 ± 0.023	0.578CysSer: 0.578 ± 0.02	0.502CysThr: 0.502 ± 0.019	0.833CysVal: 0.833 ± 0.024	0.14CysTrp: 0.14 ± 0.01	0.265CysTyr: 0.265 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.818AspAla: 5.818 ± 0.079	0.523AspCys: 0.523 ± 0.021	2.524AspAsp: 2.524 ± 0.05	2.906AspGlu: 2.906 ± 0.048	2.051AspPhe: 2.051 ± 0.039	3.885AspGly: 3.885 ± 0.072	1.172AspHis: 1.172 ± 0.034	3.031AspIle: 3.031 ± 0.054	1.791AspLys: 1.791 ± 0.035	5.372AspLeu: 5.372 ± 0.071	1.31AspMet: 1.31 ± 0.034	1.299AspAsn: 1.299 ± 0.03	2.889AspPro: 2.889 ± 0.053	1.869AspGln: 1.869 ± 0.04	3.095AspArg: 3.095 ± 0.044	2.733AspSer: 2.733 ± 0.051	2.71AspThr: 2.71 ± 0.045	3.88AspVal: 3.88 ± 0.057	0.793AspTrp: 0.793 ± 0.027	1.554AspTyr: 1.554 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.383GluAla: 5.383 ± 0.073	0.417GluCys: 0.417 ± 0.017	1.977GluAsp: 1.977 ± 0.039	2.138GluGlu: 2.138 ± 0.05	1.862GluPhe: 1.862 ± 0.037	3.284GluGly: 3.284 ± 0.054	1.424GluHis: 1.424 ± 0.034	3.042GluIle: 3.042 ± 0.054	2.068GluLys: 2.068 ± 0.04	5.264GluLeu: 5.264 ± 0.068	1.289GluMet: 1.289 ± 0.03	1.65GluAsn: 1.65 ± 0.035	2.347GluPro: 2.347 ± 0.041	2.489GluGln: 2.489 ± 0.043	3.719GluArg: 3.719 ± 0.059	2.738GluSer: 2.738 ± 0.044	2.486GluThr: 2.486 ± 0.046	3.431GluVal: 3.431 ± 0.053	0.605GluTrp: 0.605 ± 0.02	1.1GluTyr: 1.1 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.958PheAla: 3.958 ± 0.059	0.436PheCys: 0.436 ± 0.018	2.402PheAsp: 2.402 ± 0.047	1.971PheGlu: 1.971 ± 0.04	1.507PhePhe: 1.507 ± 0.042	3.5PheGly: 3.5 ± 0.056	0.804PheHis: 0.804 ± 0.027	1.989PheIle: 1.989 ± 0.044	1.337PheLys: 1.337 ± 0.033	3.333PheLeu: 3.333 ± 0.056	0.937PheMet: 0.937 ± 0.029	1.308PheAsn: 1.308 ± 0.035	1.706PhePro: 1.706 ± 0.037	1.169PheGln: 1.169 ± 0.034	1.847PheArg: 1.847 ± 0.041	2.511PheSer: 2.511 ± 0.048	1.966PheThr: 1.966 ± 0.037	2.793PheVal: 2.793 ± 0.05	0.533PheTrp: 0.533 ± 0.021	1.006PheTyr: 1.006 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.617GlyAla: 8.617 ± 0.121	0.957GlyCys: 0.957 ± 0.032	3.643GlyAsp: 3.643 ± 0.059	3.752GlyGlu: 3.752 ± 0.058	3.353GlyPhe: 3.353 ± 0.059	6.637GlyGly: 6.637 ± 0.159	2.048GlyHis: 2.048 ± 0.043	4.711GlyIle: 4.711 ± 0.074	3.542GlyLys: 3.542 ± 0.055	9.016GlyLeu: 9.016 ± 0.097	2.361GlyMet: 2.361 ± 0.043	2.25GlyAsn: 2.25 ± 0.065	3.019GlyPro: 3.019 ± 0.053	3.328GlyGln: 3.328 ± 0.057	5.112GlyArg: 5.112 ± 0.068	4.889GlySer: 4.889 ± 0.091	4.326GlyThr: 4.326 ± 0.085	6.584GlyVal: 6.584 ± 0.075	1.375GlyTrp: 1.375 ± 0.034	2.442GlyTyr: 2.442 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.679HisAla: 2.679 ± 0.049	0.299HisCys: 0.299 ± 0.015	1.276HisAsp: 1.276 ± 0.029	1.186HisGlu: 1.186 ± 0.028	0.927HisPhe: 0.927 ± 0.028	2.028HisGly: 2.028 ± 0.042	0.652HisHis: 0.652 ± 0.023	1.322HisIle: 1.322 ± 0.034	0.745HisLys: 0.745 ± 0.024	2.245HisLeu: 2.245 ± 0.044	0.566HisMet: 0.566 ± 0.018	0.665HisAsn: 0.665 ± 0.023	1.519HisPro: 1.519 ± 0.039	0.811HisGln: 0.811 ± 0.025	1.375HisArg: 1.375 ± 0.035	1.217HisSer: 1.217 ± 0.035	1.195HisThr: 1.195 ± 0.031	1.671HisVal: 1.671 ± 0.037	0.387HisTrp: 0.387 ± 0.018	0.72HisTyr: 0.72 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.747IleAla: 6.747 ± 0.082	0.529IleCys: 0.529 ± 0.02	3.553IleAsp: 3.553 ± 0.057	3.461IleGlu: 3.461 ± 0.054	1.806IlePhe: 1.806 ± 0.045	4.828IleGly: 4.828 ± 0.072	1.1IleHis: 1.1 ± 0.028	2.602IleIle: 2.602 ± 0.051	2.194IleLys: 2.194 ± 0.049	4.696IleLeu: 4.696 ± 0.068	1.176IleMet: 1.176 ± 0.025	1.935IleAsn: 1.935 ± 0.04	2.645IlePro: 2.645 ± 0.046	1.763IleGln: 1.763 ± 0.041	3.03IleArg: 3.03 ± 0.051	3.382IleSer: 3.382 ± 0.05	3.036IleThr: 3.036 ± 0.053	4.352IleVal: 4.352 ± 0.059	0.632IleTrp: 0.632 ± 0.02	1.258IleTyr: 1.258 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.961LysAla: 3.961 ± 0.064	0.192LysCys: 0.192 ± 0.012	1.705LysAsp: 1.705 ± 0.041	1.762LysGlu: 1.762 ± 0.047	1.112LysPhe: 1.112 ± 0.029	2.706LysGly: 2.706 ± 0.045	0.754LysHis: 0.754 ± 0.024	2.127LysIle: 2.127 ± 0.042	1.832LysLys: 1.832 ± 0.051	3.626LysLeu: 3.626 ± 0.05	1.015LysMet: 1.015 ± 0.03	1.375LysAsn: 1.375 ± 0.034	2.114LysPro: 2.114 ± 0.042	1.461LysGln: 1.461 ± 0.034	2.297LysArg: 2.297 ± 0.041	2.133LysSer: 2.133 ± 0.041	2.246LysThr: 2.246 ± 0.044	2.622LysVal: 2.622 ± 0.047	0.479LysTrp: 0.479 ± 0.019	0.813LysTyr: 0.813 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.72LeuAla: 13.72 ± 0.125	1.165LeuCys: 1.165 ± 0.03	5.911LeuAsp: 5.911 ± 0.069	4.886LeuGlu: 4.886 ± 0.074	3.815LeuPhe: 3.815 ± 0.058	8.786LeuGly: 8.786 ± 0.103	2.356LeuHis: 2.356 ± 0.049	5.667LeuIle: 5.667 ± 0.084	3.905LeuLys: 3.905 ± 0.057	11.054LeuLeu: 11.054 ± 0.14	2.612LeuMet: 2.612 ± 0.055	3.234LeuAsn: 3.234 ± 0.051	5.6LeuPro: 5.6 ± 0.073	3.689LeuGln: 3.689 ± 0.053	6.74LeuArg: 6.74 ± 0.077	7.002LeuSer: 7.002 ± 0.074	5.591LeuThr: 5.591 ± 0.078	7.389LeuVal: 7.389 ± 0.094	1.259LeuTrp: 1.259 ± 0.035	2.287LeuTyr: 2.287 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.057MetAla: 3.057 ± 0.053	0.191MetCys: 0.191 ± 0.011	1.134MetAsp: 1.134 ± 0.032	1.032MetGlu: 1.032 ± 0.025	0.776MetPhe: 0.776 ± 0.027	2.072MetGly: 2.072 ± 0.045	0.554MetHis: 0.554 ± 0.022	1.253MetIle: 1.253 ± 0.036	1.053MetLys: 1.053 ± 0.028	2.793MetLeu: 2.793 ± 0.054	0.655MetMet: 0.655 ± 0.025	0.97MetAsn: 0.97 ± 0.03	1.474MetPro: 1.474 ± 0.031	1.135MetGln: 1.135 ± 0.03	1.7MetArg: 1.7 ± 0.042	1.794MetSer: 1.794 ± 0.037	1.635MetThr: 1.635 ± 0.035	1.855MetVal: 1.855 ± 0.036	0.239MetTrp: 0.239 ± 0.016	0.462MetTyr: 0.462 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.341AsnAla: 3.341 ± 0.064	0.292AsnCys: 0.292 ± 0.017	1.488AsnAsp: 1.488 ± 0.036	1.312AsnGlu: 1.312 ± 0.036	1.096AsnPhe: 1.096 ± 0.03	2.469AsnGly: 2.469 ± 0.057	0.66AsnHis: 0.66 ± 0.023	1.69AsnIle: 1.69 ± 0.038	1.052AsnLys: 1.052 ± 0.028	3.062AsnLeu: 3.062 ± 0.049	0.762AsnMet: 0.762 ± 0.025	0.947AsnAsn: 0.947 ± 0.031	2.074AsnPro: 2.074 ± 0.04	1.117AsnGln: 1.117 ± 0.033	1.889AsnArg: 1.889 ± 0.039	1.667AsnSer: 1.667 ± 0.036	1.711AsnThr: 1.711 ± 0.039	2.202AsnVal: 2.202 ± 0.046	0.426AsnTrp: 0.426 ± 0.019	0.776AsnTyr: 0.776 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.86ProAla: 5.86 ± 0.077	0.392ProCys: 0.392 ± 0.014	3.23ProAsp: 3.23 ± 0.051	3.046ProGlu: 3.046 ± 0.048	1.869ProPhe: 1.869 ± 0.038	4.21ProGly: 4.21 ± 0.058	1.122ProHis: 1.122 ± 0.029	2.462ProIle: 2.462 ± 0.046	1.76ProLys: 1.76 ± 0.037	4.987ProLeu: 4.987 ± 0.067	1.228ProMet: 1.228 ± 0.03	1.513ProAsn: 1.513 ± 0.035	2.136ProPro: 2.136 ± 0.043	1.922ProGln: 1.922 ± 0.04	2.526ProArg: 2.526 ± 0.045	2.874ProSer: 2.874 ± 0.05	2.45ProThr: 2.45 ± 0.047	4.034ProVal: 4.034 ± 0.057	0.72ProTrp: 0.72 ± 0.026	1.421ProTyr: 1.421 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.589GlnAla: 5.589 ± 0.079	0.31GlnCys: 0.31 ± 0.016	1.676GlnAsp: 1.676 ± 0.04	1.806GlnGlu: 1.806 ± 0.042	1.331GlnPhe: 1.331 ± 0.033	2.979GlnGly: 2.979 ± 0.048	1.0GlnHis: 1.0 ± 0.028	2.374GlnIle: 2.374 ± 0.047	1.423GlnLys: 1.423 ± 0.037	3.846GlnLeu: 3.846 ± 0.064	1.0GlnMet: 1.0 ± 0.03	1.157GlnAsn: 1.157 ± 0.031	1.817GlnPro: 1.817 ± 0.036	1.765GlnGln: 1.765 ± 0.039	2.764GlnArg: 2.764 ± 0.05	2.273GlnSer: 2.273 ± 0.041	2.193GlnThr: 2.193 ± 0.045	2.941GlnVal: 2.941 ± 0.051	0.674GlnTrp: 0.674 ± 0.022	0.924GlnTyr: 0.924 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.6ArgAla: 6.6 ± 0.075	0.602ArgCys: 0.602 ± 0.021	3.151ArgAsp: 3.151 ± 0.052	3.381ArgGlu: 3.381 ± 0.053	2.487ArgPhe: 2.487 ± 0.044	4.137ArgGly: 4.137 ± 0.061	1.745ArgHis: 1.745 ± 0.036	3.719ArgIle: 3.719 ± 0.058	2.217ArgLys: 2.217 ± 0.042	7.163ArgLeu: 7.163 ± 0.084	1.603ArgMet: 1.603 ± 0.037	1.891ArgAsn: 1.891 ± 0.039	2.869ArgPro: 2.869 ± 0.045	2.801ArgGln: 2.801 ± 0.047	4.502ArgArg: 4.502 ± 0.065	3.417ArgSer: 3.417 ± 0.052	2.928ArgThr: 2.928 ± 0.052	4.709ArgVal: 4.709 ± 0.062	0.91ArgTrp: 0.91 ± 0.026	1.945ArgTyr: 1.945 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.365SerAla: 6.365 ± 0.076	0.549SerCys: 0.549 ± 0.02	2.873SerAsp: 2.873 ± 0.052	2.615SerGlu: 2.615 ± 0.049	2.359SerPhe: 2.359 ± 0.041	5.868SerGly: 5.868 ± 0.095	1.408SerHis: 1.408 ± 0.029	3.276SerIle: 3.276 ± 0.054	1.933SerLys: 1.933 ± 0.037	6.486SerLeu: 6.486 ± 0.07	1.604SerMet: 1.604 ± 0.033	1.729SerAsn: 1.729 ± 0.036	2.953SerPro: 2.953 ± 0.048	2.134SerGln: 2.134 ± 0.044	3.591SerArg: 3.591 ± 0.054	3.676SerSer: 3.676 ± 0.057	3.203SerThr: 3.203 ± 0.057	4.367SerVal: 4.367 ± 0.062	0.821SerTrp: 0.821 ± 0.025	1.502SerTyr: 1.502 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.43ThrAla: 5.43 ± 0.072	0.445ThrCys: 0.445 ± 0.019	2.504ThrAsp: 2.504 ± 0.045	2.346ThrGlu: 2.346 ± 0.044	1.783ThrPhe: 1.783 ± 0.037	4.669ThrGly: 4.669 ± 0.076	1.346ThrHis: 1.346 ± 0.037	2.771ThrIle: 2.771 ± 0.046	1.343ThrLys: 1.343 ± 0.036	6.555ThrLeu: 6.555 ± 0.084	1.239ThrMet: 1.239 ± 0.034	1.345ThrAsn: 1.345 ± 0.033	3.354ThrPro: 3.354 ± 0.061	2.137ThrGln: 2.137 ± 0.047	3.129ThrArg: 3.129 ± 0.049	2.889ThrSer: 2.889 ± 0.046	2.789ThrThr: 2.789 ± 0.047	4.311ThrVal: 4.311 ± 0.062	0.655ThrTrp: 0.655 ± 0.023	1.186ThrTyr: 1.186 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.831ValAla: 8.831 ± 0.082	0.817ValCys: 0.817 ± 0.025	3.88ValAsp: 3.88 ± 0.063	3.687ValGlu: 3.687 ± 0.051	3.028ValPhe: 3.028 ± 0.051	5.692ValGly: 5.692 ± 0.071	1.579ValHis: 1.579 ± 0.033	4.061ValIle: 4.061 ± 0.056	2.668ValLys: 2.668 ± 0.048	8.448ValLeu: 8.448 ± 0.1	1.972ValMet: 1.972 ± 0.04	2.3ValAsn: 2.3 ± 0.049	3.701ValPro: 3.701 ± 0.049	2.765ValGln: 2.765 ± 0.044	4.518ValArg: 4.518 ± 0.068	4.628ValSer: 4.628 ± 0.062	3.796ValThr: 3.796 ± 0.053	6.293ValVal: 6.293 ± 0.076	0.952ValTrp: 0.952 ± 0.029	1.717ValTyr: 1.717 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.229TrpAla: 1.229 ± 0.034	0.162TrpCys: 0.162 ± 0.011	0.582TrpAsp: 0.582 ± 0.022	0.533TrpGlu: 0.533 ± 0.02	0.578TrpPhe: 0.578 ± 0.024	0.941TrpGly: 0.941 ± 0.031	0.389TrpHis: 0.389 ± 0.018	0.726TrpIle: 0.726 ± 0.025	0.489TrpLys: 0.489 ± 0.02	1.96TrpLeu: 1.96 ± 0.047	0.414TrpMet: 0.414 ± 0.018	0.456TrpAsn: 0.456 ± 0.021	0.686TrpPro: 0.686 ± 0.02	0.651TrpGln: 0.651 ± 0.026	1.073TrpArg: 1.073 ± 0.033	0.814TrpSer: 0.814 ± 0.029	0.611TrpThr: 0.611 ± 0.022	0.987TrpVal: 0.987 ± 0.029	0.234TrpTrp: 0.234 ± 0.014	0.33TrpTyr: 0.33 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.702TyrAla: 2.702 ± 0.05	0.295TyrCys: 0.295 ± 0.015	1.339TyrAsp: 1.339 ± 0.038	1.203TyrGlu: 1.203 ± 0.034	1.067TyrPhe: 1.067 ± 0.032	2.281TyrGly: 2.281 ± 0.043	0.506TyrHis: 0.506 ± 0.02	1.139TyrIle: 1.139 ± 0.032	0.834TyrLys: 0.834 ± 0.028	2.587TyrLeu: 2.587 ± 0.045	0.551TyrMet: 0.551 ± 0.021	0.678TyrAsn: 0.678 ± 0.025	1.381TyrPro: 1.381 ± 0.033	1.013TyrGln: 1.013 ± 0.029	1.749TyrArg: 1.749 ± 0.038	1.487TyrSer: 1.487 ± 0.036	1.452TyrThr: 1.452 ± 0.033	1.819TyrVal: 1.819 ± 0.042	0.41TyrTrp: 0.41 ± 0.017	0.663TyrTyr: 0.663 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3977 proteins (1301549 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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