Amino acid dipepetide frequency for Cohnella kolymensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.236AlaAla: 10.236 ± 0.15	0.788AlaCys: 0.788 ± 0.031	4.81AlaAsp: 4.81 ± 0.097	6.12AlaGlu: 6.12 ± 0.093	3.424AlaPhe: 3.424 ± 0.065	7.354AlaGly: 7.354 ± 0.102	1.555AlaHis: 1.555 ± 0.041	5.569AlaIle: 5.569 ± 0.082	4.235AlaLys: 4.235 ± 0.086	8.626AlaLeu: 8.626 ± 0.105	2.564AlaMet: 2.564 ± 0.054	2.604AlaAsn: 2.604 ± 0.053	2.812AlaPro: 2.812 ± 0.066	2.943AlaGln: 2.943 ± 0.05	4.059AlaArg: 4.059 ± 0.068	5.037AlaSer: 5.037 ± 0.076	3.46AlaThr: 3.46 ± 0.076	7.347AlaVal: 7.347 ± 0.11	0.924AlaTrp: 0.924 ± 0.033	2.476AlaTyr: 2.476 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.587CysAla: 0.587 ± 0.024	0.134CysCys: 0.134 ± 0.011	0.417CysAsp: 0.417 ± 0.022	0.445CysGlu: 0.445 ± 0.021	0.265CysPhe: 0.265 ± 0.018	0.864CysGly: 0.864 ± 0.035	0.189CysHis: 0.189 ± 0.014	0.497CysIle: 0.497 ± 0.024	0.324CysLys: 0.324 ± 0.022	0.73CysLeu: 0.73 ± 0.027	0.248CysMet: 0.248 ± 0.019	0.242CysAsn: 0.242 ± 0.017	0.384CysPro: 0.384 ± 0.024	0.19CysGln: 0.19 ± 0.014	0.509CysArg: 0.509 ± 0.024	0.574CysSer: 0.574 ± 0.025	0.419CysThr: 0.419 ± 0.019	0.503CysVal: 0.503 ± 0.021	0.09CysTrp: 0.09 ± 0.009	0.253CysTyr: 0.253 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.157AspAla: 4.157 ± 0.07	0.399AspCys: 0.399 ± 0.021	2.513AspAsp: 2.513 ± 0.061	3.833AspGlu: 3.833 ± 0.065	2.152AspPhe: 2.152 ± 0.051	4.051AspGly: 4.051 ± 0.085	1.132AspHis: 1.132 ± 0.032	3.623AspIle: 3.623 ± 0.068	2.813AspLys: 2.813 ± 0.059	5.043AspLeu: 5.043 ± 0.081	1.37AspMet: 1.37 ± 0.041	1.915AspAsn: 1.915 ± 0.043	2.443AspPro: 2.443 ± 0.055	1.772AspGln: 1.772 ± 0.042	3.222AspArg: 3.222 ± 0.059	2.76AspSer: 2.76 ± 0.052	2.641AspThr: 2.641 ± 0.05	3.837AspVal: 3.837 ± 0.066	0.755AspTrp: 0.755 ± 0.03	1.891AspTyr: 1.891 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.994GluAla: 5.994 ± 0.088	0.397GluCys: 0.397 ± 0.02	3.164GluAsp: 3.164 ± 0.066	4.952GluGlu: 4.952 ± 0.1	2.17GluPhe: 2.17 ± 0.046	4.27GluGly: 4.27 ± 0.075	1.484GluHis: 1.484 ± 0.046	4.329GluIle: 4.329 ± 0.068	3.893GluLys: 3.893 ± 0.076	6.77GluLeu: 6.77 ± 0.098	2.021GluMet: 2.021 ± 0.046	2.358GluAsn: 2.358 ± 0.052	2.391GluPro: 2.391 ± 0.048	3.507GluGln: 3.507 ± 0.07	4.254GluArg: 4.254 ± 0.08	3.583GluSer: 3.583 ± 0.064	3.399GluThr: 3.399 ± 0.065	4.419GluVal: 4.419 ± 0.073	0.914GluTrp: 0.914 ± 0.034	1.883GluTyr: 1.883 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.466PheAla: 3.466 ± 0.067	0.369PheCys: 0.369 ± 0.019	2.327PheAsp: 2.327 ± 0.052	2.323PheGlu: 2.323 ± 0.06	1.818PhePhe: 1.818 ± 0.051	3.368PheGly: 3.368 ± 0.064	0.91PheHis: 0.91 ± 0.031	2.759PheIle: 2.759 ± 0.064	1.745PheLys: 1.745 ± 0.048	3.833PheLeu: 3.833 ± 0.078	1.079PheMet: 1.079 ± 0.039	1.496PheAsn: 1.496 ± 0.04	1.663PhePro: 1.663 ± 0.046	1.342PheGln: 1.342 ± 0.038	2.117PheArg: 2.117 ± 0.052	2.61PheSer: 2.61 ± 0.058	2.371PheThr: 2.371 ± 0.065	3.046PheVal: 3.046 ± 0.062	0.517PheTrp: 0.517 ± 0.024	1.361PheTyr: 1.361 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.06GlyAla: 6.06 ± 0.095	0.72GlyCys: 0.72 ± 0.032	3.567GlyAsp: 3.567 ± 0.065	4.443GlyGlu: 4.443 ± 0.069	3.323GlyPhe: 3.323 ± 0.066	5.66GlyGly: 5.66 ± 0.104	1.585GlyHis: 1.585 ± 0.044	5.628GlyIle: 5.628 ± 0.073	4.635GlyLys: 4.635 ± 0.072	7.322GlyLeu: 7.322 ± 0.102	2.521GlyMet: 2.521 ± 0.059	2.687GlyAsn: 2.687 ± 0.065	2.089GlyPro: 2.089 ± 0.05	2.563GlyGln: 2.563 ± 0.049	3.984GlyArg: 3.984 ± 0.067	4.836GlySer: 4.836 ± 0.108	4.366GlyThr: 4.366 ± 0.088	5.594GlyVal: 5.594 ± 0.086	1.142GlyTrp: 1.142 ± 0.037	2.654GlyTyr: 2.654 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.593HisAla: 1.593 ± 0.041	0.201HisCys: 0.201 ± 0.013	1.042HisAsp: 1.042 ± 0.036	1.307HisGlu: 1.307 ± 0.04	0.954HisPhe: 0.954 ± 0.034	1.651HisGly: 1.651 ± 0.043	0.601HisHis: 0.601 ± 0.028	1.293HisIle: 1.293 ± 0.045	0.881HisLys: 0.881 ± 0.031	2.142HisLeu: 2.142 ± 0.062	0.605HisMet: 0.605 ± 0.027	0.72HisAsn: 0.72 ± 0.029	1.324HisPro: 1.324 ± 0.036	0.69HisGln: 0.69 ± 0.026	1.274HisArg: 1.274 ± 0.038	1.265HisSer: 1.265 ± 0.037	1.106HisThr: 1.106 ± 0.035	1.462HisVal: 1.462 ± 0.047	0.296HisTrp: 0.296 ± 0.019	0.744HisTyr: 0.744 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.228IleAla: 6.228 ± 0.079	0.634IleCys: 0.634 ± 0.029	3.756IleAsp: 3.756 ± 0.057	4.104IleGlu: 4.104 ± 0.078	2.335IlePhe: 2.335 ± 0.054	5.456IleGly: 5.456 ± 0.089	1.47IleHis: 1.47 ± 0.043	4.123IleIle: 4.123 ± 0.079	2.985IleLys: 2.985 ± 0.067	5.847IleLeu: 5.847 ± 0.097	1.601IleMet: 1.601 ± 0.046	2.384IleAsn: 2.384 ± 0.045	3.12IlePro: 3.12 ± 0.054	2.311IleGln: 2.311 ± 0.051	3.971IleArg: 3.971 ± 0.076	4.205IleSer: 4.205 ± 0.069	3.768IleThr: 3.768 ± 0.076	5.358IleVal: 5.358 ± 0.076	0.643IleTrp: 0.643 ± 0.026	1.95IleTyr: 1.95 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.351LysAla: 4.351 ± 0.075	0.272LysCys: 0.272 ± 0.019	2.926LysAsp: 2.926 ± 0.061	4.035LysGlu: 4.035 ± 0.073	1.601LysPhe: 1.601 ± 0.038	3.524LysGly: 3.524 ± 0.064	1.051LysHis: 1.051 ± 0.034	3.127LysIle: 3.127 ± 0.06	3.093LysLys: 3.093 ± 0.069	5.3LysLeu: 5.3 ± 0.098	1.678LysMet: 1.678 ± 0.041	1.903LysAsn: 1.903 ± 0.048	2.387LysPro: 2.387 ± 0.054	2.33LysGln: 2.33 ± 0.055	2.896LysArg: 2.896 ± 0.056	2.996LysSer: 2.996 ± 0.06	2.677LysThr: 2.677 ± 0.063	3.818LysVal: 3.818 ± 0.073	0.689LysTrp: 0.689 ± 0.026	1.65LysTyr: 1.65 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	8.716LeuAla: 8.716 ± 0.123	0.81LeuCys: 0.81 ± 0.026	5.001LeuAsp: 5.001 ± 0.069	6.086LeuGlu: 6.086 ± 0.088	4.492LeuPhe: 4.492 ± 0.087	6.932LeuGly: 6.932 ± 0.089	2.12LeuHis: 2.12 ± 0.052	6.556LeuIle: 6.556 ± 0.099	5.269LeuLys: 5.269 ± 0.083	10.848LeuLeu: 10.848 ± 0.158	2.736LeuMet: 2.736 ± 0.056	3.846LeuAsn: 3.846 ± 0.063	4.45LeuPro: 4.45 ± 0.074	4.052LeuGln: 4.052 ± 0.075	5.228LeuArg: 5.228 ± 0.084	6.945LeuSer: 6.945 ± 0.087	5.678LeuThr: 5.678 ± 0.082	6.344LeuVal: 6.344 ± 0.088	1.008LeuTrp: 1.008 ± 0.038	2.821LeuTyr: 2.821 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.528MetAla: 2.528 ± 0.051	0.183MetCys: 0.183 ± 0.013	1.538MetAsp: 1.538 ± 0.043	1.962MetGlu: 1.962 ± 0.054	1.098MetPhe: 1.098 ± 0.041	1.972MetGly: 1.972 ± 0.06	0.478MetHis: 0.478 ± 0.022	1.937MetIle: 1.937 ± 0.044	1.945MetLys: 1.945 ± 0.042	2.881MetLeu: 2.881 ± 0.057	0.912MetMet: 0.912 ± 0.032	1.442MetAsn: 1.442 ± 0.041	1.307MetPro: 1.307 ± 0.05	1.107MetGln: 1.107 ± 0.033	1.53MetArg: 1.53 ± 0.042	1.885MetSer: 1.885 ± 0.048	1.71MetThr: 1.71 ± 0.038	1.807MetVal: 1.807 ± 0.044	0.235MetTrp: 0.235 ± 0.017	0.721MetTyr: 0.721 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.961AsnAla: 2.961 ± 0.069	0.285AsnCys: 0.285 ± 0.017	1.915AsnAsp: 1.915 ± 0.052	2.444AsnGlu: 2.444 ± 0.059	1.292AsnPhe: 1.292 ± 0.038	3.12AsnGly: 3.12 ± 0.073	0.726AsnHis: 0.726 ± 0.031	2.407AsnIle: 2.407 ± 0.045	1.887AsnLys: 1.887 ± 0.049	3.284AsnLeu: 3.284 ± 0.066	1.077AsnMet: 1.077 ± 0.048	1.463AsnAsn: 1.463 ± 0.047	2.084AsnPro: 2.084 ± 0.045	1.233AsnGln: 1.233 ± 0.045	2.233AsnArg: 2.233 ± 0.047	1.94AsnSer: 1.94 ± 0.05	1.829AsnThr: 1.829 ± 0.044	2.712AsnVal: 2.712 ± 0.058	0.459AsnTrp: 0.459 ± 0.021	1.201AsnTyr: 1.201 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.762ProAla: 3.762 ± 0.066	0.237ProCys: 0.237 ± 0.017	2.795ProAsp: 2.795 ± 0.053	3.466ProGlu: 3.466 ± 0.066	1.936ProPhe: 1.936 ± 0.051	3.096ProGly: 3.096 ± 0.064	0.919ProHis: 0.919 ± 0.033	2.46ProIle: 2.46 ± 0.052	1.886ProLys: 1.886 ± 0.044	4.079ProLeu: 4.079 ± 0.079	1.064ProMet: 1.064 ± 0.036	1.549ProAsn: 1.549 ± 0.041	1.398ProPro: 1.398 ± 0.048	1.392ProGln: 1.392 ± 0.038	1.652ProArg: 1.652 ± 0.046	2.568ProSer: 2.568 ± 0.054	1.911ProThr: 1.911 ± 0.051	3.429ProVal: 3.429 ± 0.072	0.512ProTrp: 0.512 ± 0.021	1.455ProTyr: 1.455 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.401GlnAla: 3.401 ± 0.06	0.22GlnCys: 0.22 ± 0.014	1.63GlnAsp: 1.63 ± 0.046	2.406GlnGlu: 2.406 ± 0.049	1.425GlnPhe: 1.425 ± 0.046	2.601GlnGly: 2.601 ± 0.053	0.784GlnHis: 0.784 ± 0.026	2.349GlnIle: 2.349 ± 0.05	1.951GlnLys: 1.951 ± 0.052	4.04GlnLeu: 4.04 ± 0.07	1.211GlnMet: 1.211 ± 0.037	1.23GlnAsn: 1.23 ± 0.035	1.576GlnPro: 1.576 ± 0.045	1.884GlnGln: 1.884 ± 0.049	2.091GlnArg: 2.091 ± 0.049	2.236GlnSer: 2.236 ± 0.049	1.909GlnThr: 1.909 ± 0.046	2.424GlnVal: 2.424 ± 0.051	0.555GlnTrp: 0.555 ± 0.025	1.216GlnTyr: 1.216 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.838ArgAla: 3.838 ± 0.064	0.375ArgCys: 0.375 ± 0.022	2.745ArgAsp: 2.745 ± 0.056	3.938ArgGlu: 3.938 ± 0.078	2.416ArgPhe: 2.416 ± 0.051	3.292ArgGly: 3.292 ± 0.064	1.305ArgHis: 1.305 ± 0.037	3.9ArgIle: 3.9 ± 0.07	3.318ArgLys: 3.318 ± 0.06	5.58ArgLeu: 5.58 ± 0.094	1.846ArgMet: 1.846 ± 0.04	2.163ArgAsn: 2.163 ± 0.04	1.92ArgPro: 1.92 ± 0.049	2.334ArgGln: 2.334 ± 0.049	3.412ArgArg: 3.412 ± 0.062	3.368ArgSer: 3.368 ± 0.067	2.882ArgThr: 2.882 ± 0.055	3.566ArgVal: 3.566 ± 0.078	0.744ArgTrp: 0.744 ± 0.032	1.907ArgTyr: 1.907 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.266SerAla: 5.266 ± 0.078	0.451SerCys: 0.451 ± 0.024	3.089SerAsp: 3.089 ± 0.052	3.667SerGlu: 3.667 ± 0.071	2.736SerPhe: 2.736 ± 0.061	5.187SerGly: 5.187 ± 0.075	1.291SerHis: 1.291 ± 0.041	4.225SerIle: 4.225 ± 0.082	3.012SerLys: 3.012 ± 0.052	6.277SerLeu: 6.277 ± 0.092	1.802SerMet: 1.802 ± 0.048	2.128SerAsn: 2.128 ± 0.052	2.572SerPro: 2.572 ± 0.056	1.955SerGln: 1.955 ± 0.05	3.395SerArg: 3.395 ± 0.064	4.017SerSer: 4.017 ± 0.074	3.117SerThr: 3.117 ± 0.059	4.618SerVal: 4.618 ± 0.094	0.814SerTrp: 0.814 ± 0.03	1.949SerTyr: 1.949 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.989ThrAla: 4.989 ± 0.09	0.353ThrCys: 0.353 ± 0.019	2.932ThrAsp: 2.932 ± 0.06	3.303ThrGlu: 3.303 ± 0.064	2.161ThrPhe: 2.161 ± 0.054	4.644ThrGly: 4.644 ± 0.073	1.036ThrHis: 1.036 ± 0.032	3.544ThrIle: 3.544 ± 0.073	2.341ThrLys: 2.341 ± 0.056	5.286ThrLeu: 5.286 ± 0.084	1.395ThrMet: 1.395 ± 0.04	1.816ThrAsn: 1.816 ± 0.045	2.571ThrPro: 2.571 ± 0.062	1.469ThrGln: 1.469 ± 0.038	2.357ThrArg: 2.357 ± 0.057	3.047ThrSer: 3.047 ± 0.075	2.71ThrThr: 2.71 ± 0.051	4.672ThrVal: 4.672 ± 0.076	0.603ThrTrp: 0.603 ± 0.026	1.651ThrTyr: 1.651 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.581ValAla: 5.581 ± 0.082	0.674ValCys: 0.674 ± 0.027	3.748ValAsp: 3.748 ± 0.066	4.436ValGlu: 4.436 ± 0.068	2.965ValPhe: 2.965 ± 0.074	4.934ValGly: 4.934 ± 0.086	1.593ValHis: 1.593 ± 0.043	5.123ValIle: 5.123 ± 0.066	3.924ValLys: 3.924 ± 0.062	7.431ValLeu: 7.431 ± 0.1	2.176ValMet: 2.176 ± 0.048	2.83ValAsn: 2.83 ± 0.054	3.297ValPro: 3.297 ± 0.056	2.527ValGln: 2.527 ± 0.047	3.924ValArg: 3.924 ± 0.064	4.996ValSer: 4.996 ± 0.076	4.643ValThr: 4.643 ± 0.084	5.466ValVal: 5.466 ± 0.087	0.866ValTrp: 0.866 ± 0.032	2.317ValTyr: 2.317 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.834TrpAla: 0.834 ± 0.035	0.087TrpCys: 0.087 ± 0.009	0.641TrpAsp: 0.641 ± 0.03	0.694TrpGlu: 0.694 ± 0.027	0.568TrpPhe: 0.568 ± 0.025	0.807TrpGly: 0.807 ± 0.035	0.232TrpHis: 0.232 ± 0.018	0.875TrpIle: 0.875 ± 0.035	0.737TrpLys: 0.737 ± 0.029	1.477TrpLeu: 1.477 ± 0.048	0.455TrpMet: 0.455 ± 0.025	0.622TrpAsn: 0.622 ± 0.024	0.356TrpPro: 0.356 ± 0.019	0.471TrpGln: 0.471 ± 0.022	0.681TrpArg: 0.681 ± 0.029	0.772TrpSer: 0.772 ± 0.032	0.679TrpThr: 0.679 ± 0.026	0.818TrpVal: 0.818 ± 0.031	0.185TrpTrp: 0.185 ± 0.015	0.367TrpTyr: 0.367 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.395TyrAla: 2.395 ± 0.056	0.277TyrCys: 0.277 ± 0.017	1.767TyrAsp: 1.767 ± 0.046	2.19TyrGlu: 2.19 ± 0.045	1.389TyrPhe: 1.389 ± 0.045	2.597TyrGly: 2.597 ± 0.051	0.688TyrHis: 0.688 ± 0.028	1.928TyrIle: 1.928 ± 0.047	1.429TyrLys: 1.429 ± 0.046	3.14TyrLeu: 3.14 ± 0.068	0.815TyrMet: 0.815 ± 0.026	1.157TyrAsn: 1.157 ± 0.042	1.423TyrPro: 1.423 ± 0.034	1.064TyrGln: 1.064 ± 0.038	2.058TyrArg: 2.058 ± 0.053	1.929TyrSer: 1.929 ± 0.049	1.605TyrThr: 1.605 ± 0.05	2.211TyrVal: 2.211 ± 0.049	0.405TyrTrp: 0.405 ± 0.02	1.172TyrTyr: 1.172 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3360 proteins (940578 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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