Amino acid dipepetide frequency for Azonexus hydrophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.597AlaAla: 15.597 ± 0.199	1.385AlaCys: 1.385 ± 0.043	6.708AlaAsp: 6.708 ± 0.09	7.416AlaGlu: 7.416 ± 0.101	4.032AlaPhe: 4.032 ± 0.068	10.693AlaGly: 10.693 ± 0.115	2.298AlaHis: 2.298 ± 0.042	6.104AlaIle: 6.104 ± 0.08	3.932AlaLys: 3.932 ± 0.084	13.262AlaLeu: 13.262 ± 0.132	3.293AlaMet: 3.293 ± 0.057	3.16AlaAsn: 3.16 ± 0.051	4.609AlaPro: 4.609 ± 0.083	4.205AlaGln: 4.205 ± 0.08	7.885AlaArg: 7.885 ± 0.098	5.897AlaSer: 5.897 ± 0.091	5.288AlaThr: 5.288 ± 0.079	8.413AlaVal: 8.413 ± 0.105	1.703AlaTrp: 1.703 ± 0.043	2.447AlaTyr: 2.447 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.115CysAla: 1.115 ± 0.035	0.168CysCys: 0.168 ± 0.014	0.615CysAsp: 0.615 ± 0.028	0.533CysGlu: 0.533 ± 0.023	0.367CysPhe: 0.367 ± 0.019	1.014CysGly: 1.014 ± 0.035	0.359CysHis: 0.359 ± 0.019	0.49CysIle: 0.49 ± 0.022	0.313CysLys: 0.313 ± 0.019	1.129CysLeu: 1.129 ± 0.032	0.195CysMet: 0.195 ± 0.013	0.304CysAsn: 0.304 ± 0.016	0.611CysPro: 0.611 ± 0.027	0.35CysGln: 0.35 ± 0.018	0.714CysArg: 0.714 ± 0.025	0.55CysSer: 0.55 ± 0.026	0.509CysThr: 0.509 ± 0.021	0.667CysVal: 0.667 ± 0.027	0.141CysTrp: 0.141 ± 0.012	0.258CysTyr: 0.258 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.23AspAla: 6.23 ± 0.093	0.602AspCys: 0.602 ± 0.023	3.129AspAsp: 3.129 ± 0.061	3.617AspGlu: 3.617 ± 0.064	2.482AspPhe: 2.482 ± 0.052	4.765AspGly: 4.765 ± 0.077	1.183AspHis: 1.183 ± 0.036	3.167AspIle: 3.167 ± 0.059	2.03AspLys: 2.03 ± 0.045	5.532AspLeu: 5.532 ± 0.076	1.293AspMet: 1.293 ± 0.039	1.558AspAsn: 1.558 ± 0.04	2.793AspPro: 2.793 ± 0.052	1.697AspGln: 1.697 ± 0.048	3.454AspArg: 3.454 ± 0.072	2.722AspSer: 2.722 ± 0.051	2.409AspThr: 2.409 ± 0.052	3.575AspVal: 3.575 ± 0.063	1.013AspTrp: 1.013 ± 0.034	1.582AspTyr: 1.582 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.984GluAla: 6.984 ± 0.092	0.488GluCys: 0.488 ± 0.021	2.469GluAsp: 2.469 ± 0.049	3.271GluGlu: 3.271 ± 0.075	2.1GluPhe: 2.1 ± 0.049	3.589GluGly: 3.589 ± 0.066	1.492GluHis: 1.492 ± 0.043	3.977GluIle: 3.977 ± 0.06	2.896GluLys: 2.896 ± 0.06	6.542GluLeu: 6.542 ± 0.083	1.622GluMet: 1.622 ± 0.042	1.942GluAsn: 1.942 ± 0.048	2.18GluPro: 2.18 ± 0.045	2.825GluGln: 2.825 ± 0.065	4.86GluArg: 4.86 ± 0.074	3.003GluSer: 3.003 ± 0.051	3.164GluThr: 3.164 ± 0.053	4.103GluVal: 4.103 ± 0.059	0.77GluTrp: 0.77 ± 0.026	1.213GluTyr: 1.213 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.691PheAla: 4.691 ± 0.072	0.487PheCys: 0.487 ± 0.023	2.443PheAsp: 2.443 ± 0.046	2.086PheGlu: 2.086 ± 0.051	1.604PhePhe: 1.604 ± 0.046	3.344PheGly: 3.344 ± 0.057	0.749PheHis: 0.749 ± 0.028	1.86PheIle: 1.86 ± 0.051	1.182PheLys: 1.182 ± 0.036	3.58PheLeu: 3.58 ± 0.061	0.834PheMet: 0.834 ± 0.028	1.207PheAsn: 1.207 ± 0.033	1.611PhePro: 1.611 ± 0.043	1.108PheGln: 1.108 ± 0.034	2.212PheArg: 2.212 ± 0.042	2.52PheSer: 2.52 ± 0.052	1.894PheThr: 1.894 ± 0.043	2.859PheVal: 2.859 ± 0.058	0.567PheTrp: 0.567 ± 0.028	0.931PheTyr: 0.931 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.457GlyAla: 7.457 ± 0.103	1.022GlyCys: 1.022 ± 0.033	4.263GlyAsp: 4.263 ± 0.066	5.28GlyGlu: 5.28 ± 0.075	3.39GlyPhe: 3.39 ± 0.059	6.234GlyGly: 6.234 ± 0.102	1.871GlyHis: 1.871 ± 0.043	4.956GlyIle: 4.956 ± 0.064	3.972GlyLys: 3.972 ± 0.074	8.603GlyLeu: 8.603 ± 0.105	2.416GlyMet: 2.416 ± 0.044	2.518GlyAsn: 2.518 ± 0.05	2.391GlyPro: 2.391 ± 0.048	3.278GlyGln: 3.278 ± 0.05	5.424GlyArg: 5.424 ± 0.07	4.406GlySer: 4.406 ± 0.072	3.728GlyThr: 3.728 ± 0.066	5.787GlyVal: 5.787 ± 0.088	1.324GlyTrp: 1.324 ± 0.036	2.211GlyTyr: 2.211 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.547HisAla: 2.547 ± 0.055	0.284HisCys: 0.284 ± 0.017	1.302HisAsp: 1.302 ± 0.038	1.243HisGlu: 1.243 ± 0.035	1.078HisPhe: 1.078 ± 0.034	2.059HisGly: 2.059 ± 0.044	0.632HisHis: 0.632 ± 0.027	1.021HisIle: 1.021 ± 0.034	0.602HisLys: 0.602 ± 0.023	2.505HisLeu: 2.505 ± 0.051	0.434HisMet: 0.434 ± 0.025	0.564HisAsn: 0.564 ± 0.023	1.475HisPro: 1.475 ± 0.034	0.744HisGln: 0.744 ± 0.028	1.45HisArg: 1.45 ± 0.031	1.007HisSer: 1.007 ± 0.031	0.91HisThr: 0.91 ± 0.028	1.505HisVal: 1.505 ± 0.041	0.385HisTrp: 0.385 ± 0.016	0.7HisTyr: 0.7 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.903IleAla: 6.903 ± 0.077	0.569IleCys: 0.569 ± 0.024	3.577IleAsp: 3.577 ± 0.059	3.729IleGlu: 3.729 ± 0.074	1.766IlePhe: 1.766 ± 0.042	4.85IleGly: 4.85 ± 0.073	1.146IleHis: 1.146 ± 0.033	2.316IleIle: 2.316 ± 0.055	1.827IleLys: 1.827 ± 0.047	4.666IleLeu: 4.666 ± 0.069	0.978IleMet: 0.978 ± 0.031	1.766IleAsn: 1.766 ± 0.039	2.38IlePro: 2.38 ± 0.048	1.456IleGln: 1.456 ± 0.034	3.398IleArg: 3.398 ± 0.06	3.019IleSer: 3.019 ± 0.057	2.545IleThr: 2.545 ± 0.056	4.072IleVal: 4.072 ± 0.065	0.505IleTrp: 0.505 ± 0.023	1.181IleTyr: 1.181 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.239LysAla: 4.239 ± 0.069	0.224LysCys: 0.224 ± 0.014	1.738LysAsp: 1.738 ± 0.042	1.919LysGlu: 1.919 ± 0.047	1.165LysPhe: 1.165 ± 0.034	2.492LysGly: 2.492 ± 0.06	0.812LysHis: 0.812 ± 0.028	2.013LysIle: 2.013 ± 0.045	1.803LysLys: 1.803 ± 0.047	4.187LysLeu: 4.187 ± 0.069	0.996LysMet: 0.996 ± 0.031	1.194LysAsn: 1.194 ± 0.039	2.165LysPro: 2.165 ± 0.061	1.516LysGln: 1.516 ± 0.042	2.35LysArg: 2.35 ± 0.047	1.989LysSer: 1.989 ± 0.038	2.099LysThr: 2.099 ± 0.051	2.564LysVal: 2.564 ± 0.054	0.376LysTrp: 0.376 ± 0.019	0.813LysTyr: 0.813 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.164LeuAla: 15.164 ± 0.166	1.09LeuCys: 1.09 ± 0.032	6.196LeuAsp: 6.196 ± 0.084	5.976LeuGlu: 5.976 ± 0.083	3.982LeuPhe: 3.982 ± 0.083	8.599LeuGly: 8.599 ± 0.102	2.369LeuHis: 2.369 ± 0.055	5.406LeuIle: 5.406 ± 0.083	4.037LeuLys: 4.037 ± 0.062	12.568LeuLeu: 12.568 ± 0.168	2.381LeuMet: 2.381 ± 0.053	3.125LeuAsn: 3.125 ± 0.057	6.399LeuPro: 6.399 ± 0.095	3.876LeuGln: 3.876 ± 0.064	7.438LeuArg: 7.438 ± 0.089	6.156LeuSer: 6.156 ± 0.091	5.641LeuThr: 5.641 ± 0.066	7.316LeuVal: 7.316 ± 0.086	1.276LeuTrp: 1.276 ± 0.037	2.119LeuTyr: 2.119 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.866MetAla: 2.866 ± 0.049	0.156MetCys: 0.156 ± 0.012	1.123MetAsp: 1.123 ± 0.034	1.185MetGlu: 1.185 ± 0.033	0.782MetPhe: 0.782 ± 0.025	1.637MetGly: 1.637 ± 0.048	0.592MetHis: 0.592 ± 0.023	1.142MetIle: 1.142 ± 0.032	1.097MetLys: 1.097 ± 0.034	2.833MetLeu: 2.833 ± 0.056	0.594MetMet: 0.594 ± 0.024	0.994MetAsn: 0.994 ± 0.027	1.446MetPro: 1.446 ± 0.039	1.103MetGln: 1.103 ± 0.034	1.647MetArg: 1.647 ± 0.038	1.621MetSer: 1.621 ± 0.038	1.425MetThr: 1.425 ± 0.044	1.583MetVal: 1.583 ± 0.045	0.214MetTrp: 0.214 ± 0.013	0.361MetTyr: 0.361 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.297AsnAla: 3.297 ± 0.056	0.339AsnCys: 0.339 ± 0.018	1.57AsnAsp: 1.57 ± 0.038	1.558AsnGlu: 1.558 ± 0.039	1.133AsnPhe: 1.133 ± 0.035	2.444AsnGly: 2.444 ± 0.052	0.624AsnHis: 0.624 ± 0.024	1.576AsnIle: 1.576 ± 0.038	0.998AsnLys: 0.998 ± 0.034	3.22AsnLeu: 3.22 ± 0.054	0.661AsnMet: 0.661 ± 0.024	0.887AsnAsn: 0.887 ± 0.032	2.023AsnPro: 2.023 ± 0.044	0.989AsnGln: 0.989 ± 0.031	1.995AsnArg: 1.995 ± 0.046	1.411AsnSer: 1.411 ± 0.036	1.431AsnThr: 1.431 ± 0.04	1.946AsnVal: 1.946 ± 0.042	0.442AsnTrp: 0.442 ± 0.021	0.774AsnTyr: 0.774 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.254ProAla: 6.254 ± 0.091	0.424ProCys: 0.424 ± 0.023	3.086ProAsp: 3.086 ± 0.051	3.771ProGlu: 3.771 ± 0.059	1.744ProPhe: 1.744 ± 0.036	4.229ProGly: 4.229 ± 0.066	0.917ProHis: 0.917 ± 0.032	1.987ProIle: 1.987 ± 0.047	1.537ProLys: 1.537 ± 0.043	5.14ProLeu: 5.14 ± 0.078	1.115ProMet: 1.115 ± 0.028	1.245ProAsn: 1.245 ± 0.036	2.282ProPro: 2.282 ± 0.056	1.716ProGln: 1.716 ± 0.048	2.443ProArg: 2.443 ± 0.047	2.086ProSer: 2.086 ± 0.048	2.157ProThr: 2.157 ± 0.044	4.133ProVal: 4.133 ± 0.068	0.672ProTrp: 0.672 ± 0.027	1.113ProTyr: 1.113 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.923GlnAla: 4.923 ± 0.074	0.303GlnCys: 0.303 ± 0.017	1.429GlnAsp: 1.429 ± 0.035	1.894GlnGlu: 1.894 ± 0.043	1.196GlnPhe: 1.196 ± 0.036	2.746GlnGly: 2.746 ± 0.058	0.957GlnHis: 0.957 ± 0.031	1.938GlnIle: 1.938 ± 0.039	1.374GlnLys: 1.374 ± 0.038	4.305GlnLeu: 4.305 ± 0.082	1.039GlnMet: 1.039 ± 0.031	0.928GlnAsn: 0.928 ± 0.031	2.002GlnPro: 2.002 ± 0.044	1.981GlnGln: 1.981 ± 0.054	3.015GlnArg: 3.015 ± 0.061	1.872GlnSer: 1.872 ± 0.049	1.803GlnThr: 1.803 ± 0.041	2.734GlnVal: 2.734 ± 0.054	0.493GlnTrp: 0.493 ± 0.024	0.786GlnTyr: 0.786 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.319ArgAla: 6.319 ± 0.086	0.657ArgCys: 0.657 ± 0.026	3.683ArgAsp: 3.683 ± 0.058	4.513ArgGlu: 4.513 ± 0.066	2.824ArgPhe: 2.824 ± 0.057	4.118ArgGly: 4.118 ± 0.065	1.865ArgHis: 1.865 ± 0.046	4.178ArgIle: 4.178 ± 0.071	2.372ArgLys: 2.372 ± 0.052	8.452ArgLeu: 8.452 ± 0.108	1.826ArgMet: 1.826 ± 0.039	2.147ArgAsn: 2.147 ± 0.045	2.96ArgPro: 2.96 ± 0.058	3.351ArgGln: 3.351 ± 0.064	4.927ArgArg: 4.927 ± 0.085	3.31ArgSer: 3.31 ± 0.057	2.807ArgThr: 2.807 ± 0.053	4.327ArgVal: 4.327 ± 0.061	1.021ArgTrp: 1.021 ± 0.035	1.883ArgTyr: 1.883 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.783SerAla: 5.783 ± 0.079	0.549SerCys: 0.549 ± 0.022	2.652SerAsp: 2.652 ± 0.049	2.95SerGlu: 2.95 ± 0.058	2.15SerPhe: 2.15 ± 0.048	5.164SerGly: 5.164 ± 0.08	1.153SerHis: 1.153 ± 0.035	2.801SerIle: 2.801 ± 0.058	1.629SerLys: 1.629 ± 0.036	5.944SerLeu: 5.944 ± 0.084	1.234SerMet: 1.234 ± 0.036	1.467SerAsn: 1.467 ± 0.042	2.588SerPro: 2.588 ± 0.046	1.841SerGln: 1.841 ± 0.044	3.635SerArg: 3.635 ± 0.064	2.915SerSer: 2.915 ± 0.057	2.739SerThr: 2.739 ± 0.051	3.706SerVal: 3.706 ± 0.063	0.646SerTrp: 0.646 ± 0.025	1.183SerTyr: 1.183 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.66ThrAla: 5.66 ± 0.081	0.448ThrCys: 0.448 ± 0.022	2.409ThrAsp: 2.409 ± 0.051	2.376ThrGlu: 2.376 ± 0.044	1.62ThrPhe: 1.62 ± 0.038	4.471ThrGly: 4.471 ± 0.056	1.097ThrHis: 1.097 ± 0.032	2.271ThrIle: 2.271 ± 0.046	1.287ThrLys: 1.287 ± 0.037	6.183ThrLeu: 6.183 ± 0.077	0.994ThrMet: 0.994 ± 0.031	1.185ThrAsn: 1.185 ± 0.037	3.09ThrPro: 3.09 ± 0.052	1.759ThrGln: 1.759 ± 0.041	3.167ThrArg: 3.167 ± 0.053	2.299ThrSer: 2.299 ± 0.051	2.498ThrThr: 2.498 ± 0.056	3.772ThrVal: 3.772 ± 0.064	0.641ThrTrp: 0.641 ± 0.026	1.007ThrTyr: 1.007 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.714ValAla: 8.714 ± 0.101	0.766ValCys: 0.766 ± 0.03	4.634ValAsp: 4.634 ± 0.065	4.37ValGlu: 4.37 ± 0.058	2.799ValPhe: 2.799 ± 0.057	5.294ValGly: 5.294 ± 0.077	1.448ValHis: 1.448 ± 0.035	3.869ValIle: 3.869 ± 0.055	2.508ValLys: 2.508 ± 0.055	7.648ValLeu: 7.648 ± 0.096	1.733ValMet: 1.733 ± 0.048	2.071ValAsn: 2.071 ± 0.049	3.233ValPro: 3.233 ± 0.051	2.061ValGln: 2.061 ± 0.042	4.574ValArg: 4.574 ± 0.068	4.029ValSer: 4.029 ± 0.066	3.508ValThr: 3.508 ± 0.059	5.811ValVal: 5.811 ± 0.085	0.806ValTrp: 0.806 ± 0.032	1.433ValTyr: 1.433 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.134TrpAla: 1.134 ± 0.033	0.151TrpCys: 0.151 ± 0.013	0.528TrpAsp: 0.528 ± 0.024	0.624TrpGlu: 0.624 ± 0.026	0.546TrpPhe: 0.546 ± 0.023	0.8TrpGly: 0.8 ± 0.028	0.358TrpHis: 0.358 ± 0.018	0.649TrpIle: 0.649 ± 0.026	0.497TrpLys: 0.497 ± 0.02	2.194TrpLeu: 2.194 ± 0.051	0.322TrpMet: 0.322 ± 0.017	0.415TrpAsn: 0.415 ± 0.022	0.633TrpPro: 0.633 ± 0.021	0.95TrpGln: 0.95 ± 0.041	1.123TrpArg: 1.123 ± 0.037	0.706TrpSer: 0.706 ± 0.028	0.568TrpThr: 0.568 ± 0.025	0.882TrpVal: 0.882 ± 0.026	0.25TrpTrp: 0.25 ± 0.017	0.28TrpTyr: 0.28 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.454TyrAla: 2.454 ± 0.044	0.292TyrCys: 0.292 ± 0.017	1.28TyrAsp: 1.28 ± 0.036	1.178TyrGlu: 1.178 ± 0.042	1.01TyrPhe: 1.01 ± 0.032	1.99TyrGly: 1.99 ± 0.045	0.523TyrHis: 0.523 ± 0.018	0.929TyrIle: 0.929 ± 0.031	0.761TyrLys: 0.761 ± 0.033	2.622TyrLeu: 2.622 ± 0.051	0.437TyrMet: 0.437 ± 0.021	0.642TyrAsn: 0.642 ± 0.026	1.181TyrPro: 1.181 ± 0.032	0.91TyrGln: 0.91 ± 0.028	1.833TyrArg: 1.833 ± 0.046	1.209TyrSer: 1.209 ± 0.031	1.108TyrThr: 1.108 ± 0.033	1.553TyrVal: 1.553 ± 0.04	0.367TyrTrp: 0.367 ± 0.018	0.596TyrTyr: 0.596 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3392 proteins (1107130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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