Amino acid dipepetide frequency for Dictyobacter sp. Uno17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.79AlaAla: 8.79 ± 0.086	1.01AlaCys: 1.01 ± 0.023	4.213AlaAsp: 4.213 ± 0.058	5.076AlaGlu: 5.076 ± 0.056	3.356AlaPhe: 3.356 ± 0.048	6.458AlaGly: 6.458 ± 0.074	2.529AlaHis: 2.529 ± 0.032	5.731AlaIle: 5.731 ± 0.063	2.561AlaLys: 2.561 ± 0.044	11.319AlaLeu: 11.319 ± 0.099	2.142AlaMet: 2.142 ± 0.034	3.089AlaAsn: 3.089 ± 0.041	3.921AlaPro: 3.921 ± 0.049	5.115AlaGln: 5.115 ± 0.063	5.717AlaArg: 5.717 ± 0.057	5.934AlaSer: 5.934 ± 0.054	5.775AlaThr: 5.775 ± 0.07	5.867AlaVal: 5.867 ± 0.073	1.23AlaTrp: 1.23 ± 0.027	2.911AlaTyr: 2.911 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.814CysAla: 0.814 ± 0.021	0.163CysCys: 0.163 ± 0.01	0.457CysAsp: 0.457 ± 0.015	0.493CysGlu: 0.493 ± 0.019	0.376CysPhe: 0.376 ± 0.014	0.862CysGly: 0.862 ± 0.023	0.277CysHis: 0.277 ± 0.013	0.625CysIle: 0.625 ± 0.017	0.271CysLys: 0.271 ± 0.012	1.053CysLeu: 1.053 ± 0.023	0.197CysMet: 0.197 ± 0.01	0.311CysAsn: 0.311 ± 0.012	0.488CysPro: 0.488 ± 0.016	0.461CysGln: 0.461 ± 0.016	0.476CysArg: 0.476 ± 0.015	0.642CysSer: 0.642 ± 0.02	0.559CysThr: 0.559 ± 0.02	0.609CysVal: 0.609 ± 0.019	0.157CysTrp: 0.157 ± 0.009	0.351CysTyr: 0.351 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.557AspAla: 4.557 ± 0.049	0.403AspCys: 0.403 ± 0.014	2.322AspAsp: 2.322 ± 0.038	3.254AspGlu: 3.254 ± 0.043	1.811AspPhe: 1.811 ± 0.03	3.395AspGly: 3.395 ± 0.045	1.214AspHis: 1.214 ± 0.025	3.196AspIle: 3.196 ± 0.037	1.517AspLys: 1.517 ± 0.03	5.272AspLeu: 5.272 ± 0.058	1.124AspMet: 1.124 ± 0.028	1.611AspAsn: 1.611 ± 0.035	2.861AspPro: 2.861 ± 0.044	2.294AspGln: 2.294 ± 0.04	2.403AspArg: 2.403 ± 0.036	2.29AspSer: 2.29 ± 0.036	2.863AspThr: 2.863 ± 0.042	3.479AspVal: 3.479 ± 0.043	0.763AspTrp: 0.763 ± 0.021	1.667AspTyr: 1.667 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.486GluAla: 5.486 ± 0.068	0.415GluCys: 0.415 ± 0.016	2.797GluAsp: 2.797 ± 0.047	4.144GluGlu: 4.144 ± 0.067	1.478GluPhe: 1.478 ± 0.029	3.134GluGly: 3.134 ± 0.042	1.905GluHis: 1.905 ± 0.033	3.587GluIle: 3.587 ± 0.049	2.494GluLys: 2.494 ± 0.036	5.8GluLeu: 5.8 ± 0.068	1.451GluMet: 1.451 ± 0.031	1.894GluAsn: 1.894 ± 0.03	2.335GluPro: 2.335 ± 0.035	4.436GluGln: 4.436 ± 0.057	4.462GluArg: 4.462 ± 0.054	2.597GluSer: 2.597 ± 0.038	3.165GluThr: 3.165 ± 0.044	3.68GluVal: 3.68 ± 0.053	0.651GluTrp: 0.651 ± 0.02	1.608GluTyr: 1.608 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.256PheAla: 3.256 ± 0.038	0.48PheCys: 0.48 ± 0.017	1.959PheAsp: 1.959 ± 0.033	1.895PheGlu: 1.895 ± 0.034	1.706PhePhe: 1.706 ± 0.035	2.711PheGly: 2.711 ± 0.039	0.919PheHis: 0.919 ± 0.02	2.072PheIle: 2.072 ± 0.032	1.052PheLys: 1.052 ± 0.024	3.788PheLeu: 3.788 ± 0.054	0.785PheMet: 0.785 ± 0.021	1.244PheAsn: 1.244 ± 0.026	1.707PhePro: 1.707 ± 0.03	1.554PheGln: 1.554 ± 0.031	1.622PheArg: 1.622 ± 0.025	2.627PheSer: 2.627 ± 0.045	2.295PheThr: 2.295 ± 0.035	2.509PheVal: 2.509 ± 0.035	0.577PheTrp: 0.577 ± 0.015	1.195PheTyr: 1.195 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	5.61GlyAla: 5.61 ± 0.063	0.713GlyCys: 0.713 ± 0.021	3.0GlyAsp: 3.0 ± 0.047	3.553GlyGlu: 3.553 ± 0.043	2.539GlyPhe: 2.539 ± 0.04	5.103GlyGly: 5.103 ± 0.07	1.783GlyHis: 1.783 ± 0.034	4.755GlyIle: 4.755 ± 0.054	3.167GlyLys: 3.167 ± 0.044	6.807GlyLeu: 6.807 ± 0.069	1.829GlyMet: 1.829 ± 0.033	2.645GlyAsn: 2.645 ± 0.045	2.525GlyPro: 2.525 ± 0.039	3.342GlyGln: 3.342 ± 0.054	3.661GlyArg: 3.661 ± 0.05	4.619GlySer: 4.619 ± 0.053	4.386GlyThr: 4.386 ± 0.055	4.674GlyVal: 4.674 ± 0.059	1.146GlyTrp: 1.146 ± 0.029	2.516GlyTyr: 2.516 ± 0.038	0.001GlyXaa: 0.001 ± 0.001
His	2.39HisAla: 2.39 ± 0.042	0.322HisCys: 0.322 ± 0.013	1.265HisAsp: 1.265 ± 0.027	1.448HisGlu: 1.448 ± 0.03	1.097HisPhe: 1.097 ± 0.024	1.822HisGly: 1.822 ± 0.034	0.841HisHis: 0.841 ± 0.022	1.868HisIle: 1.868 ± 0.034	0.781HisLys: 0.781 ± 0.02	3.044HisLeu: 3.044 ± 0.042	0.621HisMet: 0.621 ± 0.016	0.908HisAsn: 0.908 ± 0.025	1.753HisPro: 1.753 ± 0.032	1.26HisGln: 1.26 ± 0.027	1.281HisArg: 1.281 ± 0.023	1.499HisSer: 1.499 ± 0.026	1.697HisThr: 1.697 ± 0.033	1.766HisVal: 1.766 ± 0.03	0.453HisTrp: 0.453 ± 0.014	1.014HisTyr: 1.014 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.239IleAla: 6.239 ± 0.059	0.676IleCys: 0.676 ± 0.021	3.319IleAsp: 3.319 ± 0.045	3.789IleGlu: 3.789 ± 0.057	2.284IlePhe: 2.284 ± 0.042	4.446IleGly: 4.446 ± 0.055	1.599IleHis: 1.599 ± 0.032	3.766IleIle: 3.766 ± 0.063	1.962IleLys: 1.962 ± 0.035	6.203IleLeu: 6.203 ± 0.065	1.169IleMet: 1.169 ± 0.03	2.192IleAsn: 2.192 ± 0.04	3.256IlePro: 3.256 ± 0.039	2.903IleGln: 2.903 ± 0.04	2.919IleArg: 2.919 ± 0.038	3.956IleSer: 3.956 ± 0.047	3.731IleThr: 3.731 ± 0.045	4.422IleVal: 4.422 ± 0.06	0.817IleTrp: 0.817 ± 0.022	1.852IleTyr: 1.852 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.966LysAla: 2.966 ± 0.045	0.208LysCys: 0.208 ± 0.012	1.747LysAsp: 1.747 ± 0.034	2.144LysGlu: 2.144 ± 0.04	0.817LysPhe: 0.817 ± 0.023	2.137LysGly: 2.137 ± 0.035	0.937LysHis: 0.937 ± 0.021	2.024LysIle: 2.024 ± 0.038	1.716LysLys: 1.716 ± 0.04	3.253LysLeu: 3.253 ± 0.044	0.876LysMet: 0.876 ± 0.021	1.359LysAsn: 1.359 ± 0.031	1.657LysPro: 1.657 ± 0.034	2.192LysGln: 2.192 ± 0.038	2.406LysArg: 2.406 ± 0.041	1.808LysSer: 1.808 ± 0.031	2.142LysThr: 2.142 ± 0.035	2.104LysVal: 2.104 ± 0.037	0.379LysTrp: 0.379 ± 0.013	0.961LysTyr: 0.961 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.037LeuAla: 11.037 ± 0.091	1.186LeuCys: 1.186 ± 0.025	5.331LeuAsp: 5.331 ± 0.05	5.919LeuGlu: 5.919 ± 0.069	4.151LeuPhe: 4.151 ± 0.058	7.019LeuGly: 7.019 ± 0.078	2.976LeuHis: 2.976 ± 0.048	6.218LeuIle: 6.218 ± 0.069	3.667LeuLys: 3.667 ± 0.046	13.293LeuLeu: 13.293 ± 0.134	2.017LeuMet: 2.017 ± 0.029	3.501LeuAsn: 3.501 ± 0.044	6.153LeuPro: 6.153 ± 0.071	5.647LeuGln: 5.647 ± 0.065	6.406LeuArg: 6.406 ± 0.064	7.335LeuSer: 7.335 ± 0.071	6.544LeuThr: 6.544 ± 0.058	6.957LeuVal: 6.957 ± 0.074	1.381LeuTrp: 1.381 ± 0.032	3.166LeuTyr: 3.166 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.06MetAla: 2.06 ± 0.03	0.156MetCys: 0.156 ± 0.009	1.116MetAsp: 1.116 ± 0.021	1.152MetGlu: 1.152 ± 0.025	0.618MetPhe: 0.618 ± 0.017	1.491MetGly: 1.491 ± 0.031	0.62MetHis: 0.62 ± 0.019	1.283MetIle: 1.283 ± 0.028	0.871MetLys: 0.871 ± 0.021	2.595MetLeu: 2.595 ± 0.032	0.517MetMet: 0.517 ± 0.019	0.792MetAsn: 0.792 ± 0.019	1.192MetPro: 1.192 ± 0.023	1.294MetGln: 1.294 ± 0.027	1.424MetArg: 1.424 ± 0.026	1.517MetSer: 1.517 ± 0.033	1.379MetThr: 1.379 ± 0.024	1.499MetVal: 1.499 ± 0.027	0.184MetTrp: 0.184 ± 0.011	0.515MetTyr: 0.515 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.234AsnAla: 3.234 ± 0.046	0.311AsnCys: 0.311 ± 0.015	1.743AsnAsp: 1.743 ± 0.03	1.786AsnGlu: 1.786 ± 0.035	1.166AsnPhe: 1.166 ± 0.026	2.743AsnGly: 2.743 ± 0.051	0.828AsnHis: 0.828 ± 0.019	2.272AsnIle: 2.272 ± 0.039	1.176AsnLys: 1.176 ± 0.027	3.393AsnLeu: 3.393 ± 0.046	0.766AsnMet: 0.766 ± 0.023	1.503AsnAsn: 1.503 ± 0.037	2.141AsnPro: 2.141 ± 0.037	1.704AsnGln: 1.704 ± 0.034	1.726AsnArg: 1.726 ± 0.032	2.072AsnSer: 2.072 ± 0.038	2.326AsnThr: 2.326 ± 0.033	2.282AsnVal: 2.282 ± 0.037	0.568AsnTrp: 0.568 ± 0.022	1.227AsnTyr: 1.227 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.998ProAla: 4.998 ± 0.059	0.342ProCys: 0.342 ± 0.014	3.021ProAsp: 3.021 ± 0.042	3.47ProGlu: 3.47 ± 0.05	1.974ProPhe: 1.974 ± 0.037	3.6ProGly: 3.6 ± 0.062	1.273ProHis: 1.273 ± 0.026	2.746ProIle: 2.746 ± 0.036	1.28ProLys: 1.28 ± 0.029	5.575ProLeu: 5.575 ± 0.062	0.919ProMet: 0.919 ± 0.023	1.622ProAsn: 1.622 ± 0.033	2.375ProPro: 2.375 ± 0.043	2.489ProGln: 2.489 ± 0.037	2.382ProArg: 2.382 ± 0.041	2.986ProSer: 2.986 ± 0.044	3.503ProThr: 3.503 ± 0.054	3.531ProVal: 3.531 ± 0.051	0.68ProTrp: 0.68 ± 0.019	1.517ProTyr: 1.517 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.566GlnAla: 5.566 ± 0.065	0.4GlnCys: 0.4 ± 0.015	2.277GlnAsp: 2.277 ± 0.036	3.411GlnGlu: 3.411 ± 0.056	1.442GlnPhe: 1.442 ± 0.029	3.359GlnGly: 3.359 ± 0.05	1.674GlnHis: 1.674 ± 0.032	3.055GlnIle: 3.055 ± 0.044	2.076GlnLys: 2.076 ± 0.035	5.508GlnLeu: 5.508 ± 0.067	1.186GlnMet: 1.186 ± 0.023	1.713GlnAsn: 1.713 ± 0.036	2.751GlnPro: 2.751 ± 0.045	4.21GlnGln: 4.21 ± 0.072	3.823GlnArg: 3.823 ± 0.049	3.092GlnSer: 3.092 ± 0.043	3.118GlnThr: 3.118 ± 0.038	3.373GlnVal: 3.373 ± 0.042	0.696GlnTrp: 0.696 ± 0.019	1.393GlnTyr: 1.393 ± 0.027	0.001GlnXaa: 0.001 ± 0.001
Arg	4.857ArgAla: 4.857 ± 0.051	0.526ArgCys: 0.526 ± 0.018	2.66ArgAsp: 2.66 ± 0.043	3.765ArgGlu: 3.765 ± 0.051	2.213ArgPhe: 2.213 ± 0.035	3.358ArgGly: 3.358 ± 0.044	1.558ArgHis: 1.558 ± 0.027	3.557ArgIle: 3.557 ± 0.044	2.176ArgLys: 2.176 ± 0.039	6.477ArgLeu: 6.477 ± 0.065	1.424ArgMet: 1.424 ± 0.025	1.911ArgAsn: 1.911 ± 0.031	2.586ArgPro: 2.586 ± 0.036	3.299ArgGln: 3.299 ± 0.046	3.926ArgArg: 3.926 ± 0.055	3.369ArgSer: 3.369 ± 0.048	3.295ArgThr: 3.295 ± 0.046	3.617ArgVal: 3.617 ± 0.054	0.945ArgTrp: 0.945 ± 0.023	2.077ArgTyr: 2.077 ± 0.035	0.001ArgXaa: 0.001 ± 0.0
Ser	5.386SerAla: 5.386 ± 0.061	0.541SerCys: 0.541 ± 0.018	2.999SerAsp: 2.999 ± 0.045	3.239SerGlu: 3.239 ± 0.047	2.527SerPhe: 2.527 ± 0.036	4.661SerGly: 4.661 ± 0.063	1.568SerHis: 1.568 ± 0.031	3.887SerIle: 3.887 ± 0.046	1.902SerLys: 1.902 ± 0.034	6.883SerLeu: 6.883 ± 0.072	1.535SerMet: 1.535 ± 0.028	2.335SerAsn: 2.335 ± 0.036	2.975SerPro: 2.975 ± 0.043	3.027SerGln: 3.027 ± 0.041	3.035SerArg: 3.035 ± 0.04	4.761SerSer: 4.761 ± 0.063	4.153SerThr: 4.153 ± 0.053	3.887SerVal: 3.887 ± 0.053	0.981SerTrp: 0.981 ± 0.028	2.094SerTyr: 2.094 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.43ThrAla: 5.43 ± 0.059	0.577ThrCys: 0.577 ± 0.019	2.724ThrAsp: 2.724 ± 0.038	2.808ThrGlu: 2.808 ± 0.039	2.471ThrPhe: 2.471 ± 0.036	4.562ThrGly: 4.562 ± 0.06	1.646ThrHis: 1.646 ± 0.03	4.194ThrIle: 4.194 ± 0.048	1.551ThrLys: 1.551 ± 0.027	7.104ThrLeu: 7.104 ± 0.067	1.228ThrMet: 1.228 ± 0.025	2.233ThrAsn: 2.233 ± 0.038	4.054ThrPro: 4.054 ± 0.062	2.939ThrGln: 2.939 ± 0.05	3.269ThrArg: 3.269 ± 0.041	4.078ThrSer: 4.078 ± 0.046	4.286ThrThr: 4.286 ± 0.064	4.118ThrVal: 4.118 ± 0.05	0.818ThrTrp: 0.818 ± 0.019	2.017ThrTyr: 2.017 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.355ValAla: 6.355 ± 0.067	0.675ValCys: 0.675 ± 0.018	3.167ValAsp: 3.167 ± 0.044	3.787ValGlu: 3.787 ± 0.056	2.27ValPhe: 2.27 ± 0.036	4.505ValGly: 4.505 ± 0.05	1.591ValHis: 1.591 ± 0.033	4.169ValIle: 4.169 ± 0.051	2.172ValLys: 2.172 ± 0.039	7.338ValLeu: 7.338 ± 0.072	1.515ValMet: 1.515 ± 0.033	2.246ValAsn: 2.246 ± 0.037	3.354ValPro: 3.354 ± 0.044	3.025ValGln: 3.025 ± 0.045	3.721ValArg: 3.721 ± 0.056	4.338ValSer: 4.338 ± 0.048	4.166ValThr: 4.166 ± 0.055	4.944ValVal: 4.944 ± 0.075	0.803ValTrp: 0.803 ± 0.023	1.789ValTyr: 1.789 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.918TrpAla: 0.918 ± 0.022	0.156TrpCys: 0.156 ± 0.009	0.624TrpAsp: 0.624 ± 0.018	0.685TrpGlu: 0.685 ± 0.017	0.544TrpPhe: 0.544 ± 0.018	0.823TrpGly: 0.823 ± 0.023	0.448TrpHis: 0.448 ± 0.016	0.819TrpIle: 0.819 ± 0.022	0.514TrpLys: 0.514 ± 0.015	1.825TrpLeu: 1.825 ± 0.035	0.347TrpMet: 0.347 ± 0.014	0.648TrpAsn: 0.648 ± 0.024	0.554TrpPro: 0.554 ± 0.016	1.015TrpGln: 1.015 ± 0.027	0.898TrpArg: 0.898 ± 0.021	1.046TrpSer: 1.046 ± 0.029	0.752TrpThr: 0.752 ± 0.02	0.667TrpVal: 0.667 ± 0.019	0.254TrpTrp: 0.254 ± 0.011	0.464TrpTyr: 0.464 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.795TyrAla: 2.795 ± 0.039	0.385TyrCys: 0.385 ± 0.014	1.555TyrAsp: 1.555 ± 0.039	1.699TyrGlu: 1.699 ± 0.029	1.111TyrPhe: 1.111 ± 0.028	2.184TyrGly: 2.184 ± 0.035	0.943TyrHis: 0.943 ± 0.02	1.68TyrIle: 1.68 ± 0.031	0.926TyrLys: 0.926 ± 0.026	3.373TyrLeu: 3.373 ± 0.04	0.625TyrMet: 0.625 ± 0.019	1.211TyrAsn: 1.211 ± 0.03	1.645TyrPro: 1.645 ± 0.029	1.919TyrGln: 1.919 ± 0.035	2.038TyrArg: 2.038 ± 0.034	1.81TyrSer: 1.81 ± 0.037	1.972TyrThr: 1.972 ± 0.034	1.947TyrVal: 1.947 ± 0.036	0.518TyrTrp: 0.518 ± 0.02	1.073TyrTyr: 1.073 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.034XaaXaa: 0.034 ± 0.02

Statistics based on 5628 proteins (1921236 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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