Amino acid dipepetide frequency for human papillomavirus 166

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.11AlaAla: 3.11 ± 0.72
1.333AlaCys: 1.333 ± 0.712
3.998AlaAsp: 3.998 ± 1.419
7.996AlaGlu: 7.996 ± 1.737
3.554AlaPhe: 3.554 ± 0.486
2.221AlaGly: 2.221 ± 1.301
0.444AlaHis: 0.444 ± 0.42
3.554AlaIle: 3.554 ± 0.776
3.554AlaLys: 3.554 ± 1.616
7.552AlaLeu: 7.552 ± 2.393
0.444AlaMet: 0.444 ± 0.483
1.777AlaAsn: 1.777 ± 0.832
2.221AlaPro: 2.221 ± 1.03
1.333AlaGln: 1.333 ± 0.371
2.665AlaArg: 2.665 ± 1.402
5.775AlaSer: 5.775 ± 0.958
4.442AlaThr: 4.442 ± 0.733
2.665AlaVal: 2.665 ± 0.754
0.444AlaTrp: 0.444 ± 0.358
1.777AlaTyr: 1.777 ± 0.489
0.0AlaXaa: 0.0 ± 0.0
Cys
1.333CysAla: 1.333 ± 0.932
1.777CysCys: 1.777 ± 1.463
2.221CysAsp: 2.221 ± 1.293
1.333CysGlu: 1.333 ± 0.868
0.888CysPhe: 0.888 ± 0.476
0.444CysGly: 0.444 ± 0.57
0.444CysHis: 0.444 ± 0.57
1.333CysIle: 1.333 ± 1.004
2.221CysLys: 2.221 ± 1.014
1.333CysLeu: 1.333 ± 0.837
0.0CysMet: 0.0 ± 0.0
0.888CysAsn: 0.888 ± 0.581
2.665CysPro: 2.665 ± 1.343
0.0CysGln: 0.0 ± 0.0
0.888CysArg: 0.888 ± 0.961
2.221CysSer: 2.221 ± 1.538
1.777CysThr: 1.777 ± 0.751
3.554CysVal: 3.554 ± 2.563
0.888CysTrp: 0.888 ± 0.57
0.888CysTyr: 0.888 ± 0.581
0.0CysXaa: 0.0 ± 0.0
Asp
3.554AspAla: 3.554 ± 1.143
2.221AspCys: 2.221 ± 0.974
3.998AspAsp: 3.998 ± 1.337
5.331AspGlu: 5.331 ± 2.149
2.665AspPhe: 2.665 ± 0.866
2.665AspGly: 2.665 ± 1.603
0.444AspHis: 0.444 ± 0.42
6.219AspIle: 6.219 ± 2.755
0.888AspLys: 0.888 ± 0.476
5.775AspLeu: 5.775 ± 1.772
0.444AspMet: 0.444 ± 0.42
4.442AspAsn: 4.442 ± 0.642
5.775AspPro: 5.775 ± 2.016
0.888AspGln: 0.888 ± 0.57
3.11AspArg: 3.11 ± 0.725
3.998AspSer: 3.998 ± 1.191
5.331AspThr: 5.331 ± 1.081
5.775AspVal: 5.775 ± 2.591
0.444AspTrp: 0.444 ± 0.358
1.777AspTyr: 1.777 ± 0.659
0.0AspXaa: 0.0 ± 0.0
Glu
4.887GluAla: 4.887 ± 1.786
0.888GluCys: 0.888 ± 0.717
3.998GluAsp: 3.998 ± 1.261
5.775GluGlu: 5.775 ± 2.11
1.777GluPhe: 1.777 ± 0.921
3.998GluGly: 3.998 ± 0.768
0.0GluHis: 0.0 ± 0.0
6.219GluIle: 6.219 ± 1.829
2.665GluLys: 2.665 ± 1.139
6.219GluLeu: 6.219 ± 2.376
0.888GluMet: 0.888 ± 0.717
4.442GluAsn: 4.442 ± 2.25
3.554GluPro: 3.554 ± 1.131
3.554GluGln: 3.554 ± 0.641
3.554GluArg: 3.554 ± 1.774
3.998GluSer: 3.998 ± 1.367
1.777GluThr: 1.777 ± 0.571
4.442GluVal: 4.442 ± 1.526
1.777GluTrp: 1.777 ± 0.917
2.221GluTyr: 2.221 ± 1.649
0.0GluXaa: 0.0 ± 0.0
Phe
2.665PheAla: 2.665 ± 0.604
1.777PheCys: 1.777 ± 1.161
3.11PheAsp: 3.11 ± 0.786
3.554PheGlu: 3.554 ± 2.367
3.554PhePhe: 3.554 ± 1.765
2.665PheGly: 2.665 ± 0.552
0.888PheHis: 0.888 ± 0.771
2.665PheIle: 2.665 ± 1.099
2.221PheLys: 2.221 ± 0.763
3.11PheLeu: 3.11 ± 1.56
0.888PheMet: 0.888 ± 0.438
2.665PheAsn: 2.665 ± 0.805
2.665PhePro: 2.665 ± 0.907
2.665PheGln: 2.665 ± 1.285
2.221PheArg: 2.221 ± 0.665
3.11PheSer: 3.11 ± 0.617
2.221PheThr: 2.221 ± 1.111
3.554PheVal: 3.554 ± 0.486
1.333PheTrp: 1.333 ± 0.712
2.665PheTyr: 2.665 ± 0.466
0.0PheXaa: 0.0 ± 0.0
Gly
3.998GlyAla: 3.998 ± 2.213
0.888GlyCys: 0.888 ± 0.57
5.331GlyAsp: 5.331 ± 1.395
5.775GlyGlu: 5.775 ± 1.874
2.221GlyPhe: 2.221 ± 0.723
3.554GlyGly: 3.554 ± 2.034
1.333GlyHis: 1.333 ± 0.965
1.777GlyIle: 1.777 ± 0.646
2.221GlyLys: 2.221 ± 0.937
3.11GlyLeu: 3.11 ± 1.177
0.444GlyMet: 0.444 ± 0.483
3.554GlyAsn: 3.554 ± 0.852
2.221GlyPro: 2.221 ± 1.007
1.777GlyGln: 1.777 ± 0.887
4.442GlyArg: 4.442 ± 1.581
3.998GlySer: 3.998 ± 1.193
4.442GlyThr: 4.442 ± 0.594
3.11GlyVal: 3.11 ± 1.006
0.0GlyTrp: 0.0 ± 0.0
1.333GlyTyr: 1.333 ± 0.685
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.444HisCys: 0.444 ± 0.57
0.0HisAsp: 0.0 ± 0.0
0.444HisGlu: 0.444 ± 0.57
1.333HisPhe: 1.333 ± 0.644
0.444HisGly: 0.444 ± 0.57
0.0HisHis: 0.0 ± 0.0
1.777HisIle: 1.777 ± 0.899
0.888HisLys: 0.888 ± 0.643
2.221HisLeu: 2.221 ± 0.956
0.444HisMet: 0.444 ± 0.42
0.0HisAsn: 0.0 ± 0.0
1.777HisPro: 1.777 ± 0.909
0.444HisGln: 0.444 ± 0.358
1.777HisArg: 1.777 ± 0.243
1.333HisSer: 1.333 ± 0.69
0.444HisThr: 0.444 ± 0.42
0.444HisVal: 0.444 ± 0.358
0.444HisTrp: 0.444 ± 0.483
0.444HisTyr: 0.444 ± 0.358
0.0HisXaa: 0.0 ± 0.0
Ile
3.554IleAla: 3.554 ± 0.985
1.777IleCys: 1.777 ± 1.224
3.554IleAsp: 3.554 ± 1.901
4.442IleGlu: 4.442 ± 1.325
3.554IlePhe: 3.554 ± 0.911
2.221IleGly: 2.221 ± 1.301
0.444IleHis: 0.444 ± 0.358
3.554IleIle: 3.554 ± 2.302
1.777IleLys: 1.777 ± 1.108
1.333IleLeu: 1.333 ± 0.806
0.0IleMet: 0.0 ± 0.0
2.221IleAsn: 2.221 ± 0.84
2.221IlePro: 2.221 ± 1.301
2.221IleGln: 2.221 ± 0.814
2.665IleArg: 2.665 ± 0.887
3.998IleSer: 3.998 ± 0.96
3.998IleThr: 3.998 ± 1.035
3.11IleVal: 3.11 ± 1.374
0.444IleTrp: 0.444 ± 0.483
2.665IleTyr: 2.665 ± 1.174
0.0IleXaa: 0.0 ± 0.0
Lys
4.442LysAla: 4.442 ± 1.662
1.777LysCys: 1.777 ± 0.578
0.888LysAsp: 0.888 ± 0.476
3.11LysGlu: 3.11 ± 1.51
3.11LysPhe: 3.11 ± 1.52
1.777LysGly: 1.777 ± 0.489
0.888LysHis: 0.888 ± 0.476
0.888LysIle: 0.888 ± 0.461
1.333LysLys: 1.333 ± 0.89
3.554LysLeu: 3.554 ± 1.564
2.665LysMet: 2.665 ± 0.662
1.777LysAsn: 1.777 ± 0.243
1.777LysPro: 1.777 ± 0.646
2.221LysGln: 2.221 ± 0.84
5.775LysArg: 5.775 ± 1.109
5.331LysSer: 5.331 ± 2.835
3.998LysThr: 3.998 ± 1.039
2.221LysVal: 2.221 ± 1.034
1.333LysTrp: 1.333 ± 0.513
2.665LysTyr: 2.665 ± 0.731
0.0LysXaa: 0.0 ± 0.0
Leu
3.998LeuAla: 3.998 ± 1.418
2.221LeuCys: 2.221 ± 1.581
6.664LeuAsp: 6.664 ± 1.814
3.11LeuGlu: 3.11 ± 0.971
5.331LeuPhe: 5.331 ± 1.102
5.331LeuGly: 5.331 ± 1.757
2.221LeuHis: 2.221 ± 0.647
3.998LeuIle: 3.998 ± 0.637
4.887LeuLys: 4.887 ± 1.858
7.552LeuLeu: 7.552 ± 3.184
2.665LeuMet: 2.665 ± 1.513
3.998LeuAsn: 3.998 ± 1.117
4.442LeuPro: 4.442 ± 0.72
7.108LeuGln: 7.108 ± 1.776
2.665LeuArg: 2.665 ± 1.71
5.775LeuSer: 5.775 ± 2.054
3.998LeuThr: 3.998 ± 1.389
4.887LeuVal: 4.887 ± 0.981
0.0LeuTrp: 0.0 ± 0.0
5.331LeuTyr: 5.331 ± 0.597
0.0LeuXaa: 0.0 ± 0.0
Met
1.777MetAla: 1.777 ± 0.756
0.0MetCys: 0.0 ± 0.0
0.888MetAsp: 0.888 ± 0.717
0.888MetGlu: 0.888 ± 0.57
1.333MetPhe: 1.333 ± 0.392
1.333MetGly: 1.333 ± 1.075
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.665MetLeu: 2.665 ± 1.142
0.444MetMet: 0.444 ± 0.358
0.888MetAsn: 0.888 ± 0.376
0.0MetPro: 0.0 ± 0.0
1.333MetGln: 1.333 ± 0.513
1.777MetArg: 1.777 ± 1.213
1.777MetSer: 1.777 ± 0.751
0.444MetThr: 0.444 ± 0.483
0.888MetVal: 0.888 ± 0.717
0.0MetTrp: 0.0 ± 0.0
0.888MetTyr: 0.888 ± 0.461
0.0MetXaa: 0.0 ± 0.0
Asn
1.777AsnAla: 1.777 ± 1.434
0.888AsnCys: 0.888 ± 0.717
1.777AsnAsp: 1.777 ± 0.243
3.554AsnGlu: 3.554 ± 0.721
1.777AsnPhe: 1.777 ± 0.826
1.333AsnGly: 1.333 ± 0.877
0.444AsnHis: 0.444 ± 0.57
0.888AsnIle: 0.888 ± 0.454
5.331AsnLys: 5.331 ± 1.938
3.998AsnLeu: 3.998 ± 1.118
1.333AsnMet: 1.333 ± 1.075
2.665AsnAsn: 2.665 ± 0.731
5.775AsnPro: 5.775 ± 2.235
2.221AsnGln: 2.221 ± 0.884
2.665AsnArg: 2.665 ± 0.604
3.554AsnSer: 3.554 ± 2.195
3.11AsnThr: 3.11 ± 1.553
1.777AsnVal: 1.777 ± 0.751
1.777AsnTrp: 1.777 ± 0.952
1.333AsnTyr: 1.333 ± 1.027
0.0AsnXaa: 0.0 ± 0.0
Pro
6.219ProAla: 6.219 ± 2.192
0.888ProCys: 0.888 ± 0.961
5.331ProAsp: 5.331 ± 1.881
2.665ProGlu: 2.665 ± 1.334
1.333ProPhe: 1.333 ± 0.992
2.221ProGly: 2.221 ± 0.749
0.444ProHis: 0.444 ± 0.341
3.998ProIle: 3.998 ± 1.755
3.11ProLys: 3.11 ± 0.556
3.554ProLeu: 3.554 ± 1.213
0.444ProMet: 0.444 ± 0.42
2.221ProAsn: 2.221 ± 0.597
5.331ProPro: 5.331 ± 1.102
0.888ProGln: 0.888 ± 0.476
1.777ProArg: 1.777 ± 1.213
4.887ProSer: 4.887 ± 1.883
5.775ProThr: 5.775 ± 1.599
1.777ProVal: 1.777 ± 0.745
0.444ProTrp: 0.444 ± 0.42
2.665ProTyr: 2.665 ± 0.746
0.0ProXaa: 0.0 ± 0.0
Gln
2.221GlnAla: 2.221 ± 0.444
0.888GlnCys: 0.888 ± 0.461
2.665GlnAsp: 2.665 ± 0.605
4.442GlnGlu: 4.442 ± 1.621
2.221GlnPhe: 2.221 ± 0.879
1.777GlnGly: 1.777 ± 0.796
0.444GlnHis: 0.444 ± 0.483
1.333GlnIle: 1.333 ± 0.69
0.888GlnLys: 0.888 ± 0.508
5.331GlnLeu: 5.331 ± 1.142
1.777GlnMet: 1.777 ± 1.192
0.888GlnAsn: 0.888 ± 0.454
3.11GlnPro: 3.11 ± 0.765
1.777GlnGln: 1.777 ± 1.084
0.888GlnArg: 0.888 ± 0.57
1.777GlnSer: 1.777 ± 0.947
3.11GlnThr: 3.11 ± 0.607
3.998GlnVal: 3.998 ± 1.162
1.333GlnTrp: 1.333 ± 0.89
1.333GlnTyr: 1.333 ± 0.69
0.0GlnXaa: 0.0 ± 0.0
Arg
4.887ArgAla: 4.887 ± 1.189
2.665ArgCys: 2.665 ± 1.193
3.11ArgAsp: 3.11 ± 0.441
1.333ArgGlu: 1.333 ± 0.97
3.554ArgPhe: 3.554 ± 0.893
3.554ArgGly: 3.554 ± 1.558
1.777ArgHis: 1.777 ± 0.659
0.0ArgIle: 0.0 ± 0.0
5.775ArgLys: 5.775 ± 1.279
5.331ArgLeu: 5.331 ± 1.323
0.888ArgMet: 0.888 ± 0.476
2.221ArgAsn: 2.221 ± 0.723
2.665ArgPro: 2.665 ± 1.639
1.777ArgGln: 1.777 ± 0.796
4.887ArgArg: 4.887 ± 4.132
3.11ArgSer: 3.11 ± 0.665
1.333ArgThr: 1.333 ± 0.992
5.775ArgVal: 5.775 ± 1.179
0.0ArgTrp: 0.0 ± 0.0
0.444ArgTyr: 0.444 ± 0.483
0.0ArgXaa: 0.0 ± 0.0
Ser
5.331SerAla: 5.331 ± 1.042
1.777SerCys: 1.777 ± 0.489
4.442SerAsp: 4.442 ± 0.888
3.11SerGlu: 3.11 ± 1.433
1.777SerPhe: 1.777 ± 0.789
6.219SerGly: 6.219 ± 1.094
1.777SerHis: 1.777 ± 0.243
3.11SerIle: 3.11 ± 1.121
3.11SerLys: 3.11 ± 0.864
7.996SerLeu: 7.996 ± 2.674
0.888SerMet: 0.888 ± 0.376
4.442SerAsn: 4.442 ± 1.404
2.665SerPro: 2.665 ± 1.243
3.554SerGln: 3.554 ± 0.985
4.887SerArg: 4.887 ± 0.554
4.887SerSer: 4.887 ± 3.552
4.887SerThr: 4.887 ± 1.189
4.887SerVal: 4.887 ± 0.849
0.888SerTrp: 0.888 ± 0.376
1.333SerTyr: 1.333 ± 0.752
0.0SerXaa: 0.0 ± 0.0
Thr
1.777ThrAla: 1.777 ± 0.646
1.333ThrCys: 1.333 ± 0.837
6.664ThrAsp: 6.664 ± 1.444
4.442ThrGlu: 4.442 ± 1.665
3.554ThrPhe: 3.554 ± 1.014
6.219ThrGly: 6.219 ± 0.652
1.777ThrHis: 1.777 ± 1.083
4.887ThrIle: 4.887 ± 1.778
2.221ThrLys: 2.221 ± 1.612
4.887ThrLeu: 4.887 ± 1.285
0.888ThrMet: 0.888 ± 0.682
3.998ThrAsn: 3.998 ± 1.585
1.333ThrPro: 1.333 ± 0.806
0.888ThrGln: 0.888 ± 0.508
1.333ThrArg: 1.333 ± 0.685
5.775ThrSer: 5.775 ± 1.358
5.331ThrThr: 5.331 ± 2.61
5.331ThrVal: 5.331 ± 0.582
1.333ThrTrp: 1.333 ± 0.589
1.777ThrTyr: 1.777 ± 0.985
0.0ThrXaa: 0.0 ± 0.0
Val
1.333ValAla: 1.333 ± 0.912
1.333ValCys: 1.333 ± 1.151
3.998ValAsp: 3.998 ± 1.359
3.554ValGlu: 3.554 ± 0.972
2.665ValPhe: 2.665 ± 0.743
4.887ValGly: 4.887 ± 1.974
0.444ValHis: 0.444 ± 0.341
1.777ValIle: 1.777 ± 1.434
3.554ValLys: 3.554 ± 1.287
6.664ValLeu: 6.664 ± 1.736
0.888ValMet: 0.888 ± 0.841
2.221ValAsn: 2.221 ± 0.444
4.442ValPro: 4.442 ± 1.245
2.665ValGln: 2.665 ± 1.382
3.998ValArg: 3.998 ± 1.877
4.887ValSer: 4.887 ± 0.732
7.108ValThr: 7.108 ± 0.913
3.554ValVal: 3.554 ± 1.261
1.777ValTrp: 1.777 ± 0.998
1.777ValTyr: 1.777 ± 0.666
0.0ValXaa: 0.0 ± 0.0
Trp
1.333TrpAla: 1.333 ± 0.371
0.0TrpCys: 0.0 ± 0.0
1.777TrpAsp: 1.777 ± 1.252
0.0TrpGlu: 0.0 ± 0.0
1.333TrpPhe: 1.333 ± 0.468
0.888TrpGly: 0.888 ± 0.841
0.444TrpHis: 0.444 ± 0.483
0.888TrpIle: 0.888 ± 0.476
0.888TrpLys: 0.888 ± 0.376
1.777TrpLeu: 1.777 ± 0.751
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.444TrpPro: 0.444 ± 0.42
1.333TrpGln: 1.333 ± 0.69
1.777TrpArg: 1.777 ± 1.286
0.0TrpSer: 0.0 ± 0.0
1.333TrpThr: 1.333 ± 0.89
0.888TrpVal: 0.888 ± 0.476
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.665TyrAla: 2.665 ± 0.784
2.221TyrCys: 2.221 ± 1.099
1.333TyrAsp: 1.333 ± 0.69
1.777TyrGlu: 1.777 ± 1.476
2.665TyrPhe: 2.665 ± 0.754
1.777TyrGly: 1.777 ± 0.243
0.444TyrHis: 0.444 ± 0.358
0.888TyrIle: 0.888 ± 0.841
3.998TyrLys: 3.998 ± 0.864
2.665TyrLeu: 2.665 ± 0.743
0.444TyrMet: 0.444 ± 0.358
2.665TyrAsn: 2.665 ± 0.466
0.888TyrPro: 0.888 ± 0.57
3.554TyrGln: 3.554 ± 1.025
1.333TyrArg: 1.333 ± 0.811
1.777TyrSer: 1.777 ± 0.659
0.888TyrThr: 0.888 ± 0.841
0.888TyrVal: 0.888 ± 0.376
0.444TyrTrp: 0.444 ± 0.42
3.11TyrTyr: 3.11 ± 1.958
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2252 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski