Amino acid dipepetide frequency for McMurdo Ice Shelf pond-associated circular DNA virus-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.151AlaAla: 16.151 ± 7.331
1.346AlaCys: 1.346 ± 1.348
6.729AlaAsp: 6.729 ± 1.684
2.692AlaGlu: 2.692 ± 2.697
1.346AlaPhe: 1.346 ± 0.893
9.421AlaGly: 9.421 ± 3.582
2.692AlaHis: 2.692 ± 1.786
2.692AlaIle: 2.692 ± 1.786
5.384AlaLys: 5.384 ± 1.215
1.346AlaLeu: 1.346 ± 0.86
1.346AlaMet: 1.346 ± 0.86
4.038AlaAsn: 4.038 ± 4.045
1.346AlaPro: 1.346 ± 0.893
6.729AlaGln: 6.729 ± 2.254
4.038AlaArg: 4.038 ± 2.089
10.767AlaSer: 10.767 ± 2.827
9.421AlaThr: 9.421 ± 4.516
1.346AlaVal: 1.346 ± 0.86
0.0AlaTrp: 0.0 ± 0.0
1.346AlaTyr: 1.346 ± 0.893
0.0AlaXaa: 0.0 ± 0.0
Cys
1.346CysAla: 1.346 ± 0.893
1.346CysCys: 1.346 ± 0.893
1.346CysAsp: 1.346 ± 0.893
2.692CysGlu: 2.692 ± 1.104
1.346CysPhe: 1.346 ± 0.893
1.346CysGly: 1.346 ± 0.893
1.346CysHis: 1.346 ± 1.348
0.0CysIle: 0.0 ± 0.0
1.346CysLys: 1.346 ± 0.86
0.0CysLeu: 0.0 ± 0.0
1.346CysMet: 1.346 ± 0.893
0.0CysAsn: 0.0 ± 0.0
2.692CysPro: 2.692 ± 1.786
2.692CysGln: 2.692 ± 1.786
1.346CysArg: 1.346 ± 1.348
1.346CysSer: 1.346 ± 0.893
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.384AspAla: 5.384 ± 3.438
0.0AspCys: 0.0 ± 0.0
2.692AspAsp: 2.692 ± 1.786
5.384AspGlu: 5.384 ± 2.107
1.346AspPhe: 1.346 ± 0.893
4.038AspGly: 4.038 ± 1.488
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
1.346AspLys: 1.346 ± 0.893
2.692AspLeu: 2.692 ± 1.104
0.0AspMet: 0.0 ± 0.0
2.692AspAsn: 2.692 ± 1.534
4.038AspPro: 4.038 ± 1.191
1.346AspGln: 1.346 ± 0.893
2.692AspArg: 2.692 ± 0.608
1.346AspSer: 1.346 ± 1.348
4.038AspThr: 4.038 ± 1.263
5.384AspVal: 5.384 ± 0.644
0.0AspTrp: 0.0 ± 0.0
2.692AspTyr: 2.692 ± 0.608
0.0AspXaa: 0.0 ± 0.0
Glu
2.692GluAla: 2.692 ± 1.104
0.0GluCys: 0.0 ± 0.0
1.346GluAsp: 1.346 ± 0.893
5.384GluGlu: 5.384 ± 3.601
5.384GluPhe: 5.384 ± 2.192
5.384GluGly: 5.384 ± 2.192
2.692GluHis: 2.692 ± 1.786
2.692GluIle: 2.692 ± 2.697
1.346GluLys: 1.346 ± 1.348
0.0GluLeu: 0.0 ± 0.0
2.692GluMet: 2.692 ± 1.786
0.0GluAsn: 0.0 ± 0.0
1.346GluPro: 1.346 ± 0.893
1.346GluGln: 1.346 ± 1.348
0.0GluArg: 0.0 ± 0.0
1.346GluSer: 1.346 ± 1.348
1.346GluThr: 1.346 ± 0.893
8.075GluVal: 8.075 ± 3.516
1.346GluTrp: 1.346 ± 1.348
1.346GluTyr: 1.346 ± 1.348
0.0GluXaa: 0.0 ± 0.0
Phe
2.692PheAla: 2.692 ± 1.534
2.692PheCys: 2.692 ± 1.786
1.346PheAsp: 1.346 ± 0.86
2.692PheGlu: 2.692 ± 1.104
6.729PhePhe: 6.729 ± 1.356
2.692PheGly: 2.692 ± 1.786
2.692PheHis: 2.692 ± 1.786
1.346PheIle: 1.346 ± 0.893
4.038PheLys: 4.038 ± 1.488
4.038PheLeu: 4.038 ± 2.679
0.0PheMet: 0.0 ± 1.101
1.346PheAsn: 1.346 ± 0.893
2.692PhePro: 2.692 ± 0.608
4.038PheGln: 4.038 ± 0.765
0.0PheArg: 0.0 ± 0.0
1.346PheSer: 1.346 ± 0.893
8.075PheThr: 8.075 ± 0.59
5.384PheVal: 5.384 ± 1.215
2.692PheTrp: 2.692 ± 1.786
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.038GlyAla: 4.038 ± 2.089
1.346GlyCys: 1.346 ± 0.893
1.346GlyAsp: 1.346 ± 0.893
5.384GlyGlu: 5.384 ± 2.208
2.692GlyPhe: 2.692 ± 1.786
9.421GlyGly: 9.421 ± 1.97
4.038GlyHis: 4.038 ± 0.765
4.038GlyIle: 4.038 ± 1.191
1.346GlyLys: 1.346 ± 0.893
5.384GlyLeu: 5.384 ± 3.438
4.038GlyMet: 4.038 ± 1.548
2.692GlyAsn: 2.692 ± 0.608
2.692GlyPro: 2.692 ± 0.608
5.384GlyGln: 5.384 ± 2.107
4.038GlyArg: 4.038 ± 1.191
8.075GlySer: 8.075 ± 3.843
4.038GlyThr: 4.038 ± 2.089
1.346GlyVal: 1.346 ± 0.86
0.0GlyTrp: 0.0 ± 0.0
2.692GlyTyr: 2.692 ± 0.608
0.0GlyXaa: 0.0 ± 0.0
His
1.346HisAla: 1.346 ± 0.893
2.692HisCys: 2.692 ± 1.786
1.346HisAsp: 1.346 ± 0.86
2.692HisGlu: 2.692 ± 1.104
1.346HisPhe: 1.346 ± 0.893
2.692HisGly: 2.692 ± 1.786
2.692HisHis: 2.692 ± 1.104
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
2.692HisLeu: 2.692 ± 1.786
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.346HisPro: 1.346 ± 1.348
2.692HisGln: 2.692 ± 1.786
1.346HisArg: 1.346 ± 0.893
1.346HisSer: 1.346 ± 0.893
1.346HisThr: 1.346 ± 1.348
1.346HisVal: 1.346 ± 0.893
0.0HisTrp: 0.0 ± 0.0
2.692HisTyr: 2.692 ± 0.608
0.0HisXaa: 0.0 ± 0.0
Ile
4.038IleAla: 4.038 ± 1.191
1.346IleCys: 1.346 ± 0.893
4.038IleAsp: 4.038 ± 1.263
0.0IleGlu: 0.0 ± 0.0
1.346IlePhe: 1.346 ± 0.893
0.0IleGly: 0.0 ± 0.0
1.346IleHis: 1.346 ± 0.893
0.0IleIle: 0.0 ± 0.0
4.038IleLys: 4.038 ± 0.765
5.384IleLeu: 5.384 ± 1.196
0.0IleMet: 0.0 ± 0.0
2.692IleAsn: 2.692 ± 0.608
2.692IlePro: 2.692 ± 0.608
1.346IleGln: 1.346 ± 0.86
0.0IleArg: 0.0 ± 0.0
4.038IleSer: 4.038 ± 2.757
0.0IleThr: 0.0 ± 0.0
1.346IleVal: 1.346 ± 0.86
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
1.346LysAla: 1.346 ± 0.86
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
1.346LysGlu: 1.346 ± 1.348
8.075LysPhe: 8.075 ± 2.204
0.0LysGly: 0.0 ± 0.0
1.346LysHis: 1.346 ± 1.348
1.346LysIle: 1.346 ± 1.348
1.346LysLys: 1.346 ± 0.893
5.384LysLeu: 5.384 ± 1.196
1.346LysMet: 1.346 ± 0.893
1.346LysAsn: 1.346 ± 0.893
5.384LysPro: 5.384 ± 2.101
2.692LysGln: 2.692 ± 0.608
9.421LysArg: 9.421 ± 2.126
2.692LysSer: 2.692 ± 0.608
2.692LysThr: 2.692 ± 0.608
5.384LysVal: 5.384 ± 1.987
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
5.384LeuAla: 5.384 ± 3.067
1.346LeuCys: 1.346 ± 1.348
6.729LeuAsp: 6.729 ± 0.304
4.038LeuGlu: 4.038 ± 2.679
4.038LeuPhe: 4.038 ± 1.488
2.692LeuGly: 2.692 ± 0.608
0.0LeuHis: 0.0 ± 0.0
2.692LeuIle: 2.692 ± 1.719
2.692LeuLys: 2.692 ± 0.608
16.151LeuLeu: 16.151 ± 4.086
4.038LeuMet: 4.038 ± 1.103
1.346LeuAsn: 1.346 ± 0.86
4.038LeuPro: 4.038 ± 1.263
2.692LeuGln: 2.692 ± 0.608
2.692LeuArg: 2.692 ± 1.534
5.384LeuSer: 5.384 ± 2.803
4.038LeuThr: 4.038 ± 1.191
4.038LeuVal: 4.038 ± 1.263
1.346LeuTrp: 1.346 ± 0.893
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
1.346MetAla: 1.346 ± 0.86
1.346MetCys: 1.346 ± 1.348
1.346MetAsp: 1.346 ± 1.348
2.692MetGlu: 2.692 ± 1.786
0.0MetPhe: 0.0 ± 0.0
2.692MetGly: 2.692 ± 1.104
1.346MetHis: 1.346 ± 0.893
1.346MetIle: 1.346 ± 0.893
2.692MetLys: 2.692 ± 0.608
0.0MetLeu: 0.0 ± 0.0
1.346MetMet: 1.346 ± 0.86
1.346MetAsn: 1.346 ± 0.893
1.346MetPro: 1.346 ± 0.86
0.0MetGln: 0.0 ± 0.0
4.038MetArg: 4.038 ± 0.765
2.692MetSer: 2.692 ± 0.608
2.692MetThr: 2.692 ± 0.608
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.346MetTyr: 1.346 ± 0.86
0.0MetXaa: 0.0 ± 0.0
Asn
8.075AsnAla: 8.075 ± 1.702
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
0.0AsnGlu: 0.0 ± 0.0
5.384AsnPhe: 5.384 ± 1.196
2.692AsnGly: 2.692 ± 0.608
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
1.346AsnLys: 1.346 ± 0.893
1.346AsnLeu: 1.346 ± 0.86
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
1.346AsnPro: 1.346 ± 1.348
2.692AsnGln: 2.692 ± 0.608
2.692AsnArg: 2.692 ± 0.608
2.692AsnSer: 2.692 ± 1.534
1.346AsnThr: 1.346 ± 0.86
2.692AsnVal: 2.692 ± 0.608
0.0AsnTrp: 0.0 ± 0.0
4.038AsnTyr: 4.038 ± 0.765
0.0AsnXaa: 0.0 ± 0.0
Pro
4.038ProAla: 4.038 ± 1.191
1.346ProCys: 1.346 ± 0.893
1.346ProAsp: 1.346 ± 1.348
1.346ProGlu: 1.346 ± 0.893
4.038ProPhe: 4.038 ± 1.263
2.692ProGly: 2.692 ± 1.104
1.346ProHis: 1.346 ± 0.893
1.346ProIle: 1.346 ± 0.86
5.384ProLys: 5.384 ± 2.101
5.384ProLeu: 5.384 ± 1.215
2.692ProMet: 2.692 ± 1.534
1.346ProAsn: 1.346 ± 0.893
4.038ProPro: 4.038 ± 1.488
0.0ProGln: 0.0 ± 0.0
4.038ProArg: 4.038 ± 1.488
2.692ProSer: 2.692 ± 1.104
5.384ProThr: 5.384 ± 1.215
4.038ProVal: 4.038 ± 0.765
1.346ProTrp: 1.346 ± 0.893
1.346ProTyr: 1.346 ± 0.893
0.0ProXaa: 0.0 ± 0.0
Gln
2.692GlnAla: 2.692 ± 0.608
1.346GlnCys: 1.346 ± 0.893
1.346GlnAsp: 1.346 ± 1.348
1.346GlnGlu: 1.346 ± 1.348
2.692GlnPhe: 2.692 ± 1.719
2.692GlnGly: 2.692 ± 1.786
1.346GlnHis: 1.346 ± 0.893
1.346GlnIle: 1.346 ± 1.348
1.346GlnLys: 1.346 ± 0.86
4.038GlnLeu: 4.038 ± 1.191
0.0GlnMet: 0.0 ± 0.0
1.346GlnAsn: 1.346 ± 0.86
4.038GlnPro: 4.038 ± 1.488
1.346GlnGln: 1.346 ± 0.86
6.729GlnArg: 6.729 ± 2.971
5.384GlnSer: 5.384 ± 3.067
1.346GlnThr: 1.346 ± 0.893
2.692GlnVal: 2.692 ± 1.104
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.384ArgAla: 5.384 ± 2.107
1.346ArgCys: 1.346 ± 0.86
4.038ArgAsp: 4.038 ± 1.263
1.346ArgGlu: 1.346 ± 0.893
1.346ArgPhe: 1.346 ± 0.86
4.038ArgGly: 4.038 ± 1.263
1.346ArgHis: 1.346 ± 0.893
4.038ArgIle: 4.038 ± 1.263
4.038ArgLys: 4.038 ± 2.757
4.038ArgLeu: 4.038 ± 2.679
0.0ArgMet: 0.0 ± 0.0
6.729ArgAsn: 6.729 ± 1.356
2.692ArgPro: 2.692 ± 1.534
1.346ArgGln: 1.346 ± 0.86
6.729ArgArg: 6.729 ± 1.684
2.692ArgSer: 2.692 ± 0.608
1.346ArgThr: 1.346 ± 1.348
5.384ArgVal: 5.384 ± 2.803
1.346ArgTrp: 1.346 ± 0.86
2.692ArgTyr: 2.692 ± 0.608
0.0ArgXaa: 0.0 ± 0.0
Ser
9.421SerAla: 9.421 ± 2.235
0.0SerCys: 0.0 ± 0.0
4.038SerAsp: 4.038 ± 2.089
2.692SerGlu: 2.692 ± 2.697
2.692SerPhe: 2.692 ± 1.104
6.729SerGly: 6.729 ± 2.254
2.692SerHis: 2.692 ± 1.786
1.346SerIle: 1.346 ± 0.86
2.692SerLys: 2.692 ± 1.534
8.075SerLeu: 8.075 ± 2.994
2.692SerMet: 2.692 ± 1.719
2.692SerAsn: 2.692 ± 1.104
5.384SerPro: 5.384 ± 0.644
2.692SerGln: 2.692 ± 0.608
2.692SerArg: 2.692 ± 0.608
10.767SerSer: 10.767 ± 1.287
4.038SerThr: 4.038 ± 2.089
5.384SerVal: 5.384 ± 1.987
2.692SerTrp: 2.692 ± 1.786
1.346SerTyr: 1.346 ± 0.86
0.0SerXaa: 0.0 ± 0.0
Thr
6.729ThrAla: 6.729 ± 2.82
0.0ThrCys: 0.0 ± 0.0
4.038ThrAsp: 4.038 ± 1.263
1.346ThrGlu: 1.346 ± 0.86
4.038ThrPhe: 4.038 ± 1.263
6.729ThrGly: 6.729 ± 4.298
0.0ThrHis: 0.0 ± 0.0
4.038ThrIle: 4.038 ± 1.191
2.692ThrLys: 2.692 ± 0.608
2.692ThrLeu: 2.692 ± 0.608
2.692ThrMet: 2.692 ± 1.786
1.346ThrAsn: 1.346 ± 0.86
4.038ThrPro: 4.038 ± 0.765
2.692ThrGln: 2.692 ± 1.104
4.038ThrArg: 4.038 ± 2.089
6.729ThrSer: 6.729 ± 1.938
5.384ThrThr: 5.384 ± 1.987
1.346ThrVal: 1.346 ± 0.86
0.0ThrTrp: 0.0 ± 0.0
2.692ThrTyr: 2.692 ± 1.104
0.0ThrXaa: 0.0 ± 0.0
Val
2.692ValAla: 2.692 ± 1.719
1.346ValCys: 1.346 ± 0.893
2.692ValAsp: 2.692 ± 1.104
2.692ValGlu: 2.692 ± 1.786
2.692ValPhe: 2.692 ± 1.786
5.384ValGly: 5.384 ± 2.803
1.346ValHis: 1.346 ± 0.893
4.038ValIle: 4.038 ± 1.191
2.692ValLys: 2.692 ± 1.786
5.384ValLeu: 5.384 ± 2.803
1.346ValMet: 1.346 ± 1.348
2.692ValAsn: 2.692 ± 1.719
1.346ValPro: 1.346 ± 0.893
0.0ValGln: 0.0 ± 0.0
2.692ValArg: 2.692 ± 1.719
6.729ValSer: 6.729 ± 1.938
2.692ValThr: 2.692 ± 1.719
4.038ValVal: 4.038 ± 1.263
4.038ValTrp: 4.038 ± 2.757
4.038ValTyr: 4.038 ± 1.263
0.0ValXaa: 0.0 ± 0.0
Trp
1.346TrpAla: 1.346 ± 1.348
1.346TrpCys: 1.346 ± 0.893
1.346TrpAsp: 1.346 ± 1.348
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
2.692TrpLys: 2.692 ± 1.104
0.0TrpLeu: 0.0 ± 0.0
2.692TrpMet: 2.692 ± 0.608
1.346TrpAsn: 1.346 ± 0.86
1.346TrpPro: 1.346 ± 0.893
0.0TrpGln: 0.0 ± 0.0
1.346TrpArg: 1.346 ± 0.893
0.0TrpSer: 0.0 ± 0.0
1.346TrpThr: 1.346 ± 0.893
0.0TrpVal: 0.0 ± 0.0
1.346TrpTrp: 1.346 ± 0.893
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.038TyrAla: 4.038 ± 1.488
1.346TyrCys: 1.346 ± 0.893
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
1.346TyrPhe: 1.346 ± 1.348
2.692TyrGly: 2.692 ± 0.608
1.346TyrHis: 1.346 ± 0.86
1.346TyrIle: 1.346 ± 0.893
2.692TyrLys: 2.692 ± 0.608
1.346TyrLeu: 1.346 ± 1.348
0.0TyrMet: 0.0 ± 0.0
1.346TyrAsn: 1.346 ± 0.86
1.346TyrPro: 1.346 ± 0.893
1.346TyrGln: 1.346 ± 0.893
1.346TyrArg: 1.346 ± 0.86
2.692TyrSer: 2.692 ± 0.608
2.692TyrThr: 2.692 ± 1.719
1.346TyrVal: 1.346 ± 0.893
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski