Amino acid dipepetide frequency for Kamptonema sp. PCC 6506

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.763AlaAla: 7.763 ± 0.087
0.843AlaCys: 0.843 ± 0.025
4.227AlaAsp: 4.227 ± 0.06
5.693AlaGlu: 5.693 ± 0.068
2.869AlaPhe: 2.869 ± 0.045
5.64AlaGly: 5.64 ± 0.076
1.219AlaHis: 1.219 ± 0.027
7.868AlaIle: 7.868 ± 0.083
4.309AlaLys: 4.309 ± 0.063
8.562AlaLeu: 8.562 ± 0.084
1.639AlaMet: 1.639 ± 0.031
3.758AlaAsn: 3.758 ± 0.072
2.937AlaPro: 2.937 ± 0.046
3.906AlaGln: 3.906 ± 0.057
3.617AlaArg: 3.617 ± 0.054
4.934AlaSer: 4.934 ± 0.057
4.694AlaThr: 4.694 ± 0.061
5.544AlaVal: 5.544 ± 0.068
0.962AlaTrp: 0.962 ± 0.03
2.292AlaTyr: 2.292 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.617CysAla: 0.617 ± 0.019
0.183CysCys: 0.183 ± 0.009
0.642CysAsp: 0.642 ± 0.019
0.565CysGlu: 0.565 ± 0.02
0.435CysPhe: 0.435 ± 0.016
0.818CysGly: 0.818 ± 0.022
0.267CysHis: 0.267 ± 0.013
0.58CysIle: 0.58 ± 0.018
0.401CysLys: 0.401 ± 0.016
1.12CysLeu: 1.12 ± 0.024
0.161CysMet: 0.161 ± 0.01
0.366CysAsn: 0.366 ± 0.013
0.5CysPro: 0.5 ± 0.017
0.597CysGln: 0.597 ± 0.018
0.554CysArg: 0.554 ± 0.017
0.617CysSer: 0.617 ± 0.018
0.476CysThr: 0.476 ± 0.017
0.546CysVal: 0.546 ± 0.017
0.146CysTrp: 0.146 ± 0.009
0.41CysTyr: 0.41 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.781AspAla: 3.781 ± 0.059
0.545AspCys: 0.545 ± 0.019
2.284AspAsp: 2.284 ± 0.056
3.035AspGlu: 3.035 ± 0.044
2.399AspPhe: 2.399 ± 0.039
3.439AspGly: 3.439 ± 0.058
0.535AspHis: 0.535 ± 0.018
3.574AspIle: 3.574 ± 0.051
2.176AspLys: 2.176 ± 0.046
5.694AspLeu: 5.694 ± 0.065
0.804AspMet: 0.804 ± 0.023
1.976AspAsn: 1.976 ± 0.039
2.308AspPro: 2.308 ± 0.04
1.307AspGln: 1.307 ± 0.027
4.294AspArg: 4.294 ± 0.054
3.188AspSer: 3.188 ± 0.05
2.434AspThr: 2.434 ± 0.054
2.875AspVal: 2.875 ± 0.042
0.89AspTrp: 0.89 ± 0.022
1.825AspTyr: 1.825 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
5.941GluAla: 5.941 ± 0.082
0.537GluCys: 0.537 ± 0.019
2.827GluAsp: 2.827 ± 0.048
4.676GluGlu: 4.676 ± 0.072
2.592GluPhe: 2.592 ± 0.042
3.681GluGly: 3.681 ± 0.045
1.019GluHis: 1.019 ± 0.028
5.301GluIle: 5.301 ± 0.062
3.849GluLys: 3.849 ± 0.055
7.567GluLeu: 7.567 ± 0.075
1.482GluMet: 1.482 ± 0.032
2.875GluAsn: 2.875 ± 0.04
2.489GluPro: 2.489 ± 0.052
3.474GluGln: 3.474 ± 0.052
3.586GluArg: 3.586 ± 0.056
3.85GluSer: 3.85 ± 0.055
3.538GluThr: 3.538 ± 0.039
4.586GluVal: 4.586 ± 0.052
0.832GluTrp: 0.832 ± 0.021
1.898GluTyr: 1.898 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.051PheAla: 3.051 ± 0.046
0.527PheCys: 0.527 ± 0.017
2.234PheAsp: 2.234 ± 0.034
2.356PheGlu: 2.356 ± 0.037
1.712PhePhe: 1.712 ± 0.042
2.818PheGly: 2.818 ± 0.044
0.689PheHis: 0.689 ± 0.019
2.369PheIle: 2.369 ± 0.038
1.634PheLys: 1.634 ± 0.033
4.1PheLeu: 4.1 ± 0.053
0.702PheMet: 0.702 ± 0.019
1.817PheAsn: 1.817 ± 0.035
1.85PhePro: 1.85 ± 0.034
1.745PheGln: 1.745 ± 0.033
1.813PheArg: 1.813 ± 0.032
2.997PheSer: 2.997 ± 0.045
2.333PheThr: 2.333 ± 0.039
2.375PheVal: 2.375 ± 0.033
0.685PheTrp: 0.685 ± 0.021
1.368PheTyr: 1.368 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.018GlyAla: 5.018 ± 0.082
0.791GlyCys: 0.791 ± 0.023
3.586GlyAsp: 3.586 ± 0.068
4.436GlyGlu: 4.436 ± 0.05
2.879GlyPhe: 2.879 ± 0.044
5.21GlyGly: 5.21 ± 0.114
1.123GlyHis: 1.123 ± 0.033
5.085GlyIle: 5.085 ± 0.065
4.223GlyLys: 4.223 ± 0.05
6.813GlyLeu: 6.813 ± 0.078
1.592GlyMet: 1.592 ± 0.029
3.468GlyAsn: 3.468 ± 0.108
1.472GlyPro: 1.472 ± 0.029
2.934GlyGln: 2.934 ± 0.038
3.143GlyArg: 3.143 ± 0.049
4.284GlySer: 4.284 ± 0.071
3.981GlyThr: 3.981 ± 0.082
4.668GlyVal: 4.668 ± 0.06
1.075GlyTrp: 1.075 ± 0.029
2.326GlyTyr: 2.326 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
0.97HisAla: 0.97 ± 0.024
0.251HisCys: 0.251 ± 0.011
0.654HisAsp: 0.654 ± 0.021
0.871HisGlu: 0.871 ± 0.021
0.765HisPhe: 0.765 ± 0.021
0.963HisGly: 0.963 ± 0.023
0.512HisHis: 0.512 ± 0.022
1.014HisIle: 1.014 ± 0.023
0.741HisLys: 0.741 ± 0.02
2.232HisLeu: 2.232 ± 0.042
0.166HisMet: 0.166 ± 0.01
0.669HisAsn: 0.669 ± 0.021
1.299HisPro: 1.299 ± 0.031
0.995HisGln: 0.995 ± 0.025
1.039HisArg: 1.039 ± 0.025
1.185HisSer: 1.185 ± 0.025
0.773HisThr: 0.773 ± 0.021
0.684HisVal: 0.684 ± 0.02
0.298HisTrp: 0.298 ± 0.014
0.606HisTyr: 0.606 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.729IleAla: 7.729 ± 0.077
0.752IleCys: 0.752 ± 0.023
3.823IleAsp: 3.823 ± 0.056
4.811IleGlu: 4.811 ± 0.06
2.696IlePhe: 2.696 ± 0.046
4.685IleGly: 4.685 ± 0.052
1.168IleHis: 1.168 ± 0.027
3.78IleIle: 3.78 ± 0.054
3.16IleLys: 3.16 ± 0.052
6.924IleLeu: 6.924 ± 0.069
0.858IleMet: 0.858 ± 0.024
3.072IleAsn: 3.072 ± 0.042
3.493IlePro: 3.493 ± 0.049
2.804IleGln: 2.804 ± 0.042
3.193IleArg: 3.193 ± 0.047
4.663IleSer: 4.663 ± 0.053
3.493IleThr: 3.493 ± 0.05
4.454IleVal: 4.454 ± 0.058
0.869IleTrp: 0.869 ± 0.024
2.035IleTyr: 2.035 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.119LysAla: 4.119 ± 0.054
0.353LysCys: 0.353 ± 0.013
2.249LysAsp: 2.249 ± 0.037
3.054LysGlu: 3.054 ± 0.046
1.848LysPhe: 1.848 ± 0.04
2.852LysGly: 2.852 ± 0.043
0.804LysHis: 0.804 ± 0.022
3.628LysIle: 3.628 ± 0.056
2.321LysLys: 2.321 ± 0.048
5.473LysLeu: 5.473 ± 0.059
1.043LysMet: 1.043 ± 0.027
2.091LysAsn: 2.091 ± 0.036
2.49LysPro: 2.49 ± 0.045
2.602LysGln: 2.602 ± 0.044
2.394LysArg: 2.394 ± 0.034
3.215LysSer: 3.215 ± 0.045
2.824LysThr: 2.824 ± 0.046
3.152LysVal: 3.152 ± 0.046
0.552LysTrp: 0.552 ± 0.017
1.465LysTyr: 1.465 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
9.807LeuAla: 9.807 ± 0.082
1.024LeuCys: 1.024 ± 0.028
5.353LeuAsp: 5.353 ± 0.055
7.76LeuGlu: 7.76 ± 0.078
3.655LeuPhe: 3.655 ± 0.053
7.652LeuGly: 7.652 ± 0.076
1.785LeuHis: 1.785 ± 0.032
6.693LeuIle: 6.693 ± 0.074
5.661LeuLys: 5.661 ± 0.066
11.098LeuLeu: 11.098 ± 0.111
2.173LeuMet: 2.173 ± 0.037
4.664LeuAsn: 4.664 ± 0.059
5.755LeuPro: 5.755 ± 0.074
5.355LeuGln: 5.355 ± 0.075
5.755LeuArg: 5.755 ± 0.065
7.752LeuSer: 7.752 ± 0.08
6.45LeuThr: 6.45 ± 0.064
6.807LeuVal: 6.807 ± 0.063
1.482LeuTrp: 1.482 ± 0.035
2.756LeuTyr: 2.756 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
1.838MetAla: 1.838 ± 0.034
0.116MetCys: 0.116 ± 0.009
0.77MetAsp: 0.77 ± 0.021
1.108MetGlu: 1.108 ± 0.023
0.558MetPhe: 0.558 ± 0.017
1.413MetGly: 1.413 ± 0.027
0.22MetHis: 0.22 ± 0.01
1.064MetIle: 1.064 ± 0.025
0.977MetLys: 0.977 ± 0.022
1.994MetLeu: 1.994 ± 0.035
0.466MetMet: 0.466 ± 0.018
0.812MetAsn: 0.812 ± 0.021
1.055MetPro: 1.055 ± 0.027
0.934MetGln: 0.934 ± 0.02
0.978MetArg: 0.978 ± 0.027
1.355MetSer: 1.355 ± 0.027
1.303MetThr: 1.303 ± 0.031
1.285MetVal: 1.285 ± 0.027
0.177MetTrp: 0.177 ± 0.009
0.358MetTyr: 0.358 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.098AsnAla: 3.098 ± 0.05
0.554AsnCys: 0.554 ± 0.019
1.937AsnAsp: 1.937 ± 0.056
1.941AsnGlu: 1.941 ± 0.034
2.004AsnPhe: 2.004 ± 0.035
2.779AsnGly: 2.779 ± 0.06
0.766AsnHis: 0.766 ± 0.021
2.841AsnIle: 2.841 ± 0.064
1.647AsnLys: 1.647 ± 0.029
5.876AsnLeu: 5.876 ± 0.09
0.67AsnMet: 0.67 ± 0.019
2.01AsnAsn: 2.01 ± 0.054
2.917AsnPro: 2.917 ± 0.05
2.609AsnGln: 2.609 ± 0.048
2.425AsnArg: 2.425 ± 0.036
3.353AsnSer: 3.353 ± 0.053
2.15AsnThr: 2.15 ± 0.048
2.182AsnVal: 2.182 ± 0.038
0.771AsnTrp: 0.771 ± 0.02
1.509AsnTyr: 1.509 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
3.476ProAla: 3.476 ± 0.051
0.339ProCys: 0.339 ± 0.014
2.993ProAsp: 2.993 ± 0.041
4.041ProGlu: 4.041 ± 0.058
1.743ProPhe: 1.743 ± 0.032
2.972ProGly: 2.972 ± 0.041
0.847ProHis: 0.847 ± 0.023
3.189ProIle: 3.189 ± 0.047
2.174ProLys: 2.174 ± 0.044
4.736ProLeu: 4.736 ± 0.051
0.779ProMet: 0.779 ± 0.021
2.291ProAsn: 2.291 ± 0.039
2.405ProPro: 2.405 ± 0.051
2.447ProGln: 2.447 ± 0.041
1.746ProArg: 1.746 ± 0.031
3.045ProSer: 3.045 ± 0.046
3.095ProThr: 3.095 ± 0.084
3.338ProVal: 3.338 ± 0.061
0.55ProTrp: 0.55 ± 0.022
1.217ProTyr: 1.217 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.501GlnAla: 4.501 ± 0.057
0.329GlnCys: 0.329 ± 0.014
1.856GlnAsp: 1.856 ± 0.033
3.441GlnGlu: 3.441 ± 0.049
1.758GlnPhe: 1.758 ± 0.035
3.028GlnGly: 3.028 ± 0.043
0.789GlnHis: 0.789 ± 0.023
3.623GlnIle: 3.623 ± 0.047
2.585GlnLys: 2.585 ± 0.041
5.933GlnLeu: 5.933 ± 0.069
1.035GlnMet: 1.035 ± 0.023
2.051GlnAsn: 2.051 ± 0.037
2.413GlnPro: 2.413 ± 0.039
3.438GlnGln: 3.438 ± 0.059
2.656GlnArg: 2.656 ± 0.045
2.869GlnSer: 2.869 ± 0.041
2.699GlnThr: 2.699 ± 0.039
3.447GlnVal: 3.447 ± 0.045
0.599GlnTrp: 0.599 ± 0.021
1.143GlnTyr: 1.143 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
3.385ArgAla: 3.385 ± 0.047
0.524ArgCys: 0.524 ± 0.018
2.778ArgAsp: 2.778 ± 0.042
3.682ArgGlu: 3.682 ± 0.049
2.178ArgPhe: 2.178 ± 0.036
3.216ArgGly: 3.216 ± 0.045
0.996ArgHis: 0.996 ± 0.025
3.489ArgIle: 3.489 ± 0.043
2.328ArgLys: 2.328 ± 0.042
5.99ArgLeu: 5.99 ± 0.076
1.075ArgMet: 1.075 ± 0.026
2.168ArgAsn: 2.168 ± 0.039
1.988ArgPro: 1.988 ± 0.037
3.161ArgGln: 3.161 ± 0.052
3.049ArgArg: 3.049 ± 0.047
3.521ArgSer: 3.521 ± 0.053
2.547ArgThr: 2.547 ± 0.043
3.303ArgVal: 3.303 ± 0.042
0.811ArgTrp: 0.811 ± 0.022
1.812ArgTyr: 1.812 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
4.8SerAla: 4.8 ± 0.059
0.629SerCys: 0.629 ± 0.019
3.365SerAsp: 3.365 ± 0.044
4.375SerGlu: 4.375 ± 0.052
2.585SerPhe: 2.585 ± 0.04
4.95SerGly: 4.95 ± 0.078
1.241SerHis: 1.241 ± 0.032
3.951SerIle: 3.951 ± 0.051
2.838SerLys: 2.838 ± 0.039
7.593SerLeu: 7.593 ± 0.072
1.2SerMet: 1.2 ± 0.023
2.783SerAsn: 2.783 ± 0.045
3.705SerPro: 3.705 ± 0.051
3.648SerGln: 3.648 ± 0.045
3.251SerArg: 3.251 ± 0.041
4.52SerSer: 4.52 ± 0.064
3.344SerThr: 3.344 ± 0.053
4.009SerVal: 4.009 ± 0.047
0.866SerTrp: 0.866 ± 0.02
1.876SerTyr: 1.876 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
4.816ThrAla: 4.816 ± 0.057
0.467ThrCys: 0.467 ± 0.018
2.627ThrAsp: 2.627 ± 0.042
3.324ThrGlu: 3.324 ± 0.047
2.101ThrPhe: 2.101 ± 0.039
4.454ThrGly: 4.454 ± 0.088
0.885ThrHis: 0.885 ± 0.023
3.895ThrIle: 3.895 ± 0.058
2.216ThrLys: 2.216 ± 0.034
6.138ThrLeu: 6.138 ± 0.071
0.759ThrMet: 0.759 ± 0.02
2.379ThrAsn: 2.379 ± 0.049
3.545ThrPro: 3.545 ± 0.09
2.534ThrGln: 2.534 ± 0.04
2.33ThrArg: 2.33 ± 0.035
3.244ThrSer: 3.244 ± 0.049
3.13ThrThr: 3.13 ± 0.066
3.931ThrVal: 3.931 ± 0.061
0.66ThrTrp: 0.66 ± 0.022
1.52ThrTyr: 1.52 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
5.657ValAla: 5.657 ± 0.058
0.685ValCys: 0.685 ± 0.017
3.14ValAsp: 3.14 ± 0.048
4.676ValGlu: 4.676 ± 0.054
2.507ValPhe: 2.507 ± 0.042
4.586ValGly: 4.586 ± 0.056
0.896ValHis: 0.896 ± 0.022
3.969ValIle: 3.969 ± 0.052
3.454ValLys: 3.454 ± 0.047
6.287ValLeu: 6.287 ± 0.073
1.407ValMet: 1.407 ± 0.033
2.973ValAsn: 2.973 ± 0.044
2.837ValPro: 2.837 ± 0.062
2.713ValGln: 2.713 ± 0.044
3.355ValArg: 3.355 ± 0.053
4.245ValSer: 4.245 ± 0.048
3.69ValThr: 3.69 ± 0.056
4.34ValVal: 4.34 ± 0.054
0.831ValTrp: 0.831 ± 0.021
1.767ValTyr: 1.767 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
0.862TrpAla: 0.862 ± 0.021
0.151TrpCys: 0.151 ± 0.009
0.639TrpAsp: 0.639 ± 0.019
0.996TrpGlu: 0.996 ± 0.027
0.547TrpPhe: 0.547 ± 0.019
0.962TrpGly: 0.962 ± 0.025
0.303TrpHis: 0.303 ± 0.014
0.827TrpIle: 0.827 ± 0.024
0.6TrpLys: 0.6 ± 0.018
1.76TrpLeu: 1.76 ± 0.034
0.364TrpMet: 0.364 ± 0.014
0.634TrpAsn: 0.634 ± 0.021
0.402TrpPro: 0.402 ± 0.015
1.022TrpGln: 1.022 ± 0.025
0.816TrpArg: 0.816 ± 0.028
0.775TrpSer: 0.775 ± 0.023
0.54TrpThr: 0.54 ± 0.015
0.96TrpVal: 0.96 ± 0.028
0.219TrpTrp: 0.219 ± 0.012
0.399TrpTyr: 0.399 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.046TyrAla: 2.046 ± 0.038
0.397TyrCys: 0.397 ± 0.013
1.378TyrAsp: 1.378 ± 0.028
1.761TyrGlu: 1.761 ± 0.038
1.344TyrPhe: 1.344 ± 0.032
1.992TyrGly: 1.992 ± 0.038
0.624TyrHis: 0.624 ± 0.02
1.719TyrIle: 1.719 ± 0.034
1.234TyrLys: 1.234 ± 0.028
3.551TyrLeu: 3.551 ± 0.047
0.404TyrMet: 0.404 ± 0.016
1.182TyrAsn: 1.182 ± 0.03
1.564TyrPro: 1.564 ± 0.034
1.968TyrGln: 1.968 ± 0.038
2.008TyrArg: 2.008 ± 0.039
1.919TyrSer: 1.919 ± 0.038
1.46TyrThr: 1.46 ± 0.03
1.529TyrVal: 1.529 ± 0.033
0.503TyrTrp: 0.503 ± 0.019
1.076TyrTyr: 1.076 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5822 proteins (1812636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski