Amino acid dipepetide frequency for Robiginitalea myxolifaciens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.061AlaAla: 7.061 ± 0.111	0.65AlaCys: 0.65 ± 0.028	4.548AlaAsp: 4.548 ± 0.076	5.383AlaGlu: 5.383 ± 0.076	3.653AlaPhe: 3.653 ± 0.058	6.254AlaGly: 6.254 ± 0.106	1.43AlaHis: 1.43 ± 0.047	5.188AlaIle: 5.188 ± 0.093	3.441AlaLys: 3.441 ± 0.075	8.648AlaLeu: 8.648 ± 0.113	1.882AlaMet: 1.882 ± 0.049	3.173AlaAsn: 3.173 ± 0.071	2.806AlaPro: 2.806 ± 0.073	3.192AlaGln: 3.192 ± 0.049	3.815AlaArg: 3.815 ± 0.066	4.951AlaSer: 4.951 ± 0.078	4.189AlaThr: 4.189 ± 0.094	5.214AlaVal: 5.214 ± 0.082	0.877AlaTrp: 0.877 ± 0.036	2.888AlaTyr: 2.888 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.022	0.117CysCys: 0.117 ± 0.011	0.417CysAsp: 0.417 ± 0.021	0.451CysGlu: 0.451 ± 0.022	0.373CysPhe: 0.373 ± 0.024	0.672CysGly: 0.672 ± 0.029	0.163CysHis: 0.163 ± 0.013	0.455CysIle: 0.455 ± 0.024	0.301CysLys: 0.301 ± 0.016	0.751CysLeu: 0.751 ± 0.029	0.158CysMet: 0.158 ± 0.012	0.306CysAsn: 0.306 ± 0.022	0.351CysPro: 0.351 ± 0.023	0.246CysGln: 0.246 ± 0.017	0.302CysArg: 0.302 ± 0.016	0.55CysSer: 0.55 ± 0.029	0.441CysThr: 0.441 ± 0.032	0.382CysVal: 0.382 ± 0.024	0.07CysTrp: 0.07 ± 0.009	0.283CysTyr: 0.283 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.338AspAla: 4.338 ± 0.072	0.4AspCys: 0.4 ± 0.023	2.713AspAsp: 2.713 ± 0.09	3.206AspGlu: 3.206 ± 0.068	3.432AspPhe: 3.432 ± 0.056	4.467AspGly: 4.467 ± 0.122	1.07AspHis: 1.07 ± 0.034	3.682AspIle: 3.682 ± 0.074	2.799AspLys: 2.799 ± 0.064	5.843AspLeu: 5.843 ± 0.091	1.255AspMet: 1.255 ± 0.038	2.576AspAsn: 2.576 ± 0.082	2.94AspPro: 2.94 ± 0.081	2.182AspGln: 2.182 ± 0.054	2.886AspArg: 2.886 ± 0.067	3.739AspSer: 3.739 ± 0.073	2.873AspThr: 2.873 ± 0.066	3.25AspVal: 3.25 ± 0.069	0.792AspTrp: 0.792 ± 0.029	2.585AspTyr: 2.585 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.301GluAla: 6.301 ± 0.1	0.324GluCys: 0.324 ± 0.02	3.942GluAsp: 3.942 ± 0.066	5.516GluGlu: 5.516 ± 0.096	2.996GluPhe: 2.996 ± 0.055	4.684GluGly: 4.684 ± 0.082	1.21GluHis: 1.21 ± 0.037	4.967GluIle: 4.967 ± 0.077	4.033GluLys: 4.033 ± 0.087	6.914GluLeu: 6.914 ± 0.098	1.695GluMet: 1.695 ± 0.042	3.497GluAsn: 3.497 ± 0.063	2.115GluPro: 2.115 ± 0.053	2.759GluGln: 2.759 ± 0.053	3.411GluArg: 3.411 ± 0.079	3.716GluSer: 3.716 ± 0.072	3.507GluThr: 3.507 ± 0.055	5.04GluVal: 5.04 ± 0.087	0.641GluTrp: 0.641 ± 0.025	2.293GluTyr: 2.293 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.393PheAla: 3.393 ± 0.062	0.402PheCys: 0.402 ± 0.021	3.034PheAsp: 3.034 ± 0.054	3.383PheGlu: 3.383 ± 0.064	2.434PhePhe: 2.434 ± 0.062	3.872PheGly: 3.872 ± 0.076	0.81PheHis: 0.81 ± 0.032	2.758PheIle: 2.758 ± 0.055	2.301PheLys: 2.301 ± 0.051	4.79PheLeu: 4.79 ± 0.101	1.081PheMet: 1.081 ± 0.037	2.286PheAsn: 2.286 ± 0.057	1.914PhePro: 1.914 ± 0.042	1.687PheGln: 1.687 ± 0.045	2.55PheArg: 2.55 ± 0.052	3.31PheSer: 3.31 ± 0.064	2.938PheThr: 2.938 ± 0.06	2.754PheVal: 2.754 ± 0.05	0.673PheTrp: 0.673 ± 0.025	1.838PheTyr: 1.838 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.479GlyAla: 5.479 ± 0.106	0.72GlyCys: 0.72 ± 0.05	4.113GlyAsp: 4.113 ± 0.086	4.576GlyGlu: 4.576 ± 0.086	3.85GlyPhe: 3.85 ± 0.071	5.787GlyGly: 5.787 ± 0.148	1.296GlyHis: 1.296 ± 0.044	5.812GlyIle: 5.812 ± 0.087	4.446GlyLys: 4.446 ± 0.076	7.333GlyLeu: 7.333 ± 0.116	2.101GlyMet: 2.101 ± 0.049	3.682GlyAsn: 3.682 ± 0.087	2.207GlyPro: 2.207 ± 0.057	2.578GlyGln: 2.578 ± 0.055	3.21GlyArg: 3.21 ± 0.055	4.873GlySer: 4.873 ± 0.088	4.486GlyThr: 4.486 ± 0.127	4.845GlyVal: 4.845 ± 0.07	0.975GlyTrp: 0.975 ± 0.034	2.962GlyTyr: 2.962 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.142HisAla: 1.142 ± 0.038	0.175HisCys: 0.175 ± 0.013	0.773HisAsp: 0.773 ± 0.029	0.984HisGlu: 0.984 ± 0.033	1.117HisPhe: 1.117 ± 0.037	1.249HisGly: 1.249 ± 0.04	0.431HisHis: 0.431 ± 0.027	1.149HisIle: 1.149 ± 0.037	0.915HisLys: 0.915 ± 0.035	1.953HisLeu: 1.953 ± 0.053	0.355HisMet: 0.355 ± 0.02	0.786HisAsn: 0.786 ± 0.027	1.144HisPro: 1.144 ± 0.039	0.74HisGln: 0.74 ± 0.027	1.008HisArg: 1.008 ± 0.036	1.034HisSer: 1.034 ± 0.041	0.991HisThr: 0.991 ± 0.029	0.937HisVal: 0.937 ± 0.033	0.302HisTrp: 0.302 ± 0.02	0.8HisTyr: 0.8 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.621IleAla: 5.621 ± 0.084	0.511IleCys: 0.511 ± 0.024	3.805IleAsp: 3.805 ± 0.071	4.143IleGlu: 4.143 ± 0.064	2.919IlePhe: 2.919 ± 0.06	4.721IleGly: 4.721 ± 0.072	1.219IleHis: 1.219 ± 0.035	3.785IleIle: 3.785 ± 0.073	2.855IleLys: 2.855 ± 0.062	6.447IleLeu: 6.447 ± 0.105	1.136IleMet: 1.136 ± 0.035	2.788IleAsn: 2.788 ± 0.051	3.365IlePro: 3.365 ± 0.06	2.296IleGln: 2.296 ± 0.054	3.668IleArg: 3.668 ± 0.064	4.634IleSer: 4.634 ± 0.066	3.709IleThr: 3.709 ± 0.08	3.803IleVal: 3.803 ± 0.07	0.754IleTrp: 0.754 ± 0.031	2.247IleTyr: 2.247 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.563LysAla: 4.563 ± 0.083	0.204LysCys: 0.204 ± 0.015	2.899LysAsp: 2.899 ± 0.058	3.879LysGlu: 3.879 ± 0.095	1.892LysPhe: 1.892 ± 0.049	3.583LysGly: 3.583 ± 0.063	0.897LysHis: 0.897 ± 0.032	3.405LysIle: 3.405 ± 0.08	3.481LysLys: 3.481 ± 0.088	4.562LysLeu: 4.562 ± 0.098	1.314LysMet: 1.314 ± 0.04	2.322LysAsn: 2.322 ± 0.052	2.102LysPro: 2.102 ± 0.049	1.979LysGln: 1.979 ± 0.042	2.804LysArg: 2.804 ± 0.062	3.181LysSer: 3.181 ± 0.067	2.861LysThr: 2.861 ± 0.07	3.183LysVal: 3.183 ± 0.072	0.584LysTrp: 0.584 ± 0.026	1.823LysTyr: 1.823 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.957LeuAla: 7.957 ± 0.103	0.758LeuCys: 0.758 ± 0.029	5.81LeuAsp: 5.81 ± 0.078	7.743LeuGlu: 7.743 ± 0.102	4.684LeuPhe: 4.684 ± 0.086	7.401LeuGly: 7.401 ± 0.106	1.731LeuHis: 1.731 ± 0.046	6.254LeuIle: 6.254 ± 0.105	5.908LeuLys: 5.908 ± 0.105	10.711LeuLeu: 10.711 ± 0.185	2.324LeuMet: 2.324 ± 0.059	4.554LeuAsn: 4.554 ± 0.072	4.553LeuPro: 4.553 ± 0.08	3.945LeuGln: 3.945 ± 0.066	5.034LeuArg: 5.034 ± 0.083	6.96LeuSer: 6.96 ± 0.113	5.19LeuThr: 5.19 ± 0.094	6.102LeuVal: 6.102 ± 0.077	1.084LeuTrp: 1.084 ± 0.041	3.12LeuTyr: 3.12 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.052MetAla: 2.052 ± 0.06	0.111MetCys: 0.111 ± 0.011	1.373MetAsp: 1.373 ± 0.035	1.855MetGlu: 1.855 ± 0.048	0.683MetPhe: 0.683 ± 0.026	1.781MetGly: 1.781 ± 0.046	0.432MetHis: 0.432 ± 0.021	1.323MetIle: 1.323 ± 0.037	1.631MetLys: 1.631 ± 0.04	2.049MetLeu: 2.049 ± 0.051	0.565MetMet: 0.565 ± 0.027	1.112MetAsn: 1.112 ± 0.034	1.026MetPro: 1.026 ± 0.035	0.926MetGln: 0.926 ± 0.027	1.256MetArg: 1.256 ± 0.038	1.341MetSer: 1.341 ± 0.045	1.091MetThr: 1.091 ± 0.033	1.388MetVal: 1.388 ± 0.048	0.168MetTrp: 0.168 ± 0.013	0.602MetTyr: 0.602 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.505AsnAla: 3.505 ± 0.064	0.331AsnCys: 0.331 ± 0.024	2.157AsnAsp: 2.157 ± 0.064	2.439AsnGlu: 2.439 ± 0.058	2.295AsnPhe: 2.295 ± 0.053	3.381AsnGly: 3.381 ± 0.099	0.767AsnHis: 0.767 ± 0.028	2.885AsnIle: 2.885 ± 0.06	1.959AsnLys: 1.959 ± 0.048	4.583AsnLeu: 4.583 ± 0.08	0.97AsnMet: 0.97 ± 0.026	2.093AsnAsn: 2.093 ± 0.064	2.976AsnPro: 2.976 ± 0.058	1.856AsnGln: 1.856 ± 0.042	2.575AsnArg: 2.575 ± 0.057	2.808AsnSer: 2.808 ± 0.06	2.847AsnThr: 2.847 ± 0.092	2.459AsnVal: 2.459 ± 0.062	0.658AsnTrp: 0.658 ± 0.026	1.997AsnTyr: 1.997 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	3.278ProAla: 3.278 ± 0.061	0.238ProCys: 0.238 ± 0.014	3.105ProAsp: 3.105 ± 0.081	4.457ProGlu: 4.457 ± 0.074	1.942ProPhe: 1.942 ± 0.046	3.469ProGly: 3.469 ± 0.076	0.699ProHis: 0.699 ± 0.027	2.389ProIle: 2.389 ± 0.049	2.055ProLys: 2.055 ± 0.054	3.91ProLeu: 3.91 ± 0.072	0.952ProMet: 0.952 ± 0.029	1.901ProAsn: 1.901 ± 0.043	1.356ProPro: 1.356 ± 0.044	1.501ProGln: 1.501 ± 0.038	1.509ProArg: 1.509 ± 0.042	2.269ProSer: 2.269 ± 0.048	2.072ProThr: 2.072 ± 0.049	3.035ProVal: 3.035 ± 0.056	0.544ProTrp: 0.544 ± 0.025	1.504ProTyr: 1.504 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.202GlnAla: 3.202 ± 0.067	0.228GlnCys: 0.228 ± 0.015	2.016GlnAsp: 2.016 ± 0.041	3.075GlnGlu: 3.075 ± 0.073	1.584GlnPhe: 1.584 ± 0.043	2.771GlnGly: 2.771 ± 0.057	0.684GlnHis: 0.684 ± 0.032	2.343GlnIle: 2.343 ± 0.044	1.922GlnLys: 1.922 ± 0.047	3.802GlnLeu: 3.802 ± 0.068	0.878GlnMet: 0.878 ± 0.031	1.645GlnAsn: 1.645 ± 0.055	1.504GlnPro: 1.504 ± 0.044	1.956GlnGln: 1.956 ± 0.053	2.044GlnArg: 2.044 ± 0.059	1.953GlnSer: 1.953 ± 0.037	1.989GlnThr: 1.989 ± 0.048	2.52GlnVal: 2.52 ± 0.047	0.573GlnTrp: 0.573 ± 0.024	1.318GlnTyr: 1.318 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.285ArgAla: 3.285 ± 0.067	0.268ArgCys: 0.268 ± 0.017	2.899ArgAsp: 2.899 ± 0.059	4.101ArgGlu: 4.101 ± 0.073	2.549ArgPhe: 2.549 ± 0.058	2.966ArgGly: 2.966 ± 0.059	0.904ArgHis: 0.904 ± 0.032	4.049ArgIle: 4.049 ± 0.068	3.342ArgLys: 3.342 ± 0.066	4.988ArgLeu: 4.988 ± 0.084	1.38ArgMet: 1.38 ± 0.04	2.61ArgAsn: 2.61 ± 0.053	1.775ArgPro: 1.775 ± 0.047	1.907ArgGln: 1.907 ± 0.048	2.505ArgArg: 2.505 ± 0.059	2.884ArgSer: 2.884 ± 0.058	2.403ArgThr: 2.403 ± 0.048	3.079ArgVal: 3.079 ± 0.052	0.643ArgTrp: 0.643 ± 0.025	2.096ArgTyr: 2.096 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	4.487SerAla: 4.487 ± 0.071	0.616SerCys: 0.616 ± 0.03	3.584SerAsp: 3.584 ± 0.069	4.115SerGlu: 4.115 ± 0.075	3.203SerPhe: 3.203 ± 0.06	5.895SerGly: 5.895 ± 0.117	1.028SerHis: 1.028 ± 0.033	3.726SerIle: 3.726 ± 0.072	2.928SerLys: 2.928 ± 0.076	6.676SerLeu: 6.676 ± 0.089	1.334SerMet: 1.334 ± 0.04	2.704SerAsn: 2.704 ± 0.067	2.631SerPro: 2.631 ± 0.048	2.246SerGln: 2.246 ± 0.051	3.314SerArg: 3.314 ± 0.064	3.706SerSer: 3.706 ± 0.083	3.139SerThr: 3.139 ± 0.068	3.679SerVal: 3.679 ± 0.067	0.889SerTrp: 0.889 ± 0.034	2.41SerTyr: 2.41 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.528ThrAla: 4.528 ± 0.107	0.322ThrCys: 0.322 ± 0.027	3.397ThrAsp: 3.397 ± 0.117	3.254ThrGlu: 3.254 ± 0.062	2.654ThrPhe: 2.654 ± 0.073	4.535ThrGly: 4.535 ± 0.098	1.022ThrHis: 1.022 ± 0.033	3.339ThrIle: 3.339 ± 0.073	1.968ThrLys: 1.968 ± 0.061	5.868ThrLeu: 5.868 ± 0.075	0.902ThrMet: 0.902 ± 0.033	2.177ThrAsn: 2.177 ± 0.061	2.754ThrPro: 2.754 ± 0.059	1.903ThrGln: 1.903 ± 0.046	2.585ThrArg: 2.585 ± 0.06	3.151ThrSer: 3.151 ± 0.058	3.019ThrThr: 3.019 ± 0.071	3.712ThrVal: 3.712 ± 0.11	0.631ThrTrp: 0.631 ± 0.028	2.209ThrTyr: 2.209 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	5.113ValAla: 5.113 ± 0.069	0.521ValCys: 0.521 ± 0.027	3.561ValAsp: 3.561 ± 0.083	3.797ValGlu: 3.797 ± 0.071	3.222ValPhe: 3.222 ± 0.068	4.276ValGly: 4.276 ± 0.071	1.142ValHis: 1.142 ± 0.036	4.06ValIle: 4.06 ± 0.06	2.772ValLys: 2.772 ± 0.066	6.854ValLeu: 6.854 ± 0.097	1.402ValMet: 1.402 ± 0.039	2.934ValAsn: 2.934 ± 0.069	2.678ValPro: 2.678 ± 0.046	2.064ValGln: 2.064 ± 0.048	3.282ValArg: 3.282 ± 0.062	4.259ValSer: 4.259 ± 0.067	3.404ValThr: 3.404 ± 0.135	4.57ValVal: 4.57 ± 0.077	0.655ValTrp: 0.655 ± 0.03	2.216ValTyr: 2.216 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.76TrpAla: 0.76 ± 0.03	0.088TrpCys: 0.088 ± 0.009	0.758TrpAsp: 0.758 ± 0.03	0.928TrpGlu: 0.928 ± 0.034	0.588TrpPhe: 0.588 ± 0.025	0.83TrpGly: 0.83 ± 0.026	0.256TrpHis: 0.256 ± 0.017	0.876TrpIle: 0.876 ± 0.037	0.741TrpLys: 0.741 ± 0.031	1.196TrpLeu: 1.196 ± 0.038	0.354TrpMet: 0.354 ± 0.018	0.692TrpAsn: 0.692 ± 0.028	0.364TrpPro: 0.364 ± 0.021	0.471TrpGln: 0.471 ± 0.021	0.562TrpArg: 0.562 ± 0.024	0.678TrpSer: 0.678 ± 0.028	0.613TrpThr: 0.613 ± 0.029	0.796TrpVal: 0.796 ± 0.035	0.191TrpTrp: 0.191 ± 0.015	0.457TrpTyr: 0.457 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.046	0.29TyrCys: 0.29 ± 0.017	2.124TyrAsp: 2.124 ± 0.051	2.278TyrGlu: 2.278 ± 0.051	2.138TyrPhe: 2.138 ± 0.051	2.735TyrGly: 2.735 ± 0.053	0.795TyrHis: 0.795 ± 0.028	1.986TyrIle: 1.986 ± 0.045	1.72TyrLys: 1.72 ± 0.045	3.943TyrLeu: 3.943 ± 0.06	0.726TyrMet: 0.726 ± 0.028	1.704TyrAsn: 1.704 ± 0.041	1.621TyrPro: 1.621 ± 0.043	1.574TyrGln: 1.574 ± 0.046	2.312TyrArg: 2.312 ± 0.056	2.313TyrSer: 2.313 ± 0.048	2.167TyrThr: 2.167 ± 0.069	2.033TyrVal: 2.033 ± 0.045	0.496TyrTrp: 0.496 ± 0.023	1.593TyrTyr: 1.593 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2844 proteins (998853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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