Amino acid dipepetide frequency for Acetivibrio saccincola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.26AlaAla: 4.26 ± 0.08	0.621AlaCys: 0.621 ± 0.029	3.092AlaAsp: 3.092 ± 0.055	4.042AlaGlu: 4.042 ± 0.075	2.486AlaPhe: 2.486 ± 0.058	4.322AlaGly: 4.322 ± 0.076	0.828AlaHis: 0.828 ± 0.03	4.876AlaIle: 4.876 ± 0.084	4.587AlaLys: 4.587 ± 0.077	5.527AlaLeu: 5.527 ± 0.085	1.404AlaMet: 1.404 ± 0.043	2.586AlaAsn: 2.586 ± 0.052	1.497AlaPro: 1.497 ± 0.038	1.502AlaGln: 1.502 ± 0.041	2.246AlaArg: 2.246 ± 0.05	3.307AlaSer: 3.307 ± 0.065	2.53AlaThr: 2.53 ± 0.061	4.72AlaVal: 4.72 ± 0.079	0.464AlaTrp: 0.464 ± 0.023	2.134AlaTyr: 2.134 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.629CysAla: 0.629 ± 0.029	0.16CysCys: 0.16 ± 0.013	0.592CysAsp: 0.592 ± 0.03	0.736CysGlu: 0.736 ± 0.028	0.496CysPhe: 0.496 ± 0.022	0.912CysGly: 0.912 ± 0.037	0.234CysHis: 0.234 ± 0.014	0.98CysIle: 0.98 ± 0.037	0.813CysLys: 0.813 ± 0.031	0.728CysLeu: 0.728 ± 0.032	0.261CysMet: 0.261 ± 0.019	0.532CysAsn: 0.532 ± 0.028	0.468CysPro: 0.468 ± 0.024	0.22CysGln: 0.22 ± 0.017	0.461CysArg: 0.461 ± 0.022	0.693CysSer: 0.693 ± 0.025	0.499CysThr: 0.499 ± 0.023	0.686CysVal: 0.686 ± 0.028	0.106CysTrp: 0.106 ± 0.011	0.42CysTyr: 0.42 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.191AspAla: 3.191 ± 0.063	0.597AspCys: 0.597 ± 0.024	2.959AspAsp: 2.959 ± 0.06	4.939AspGlu: 4.939 ± 0.08	2.959AspPhe: 2.959 ± 0.068	4.447AspGly: 4.447 ± 0.103	0.603AspHis: 0.603 ± 0.023	6.22AspIle: 6.22 ± 0.085	4.6AspLys: 4.6 ± 0.062	4.682AspLeu: 4.682 ± 0.067	1.501AspMet: 1.501 ± 0.038	2.84AspAsn: 2.84 ± 0.067	1.784AspPro: 1.784 ± 0.054	0.791AspGln: 0.791 ± 0.031	2.287AspArg: 2.287 ± 0.044	3.34AspSer: 3.34 ± 0.064	2.763AspThr: 2.763 ± 0.058	4.163AspVal: 4.163 ± 0.068	0.652AspTrp: 0.652 ± 0.032	2.778AspTyr: 2.778 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.559GluAla: 4.559 ± 0.086	0.643GluCys: 0.643 ± 0.023	4.622GluAsp: 4.622 ± 0.07	7.785GluGlu: 7.785 ± 0.125	3.151GluPhe: 3.151 ± 0.066	4.872GluGly: 4.872 ± 0.074	1.031GluHis: 1.031 ± 0.031	7.828GluIle: 7.828 ± 0.102	8.063GluLys: 8.063 ± 0.126	6.226GluLeu: 6.226 ± 0.109	2.045GluMet: 2.045 ± 0.043	5.091GluAsn: 5.091 ± 0.087	2.024GluPro: 2.024 ± 0.085	1.832GluGln: 1.832 ± 0.05	3.311GluArg: 3.311 ± 0.068	3.782GluSer: 3.782 ± 0.072	3.362GluThr: 3.362 ± 0.07	5.243GluVal: 5.243 ± 0.086	0.673GluTrp: 0.673 ± 0.027	3.704GluTyr: 3.704 ± 0.088	0.0GluXaa: 0.0 ± 0.0
Phe	2.364PheAla: 2.364 ± 0.056	0.573PheCys: 0.573 ± 0.023	2.665PheAsp: 2.665 ± 0.053	3.278PheGlu: 3.278 ± 0.06	1.994PhePhe: 1.994 ± 0.054	2.765PheGly: 2.765 ± 0.053	0.588PheHis: 0.588 ± 0.025	4.034PheIle: 4.034 ± 0.077	3.583PheLys: 3.583 ± 0.076	3.921PheLeu: 3.921 ± 0.091	0.977PheMet: 0.977 ± 0.033	2.542PheAsn: 2.542 ± 0.052	1.427PhePro: 1.427 ± 0.036	0.886PheGln: 0.886 ± 0.032	1.534PheArg: 1.534 ± 0.037	3.19PheSer: 3.19 ± 0.063	2.353PheThr: 2.353 ± 0.043	2.857PheVal: 2.857 ± 0.057	0.409PheTrp: 0.409 ± 0.022	1.906PheTyr: 1.906 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	3.706GlyAla: 3.706 ± 0.074	0.79GlyCys: 0.79 ± 0.027	3.854GlyAsp: 3.854 ± 0.072	4.908GlyGlu: 4.908 ± 0.079	3.106GlyPhe: 3.106 ± 0.054	4.556GlyGly: 4.556 ± 0.102	1.014GlyHis: 1.014 ± 0.035	6.43GlyIle: 6.43 ± 0.081	5.628GlyLys: 5.628 ± 0.085	5.101GlyLeu: 5.101 ± 0.081	1.803GlyMet: 1.803 ± 0.053	3.646GlyAsn: 3.646 ± 0.105	1.308GlyPro: 1.308 ± 0.042	1.59GlyGln: 1.59 ± 0.044	2.993GlyArg: 2.993 ± 0.063	3.795GlySer: 3.795 ± 0.069	3.721GlyThr: 3.721 ± 0.076	4.673GlyVal: 4.673 ± 0.089	0.72GlyTrp: 0.72 ± 0.029	3.082GlyTyr: 3.082 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.763HisAla: 0.763 ± 0.031	0.188HisCys: 0.188 ± 0.016	0.674HisAsp: 0.674 ± 0.032	0.963HisGlu: 0.963 ± 0.034	0.685HisPhe: 0.685 ± 0.028	1.036HisGly: 1.036 ± 0.034	0.345HisHis: 0.345 ± 0.022	1.344HisIle: 1.344 ± 0.038	1.092HisLys: 1.092 ± 0.035	1.221HisLeu: 1.221 ± 0.041	0.392HisMet: 0.392 ± 0.018	0.774HisAsn: 0.774 ± 0.031	0.701HisPro: 0.701 ± 0.027	0.415HisGln: 0.415 ± 0.025	0.633HisArg: 0.633 ± 0.028	0.922HisSer: 0.922 ± 0.033	0.717HisThr: 0.717 ± 0.029	0.944HisVal: 0.944 ± 0.031	0.19HisTrp: 0.19 ± 0.015	0.689HisTyr: 0.689 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.224IleAla: 5.224 ± 0.079	0.936IleCys: 0.936 ± 0.032	5.799IleAsp: 5.799 ± 0.082	7.223IleGlu: 7.223 ± 0.094	3.651IlePhe: 3.651 ± 0.076	5.133IleGly: 5.133 ± 0.074	1.216IleHis: 1.216 ± 0.037	8.051IleIle: 8.051 ± 0.115	8.098IleLys: 8.098 ± 0.1	7.978IleLeu: 7.978 ± 0.099	1.985IleMet: 1.985 ± 0.045	5.505IleAsn: 5.505 ± 0.093	3.422IlePro: 3.422 ± 0.065	2.139IleGln: 2.139 ± 0.046	3.459IleArg: 3.459 ± 0.068	6.411IleSer: 6.411 ± 0.068	4.719IleThr: 4.719 ± 0.08	5.668IleVal: 5.668 ± 0.078	0.576IleTrp: 0.576 ± 0.027	3.41IleTyr: 3.41 ± 0.071	0.0IleXaa: 0.0 ± 0.0
Lys	4.822LysAla: 4.822 ± 0.079	0.775LysCys: 0.775 ± 0.035	5.468LysAsp: 5.468 ± 0.082	8.072LysGlu: 8.072 ± 0.109	2.885LysPhe: 2.885 ± 0.057	5.252LysGly: 5.252 ± 0.074	1.301LysHis: 1.301 ± 0.037	7.72LysIle: 7.72 ± 0.104	8.212LysLys: 8.212 ± 0.111	6.494LysLeu: 6.494 ± 0.098	2.257LysMet: 2.257 ± 0.045	5.425LysAsn: 5.425 ± 0.089	2.424LysPro: 2.424 ± 0.051	1.873LysGln: 1.873 ± 0.044	3.753LysArg: 3.753 ± 0.076	4.632LysSer: 4.632 ± 0.07	4.162LysThr: 4.162 ± 0.07	5.619LysVal: 5.619 ± 0.083	0.684LysTrp: 0.684 ± 0.028	3.907LysTyr: 3.907 ± 0.075	0.0LysXaa: 0.0 ± 0.0
Leu	4.917LeuAla: 4.917 ± 0.072	0.961LeuCys: 0.961 ± 0.031	5.012LeuAsp: 5.012 ± 0.082	6.73LeuGlu: 6.73 ± 0.109	3.587LeuPhe: 3.587 ± 0.071	5.508LeuGly: 5.508 ± 0.088	1.115LeuHis: 1.115 ± 0.032	7.011LeuIle: 7.011 ± 0.1	8.309LeuLys: 8.309 ± 0.121	7.482LeuLeu: 7.482 ± 0.115	2.24LeuMet: 2.24 ± 0.055	4.906LeuAsn: 4.906 ± 0.077	2.869LeuPro: 2.869 ± 0.054	1.934LeuGln: 1.934 ± 0.045	3.322LeuArg: 3.322 ± 0.067	5.951LeuSer: 5.951 ± 0.094	4.12LeuThr: 4.12 ± 0.067	5.154LeuVal: 5.154 ± 0.079	0.648LeuTrp: 0.648 ± 0.029	3.217LeuTyr: 3.217 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.685MetAla: 1.685 ± 0.039	0.245MetCys: 0.245 ± 0.015	1.519MetAsp: 1.519 ± 0.035	1.89MetGlu: 1.89 ± 0.043	0.977MetPhe: 0.977 ± 0.037	1.627MetGly: 1.627 ± 0.044	0.36MetHis: 0.36 ± 0.021	1.78MetIle: 1.78 ± 0.045	2.171MetLys: 2.171 ± 0.05	2.277MetLeu: 2.277 ± 0.053	0.566MetMet: 0.566 ± 0.025	1.26MetAsn: 1.26 ± 0.036	1.024MetPro: 1.024 ± 0.035	0.669MetGln: 0.669 ± 0.03	0.983MetArg: 0.983 ± 0.032	1.551MetSer: 1.551 ± 0.039	1.194MetThr: 1.194 ± 0.039	1.723MetVal: 1.723 ± 0.044	0.159MetTrp: 0.159 ± 0.013	0.96MetTyr: 0.96 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.06	0.593AsnCys: 0.593 ± 0.03	2.478AsnAsp: 2.478 ± 0.054	3.945AsnGlu: 3.945 ± 0.075	2.454AsnPhe: 2.454 ± 0.058	3.662AsnGly: 3.662 ± 0.071	0.782AsnHis: 0.782 ± 0.03	5.901AsnIle: 5.901 ± 0.09	4.581AsnLys: 4.581 ± 0.069	4.795AsnLeu: 4.795 ± 0.083	1.45AsnMet: 1.45 ± 0.04	3.33AsnAsn: 3.33 ± 0.067	2.346AsnPro: 2.346 ± 0.046	1.397AsnGln: 1.397 ± 0.044	2.235AsnArg: 2.235 ± 0.056	3.607AsnSer: 3.607 ± 0.071	2.733AsnThr: 2.733 ± 0.059	3.586AsnVal: 3.586 ± 0.062	0.519AsnTrp: 0.519 ± 0.027	2.322AsnTyr: 2.322 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.766ProAla: 1.766 ± 0.049	0.313ProCys: 0.313 ± 0.019	2.459ProAsp: 2.459 ± 0.058	3.283ProGlu: 3.283 ± 0.093	1.576ProPhe: 1.576 ± 0.045	2.399ProGly: 2.399 ± 0.057	0.613ProHis: 0.613 ± 0.027	2.119ProIle: 2.119 ± 0.046	2.166ProLys: 2.166 ± 0.057	2.645ProLeu: 2.645 ± 0.049	0.681ProMet: 0.681 ± 0.026	1.397ProAsn: 1.397 ± 0.047	1.117ProPro: 1.117 ± 0.041	0.978ProGln: 0.978 ± 0.049	0.996ProArg: 0.996 ± 0.032	1.942ProSer: 1.942 ± 0.046	1.77ProThr: 1.77 ± 0.114	2.985ProVal: 2.985 ± 0.06	0.309ProTrp: 0.309 ± 0.02	1.35ProTyr: 1.35 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.434GlnAla: 1.434 ± 0.04	0.221GlnCys: 0.221 ± 0.016	1.14GlnAsp: 1.14 ± 0.036	1.845GlnGlu: 1.845 ± 0.049	0.935GlnPhe: 0.935 ± 0.031	1.481GlnGly: 1.481 ± 0.047	0.368GlnHis: 0.368 ± 0.029	2.057GlnIle: 2.057 ± 0.046	2.272GlnLys: 2.272 ± 0.054	2.12GlnLeu: 2.12 ± 0.05	0.705GlnMet: 0.705 ± 0.038	1.44GlnAsn: 1.44 ± 0.048	0.77GlnPro: 0.77 ± 0.045	0.794GlnGln: 0.794 ± 0.04	1.139GlnArg: 1.139 ± 0.038	1.341GlnSer: 1.341 ± 0.035	1.025GlnThr: 1.025 ± 0.033	1.479GlnVal: 1.479 ± 0.034	0.253GlnTrp: 0.253 ± 0.014	1.11GlnTyr: 1.11 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.127ArgAla: 2.127 ± 0.057	0.434ArgCys: 0.434 ± 0.024	2.25ArgAsp: 2.25 ± 0.045	3.564ArgGlu: 3.564 ± 0.061	1.859ArgPhe: 1.859 ± 0.047	2.419ArgGly: 2.419 ± 0.056	0.674ArgHis: 0.674 ± 0.028	3.639ArgIle: 3.639 ± 0.062	3.532ArgLys: 3.532 ± 0.066	3.594ArgLeu: 3.594 ± 0.073	1.009ArgMet: 1.009 ± 0.035	2.148ArgAsn: 2.148 ± 0.043	1.253ArgPro: 1.253 ± 0.037	1.264ArgGln: 1.264 ± 0.04	1.837ArgArg: 1.837 ± 0.051	1.797ArgSer: 1.797 ± 0.05	1.989ArgThr: 1.989 ± 0.044	2.716ArgVal: 2.716 ± 0.053	0.373ArgTrp: 0.373 ± 0.022	1.996ArgTyr: 1.996 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	3.142SerAla: 3.142 ± 0.063	0.651SerCys: 0.651 ± 0.025	3.374SerAsp: 3.374 ± 0.072	4.354SerGlu: 4.354 ± 0.072	3.041SerPhe: 3.041 ± 0.059	4.663SerGly: 4.663 ± 0.088	0.975SerHis: 0.975 ± 0.036	5.499SerIle: 5.499 ± 0.085	5.051SerLys: 5.051 ± 0.077	5.382SerLeu: 5.382 ± 0.084	1.495SerMet: 1.495 ± 0.04	3.123SerAsn: 3.123 ± 0.064	2.047SerPro: 2.047 ± 0.083	1.676SerGln: 1.676 ± 0.043	2.54SerArg: 2.54 ± 0.049	3.971SerSer: 3.971 ± 0.082	2.981SerThr: 2.981 ± 0.065	4.083SerVal: 4.083 ± 0.065	0.587SerTrp: 0.587 ± 0.027	2.479SerTyr: 2.479 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.033ThrAla: 3.033 ± 0.058	0.472ThrCys: 0.472 ± 0.019	2.773ThrAsp: 2.773 ± 0.054	3.281ThrGlu: 3.281 ± 0.07	2.199ThrPhe: 2.199 ± 0.061	4.281ThrGly: 4.281 ± 0.066	0.831ThrHis: 0.831 ± 0.031	4.35ThrIle: 4.35 ± 0.072	3.458ThrLys: 3.458 ± 0.06	4.111ThrLeu: 4.111 ± 0.078	0.99ThrMet: 0.99 ± 0.029	2.273ThrAsn: 2.273 ± 0.055	2.304ThrPro: 2.304 ± 0.096	1.15ThrGln: 1.15 ± 0.038	1.836ThrArg: 1.836 ± 0.045	3.059ThrSer: 3.059 ± 0.096	2.684ThrThr: 2.684 ± 0.106	3.905ThrVal: 3.905 ± 0.072	0.397ThrTrp: 0.397 ± 0.025	2.069ThrTyr: 2.069 ± 0.072	0.0ThrXaa: 0.0 ± 0.0
Val	3.812ValAla: 3.812 ± 0.077	0.787ValCys: 0.787 ± 0.033	3.953ValAsp: 3.953 ± 0.064	5.235ValGlu: 5.235 ± 0.083	3.458ValPhe: 3.458 ± 0.064	3.785ValGly: 3.785 ± 0.079	0.955ValHis: 0.955 ± 0.03	6.016ValIle: 6.016 ± 0.085	5.502ValLys: 5.502 ± 0.079	6.526ValLeu: 6.526 ± 0.095	1.618ValMet: 1.618 ± 0.044	3.661ValAsn: 3.661 ± 0.059	2.493ValPro: 2.493 ± 0.057	1.437ValGln: 1.437 ± 0.038	2.677ValArg: 2.677 ± 0.062	4.485ValSer: 4.485 ± 0.064	3.507ValThr: 3.507 ± 0.078	4.936ValVal: 4.936 ± 0.089	0.561ValTrp: 0.561 ± 0.025	2.919ValTyr: 2.919 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.538TrpAla: 0.538 ± 0.026	0.104TrpCys: 0.104 ± 0.011	0.653TrpAsp: 0.653 ± 0.026	0.726TrpGlu: 0.726 ± 0.03	0.376TrpPhe: 0.376 ± 0.023	0.622TrpGly: 0.622 ± 0.031	0.192TrpHis: 0.192 ± 0.013	0.703TrpIle: 0.703 ± 0.028	0.596TrpLys: 0.596 ± 0.031	0.691TrpLeu: 0.691 ± 0.023	0.255TrpMet: 0.255 ± 0.016	0.535TrpAsn: 0.535 ± 0.03	0.168TrpPro: 0.168 ± 0.014	0.269TrpGln: 0.269 ± 0.019	0.351TrpArg: 0.351 ± 0.023	0.514TrpSer: 0.514 ± 0.025	0.397TrpThr: 0.397 ± 0.021	0.588TrpVal: 0.588 ± 0.028	0.118TrpTrp: 0.118 ± 0.01	0.371TrpTyr: 0.371 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.088TyrAla: 2.088 ± 0.055	0.561TyrCys: 0.561 ± 0.025	2.763TyrAsp: 2.763 ± 0.104	3.049TyrGlu: 3.049 ± 0.07	1.97TyrPhe: 1.97 ± 0.05	2.683TyrGly: 2.683 ± 0.057	0.665TyrHis: 0.665 ± 0.03	4.045TyrIle: 4.045 ± 0.072	3.422TyrLys: 3.422 ± 0.073	3.489TyrLeu: 3.489 ± 0.07	0.985TyrMet: 0.985 ± 0.033	2.672TyrAsn: 2.672 ± 0.061	1.417TyrPro: 1.417 ± 0.035	1.112TyrGln: 1.112 ± 0.035	1.882TyrArg: 1.882 ± 0.045	2.824TyrSer: 2.824 ± 0.055	2.23TyrThr: 2.23 ± 0.057	2.593TyrVal: 2.593 ± 0.059	0.371TyrTrp: 0.371 ± 0.021	2.046TyrTyr: 2.046 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3020 proteins (967809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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