Amino acid dipepetide frequency for Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.856AlaAla: 13.856 ± 0.268
1.167AlaCys: 1.167 ± 0.044
6.415AlaAsp: 6.415 ± 0.148
7.384AlaGlu: 7.384 ± 0.145
3.956AlaPhe: 3.956 ± 0.088
8.255AlaGly: 8.255 ± 0.134
1.902AlaHis: 1.902 ± 0.053
3.926AlaIle: 3.926 ± 0.096
5.568AlaLys: 5.568 ± 0.109
10.227AlaLeu: 10.227 ± 0.143
2.567AlaMet: 2.567 ± 0.077
3.185AlaAsn: 3.185 ± 0.08
3.524AlaPro: 3.524 ± 0.087
4.518AlaGln: 4.518 ± 0.093
5.249AlaArg: 5.249 ± 0.101
4.471AlaSer: 4.471 ± 0.098
3.451AlaThr: 3.451 ± 0.084
9.199AlaVal: 9.199 ± 0.137
1.085AlaTrp: 1.085 ± 0.049
2.906AlaTyr: 2.906 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
1.05CysAla: 1.05 ± 0.044
0.168CysCys: 0.168 ± 0.017
0.471CysAsp: 0.471 ± 0.029
0.546CysGlu: 0.546 ± 0.031
0.448CysPhe: 0.448 ± 0.026
1.251CysGly: 1.251 ± 0.048
0.273CysHis: 0.273 ± 0.021
0.611CysIle: 0.611 ± 0.034
0.488CysLys: 0.488 ± 0.026
1.074CysLeu: 1.074 ± 0.047
0.238CysMet: 0.238 ± 0.021
0.331CysAsn: 0.331 ± 0.027
0.583CysPro: 0.583 ± 0.032
0.381CysGln: 0.381 ± 0.024
1.067CysArg: 1.067 ± 0.042
0.579CysSer: 0.579 ± 0.032
0.506CysThr: 0.506 ± 0.025
0.625CysVal: 0.625 ± 0.03
0.079CysTrp: 0.079 ± 0.014
0.264CysTyr: 0.264 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
5.039AspAla: 5.039 ± 0.126
0.544AspCys: 0.544 ± 0.036
2.6AspAsp: 2.6 ± 0.078
3.528AspGlu: 3.528 ± 0.083
2.609AspPhe: 2.609 ± 0.064
4.884AspGly: 4.884 ± 0.09
0.735AspHis: 0.735 ± 0.041
3.61AspIle: 3.61 ± 0.089
3.312AspLys: 3.312 ± 0.089
5.015AspLeu: 5.015 ± 0.099
1.391AspMet: 1.391 ± 0.048
2.089AspAsn: 2.089 ± 0.06
1.753AspPro: 1.753 ± 0.058
1.08AspGln: 1.08 ± 0.042
2.577AspArg: 2.577 ± 0.073
2.637AspSer: 2.637 ± 0.072
2.959AspThr: 2.959 ± 0.08
3.491AspVal: 3.491 ± 0.083
0.824AspTrp: 0.824 ± 0.04
1.991AspTyr: 1.991 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
6.563GluAla: 6.563 ± 0.127
0.586GluCys: 0.586 ± 0.034
2.658GluAsp: 2.658 ± 0.075
3.689GluGlu: 3.689 ± 0.106
2.075GluPhe: 2.075 ± 0.063
4.021GluGly: 4.021 ± 0.092
1.601GluHis: 1.601 ± 0.058
4.117GluIle: 4.117 ± 0.092
4.241GluLys: 4.241 ± 0.1
5.592GluLeu: 5.592 ± 0.122
1.678GluMet: 1.678 ± 0.058
3.297GluAsn: 3.297 ± 0.091
2.061GluPro: 2.061 ± 0.06
2.878GluGln: 2.878 ± 0.083
3.577GluArg: 3.577 ± 0.085
3.022GluSer: 3.022 ± 0.083
3.907GluThr: 3.907 ± 0.095
3.547GluVal: 3.547 ± 0.089
0.78GluTrp: 0.78 ± 0.038
1.745GluTyr: 1.745 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
4.39PheAla: 4.39 ± 0.103
0.609PheCys: 0.609 ± 0.035
2.829PheAsp: 2.829 ± 0.076
2.383PheGlu: 2.383 ± 0.063
1.827PhePhe: 1.827 ± 0.072
3.767PheGly: 3.767 ± 0.086
0.866PheHis: 0.866 ± 0.033
2.156PheIle: 2.156 ± 0.072
2.142PheLys: 2.142 ± 0.063
3.508PheLeu: 3.508 ± 0.107
0.98PheMet: 0.98 ± 0.047
1.622PheAsn: 1.622 ± 0.056
1.671PhePro: 1.671 ± 0.064
1.372PheGln: 1.372 ± 0.043
1.912PheArg: 1.912 ± 0.052
2.752PheSer: 2.752 ± 0.067
2.075PheThr: 2.075 ± 0.059
2.892PheVal: 2.892 ± 0.072
0.567PheTrp: 0.567 ± 0.035
1.297PheTyr: 1.297 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
6.593GlyAla: 6.593 ± 0.121
0.973GlyCys: 0.973 ± 0.043
3.452GlyAsp: 3.452 ± 0.087
4.672GlyGlu: 4.672 ± 0.12
3.725GlyPhe: 3.725 ± 0.079
7.025GlyGly: 7.025 ± 0.14
1.587GlyHis: 1.587 ± 0.053
5.772GlyIle: 5.772 ± 0.106
5.981GlyLys: 5.981 ± 0.114
7.496GlyLeu: 7.496 ± 0.116
2.206GlyMet: 2.206 ± 0.071
3.409GlyAsn: 3.409 ± 0.081
1.347GlyPro: 1.347 ± 0.06
2.688GlyGln: 2.688 ± 0.069
4.891GlyArg: 4.891 ± 0.1
4.49GlySer: 4.49 ± 0.105
3.732GlyThr: 3.732 ± 0.091
5.274GlyVal: 5.274 ± 0.104
1.06GlyTrp: 1.06 ± 0.047
2.591GlyTyr: 2.591 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
1.769HisAla: 1.769 ± 0.058
0.313HisCys: 0.313 ± 0.026
0.973HisAsp: 0.973 ± 0.041
1.211HisGlu: 1.211 ± 0.051
0.938HisPhe: 0.938 ± 0.043
1.774HisGly: 1.774 ± 0.053
0.642HisHis: 0.642 ± 0.037
1.678HisIle: 1.678 ± 0.059
0.926HisLys: 0.926 ± 0.044
2.031HisLeu: 2.031 ± 0.061
0.411HisMet: 0.411 ± 0.024
0.884HisAsn: 0.884 ± 0.046
1.41HisPro: 1.41 ± 0.047
0.794HisGln: 0.794 ± 0.042
1.183HisArg: 1.183 ± 0.046
1.192HisSer: 1.192 ± 0.045
1.37HisThr: 1.37 ± 0.055
1.025HisVal: 1.025 ± 0.045
0.287HisTrp: 0.287 ± 0.02
0.807HisTyr: 0.807 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.007IleAla: 6.007 ± 0.113
0.702IleCys: 0.702 ± 0.032
3.328IleAsp: 3.328 ± 0.089
3.704IleGlu: 3.704 ± 0.085
2.096IlePhe: 2.096 ± 0.068
5.059IleGly: 5.059 ± 0.096
1.297IleHis: 1.297 ± 0.046
3.031IleIle: 3.031 ± 0.091
2.861IleLys: 2.861 ± 0.093
5.27IleLeu: 5.27 ± 0.112
1.256IleMet: 1.256 ± 0.06
2.215IleAsn: 2.215 ± 0.062
2.812IlePro: 2.812 ± 0.077
1.745IleGln: 1.745 ± 0.061
3.627IleArg: 3.627 ± 0.084
3.34IleSer: 3.34 ± 0.074
3.052IleThr: 3.052 ± 0.071
3.94IleVal: 3.94 ± 0.091
0.553IleTrp: 0.553 ± 0.033
1.449IleTyr: 1.449 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
5.512LysAla: 5.512 ± 0.119
0.36LysCys: 0.36 ± 0.026
2.861LysAsp: 2.861 ± 0.08
3.409LysGlu: 3.409 ± 0.09
1.738LysPhe: 1.738 ± 0.061
3.919LysGly: 3.919 ± 0.089
1.305LysHis: 1.305 ± 0.048
3.872LysIle: 3.872 ± 0.097
3.461LysLys: 3.461 ± 0.088
5.162LysLeu: 5.162 ± 0.087
1.65LysMet: 1.65 ± 0.055
2.791LysAsn: 2.791 ± 0.083
2.948LysPro: 2.948 ± 0.081
2.525LysGln: 2.525 ± 0.068
3.162LysArg: 3.162 ± 0.084
2.885LysSer: 2.885 ± 0.083
3.709LysThr: 3.709 ± 0.089
3.22LysVal: 3.22 ± 0.089
0.679LysTrp: 0.679 ± 0.033
1.575LysTyr: 1.575 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.037LeuAla: 10.037 ± 0.161
1.015LeuCys: 1.015 ± 0.041
5.396LeuAsp: 5.396 ± 0.101
5.318LeuGlu: 5.318 ± 0.104
4.166LeuPhe: 4.166 ± 0.113
6.961LeuGly: 6.961 ± 0.111
2.089LeuHis: 2.089 ± 0.053
5.304LeuIle: 5.304 ± 0.098
6.215LeuLys: 6.215 ± 0.108
9.361LeuLeu: 9.361 ± 0.159
2.504LeuMet: 2.504 ± 0.065
4.376LeuAsn: 4.376 ± 0.083
5.622LeuPro: 5.622 ± 0.122
3.524LeuGln: 3.524 ± 0.082
4.719LeuArg: 4.719 ± 0.098
6.402LeuSer: 6.402 ± 0.128
5.297LeuThr: 5.297 ± 0.085
5.486LeuVal: 5.486 ± 0.114
1.104LeuTrp: 1.104 ± 0.052
2.458LeuTyr: 2.458 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.394MetAla: 2.394 ± 0.071
0.252MetCys: 0.252 ± 0.02
1.137MetAsp: 1.137 ± 0.046
1.277MetGlu: 1.277 ± 0.05
0.929MetPhe: 0.929 ± 0.04
1.767MetGly: 1.767 ± 0.059
0.457MetHis: 0.457 ± 0.025
1.27MetIle: 1.27 ± 0.045
1.65MetLys: 1.65 ± 0.054
2.579MetLeu: 2.579 ± 0.069
0.78MetMet: 0.78 ± 0.042
1.174MetAsn: 1.174 ± 0.046
1.692MetPro: 1.692 ± 0.054
1.046MetGln: 1.046 ± 0.042
1.445MetArg: 1.445 ± 0.055
1.496MetSer: 1.496 ± 0.045
1.395MetThr: 1.395 ± 0.048
1.5MetVal: 1.5 ± 0.062
0.261MetTrp: 0.261 ± 0.022
0.525MetTyr: 0.525 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.858AsnAla: 3.858 ± 0.085
0.345AsnCys: 0.345 ± 0.023
1.771AsnAsp: 1.771 ± 0.058
2.012AsnGlu: 2.012 ± 0.062
1.4AsnPhe: 1.4 ± 0.05
3.709AsnGly: 3.709 ± 0.101
0.929AsnHis: 0.929 ± 0.046
2.985AsnIle: 2.985 ± 0.083
2.0AsnLys: 2.0 ± 0.066
3.746AsnLeu: 3.746 ± 0.083
0.931AsnMet: 0.931 ± 0.042
1.578AsnAsn: 1.578 ± 0.06
2.544AsnPro: 2.544 ± 0.078
1.491AsnGln: 1.491 ± 0.056
2.656AsnArg: 2.656 ± 0.07
1.822AsnSer: 1.822 ± 0.065
2.259AsnThr: 2.259 ± 0.067
2.453AsnVal: 2.453 ± 0.072
0.507AsnTrp: 0.507 ± 0.03
1.074AsnTyr: 1.074 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.299ProAla: 4.299 ± 0.106
0.469ProCys: 0.469 ± 0.029
3.05ProAsp: 3.05 ± 0.089
3.949ProGlu: 3.949 ± 0.089
1.963ProPhe: 1.963 ± 0.058
2.28ProGly: 2.28 ± 0.072
1.041ProHis: 1.041 ± 0.047
1.933ProIle: 1.933 ± 0.058
2.395ProLys: 2.395 ± 0.072
3.937ProLeu: 3.937 ± 0.092
1.001ProMet: 1.001 ± 0.035
1.641ProAsn: 1.641 ± 0.05
1.809ProPro: 1.809 ± 0.062
1.886ProGln: 1.886 ± 0.062
1.781ProArg: 1.781 ± 0.059
2.579ProSer: 2.579 ± 0.067
1.968ProThr: 1.968 ± 0.057
3.566ProVal: 3.566 ± 0.086
0.395ProTrp: 0.395 ± 0.028
1.36ProTyr: 1.36 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.275GlnAla: 4.275 ± 0.104
0.317GlnCys: 0.317 ± 0.025
1.846GlnAsp: 1.846 ± 0.056
2.252GlnGlu: 2.252 ± 0.074
1.258GlnPhe: 1.258 ± 0.051
2.707GlnGly: 2.707 ± 0.073
0.805GlnHis: 0.805 ± 0.04
2.457GlnIle: 2.457 ± 0.062
2.261GlnLys: 2.261 ± 0.074
2.968GlnLeu: 2.968 ± 0.069
1.053GlnMet: 1.053 ± 0.047
2.021GlnAsn: 2.021 ± 0.059
1.608GlnPro: 1.608 ± 0.056
1.629GlnGln: 1.629 ± 0.075
1.87GlnArg: 1.87 ± 0.058
2.22GlnSer: 2.22 ± 0.07
2.941GlnThr: 2.941 ± 0.081
2.229GlnVal: 2.229 ± 0.062
0.439GlnTrp: 0.439 ± 0.03
1.228GlnTyr: 1.228 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
4.87ArgAla: 4.87 ± 0.116
0.535ArgCys: 0.535 ± 0.03
2.635ArgAsp: 2.635 ± 0.076
3.626ArgGlu: 3.626 ± 0.097
3.004ArgPhe: 3.004 ± 0.071
3.353ArgGly: 3.353 ± 0.075
1.549ArgHis: 1.549 ± 0.056
3.512ArgIle: 3.512 ± 0.076
3.039ArgLys: 3.039 ± 0.078
6.443ArgLeu: 6.443 ± 0.131
1.535ArgMet: 1.535 ± 0.052
2.334ArgAsn: 2.334 ± 0.069
2.39ArgPro: 2.39 ± 0.058
2.885ArgGln: 2.885 ± 0.081
4.142ArgArg: 4.142 ± 0.1
2.717ArgSer: 2.717 ± 0.076
2.661ArgThr: 2.661 ± 0.07
3.251ArgVal: 3.251 ± 0.081
0.558ArgTrp: 0.558 ± 0.036
2.175ArgTyr: 2.175 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.449SerAla: 5.449 ± 0.099
0.679SerCys: 0.679 ± 0.037
3.332SerAsp: 3.332 ± 0.073
3.456SerGlu: 3.456 ± 0.083
2.32SerPhe: 2.32 ± 0.064
5.405SerGly: 5.405 ± 0.097
1.125SerHis: 1.125 ± 0.045
2.71SerIle: 2.71 ± 0.071
2.499SerLys: 2.499 ± 0.069
5.538SerLeu: 5.538 ± 0.106
1.174SerMet: 1.174 ± 0.044
1.799SerAsn: 1.799 ± 0.066
2.334SerPro: 2.334 ± 0.068
1.704SerGln: 1.704 ± 0.06
3.277SerArg: 3.277 ± 0.098
2.754SerSer: 2.754 ± 0.073
2.287SerThr: 2.287 ± 0.063
4.24SerVal: 4.24 ± 0.094
0.593SerTrp: 0.593 ± 0.036
1.566SerTyr: 1.566 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
6.479ThrAla: 6.479 ± 0.124
0.502ThrCys: 0.502 ± 0.033
2.954ThrAsp: 2.954 ± 0.072
3.069ThrGlu: 3.069 ± 0.069
1.898ThrPhe: 1.898 ± 0.054
4.486ThrGly: 4.486 ± 0.1
1.16ThrHis: 1.16 ± 0.045
2.374ThrIle: 2.374 ± 0.063
1.942ThrLys: 1.942 ± 0.062
5.496ThrLeu: 5.496 ± 0.113
0.98ThrMet: 0.98 ± 0.042
1.377ThrAsn: 1.377 ± 0.05
2.726ThrPro: 2.726 ± 0.07
1.815ThrGln: 1.815 ± 0.054
2.702ThrArg: 2.702 ± 0.076
2.114ThrSer: 2.114 ± 0.055
1.961ThrThr: 1.961 ± 0.063
4.877ThrVal: 4.877 ± 0.085
0.476ThrTrp: 0.476 ± 0.029
1.3ThrTyr: 1.3 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
6.388ValAla: 6.388 ± 0.125
0.99ValCys: 0.99 ± 0.039
2.842ValAsp: 2.842 ± 0.08
3.989ValGlu: 3.989 ± 0.094
3.148ValPhe: 3.148 ± 0.093
5.013ValGly: 5.013 ± 0.105
1.249ValHis: 1.249 ± 0.053
3.709ValIle: 3.709 ± 0.098
3.862ValLys: 3.862 ± 0.088
7.354ValLeu: 7.354 ± 0.126
1.832ValMet: 1.832 ± 0.054
2.548ValAsn: 2.548 ± 0.069
2.815ValPro: 2.815 ± 0.07
2.376ValGln: 2.376 ± 0.066
4.199ValArg: 4.199 ± 0.105
4.754ValSer: 4.754 ± 0.095
3.057ValThr: 3.057 ± 0.075
4.609ValVal: 4.609 ± 0.1
0.999ValTrp: 0.999 ± 0.047
2.07ValTyr: 2.07 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.027TrpAla: 1.027 ± 0.048
0.136TrpCys: 0.136 ± 0.015
0.581TrpAsp: 0.581 ± 0.031
0.574TrpGlu: 0.574 ± 0.037
0.625TrpPhe: 0.625 ± 0.031
0.768TrpGly: 0.768 ± 0.039
0.369TrpHis: 0.369 ± 0.022
0.633TrpIle: 0.633 ± 0.03
0.628TrpLys: 0.628 ± 0.034
1.563TrpLeu: 1.563 ± 0.06
0.32TrpMet: 0.32 ± 0.024
0.436TrpAsn: 0.436 ± 0.028
0.275TrpPro: 0.275 ± 0.022
0.85TrpGln: 0.85 ± 0.041
0.805TrpArg: 0.805 ± 0.042
0.45TrpSer: 0.45 ± 0.03
0.485TrpThr: 0.485 ± 0.031
0.773TrpVal: 0.773 ± 0.037
0.159TrpTrp: 0.159 ± 0.021
0.357TrpTyr: 0.357 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.955TyrAla: 2.955 ± 0.074
0.369TyrCys: 0.369 ± 0.028
1.538TyrAsp: 1.538 ± 0.063
1.589TyrGlu: 1.589 ± 0.057
1.494TyrPhe: 1.494 ± 0.048
2.56TyrGly: 2.56 ± 0.065
0.637TyrHis: 0.637 ± 0.032
1.682TyrIle: 1.682 ± 0.063
1.274TyrLys: 1.274 ± 0.051
2.992TyrLeu: 2.992 ± 0.077
0.537TyrMet: 0.537 ± 0.03
0.966TyrAsn: 0.966 ± 0.048
1.379TyrPro: 1.379 ± 0.047
1.197TyrGln: 1.197 ± 0.049
2.371TyrArg: 2.371 ± 0.065
1.564TyrSer: 1.564 ± 0.048
1.617TyrThr: 1.617 ± 0.056
1.61TyrVal: 1.61 ± 0.05
0.408TyrTrp: 0.408 ± 0.028
0.924TyrTyr: 0.924 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2106 proteins (571507 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski