Amino acid dipepetide frequency for Halolamina pelagica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.189AlaAla: 16.189 ± 0.223	0.771AlaCys: 0.771 ± 0.028	10.302AlaAsp: 10.302 ± 0.128	9.482AlaGlu: 9.482 ± 0.139	4.246AlaPhe: 4.246 ± 0.077	10.903AlaGly: 10.903 ± 0.137	1.904AlaHis: 1.904 ± 0.053	4.618AlaIle: 4.618 ± 0.088	1.709AlaLys: 1.709 ± 0.049	10.724AlaLeu: 10.724 ± 0.16	2.364AlaMet: 2.364 ± 0.058	2.308AlaAsn: 2.308 ± 0.049	4.479AlaPro: 4.479 ± 0.077	2.206AlaGln: 2.206 ± 0.054	6.591AlaArg: 6.591 ± 0.11	5.927AlaSer: 5.927 ± 0.085	7.4AlaThr: 7.4 ± 0.116	11.746AlaVal: 11.746 ± 0.151	1.241AlaTrp: 1.241 ± 0.037	2.702AlaTyr: 2.702 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.589CysAla: 0.589 ± 0.027	0.123CysCys: 0.123 ± 0.011	0.522CysAsp: 0.522 ± 0.029	0.544CysGlu: 0.544 ± 0.025	0.212CysPhe: 0.212 ± 0.016	0.878CysGly: 0.878 ± 0.038	0.155CysHis: 0.155 ± 0.014	0.241CysIle: 0.241 ± 0.017	0.103CysLys: 0.103 ± 0.012	0.52CysLeu: 0.52 ± 0.023	0.145CysMet: 0.145 ± 0.012	0.166CysAsn: 0.166 ± 0.015	0.609CysPro: 0.609 ± 0.03	0.151CysGln: 0.151 ± 0.014	0.62CysArg: 0.62 ± 0.03	0.681CysSer: 0.681 ± 0.029	0.432CysThr: 0.432 ± 0.026	0.457CysVal: 0.457 ± 0.023	0.137CysTrp: 0.137 ± 0.012	0.197CysTyr: 0.197 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	11.498AspAla: 11.498 ± 0.169	0.732AspCys: 0.732 ± 0.034	7.594AspAsp: 7.594 ± 0.106	7.585AspGlu: 7.585 ± 0.118	1.562AspPhe: 1.562 ± 0.044	7.997AspGly: 7.997 ± 0.106	1.772AspHis: 1.772 ± 0.053	2.552AspIle: 2.552 ± 0.064	0.799AspLys: 0.799 ± 0.031	6.534AspLeu: 6.534 ± 0.094	1.161AspMet: 1.161 ± 0.036	1.127AspAsn: 1.127 ± 0.042	4.518AspPro: 4.518 ± 0.071	1.588AspGln: 1.588 ± 0.043	6.41AspArg: 6.41 ± 0.091	3.546AspSer: 3.546 ± 0.072	4.147AspThr: 4.147 ± 0.076	6.57AspVal: 6.57 ± 0.107	1.111AspTrp: 1.111 ± 0.039	1.735AspTyr: 1.735 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	9.088GluAla: 9.088 ± 0.124	0.489GluCys: 0.489 ± 0.028	4.737GluAsp: 4.737 ± 0.088	6.828GluGlu: 6.828 ± 0.13	3.007GluPhe: 3.007 ± 0.071	5.536GluGly: 5.536 ± 0.09	1.961GluHis: 1.961 ± 0.057	3.777GluIle: 3.777 ± 0.086	1.724GluLys: 1.724 ± 0.058	7.942GluLeu: 7.942 ± 0.111	1.851GluMet: 1.851 ± 0.043	2.347GluAsn: 2.347 ± 0.058	4.169GluPro: 4.169 ± 0.07	2.971GluGln: 2.971 ± 0.061	7.275GluArg: 7.275 ± 0.116	4.876GluSer: 4.876 ± 0.079	6.057GluThr: 6.057 ± 0.094	5.314GluVal: 5.314 ± 0.102	1.107GluTrp: 1.107 ± 0.037	2.53GluTyr: 2.53 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.826PheAla: 3.826 ± 0.078	0.235PheCys: 0.235 ± 0.016	3.254PheAsp: 3.254 ± 0.063	2.946PheGlu: 2.946 ± 0.063	0.943PhePhe: 0.943 ± 0.037	3.268PheGly: 3.268 ± 0.067	0.632PheHis: 0.632 ± 0.031	0.925PheIle: 0.925 ± 0.034	0.446PheLys: 0.446 ± 0.023	2.762PheLeu: 2.762 ± 0.072	0.496PheMet: 0.496 ± 0.026	0.657PheAsn: 0.657 ± 0.028	1.396PhePro: 1.396 ± 0.044	0.727PheGln: 0.727 ± 0.029	1.859PheArg: 1.859 ± 0.049	1.705PheSer: 1.705 ± 0.047	1.89PheThr: 1.89 ± 0.05	3.283PheVal: 3.283 ± 0.07	0.422PheTrp: 0.422 ± 0.023	0.807PheTyr: 0.807 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.072GlyAla: 9.072 ± 0.131	0.733GlyCys: 0.733 ± 0.028	6.849GlyAsp: 6.849 ± 0.101	7.552GlyGlu: 7.552 ± 0.106	3.142GlyPhe: 3.142 ± 0.056	7.579GlyGly: 7.579 ± 0.124	1.672GlyHis: 1.672 ± 0.045	3.822GlyIle: 3.822 ± 0.077	1.747GlyLys: 1.747 ± 0.055	7.451GlyLeu: 7.451 ± 0.125	1.806GlyMet: 1.806 ± 0.051	1.922GlyAsn: 1.922 ± 0.053	3.544GlyPro: 3.544 ± 0.066	1.971GlyGln: 1.971 ± 0.045	5.266GlyArg: 5.266 ± 0.088	5.279GlySer: 5.279 ± 0.09	5.707GlyThr: 5.707 ± 0.088	8.297GlyVal: 8.297 ± 0.105	1.192GlyTrp: 1.192 ± 0.045	2.698GlyTyr: 2.698 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.003HisAla: 2.003 ± 0.051	0.211HisCys: 0.211 ± 0.017	1.742HisAsp: 1.742 ± 0.049	1.704HisGlu: 1.704 ± 0.052	0.471HisPhe: 0.471 ± 0.023	1.892HisGly: 1.892 ± 0.049	0.519HisHis: 0.519 ± 0.028	0.588HisIle: 0.588 ± 0.026	0.262HisLys: 0.262 ± 0.019	1.637HisLeu: 1.637 ± 0.05	0.284HisMet: 0.284 ± 0.017	0.408HisAsn: 0.408 ± 0.022	1.295HisPro: 1.295 ± 0.045	0.402HisGln: 0.402 ± 0.022	1.417HisArg: 1.417 ± 0.045	0.838HisSer: 0.838 ± 0.034	1.071HisThr: 1.071 ± 0.037	1.851HisVal: 1.851 ± 0.043	0.236HisTrp: 0.236 ± 0.017	0.552HisTyr: 0.552 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.554IleAla: 4.554 ± 0.085	0.253IleCys: 0.253 ± 0.016	3.833IleAsp: 3.833 ± 0.071	3.907IleGlu: 3.907 ± 0.084	0.748IlePhe: 0.748 ± 0.035	3.513IleGly: 3.513 ± 0.078	0.797IleHis: 0.797 ± 0.035	1.005IleIle: 1.005 ± 0.045	0.609IleLys: 0.609 ± 0.028	2.437IleLeu: 2.437 ± 0.063	0.447IleMet: 0.447 ± 0.022	0.837IleAsn: 0.837 ± 0.035	1.953IlePro: 1.953 ± 0.052	0.998IleGln: 0.998 ± 0.039	2.459IleArg: 2.459 ± 0.056	1.97IleSer: 1.97 ± 0.052	2.167IleThr: 2.167 ± 0.053	3.502IleVal: 3.502 ± 0.072	0.311IleTrp: 0.311 ± 0.019	0.792IleTyr: 0.792 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.655LysAla: 1.655 ± 0.05	0.109LysCys: 0.109 ± 0.012	0.928LysAsp: 0.928 ± 0.036	1.295LysGlu: 1.295 ± 0.048	0.503LysPhe: 0.503 ± 0.025	1.195LysGly: 1.195 ± 0.042	0.444LysHis: 0.444 ± 0.026	0.664LysIle: 0.664 ± 0.028	0.411LysLys: 0.411 ± 0.026	1.642LysLeu: 1.642 ± 0.042	0.346LysMet: 0.346 ± 0.023	0.455LysAsn: 0.455 ± 0.03	0.866LysPro: 0.866 ± 0.033	0.699LysGln: 0.699 ± 0.028	1.517LysArg: 1.517 ± 0.041	0.986LysSer: 0.986 ± 0.036	1.161LysThr: 1.161 ± 0.042	1.104LysVal: 1.104 ± 0.038	0.207LysTrp: 0.207 ± 0.016	0.49LysTyr: 0.49 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.44LeuAla: 11.44 ± 0.156	0.548LeuCys: 0.548 ± 0.024	7.369LeuAsp: 7.369 ± 0.105	5.924LeuGlu: 5.924 ± 0.086	3.14LeuPhe: 3.14 ± 0.079	7.905LeuGly: 7.905 ± 0.125	1.436LeuHis: 1.436 ± 0.046	2.926LeuIle: 2.926 ± 0.075	1.475LeuLys: 1.475 ± 0.048	9.225LeuLeu: 9.225 ± 0.163	1.282LeuMet: 1.282 ± 0.042	1.836LeuAsn: 1.836 ± 0.05	4.485LeuPro: 4.485 ± 0.077	2.12LeuGln: 2.12 ± 0.05	5.748LeuArg: 5.748 ± 0.087	5.618LeuSer: 5.618 ± 0.087	5.347LeuThr: 5.347 ± 0.089	8.022LeuVal: 8.022 ± 0.123	0.862LeuTrp: 0.862 ± 0.03	2.084LeuTyr: 2.084 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.035MetAla: 2.035 ± 0.051	0.092MetCys: 0.092 ± 0.009	1.196MetAsp: 1.196 ± 0.038	1.154MetGlu: 1.154 ± 0.038	0.579MetPhe: 0.579 ± 0.028	1.529MetGly: 1.529 ± 0.048	0.342MetHis: 0.342 ± 0.017	0.65MetIle: 0.65 ± 0.027	0.405MetLys: 0.405 ± 0.023	1.692MetLeu: 1.692 ± 0.05	0.292MetMet: 0.292 ± 0.021	0.547MetAsn: 0.547 ± 0.026	0.878MetPro: 0.878 ± 0.03	0.541MetGln: 0.541 ± 0.024	1.099MetArg: 1.099 ± 0.039	1.511MetSer: 1.511 ± 0.034	1.455MetThr: 1.455 ± 0.038	1.34MetVal: 1.34 ± 0.038	0.175MetTrp: 0.175 ± 0.015	0.384MetTyr: 0.384 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.574AsnAla: 2.574 ± 0.057	0.223AsnCys: 0.223 ± 0.017	1.568AsnAsp: 1.568 ± 0.052	1.651AsnGlu: 1.651 ± 0.051	0.614AsnPhe: 0.614 ± 0.027	1.82AsnGly: 1.82 ± 0.052	0.424AsnHis: 0.424 ± 0.021	0.743AsnIle: 0.743 ± 0.03	0.408AsnLys: 0.408 ± 0.023	1.707AsnLeu: 1.707 ± 0.046	0.403AsnMet: 0.403 ± 0.025	0.537AsnAsn: 0.537 ± 0.033	1.506AsnPro: 1.506 ± 0.043	0.557AsnGln: 0.557 ± 0.029	1.499AsnArg: 1.499 ± 0.043	1.078AsnSer: 1.078 ± 0.043	1.251AsnThr: 1.251 ± 0.041	2.208AsnVal: 2.208 ± 0.061	0.31AsnTrp: 0.31 ± 0.02	0.658AsnTyr: 0.658 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.769ProAla: 5.769 ± 0.093	0.279ProCys: 0.279 ± 0.02	4.657ProAsp: 4.657 ± 0.083	4.936ProGlu: 4.936 ± 0.091	1.604ProPhe: 1.604 ± 0.047	4.208ProGly: 4.208 ± 0.063	0.867ProHis: 0.867 ± 0.033	1.864ProIle: 1.864 ± 0.038	0.795ProLys: 0.795 ± 0.029	3.563ProLeu: 3.563 ± 0.075	0.897ProMet: 0.897 ± 0.03	1.134ProAsn: 1.134 ± 0.04	2.505ProPro: 2.505 ± 0.051	0.988ProGln: 0.988 ± 0.033	2.815ProArg: 2.815 ± 0.072	2.995ProSer: 2.995 ± 0.061	3.802ProThr: 3.802 ± 0.073	4.209ProVal: 4.209 ± 0.069	0.558ProTrp: 0.558 ± 0.028	1.096ProTyr: 1.096 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.516GlnAla: 2.516 ± 0.059	0.155GlnCys: 0.155 ± 0.014	1.241GlnAsp: 1.241 ± 0.038	1.738GlnGlu: 1.738 ± 0.049	1.209GlnPhe: 1.209 ± 0.04	1.718GlnGly: 1.718 ± 0.047	0.551GlnHis: 0.551 ± 0.023	1.048GlnIle: 1.048 ± 0.036	0.519GlnLys: 0.519 ± 0.028	2.267GlnLeu: 2.267 ± 0.051	0.47GlnMet: 0.47 ± 0.026	0.661GlnAsn: 0.661 ± 0.03	1.2GlnPro: 1.2 ± 0.042	1.027GlnGln: 1.027 ± 0.044	2.071GlnArg: 2.071 ± 0.06	1.587GlnSer: 1.587 ± 0.044	1.432GlnThr: 1.432 ± 0.049	1.803GlnVal: 1.803 ± 0.045	0.329GlnTrp: 0.329 ± 0.02	0.824GlnTyr: 0.824 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	7.027ArgAla: 7.027 ± 0.11	0.727ArgCys: 0.727 ± 0.035	4.728ArgAsp: 4.728 ± 0.08	6.795ArgGlu: 6.795 ± 0.126	2.323ArgPhe: 2.323 ± 0.059	4.748ArgGly: 4.748 ± 0.077	1.239ArgHis: 1.239 ± 0.04	2.806ArgIle: 2.806 ± 0.059	1.366ArgLys: 1.366 ± 0.043	6.329ArgLeu: 6.329 ± 0.097	1.461ArgMet: 1.461 ± 0.04	1.613ArgAsn: 1.613 ± 0.047	3.056ArgPro: 3.056 ± 0.072	1.812ArgGln: 1.812 ± 0.051	6.123ArgArg: 6.123 ± 0.137	4.29ArgSer: 4.29 ± 0.087	4.13ArgThr: 4.13 ± 0.071	5.227ArgVal: 5.227 ± 0.083	0.924ArgTrp: 0.924 ± 0.037	1.888ArgTyr: 1.888 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.737SerAla: 5.737 ± 0.096	0.411SerCys: 0.411 ± 0.022	3.707SerAsp: 3.707 ± 0.079	4.031SerGlu: 4.031 ± 0.074	1.914SerPhe: 1.914 ± 0.052	5.281SerGly: 5.281 ± 0.097	1.081SerHis: 1.081 ± 0.031	2.37SerIle: 2.37 ± 0.061	1.054SerLys: 1.054 ± 0.036	5.001SerLeu: 5.001 ± 0.079	1.146SerMet: 1.146 ± 0.034	1.184SerAsn: 1.184 ± 0.041	3.255SerPro: 3.255 ± 0.065	1.308SerGln: 1.308 ± 0.046	3.907SerArg: 3.907 ± 0.077	3.559SerSer: 3.559 ± 0.086	4.115SerThr: 4.115 ± 0.084	5.039SerVal: 5.039 ± 0.081	0.706SerTrp: 0.706 ± 0.03	1.397SerTyr: 1.397 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.489ThrAla: 7.489 ± 0.097	0.433ThrCys: 0.433 ± 0.022	4.985ThrAsp: 4.985 ± 0.092	4.68ThrGlu: 4.68 ± 0.078	2.283ThrPhe: 2.283 ± 0.062	5.882ThrGly: 5.882 ± 0.09	1.149ThrHis: 1.149 ± 0.037	2.472ThrIle: 2.472 ± 0.052	0.953ThrLys: 0.953 ± 0.039	5.777ThrLeu: 5.777 ± 0.079	1.095ThrMet: 1.095 ± 0.041	1.368ThrAsn: 1.368 ± 0.043	3.824ThrPro: 3.824 ± 0.074	1.327ThrGln: 1.327 ± 0.044	3.633ThrArg: 3.633 ± 0.076	2.998ThrSer: 2.998 ± 0.073	4.426ThrThr: 4.426 ± 0.095	6.941ThrVal: 6.941 ± 0.106	0.686ThrTrp: 0.686 ± 0.03	1.567ThrTyr: 1.567 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	10.925ValAla: 10.925 ± 0.151	0.612ValCys: 0.612 ± 0.029	8.196ValAsp: 8.196 ± 0.101	7.511ValGlu: 7.511 ± 0.106	2.807ValPhe: 2.807 ± 0.061	8.151ValGly: 8.151 ± 0.115	1.592ValHis: 1.592 ± 0.04	2.943ValIle: 2.943 ± 0.067	1.25ValLys: 1.25 ± 0.044	7.775ValLeu: 7.775 ± 0.121	1.324ValMet: 1.324 ± 0.042	1.779ValAsn: 1.779 ± 0.047	4.319ValPro: 4.319 ± 0.071	1.876ValGln: 1.876 ± 0.046	5.462ValArg: 5.462 ± 0.082	4.877ValSer: 4.877 ± 0.083	5.813ValThr: 5.813 ± 0.087	9.154ValVal: 9.154 ± 0.113	0.867ValTrp: 0.867 ± 0.034	1.935ValTyr: 1.935 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.097TrpAla: 1.097 ± 0.036	0.109TrpCys: 0.109 ± 0.012	0.755TrpAsp: 0.755 ± 0.031	0.911TrpGlu: 0.911 ± 0.036	0.419TrpPhe: 0.419 ± 0.025	0.916TrpGly: 0.916 ± 0.03	0.285TrpHis: 0.285 ± 0.018	0.469TrpIle: 0.469 ± 0.024	0.264TrpLys: 0.264 ± 0.019	1.34TrpLeu: 1.34 ± 0.048	0.252TrpMet: 0.252 ± 0.021	0.326TrpAsn: 0.326 ± 0.023	0.497TrpPro: 0.497 ± 0.022	0.423TrpGln: 0.423 ± 0.025	0.937TrpArg: 0.937 ± 0.039	0.692TrpSer: 0.692 ± 0.033	0.824TrpThr: 0.824 ± 0.034	0.825TrpVal: 0.825 ± 0.039	0.198TrpTrp: 0.198 ± 0.016	0.362TrpTyr: 0.362 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.732TyrAla: 2.732 ± 0.054	0.236TyrCys: 0.236 ± 0.017	2.374TyrAsp: 2.374 ± 0.067	2.411TyrGlu: 2.411 ± 0.054	0.755TyrPhe: 0.755 ± 0.026	2.381TyrGly: 2.381 ± 0.056	0.56TyrHis: 0.56 ± 0.029	0.609TyrIle: 0.609 ± 0.027	0.379TyrLys: 0.379 ± 0.023	2.466TyrLeu: 2.466 ± 0.058	0.376TyrMet: 0.376 ± 0.022	0.528TyrAsn: 0.528 ± 0.029	1.19TyrPro: 1.19 ± 0.044	0.671TyrGln: 0.671 ± 0.029	1.904TyrArg: 1.904 ± 0.048	1.192TyrSer: 1.192 ± 0.037	1.341TyrThr: 1.341 ± 0.039	2.274TyrVal: 2.274 ± 0.057	0.318TyrTrp: 0.318 ± 0.02	0.767TyrTyr: 0.767 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3464 proteins (838665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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