Amino acid dipepetide frequency for Amphritea balenae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.82AlaAla: 8.82 ± 0.104
0.997AlaCys: 0.997 ± 0.033
5.561AlaAsp: 5.561 ± 0.152
6.467AlaGlu: 6.467 ± 0.11
3.122AlaPhe: 3.122 ± 0.063
7.226AlaGly: 7.226 ± 0.131
1.493AlaHis: 1.493 ± 0.04
5.649AlaIle: 5.649 ± 0.077
3.769AlaLys: 3.769 ± 0.072
9.669AlaLeu: 9.669 ± 0.138
2.536AlaMet: 2.536 ± 0.054
3.06AlaAsn: 3.06 ± 0.077
3.011AlaPro: 3.011 ± 0.068
3.665AlaGln: 3.665 ± 0.07
4.173AlaArg: 4.173 ± 0.094
5.211AlaSer: 5.211 ± 0.11
4.555AlaThr: 4.555 ± 0.135
6.481AlaVal: 6.481 ± 0.082
1.002AlaTrp: 1.002 ± 0.036
2.199AlaTyr: 2.199 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.843CysAla: 0.843 ± 0.03
0.192CysCys: 0.192 ± 0.013
0.628CysAsp: 0.628 ± 0.026
0.551CysGlu: 0.551 ± 0.028
0.457CysPhe: 0.457 ± 0.019
0.955CysGly: 0.955 ± 0.033
0.337CysHis: 0.337 ± 0.019
0.643CysIle: 0.643 ± 0.023
0.408CysLys: 0.408 ± 0.016
0.989CysLeu: 0.989 ± 0.035
0.226CysMet: 0.226 ± 0.015
0.419CysAsn: 0.419 ± 0.018
0.507CysPro: 0.507 ± 0.024
0.471CysGln: 0.471 ± 0.022
0.562CysArg: 0.562 ± 0.026
0.811CysSer: 0.811 ± 0.03
0.493CysThr: 0.493 ± 0.02
0.611CysVal: 0.611 ± 0.025
0.157CysTrp: 0.157 ± 0.011
0.342CysTyr: 0.342 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.853AspAla: 4.853 ± 0.157
0.584AspCys: 0.584 ± 0.02
3.44AspAsp: 3.44 ± 0.155
3.788AspGlu: 3.788 ± 0.074
2.259AspPhe: 2.259 ± 0.045
4.132AspGly: 4.132 ± 0.193
1.251AspHis: 1.251 ± 0.034
3.941AspIle: 3.941 ± 0.085
2.765AspLys: 2.765 ± 0.051
6.235AspLeu: 6.235 ± 0.118
1.447AspMet: 1.447 ± 0.033
2.465AspAsn: 2.465 ± 0.066
2.484AspPro: 2.484 ± 0.065
3.121AspGln: 3.121 ± 0.054
2.792AspArg: 2.792 ± 0.056
3.902AspSer: 3.902 ± 0.171
3.147AspThr: 3.147 ± 0.206
3.605AspVal: 3.605 ± 0.13
0.823AspTrp: 0.823 ± 0.027
1.93AspTyr: 1.93 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.435GluAla: 5.435 ± 0.085
0.489GluCys: 0.489 ± 0.021
2.948GluAsp: 2.948 ± 0.055
3.661GluGlu: 3.661 ± 0.082
2.218GluPhe: 2.218 ± 0.042
4.169GluGly: 4.169 ± 0.078
1.445GluHis: 1.445 ± 0.041
3.952GluIle: 3.952 ± 0.065
3.031GluLys: 3.031 ± 0.07
7.55GluLeu: 7.55 ± 0.115
1.735GluMet: 1.735 ± 0.048
2.381GluAsn: 2.381 ± 0.042
2.222GluPro: 2.222 ± 0.049
4.576GluGln: 4.576 ± 0.099
3.409GluArg: 3.409 ± 0.072
3.658GluSer: 3.658 ± 0.063
3.222GluThr: 3.222 ± 0.06
4.199GluVal: 4.199 ± 0.056
0.725GluTrp: 0.725 ± 0.023
1.66GluTyr: 1.66 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.097PheAla: 3.097 ± 0.051
0.525PheCys: 0.525 ± 0.024
2.652PheAsp: 2.652 ± 0.055
2.246PheGlu: 2.246 ± 0.05
1.633PhePhe: 1.633 ± 0.048
3.141PheGly: 3.141 ± 0.069
0.737PheHis: 0.737 ± 0.028
2.678PheIle: 2.678 ± 0.061
1.612PheLys: 1.612 ± 0.04
3.345PheLeu: 3.345 ± 0.074
0.968PheMet: 0.968 ± 0.029
1.868PheAsn: 1.868 ± 0.038
1.438PhePro: 1.438 ± 0.04
1.271PheGln: 1.271 ± 0.036
1.666PheArg: 1.666 ± 0.038
3.267PheSer: 3.267 ± 0.071
2.282PheThr: 2.282 ± 0.111
2.412PheVal: 2.412 ± 0.051
0.529PheTrp: 0.529 ± 0.025
1.301PheTyr: 1.301 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.902GlyAla: 5.902 ± 0.109
1.015GlyCys: 1.015 ± 0.034
4.354GlyAsp: 4.354 ± 0.222
4.391GlyGlu: 4.391 ± 0.073
3.429GlyPhe: 3.429 ± 0.053
5.418GlyGly: 5.418 ± 0.136
1.656GlyHis: 1.656 ± 0.044
4.906GlyIle: 4.906 ± 0.072
3.424GlyLys: 3.424 ± 0.067
7.806GlyLeu: 7.806 ± 0.08
2.171GlyMet: 2.171 ± 0.046
2.771GlyAsn: 2.771 ± 0.117
1.979GlyPro: 1.979 ± 0.044
3.085GlyGln: 3.085 ± 0.049
3.533GlyArg: 3.533 ± 0.06
4.769GlySer: 4.769 ± 0.126
3.884GlyThr: 3.884 ± 0.186
5.299GlyVal: 5.299 ± 0.088
1.081GlyTrp: 1.081 ± 0.034
2.554GlyTyr: 2.554 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.496HisAla: 1.496 ± 0.041
0.302HisCys: 0.302 ± 0.016
1.055HisAsp: 1.055 ± 0.028
1.061HisGlu: 1.061 ± 0.036
0.923HisPhe: 0.923 ± 0.031
1.435HisGly: 1.435 ± 0.037
0.609HisHis: 0.609 ± 0.024
1.304HisIle: 1.304 ± 0.033
0.968HisLys: 0.968 ± 0.032
2.161HisLeu: 2.161 ± 0.049
0.547HisMet: 0.547 ± 0.025
0.851HisAsn: 0.851 ± 0.023
1.219HisPro: 1.219 ± 0.038
1.143HisGln: 1.143 ± 0.04
1.159HisArg: 1.159 ± 0.034
1.415HisSer: 1.415 ± 0.043
0.939HisThr: 0.939 ± 0.033
0.992HisVal: 0.992 ± 0.029
0.367HisTrp: 0.367 ± 0.019
0.793HisTyr: 0.793 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.138IleAla: 6.138 ± 0.084
0.781IleCys: 0.781 ± 0.033
4.227IleAsp: 4.227 ± 0.082
4.357IleGlu: 4.357 ± 0.068
2.062IlePhe: 2.062 ± 0.047
4.57IleGly: 4.57 ± 0.081
1.212IleHis: 1.212 ± 0.035
3.591IleIle: 3.591 ± 0.07
2.87IleLys: 2.87 ± 0.067
5.362IleLeu: 5.362 ± 0.09
1.318IleMet: 1.318 ± 0.035
2.923IleAsn: 2.923 ± 0.055
2.819IlePro: 2.819 ± 0.053
2.242IleGln: 2.242 ± 0.053
3.266IleArg: 3.266 ± 0.067
4.968IleSer: 4.968 ± 0.096
3.721IleThr: 3.721 ± 0.114
3.865IleVal: 3.865 ± 0.063
0.673IleTrp: 0.673 ± 0.024
1.661IleTyr: 1.661 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.258LysAla: 4.258 ± 0.078
0.293LysCys: 0.293 ± 0.017
2.236LysAsp: 2.236 ± 0.045
2.726LysGlu: 2.726 ± 0.067
1.209LysPhe: 1.209 ± 0.032
3.129LysGly: 3.129 ± 0.062
0.972LysHis: 0.972 ± 0.032
2.566LysIle: 2.566 ± 0.064
2.329LysLys: 2.329 ± 0.058
4.616LysLeu: 4.616 ± 0.07
1.223LysMet: 1.223 ± 0.037
1.64LysAsn: 1.64 ± 0.045
2.256LysPro: 2.256 ± 0.05
2.728LysGln: 2.728 ± 0.065
2.436LysArg: 2.436 ± 0.062
2.539LysSer: 2.539 ± 0.054
2.408LysThr: 2.408 ± 0.047
3.246LysVal: 3.246 ± 0.058
0.399LysTrp: 0.399 ± 0.017
1.077LysTyr: 1.077 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
9.717LeuAla: 9.717 ± 0.134
1.141LeuCys: 1.141 ± 0.037
6.04LeuAsp: 6.04 ± 0.081
6.412LeuGlu: 6.412 ± 0.098
4.352LeuPhe: 4.352 ± 0.091
7.168LeuGly: 7.168 ± 0.087
2.025LeuHis: 2.025 ± 0.044
6.969LeuIle: 6.969 ± 0.103
5.115LeuLys: 5.115 ± 0.098
11.676LeuLeu: 11.676 ± 0.217
2.84LeuMet: 2.84 ± 0.058
4.837LeuAsn: 4.837 ± 0.072
4.983LeuPro: 4.983 ± 0.071
4.795LeuGln: 4.795 ± 0.093
4.792LeuArg: 4.792 ± 0.085
7.991LeuSer: 7.991 ± 0.092
5.974LeuThr: 5.974 ± 0.109
6.711LeuVal: 6.711 ± 0.097
1.06LeuTrp: 1.06 ± 0.038
2.674LeuTyr: 2.674 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.614MetAla: 2.614 ± 0.054
0.179MetCys: 0.179 ± 0.012
1.367MetAsp: 1.367 ± 0.041
1.346MetGlu: 1.346 ± 0.037
0.906MetPhe: 0.906 ± 0.027
1.842MetGly: 1.842 ± 0.043
0.459MetHis: 0.459 ± 0.019
1.572MetIle: 1.572 ± 0.043
1.277MetLys: 1.277 ± 0.038
2.923MetLeu: 2.923 ± 0.069
0.781MetMet: 0.781 ± 0.028
1.125MetAsn: 1.125 ± 0.034
1.265MetPro: 1.265 ± 0.034
1.249MetGln: 1.249 ± 0.034
1.247MetArg: 1.247 ± 0.038
1.933MetSer: 1.933 ± 0.05
1.573MetThr: 1.573 ± 0.039
1.793MetVal: 1.793 ± 0.037
0.179MetTrp: 0.179 ± 0.011
0.445MetTyr: 0.445 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.059
0.466AsnCys: 0.466 ± 0.022
2.354AsnAsp: 2.354 ± 0.088
2.206AsnGlu: 2.206 ± 0.052
1.402AsnPhe: 1.402 ± 0.041
2.954AsnGly: 2.954 ± 0.097
0.833AsnHis: 0.833 ± 0.027
2.465AsnIle: 2.465 ± 0.04
1.813AsnLys: 1.813 ± 0.047
3.944AsnLeu: 3.944 ± 0.062
0.933AsnMet: 0.933 ± 0.029
1.828AsnAsn: 1.828 ± 0.039
2.091AsnPro: 2.091 ± 0.054
1.897AsnGln: 1.897 ± 0.04
2.218AsnArg: 2.218 ± 0.05
2.694AsnSer: 2.694 ± 0.049
2.181AsnThr: 2.181 ± 0.059
2.195AsnVal: 2.195 ± 0.062
0.637AsnTrp: 0.637 ± 0.044
1.212AsnTyr: 1.212 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
3.951ProAla: 3.951 ± 0.097
0.335ProCys: 0.335 ± 0.018
3.052ProAsp: 3.052 ± 0.053
3.757ProGlu: 3.757 ± 0.06
1.621ProPhe: 1.621 ± 0.04
3.104ProGly: 3.104 ± 0.058
0.798ProHis: 0.798 ± 0.028
2.056ProIle: 2.056 ± 0.04
1.614ProLys: 1.614 ± 0.042
4.29ProLeu: 4.29 ± 0.07
1.024ProMet: 1.024 ± 0.031
1.275ProAsn: 1.275 ± 0.03
1.297ProPro: 1.297 ± 0.033
1.739ProGln: 1.739 ± 0.045
1.505ProArg: 1.505 ± 0.037
2.126ProSer: 2.126 ± 0.043
2.002ProThr: 2.002 ± 0.076
3.853ProVal: 3.853 ± 0.076
0.474ProTrp: 0.474 ± 0.022
1.152ProTyr: 1.152 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.489GlnAla: 4.489 ± 0.081
0.389GlnCys: 0.389 ± 0.017
2.102GlnAsp: 2.102 ± 0.047
2.426GlnGlu: 2.426 ± 0.059
1.669GlnPhe: 1.669 ± 0.04
3.355GlnGly: 3.355 ± 0.053
1.194GlnHis: 1.194 ± 0.037
2.85GlnIle: 2.85 ± 0.053
1.846GlnLys: 1.846 ± 0.048
6.2GlnLeu: 6.2 ± 0.111
1.22GlnMet: 1.22 ± 0.034
1.619GlnAsn: 1.619 ± 0.037
2.107GlnPro: 2.107 ± 0.047
3.808GlnGln: 3.808 ± 0.096
2.771GlnArg: 2.771 ± 0.064
2.815GlnSer: 2.815 ± 0.047
2.124GlnThr: 2.124 ± 0.043
3.247GlnVal: 3.247 ± 0.068
0.618GlnTrp: 0.618 ± 0.024
1.233GlnTyr: 1.233 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.704ArgAla: 3.704 ± 0.072
0.564ArgCys: 0.564 ± 0.021
2.676ArgAsp: 2.676 ± 0.056
3.131ArgGlu: 3.131 ± 0.068
2.304ArgPhe: 2.304 ± 0.055
2.837ArgGly: 2.837 ± 0.056
1.154ArgHis: 1.154 ± 0.035
3.376ArgIle: 3.376 ± 0.058
2.373ArgLys: 2.373 ± 0.059
5.578ArgLeu: 5.578 ± 0.106
1.402ArgMet: 1.402 ± 0.041
1.978ArgAsn: 1.978 ± 0.044
1.802ArgPro: 1.802 ± 0.053
2.621ArgGln: 2.621 ± 0.058
2.724ArgArg: 2.724 ± 0.064
3.082ArgSer: 3.082 ± 0.066
2.29ArgThr: 2.29 ± 0.044
3.239ArgVal: 3.239 ± 0.064
0.715ArgTrp: 0.715 ± 0.027
1.844ArgTyr: 1.844 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.787SerAla: 5.787 ± 0.086
0.661SerCys: 0.661 ± 0.024
4.231SerAsp: 4.231 ± 0.179
4.169SerGlu: 4.169 ± 0.063
2.935SerPhe: 2.935 ± 0.1
5.76SerGly: 5.76 ± 0.125
1.387SerHis: 1.387 ± 0.032
3.889SerIle: 3.889 ± 0.073
2.542SerLys: 2.542 ± 0.057
7.039SerLeu: 7.039 ± 0.083
1.716SerMet: 1.716 ± 0.045
2.39SerAsn: 2.39 ± 0.065
2.537SerPro: 2.537 ± 0.05
2.695SerGln: 2.695 ± 0.057
3.239SerArg: 3.239 ± 0.069
4.458SerSer: 4.458 ± 0.068
3.139SerThr: 3.139 ± 0.083
4.721SerVal: 4.721 ± 0.099
0.896SerTrp: 0.896 ± 0.028
2.044SerTyr: 2.044 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.025ThrAla: 5.025 ± 0.132
0.474ThrCys: 0.474 ± 0.021
3.635ThrAsp: 3.635 ± 0.243
3.582ThrGlu: 3.582 ± 0.061
1.86ThrPhe: 1.86 ± 0.063
4.889ThrGly: 4.889 ± 0.191
0.955ThrHis: 0.955 ± 0.027
3.143ThrIle: 3.143 ± 0.096
1.76ThrLys: 1.76 ± 0.042
6.003ThrLeu: 6.003 ± 0.117
1.128ThrMet: 1.128 ± 0.029
1.773ThrAsn: 1.773 ± 0.08
2.707ThrPro: 2.707 ± 0.092
2.094ThrGln: 2.094 ± 0.069
2.357ThrArg: 2.357 ± 0.044
3.061ThrSer: 3.061 ± 0.07
2.925ThrThr: 2.925 ± 0.135
3.998ThrVal: 3.998 ± 0.232
0.493ThrTrp: 0.493 ± 0.023
1.398ThrTyr: 1.398 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
6.446ValAla: 6.446 ± 0.084
0.696ValCys: 0.696 ± 0.027
4.18ValAsp: 4.18 ± 0.138
4.387ValGlu: 4.387 ± 0.06
2.494ValPhe: 2.494 ± 0.048
4.51ValGly: 4.51 ± 0.071
1.19ValHis: 1.19 ± 0.034
4.739ValIle: 4.739 ± 0.067
3.105ValLys: 3.105 ± 0.059
6.867ValLeu: 6.867 ± 0.087
1.916ValMet: 1.916 ± 0.051
2.771ValAsn: 2.771 ± 0.06
2.527ValPro: 2.527 ± 0.043
2.327ValGln: 2.327 ± 0.044
3.098ValArg: 3.098 ± 0.065
4.669ValSer: 4.669 ± 0.073
4.414ValThr: 4.414 ± 0.266
5.064ValVal: 5.064 ± 0.08
0.737ValTrp: 0.737 ± 0.026
1.699ValTyr: 1.699 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.819TrpAla: 0.819 ± 0.026
0.158TrpCys: 0.158 ± 0.01
0.586TrpAsp: 0.586 ± 0.022
0.515TrpGlu: 0.515 ± 0.02
0.589TrpPhe: 0.589 ± 0.035
0.777TrpGly: 0.777 ± 0.031
0.344TrpHis: 0.344 ± 0.022
0.728TrpIle: 0.728 ± 0.027
0.461TrpLys: 0.461 ± 0.02
1.687TrpLeu: 1.687 ± 0.053
0.323TrpMet: 0.323 ± 0.014
0.493TrpAsn: 0.493 ± 0.02
0.495TrpPro: 0.495 ± 0.023
0.899TrpGln: 0.899 ± 0.031
0.652TrpArg: 0.652 ± 0.025
0.79TrpSer: 0.79 ± 0.031
0.503TrpThr: 0.503 ± 0.036
0.803TrpVal: 0.803 ± 0.024
0.171TrpTrp: 0.171 ± 0.014
0.338TrpTyr: 0.338 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.06TyrAla: 2.06 ± 0.042
0.364TyrCys: 0.364 ± 0.016
1.639TyrAsp: 1.639 ± 0.04
1.506TyrGlu: 1.506 ± 0.042
1.226TyrPhe: 1.226 ± 0.055
2.055TyrGly: 2.055 ± 0.045
0.688TyrHis: 0.688 ± 0.026
1.608TyrIle: 1.608 ± 0.038
1.204TyrLys: 1.204 ± 0.035
3.327TyrLeu: 3.327 ± 0.061
0.62TyrMet: 0.62 ± 0.024
1.067TyrAsn: 1.067 ± 0.027
1.279TyrPro: 1.279 ± 0.038
1.658TyrGln: 1.658 ± 0.039
1.797TyrArg: 1.797 ± 0.043
2.077TyrSer: 2.077 ± 0.057
1.483TyrThr: 1.483 ± 0.068
1.501TyrVal: 1.501 ± 0.033
0.397TyrTrp: 0.397 ± 0.018
0.934TyrTyr: 0.934 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4082 proteins (1376603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski