Amino acid dipepetide frequency for Geosporobacter subterraneus DSM 17957

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.908AlaAla: 6.908 ± 0.107	0.832AlaCys: 0.832 ± 0.03	3.31AlaAsp: 3.31 ± 0.062	4.85AlaGlu: 4.85 ± 0.074	3.102AlaPhe: 3.102 ± 0.053	5.372AlaGly: 5.372 ± 0.084	1.197AlaHis: 1.197 ± 0.035	5.836AlaIle: 5.836 ± 0.085	4.833AlaLys: 4.833 ± 0.076	7.48AlaLeu: 7.48 ± 0.088	2.279AlaMet: 2.279 ± 0.047	2.549AlaAsn: 2.549 ± 0.045	2.026AlaPro: 2.026 ± 0.047	2.394AlaGln: 2.394 ± 0.047	2.812AlaArg: 2.812 ± 0.058	3.718AlaSer: 3.718 ± 0.065	3.008AlaThr: 3.008 ± 0.061	6.039AlaVal: 6.039 ± 0.085	0.46AlaTrp: 0.46 ± 0.022	2.533AlaTyr: 2.533 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.602CysAla: 0.602 ± 0.026	0.186CysCys: 0.186 ± 0.017	0.529CysAsp: 0.529 ± 0.025	0.692CysGlu: 0.692 ± 0.027	0.412CysPhe: 0.412 ± 0.02	1.002CysGly: 1.002 ± 0.034	0.245CysHis: 0.245 ± 0.016	0.964CysIle: 0.964 ± 0.032	0.637CysLys: 0.637 ± 0.026	0.749CysLeu: 0.749 ± 0.026	0.31CysMet: 0.31 ± 0.018	0.436CysAsn: 0.436 ± 0.018	0.506CysPro: 0.506 ± 0.022	0.274CysGln: 0.274 ± 0.015	0.528CysArg: 0.528 ± 0.025	0.683CysSer: 0.683 ± 0.026	0.506CysThr: 0.506 ± 0.021	0.59CysVal: 0.59 ± 0.025	0.084CysTrp: 0.084 ± 0.008	0.366CysTyr: 0.366 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.475AspAla: 3.475 ± 0.056	0.543AspCys: 0.543 ± 0.025	2.05AspAsp: 2.05 ± 0.049	3.903AspGlu: 3.903 ± 0.057	2.499AspPhe: 2.499 ± 0.05	3.168AspGly: 3.168 ± 0.064	1.112AspHis: 1.112 ± 0.032	5.047AspIle: 5.047 ± 0.066	3.618AspLys: 3.618 ± 0.06	5.082AspLeu: 5.082 ± 0.068	1.572AspMet: 1.572 ± 0.041	1.89AspAsn: 1.89 ± 0.043	1.814AspPro: 1.814 ± 0.049	1.889AspGln: 1.889 ± 0.045	2.57AspArg: 2.57 ± 0.051	2.336AspSer: 2.336 ± 0.045	2.594AspThr: 2.594 ± 0.054	3.387AspVal: 3.387 ± 0.06	0.474AspTrp: 0.474 ± 0.024	2.23AspTyr: 2.23 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.731GluAla: 5.731 ± 0.08	0.488GluCys: 0.488 ± 0.022	4.189GluAsp: 4.189 ± 0.071	6.975GluGlu: 6.975 ± 0.11	2.263GluPhe: 2.263 ± 0.048	4.829GluGly: 4.829 ± 0.072	1.253GluHis: 1.253 ± 0.038	7.04GluIle: 7.04 ± 0.09	7.392GluLys: 7.392 ± 0.114	6.628GluLeu: 6.628 ± 0.084	2.364GluMet: 2.364 ± 0.046	3.956GluAsn: 3.956 ± 0.058	1.843GluPro: 1.843 ± 0.048	2.719GluGln: 2.719 ± 0.063	3.511GluArg: 3.511 ± 0.064	3.215GluSer: 3.215 ± 0.058	3.406GluThr: 3.406 ± 0.059	5.013GluVal: 5.013 ± 0.062	0.5GluTrp: 0.5 ± 0.022	2.491GluTyr: 2.491 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.633PheAla: 2.633 ± 0.046	0.448PheCys: 0.448 ± 0.018	2.269PheAsp: 2.269 ± 0.044	2.669PheGlu: 2.669 ± 0.048	1.897PhePhe: 1.897 ± 0.049	3.018PheGly: 3.018 ± 0.064	0.854PheHis: 0.854 ± 0.029	3.739PheIle: 3.739 ± 0.063	2.419PheLys: 2.419 ± 0.048	3.725PheLeu: 3.725 ± 0.07	1.214PheMet: 1.214 ± 0.036	1.76PheAsn: 1.76 ± 0.044	1.349PhePro: 1.349 ± 0.033	1.479PheGln: 1.479 ± 0.037	1.621PheArg: 1.621 ± 0.04	2.702PheSer: 2.702 ± 0.057	2.256PheThr: 2.256 ± 0.051	2.663PheVal: 2.663 ± 0.052	0.29PheTrp: 0.29 ± 0.02	1.514PheTyr: 1.514 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.053GlyAla: 5.053 ± 0.088	0.937GlyCys: 0.937 ± 0.034	3.465GlyAsp: 3.465 ± 0.061	4.647GlyGlu: 4.647 ± 0.067	3.297GlyPhe: 3.297 ± 0.063	4.922GlyGly: 4.922 ± 0.101	1.278GlyHis: 1.278 ± 0.041	7.157GlyIle: 7.157 ± 0.101	5.633GlyLys: 5.633 ± 0.077	6.648GlyLeu: 6.648 ± 0.088	2.181GlyMet: 2.181 ± 0.051	2.972GlyAsn: 2.972 ± 0.059	1.589GlyPro: 1.589 ± 0.039	2.078GlyGln: 2.078 ± 0.043	2.928GlyArg: 2.928 ± 0.052	3.814GlySer: 3.814 ± 0.064	3.96GlyThr: 3.96 ± 0.077	4.906GlyVal: 4.906 ± 0.076	0.583GlyTrp: 0.583 ± 0.024	3.003GlyTyr: 3.003 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.069HisAla: 1.069 ± 0.028	0.228HisCys: 0.228 ± 0.013	0.816HisAsp: 0.816 ± 0.027	1.247HisGlu: 1.247 ± 0.035	0.826HisPhe: 0.826 ± 0.032	1.339HisGly: 1.339 ± 0.038	0.535HisHis: 0.535 ± 0.024	1.712HisIle: 1.712 ± 0.043	1.227HisLys: 1.227 ± 0.032	1.777HisLeu: 1.777 ± 0.042	0.559HisMet: 0.559 ± 0.023	0.791HisAsn: 0.791 ± 0.027	0.946HisPro: 0.946 ± 0.032	0.808HisGln: 0.808 ± 0.025	0.981HisArg: 0.981 ± 0.031	1.029HisSer: 1.029 ± 0.035	0.929HisThr: 0.929 ± 0.032	1.097HisVal: 1.097 ± 0.033	0.17HisTrp: 0.17 ± 0.013	0.799HisTyr: 0.799 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.552IleAla: 6.552 ± 0.083	0.929IleCys: 0.929 ± 0.031	5.088IleAsp: 5.088 ± 0.07	6.796IleGlu: 6.796 ± 0.097	3.481IlePhe: 3.481 ± 0.064	6.404IleGly: 6.404 ± 0.094	1.885IleHis: 1.885 ± 0.047	6.897IleIle: 6.897 ± 0.092	5.803IleLys: 5.803 ± 0.074	8.706IleLeu: 8.706 ± 0.101	2.15IleMet: 2.15 ± 0.046	3.669IleAsn: 3.669 ± 0.061	3.669IlePro: 3.669 ± 0.06	3.279IleGln: 3.279 ± 0.052	4.083IleArg: 4.083 ± 0.066	5.299IleSer: 5.299 ± 0.068	4.593IleThr: 4.593 ± 0.07	5.508IleVal: 5.508 ± 0.076	0.527IleTrp: 0.527 ± 0.023	2.925IleTyr: 2.925 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.418LysAla: 5.418 ± 0.073	0.553LysCys: 0.553 ± 0.025	4.307LysAsp: 4.307 ± 0.069	6.855LysGlu: 6.855 ± 0.087	1.988LysPhe: 1.988 ± 0.042	5.062LysGly: 5.062 ± 0.065	1.249LysHis: 1.249 ± 0.038	6.43LysIle: 6.43 ± 0.079	6.061LysLys: 6.061 ± 0.101	6.267LysLeu: 6.267 ± 0.079	2.331LysMet: 2.331 ± 0.044	3.925LysAsn: 3.925 ± 0.071	2.329LysPro: 2.329 ± 0.043	2.571LysGln: 2.571 ± 0.048	3.174LysArg: 3.174 ± 0.052	3.597LysSer: 3.597 ± 0.057	3.664LysThr: 3.664 ± 0.056	4.896LysVal: 4.896 ± 0.079	0.499LysTrp: 0.499 ± 0.023	2.727LysTyr: 2.727 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.566LeuAla: 6.566 ± 0.085	1.034LeuCys: 1.034 ± 0.032	4.875LeuAsp: 4.875 ± 0.067	7.308LeuGlu: 7.308 ± 0.088	3.963LeuPhe: 3.963 ± 0.076	6.938LeuGly: 6.938 ± 0.092	1.699LeuHis: 1.699 ± 0.036	7.241LeuIle: 7.241 ± 0.089	7.413LeuLys: 7.413 ± 0.088	9.644LeuLeu: 9.644 ± 0.107	2.85LeuMet: 2.85 ± 0.05	4.268LeuAsn: 4.268 ± 0.062	3.429LeuPro: 3.429 ± 0.064	3.429LeuGln: 3.429 ± 0.059	4.087LeuArg: 4.087 ± 0.059	6.243LeuSer: 6.243 ± 0.082	4.758LeuThr: 4.758 ± 0.074	5.816LeuVal: 5.816 ± 0.074	0.737LeuTrp: 0.737 ± 0.03	3.128LeuTyr: 3.128 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.325MetAla: 2.325 ± 0.045	0.204MetCys: 0.204 ± 0.016	1.743MetAsp: 1.743 ± 0.042	2.54MetGlu: 2.54 ± 0.05	0.883MetPhe: 0.883 ± 0.03	2.319MetGly: 2.319 ± 0.055	0.461MetHis: 0.461 ± 0.018	2.601MetIle: 2.601 ± 0.041	2.542MetLys: 2.542 ± 0.046	2.635MetLeu: 2.635 ± 0.056	0.994MetMet: 0.994 ± 0.034	1.532MetAsn: 1.532 ± 0.047	1.052MetPro: 1.052 ± 0.037	0.897MetGln: 0.897 ± 0.029	1.19MetArg: 1.19 ± 0.033	1.522MetSer: 1.522 ± 0.037	1.493MetThr: 1.493 ± 0.037	2.016MetVal: 2.016 ± 0.048	0.162MetTrp: 0.162 ± 0.011	0.689MetTyr: 0.689 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.746AsnAla: 2.746 ± 0.058	0.491AsnCys: 0.491 ± 0.022	1.774AsnAsp: 1.774 ± 0.041	2.712AsnGlu: 2.712 ± 0.047	1.637AsnPhe: 1.637 ± 0.036	2.778AsnGly: 2.778 ± 0.053	0.975AsnHis: 0.975 ± 0.025	4.593AsnIle: 4.593 ± 0.072	3.025AsnLys: 3.025 ± 0.058	4.324AsnLeu: 4.324 ± 0.074	1.343AsnMet: 1.343 ± 0.035	2.044AsnAsn: 2.044 ± 0.047	2.265AsnPro: 2.265 ± 0.046	1.736AsnGln: 1.736 ± 0.048	2.343AsnArg: 2.343 ± 0.053	2.195AsnSer: 2.195 ± 0.049	2.347AsnThr: 2.347 ± 0.054	2.699AsnVal: 2.699 ± 0.052	0.361AsnTrp: 0.361 ± 0.018	1.71AsnTyr: 1.71 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.317ProAla: 2.317 ± 0.058	0.352ProCys: 0.352 ± 0.018	1.832ProAsp: 1.832 ± 0.048	2.925ProGlu: 2.925 ± 0.064	1.55ProPhe: 1.55 ± 0.038	2.471ProGly: 2.471 ± 0.054	0.712ProHis: 0.712 ± 0.025	2.905ProIle: 2.905 ± 0.054	2.291ProLys: 2.291 ± 0.049	3.14ProLeu: 3.14 ± 0.055	0.929ProMet: 0.929 ± 0.027	1.35ProAsn: 1.35 ± 0.034	1.042ProPro: 1.042 ± 0.042	1.27ProGln: 1.27 ± 0.035	1.162ProArg: 1.162 ± 0.032	1.807ProSer: 1.807 ± 0.042	1.724ProThr: 1.724 ± 0.042	2.768ProVal: 2.768 ± 0.049	0.333ProTrp: 0.333 ± 0.017	1.386ProTyr: 1.386 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.351GlnAla: 2.351 ± 0.044	0.314GlnCys: 0.314 ± 0.018	1.715GlnAsp: 1.715 ± 0.046	3.043GlnGlu: 3.043 ± 0.057	1.177GlnPhe: 1.177 ± 0.034	2.256GlnGly: 2.256 ± 0.05	0.648GlnHis: 0.648 ± 0.025	2.997GlnIle: 2.997 ± 0.054	2.757GlnLys: 2.757 ± 0.052	3.338GlnLeu: 3.338 ± 0.065	1.142GlnMet: 1.142 ± 0.034	1.601GlnAsn: 1.601 ± 0.038	1.023GlnPro: 1.023 ± 0.033	1.658GlnGln: 1.658 ± 0.056	1.686GlnArg: 1.686 ± 0.038	1.79GlnSer: 1.79 ± 0.045	1.498GlnThr: 1.498 ± 0.039	2.296GlnVal: 2.296 ± 0.045	0.405GlnTrp: 0.405 ± 0.019	1.381GlnTyr: 1.381 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.756ArgAla: 2.756 ± 0.055	0.448ArgCys: 0.448 ± 0.02	2.302ArgAsp: 2.302 ± 0.049	3.79ArgGlu: 3.79 ± 0.066	1.853ArgPhe: 1.853 ± 0.047	2.739ArgGly: 2.739 ± 0.051	0.705ArgHis: 0.705 ± 0.027	4.142ArgIle: 4.142 ± 0.061	3.495ArgLys: 3.495 ± 0.056	4.28ArgLeu: 4.28 ± 0.059	1.397ArgMet: 1.397 ± 0.037	2.103ArgAsn: 2.103 ± 0.047	1.307ArgPro: 1.307 ± 0.039	1.678ArgGln: 1.678 ± 0.043	2.088ArgArg: 2.088 ± 0.05	2.068ArgSer: 2.068 ± 0.044	1.956ArgThr: 1.956 ± 0.042	2.892ArgVal: 2.892 ± 0.053	0.371ArgTrp: 0.371 ± 0.017	1.679ArgTyr: 1.679 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.485SerAla: 3.485 ± 0.053	0.623SerCys: 0.623 ± 0.022	2.408SerAsp: 2.408 ± 0.045	3.401SerGlu: 3.401 ± 0.057	2.675SerPhe: 2.675 ± 0.054	4.193SerGly: 4.193 ± 0.085	1.034SerHis: 1.034 ± 0.033	5.243SerIle: 5.243 ± 0.074	3.83SerLys: 3.83 ± 0.064	5.418SerLeu: 5.418 ± 0.079	1.74SerMet: 1.74 ± 0.038	2.272SerAsn: 2.272 ± 0.045	1.904SerPro: 1.904 ± 0.043	1.726SerGln: 1.726 ± 0.043	2.35SerArg: 2.35 ± 0.048	3.3SerSer: 3.3 ± 0.059	2.655SerThr: 2.655 ± 0.054	3.592SerVal: 3.592 ± 0.062	0.425SerTrp: 0.425 ± 0.022	2.059SerTyr: 2.059 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.166ThrAla: 4.166 ± 0.061	0.438ThrCys: 0.438 ± 0.02	2.431ThrAsp: 2.431 ± 0.051	3.279ThrGlu: 3.279 ± 0.056	1.979ThrPhe: 1.979 ± 0.044	4.281ThrGly: 4.281 ± 0.069	0.91ThrHis: 0.91 ± 0.03	4.297ThrIle: 4.297 ± 0.075	3.116ThrLys: 3.116 ± 0.054	4.893ThrLeu: 4.893 ± 0.077	1.288ThrMet: 1.288 ± 0.035	1.993ThrAsn: 1.993 ± 0.044	2.117ThrPro: 2.117 ± 0.043	1.439ThrGln: 1.439 ± 0.034	1.899ThrArg: 1.899 ± 0.042	2.584ThrSer: 2.584 ± 0.049	2.671ThrThr: 2.671 ± 0.065	3.793ThrVal: 3.793 ± 0.06	0.382ThrTrp: 0.382 ± 0.018	1.725ThrTyr: 1.725 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.638ValAla: 4.638 ± 0.072	0.719ValCys: 0.719 ± 0.031	3.769ValAsp: 3.769 ± 0.061	5.156ValGlu: 5.156 ± 0.072	2.997ValPhe: 2.997 ± 0.059	4.68ValGly: 4.68 ± 0.081	1.114ValHis: 1.114 ± 0.034	5.77ValIle: 5.77 ± 0.077	4.96ValLys: 4.96 ± 0.069	6.567ValLeu: 6.567 ± 0.076	1.87ValMet: 1.87 ± 0.043	2.94ValAsn: 2.94 ± 0.055	2.453ValPro: 2.453 ± 0.05	2.033ValGln: 2.033 ± 0.042	2.712ValArg: 2.712 ± 0.052	3.987ValSer: 3.987 ± 0.062	3.443ValThr: 3.443 ± 0.06	4.879ValVal: 4.879 ± 0.082	0.476ValTrp: 0.476 ± 0.022	2.379ValTyr: 2.379 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.498TrpAla: 0.498 ± 0.024	0.079TrpCys: 0.079 ± 0.008	0.406TrpAsp: 0.406 ± 0.02	0.508TrpGlu: 0.508 ± 0.021	0.348TrpPhe: 0.348 ± 0.018	0.567TrpGly: 0.567 ± 0.025	0.136TrpHis: 0.136 ± 0.011	0.701TrpIle: 0.701 ± 0.029	0.529TrpLys: 0.529 ± 0.024	0.694TrpLeu: 0.694 ± 0.025	0.294TrpMet: 0.294 ± 0.018	0.439TrpAsn: 0.439 ± 0.021	0.187TrpPro: 0.187 ± 0.014	0.299TrpGln: 0.299 ± 0.015	0.334TrpArg: 0.334 ± 0.018	0.388TrpSer: 0.388 ± 0.021	0.373TrpThr: 0.373 ± 0.019	0.505TrpVal: 0.505 ± 0.025	0.096TrpTrp: 0.096 ± 0.011	0.255TrpTyr: 0.255 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.248TyrAla: 2.248 ± 0.048	0.454TyrCys: 0.454 ± 0.021	1.973TyrAsp: 1.973 ± 0.045	2.511TyrGlu: 2.511 ± 0.05	1.692TyrPhe: 1.692 ± 0.042	2.715TyrGly: 2.715 ± 0.057	0.883TyrHis: 0.883 ± 0.028	2.931TyrIle: 2.931 ± 0.051	2.324TyrLys: 2.324 ± 0.05	3.429TyrLeu: 3.429 ± 0.063	0.991TyrMet: 0.991 ± 0.029	1.609TyrAsn: 1.609 ± 0.037	1.417TyrPro: 1.417 ± 0.038	1.422TyrGln: 1.422 ± 0.032	1.992TyrArg: 1.992 ± 0.043	2.058TyrSer: 2.058 ± 0.037	1.848TyrThr: 1.848 ± 0.048	2.185TyrVal: 2.185 ± 0.045	0.303TyrTrp: 0.303 ± 0.019	1.607TyrTyr: 1.607 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3760 proteins (1097426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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